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| 1 | 麝香保心丸对内皮素-1诱导原代培养的人脐动脉血管平滑肌细胞增殖的影响显示文摘目的:观察麝香保心丸(SXBXW)对内皮素-1(ET-1)诱导原代培养的人脐动脉血管平滑肌细胞(VSMCs)增殖作用的影响。方法:建立ET-1刺激原代培养人脐动脉VSMCs增殖的细胞模型,设对照组、ET-1组、ET-1+SXBXW0.25g/L组、ET-1+SXBXW0.5g/L组、ET-1+SXBXW1.0g/L组和ET-1+SXBXW2.0g/L组,采用MTT法测定ET-1和SXBXW对细胞增殖的影响;用台盼蓝拒染和乳酸脱氢酶检测方法观察不同浓度的SXBXW对VSMCs的毒性作用;用流式细胞术观察ET-1和SXBXW对VSMCs增殖周期的影响。结果:与对照组相比,ET-1可显著促进VSMCs的增殖,一定剂量的SXBXW能够有效地抑制ET-1诱导的VSMCs细胞增殖,呈剂量依赖性;SXBXW抑制细胞增殖,但对活细胞数目和乳酸脱氢酶释放量均没有影响,提示对VSMCs无毒性作用。ET-1能够刺激VSMCs从G1期进入S期,从而促进细胞增殖,而SXBXW能抑制这一作用。结论:SXBXW能够有效抑制ET-1诱导的VSMCs增殖作用,其作用机制可能与其抑制细胞周期从G1期进入S期有关。 | 车贤达 张庆刚 钱琳艳 张晓慧 高瑞兰 Beng HC Simon XL Xinmai J | 2010 | 中国病理生理杂志2010，26，2： | 8 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | The sleep disorders invcnroty an instrument for studiees of sleep disturbancc in persons with Alzheimets disease 显示文摘 | TRACTEN BENG R E SINGER C M CUMMINGS J L | 2003 | J Sleep Res2003，12，4： | 1 |
| 4 | Ionic liquid as a green catalytic reaction medium for esterifications 显示文摘 | Deng Y Q Shi F Beng J J | 2001 | J Mol Catal A : Chem2001，165，： | 1 |
| 5 | Antimicrobial activity of the methanolic extracts and compounds from Vistula laurentii De Wild (Guttiferae) 显示文摘 | Kuete V Nguemeving J R Beng V P | 2007 | Journal of Ethnopharmacology2007，109，： | 1 |
| 6 | Revised terminology and concepts for organization of seizures and epilepsise : Report of the IL- AE Commission on classification and terminology ;2005 - 2009 显示文摘 | Beng AT Berkovic SF Brodie M J | 2010 | Epilepsia2010，51，4： | 1 |
| 7 | Ionic liquid as a green catalytic reaction medium for esterifications显示文摘 | Deng Y Q Shi F Beng J J | 2001 | Journal of Molecular Catalysis A : Chemical2001，165，： | 1 |
| 8 | Reverse Engineering Physical Models Employing Wrap-around B - spline Surfaces and Quadrics 显示文摘 | WEIR D J BENG MILROY M J BRADLEY C | 1996 | Proc Instn Mech Engrs1996，210，8： | 1 |
| 9 | Comparison of soil quality and nutrient budgets between organic and conventional kiwifruit orchards 显示文摘 | Carey P Benge J Haynes R | 2009 | Agriculture Ecosystems & Environment2009，132，1： | 1 |
| 10 | Personal recognition using multi-angles gait sequences显示文摘 | TEE Connie KAH O G M BENG J T A | 2011 | Communications in Computer and Information Science2011，189，2： | 1 |
| 11 | Evaluation of antimierobial activity of the stem bark of Cylicodiscus gabunensis (Mimosaceae) 显示文摘 | Laure B Kouitcheu Mabeku J Kouam Beng V Penlap | 2007 | African Journal Traditional Complementary and Alternative Medicines2007，4，1： | 1 |
| 12 | Seismic shear strength of circular reinforced concrete 显示文摘 | Ang Beng Ghee Priestley M J N Pauly T | 1994 | Journal of Structural Engineering1994，120，8： | 1 |
| 13 | Failure in- vestigation on rear water wall tube of boiler显示文摘 | AHMAD J PURBOLAKSONO J BENG L C | 2009 | Engineering fail- ure analysis2009，16，7： | 1 |
| 14 | Optimal stride frequency computed from the double- compound pendulum of the leg, and verified experimentally as the preferred stride frequency of jogging显示文摘 | HUAT O J GHISTA D N BENG N K | 2004 | Inte J Computer Applications Technol2004，21，1： | 1 |
| 15 | Team Mental Models and Team Performance: A Field Study of the Effects of Team Mental Model Similarity and Accuracy 显示文摘 | Beng - Chong Lim Katherine J K | 2006 | Journal of Organizational Behavior2006，27，4： | 1 |
| 16 | The performance of MapReduce: An In-depth study 显示文摘 | Dawei J Beng C O Lei S | 2010 | Proceedings of the VLDB Endowment2010，3，12： | 1 |
| 17 | Seismic shear strength of circular reinforced concrete columns 显示文摘 | Ang Beng Ghee Priestley M J N Paulay T | 1989 | ACI Structural Journal1989，86，1： | 1 |
| 18 | Failure analysis on a primarysuperheater tube of a power plant显示文摘 | PURBOLAKSONO J AHMAD J BENG L C | 2010 | Engineering Failure Analysis2010，17，1： | 1 |
| 19 | Antimicrobial activity of the methanolic extract from the stem bark of Tridesmostemon omphalocarpoides ( Sapotaceae ) 显示文摘 | Kuete V Tangmouo J G Beng V P | 2006 | Journal of Ethnophar-macology2006，104，12： | 1 |
| 20 | Micresage:a modified procedure for serial analysis of gene expression显示文摘 | Datson N A Jong J Beng M P | 1999 | Nucleic Acids Res1999，27，： | 1 |
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