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| 1 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 2 | HBsAg loading on dendritic cells in patients with chronic hepatitis B: expressions of phenotypic molecules显示文摘BACKGROUND: The antigen reducing ability of dentritic cells (DCs), a kind of antigen presenting cells (APCs) initiating immune response, is associated with the specific immune tolerance of chronic hepatitis B(CHB) patients. However, the dysfunction of DCs can be possibly reversed by the stimulation of antigen peptides. In this study, DCs were cultured from peripheral blood monocytes (PBMCs) in patients with CHB in vitro, and the expression of phenotypic molecules on DCs loaded by different concentrations of HBsAg was observed. METHODS: Forty patients with CHB were divided randomly into 4 groups(10 patients in each group). PBMCs were isolated, and DCs were cultured after addition of granulocyte/macrophage colony-stimulating factor (GMCSF) and interleukin 4(IL-4). On the 9th day, DCs of the experimental groups were loaded at HBsAg concentrations of 2.5mg/L, 5mg/L and 10mg/L for 24 hours, whereas those of the control group were not loaded. An electron microscope was used to analyze the morphological changes of the DCs. The expression of phenotypic molecules on DCs in different groups was detected with flow cytometry. RESULTS: A combination of GM-CSF and IL-4 produced DCs from PBMCs in patients with CHB after being cultured for 9 days, whose morphological changes were tested by an electron microscope. The expression of phenotypic molecules on DCs in the control group was as low as CD83 (8.02±3.99)%, CD80(8.77±2.06)%, and MHC-DR (14.05±2.66)%. Loaded by different concentrations of HBsAg, the up-regulation of phenotypic molecules on DCs was found, with CD83(18.35±2.93)%, CD80(42.63±7.15)% and MHC-DR(47.49±6.59)% in 2.5mg/L HBsAg loading group, CD83(17.88±3.12)%, CD80(45.24± 10.93)% and MHC-DR(47.07±8.52)% in 5mg/L HBsAg loading group and CD83(16.74±2.86)%, CD80(44.59±6.99)% and MHC-DR(48.59±7.42)% in 10mg/L HBsAg loading group, respectively. Compared with the control group, the phenotypic molecules in the experimental groups were all different significantly (P<0.01), but among them, there were no differences (P>0.05). CONCLUSIONS: DCs cultured from PBMCs in the patients with CHB under the conditions of GM-CSF and IL-4 present on the typical dendritic morphology but are immature for expressing low phenotypic molecules. Loaded by different concentrations of HBsAg, the immature DCs can differentiate to mature DCs for expressing increasing phenotypic molecules. | Hua-Sheng Tong, Yi Zhang, Keng Yuan and Xin-Wen Fu Institute for Digestive Disease, Affiliated Nanfang Hospital of Nanfang Medical University, Guangzhou 510515, China Department of Infectious Disease, First Affiliated Hospital of Jiangxi Medical College Key Oncolog’y Laboratory of Institute for Medical Science, Jiangxi Province and Department of Laboratory, Jiangxi Province People’s Hospital, Nanchang 330000, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，1： | 4 |
| 3 | Charged fermions tunneling radiation from the charged Gdel black hole in minimal five-dimensional gauged supergravity显示文摘In this paper,we extend fermions tunneling radiation to the case of five-dimensional charged black holes by introducing a set of appropriate matrices γμ for general covariant Dirac equation of 1/2 spin charged Dirac particles in the electromagnetic field.It is expected that our result can strengthen the validity and power of the tunneling method.We take the charged Gdel black holes in minimal five-dimensional gauged supergravity for example in order to present a reasonable extension of the tunneling method.As a result,we get fermions tunneling probability of the black hole and the Hawking temperature near the event horizon. | LI HuiLing* & DENG YFu College of Physics Science and Technology,Shenyang Normal University,Shenyang 110034,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 2 |
| 4 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 5 | Subcarrier and power allocation in OFDM-based relaying system显示文摘 | Fu Y and Zhu Q | 2012 | Journal of Computational Information Systems2012，7，21： | 1 |
| 6 | Generalized Vector Equilibrium Problems with Set-valued Mappings显示文摘 | Fu J Y and Wan A H | 2002 | Mathematical Methods of Operations Research2002，56，： | 1 |
| 7 | Fungal decolorization of dye wastewaters:a review显示文摘 | Fu Y Z and Viraraghavan T | 2001 | Bioresource Technology2001，79，3： | 1 |
| 8 | Contestability of the urban land market: an event study of Hong Kong land auctions显示文摘 | Ching S and Fu Y | 2003 | Regional Science and Urban Economics2003，33，6： | 1 |
| 9 | Efficient mining of association rules in distributed databases 显示文摘 | D Cheung V T Ng A Fu and Y Fu | 1996 | In IEEE Transactions on Knowledge and Data Engineering pages1996，123，： | 1 |
| 10 | Adaptive evolution of newly emerged micro-RNA genes in Drosophila显示文摘 | Lu J Fu Y Kumar S Shen Y Zeng K Xu A Carthew R and Wu C I | | 0，，05： | 1 |
| 11 | Effect ofdraw solution concentration and operating conditions on forwardosmosis and pressure retarded osmosis performance in a spiralwound module显示文摘 | Xu Y Peng X Y Tang C Y Y Fu Q S A and Nie S Z | 2010 | Journal of Membrane Science2010，348，12： | 1 |
| 12 | Glucose regulated protein in Cancer progression,drug resistance and immunotherapy显示文摘 | Fu Y and Lee AS | 2006 | Cancer Biol Ther2006，5，： | 1 |
| 13 | Contestability of theUrban land market: an event study of Hong Kong landauctions 显示文摘 | Ching S and Fu Y | 2003 | Regional Science and Urban Economics2003，，33： | 1 |
| 14 | Form and distribution characterization of reaction products at the brazing interface between Ni-Cr alloy and diamond显示文摘 | Xiao B Xu H J and Fu Y C | 2003 | Key Engineering Materials2003，，： | 1 |
| 15 | Adiponeetin promotes adipoeyte differentiation,insulin sensitivity, and lipid accumulation 显示文摘 | Fu Y Luo N and Kleinr L | 2005 | Journal of Lipid Research2005，46，7： | 1 |
| 16 | A new ranging method for OFDMA systems 显示文摘 | Fu X Li Y and Minn H | 2007 | IEEE Transactions on Wireless Communications2007，6，2： | 1 |
| 17 | A quantum chemistry approach for current- voltage characterization of molecular junction 显示文摘 | Wang C K Fu Y and Luo Y | 2001 | Physical Chemistry Chemical Physics2001，3，22： | 1 |
| 18 | RKIP sensitizes prostate and breast cancercells to drug-induced apoptosis显示文摘 | Chatterjee D Bai Y Wang Z Beach S Mott S Roy R Braastad C Sun Y Mukhopadhyay A Aggarwal B B Darnowski J Pantazis P Wyche J Fu Z Kitagwa Y Keller E T Sedivy J M and Yeung K C | | 0，，17： | 1 |
| 19 | MAP/ML estimation of the frequency and phase of a single sinusoid in noise显示文摘 | Fu H and Kam P Y | 2007 | IEEE Transactions on Signal Processing2007，55，3： | 1 |
| 20 | Protein kinase D:coupling extracel- lular stimuli to the regulation of cell physiology显示文摘 | Fu Y and Rubin CS | 2011 | EM- BO Rep2011，12，8： | 1 |
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