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| 1 | The tumor-selective over-expression of the human Hsp 70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription显示文摘The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors,linked to the poor prognosis,being refractory to chemo-and radio-therapies as well as the advanced stage of tumorous lesions in particular.However,both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic.By comparing various upstream segments of the Hsp70 gene for each''s ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line,we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression.Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene,but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 at the central stage fortargeting the therapeutic gene expression to human tumors. | LING CAI, JING DE ZHU,The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 25/2200, Xie-tu Road, Shanghai 200032, China | 2003 | Cell Research2003，13，2： | 13 |
| 2 | The promoter analysis of the human C17orf25 gene, a novel chromosome 17pl3.3 gene显示文摘The human C17orf25 gene (Accession No. AF177342) is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13.3 in human hepatocellular car-cinoma in China[l]. To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis, we looked into the relevant aspects by both bioinformatic and experimental executions. We found: 1, The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested, showing little hepatoma-selectivity; 2, Its tran-scription starts at a single site, locating at -60 from the translation initiation codon; 3, A 58 bp fragment containing the transcription start, extending from -112 to -55, represents the minimal promoter; 4, The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter; 5, The bioinformatic analysis suggests that the C17ort25 gene may encode a protein in the family of the glyoxalase. Our data has provided some deep insight into both function and regulation of the C17orf25 gene in the context of the normal liver and hepatocellular carcinoma. | JIAN YING GUO, JIAN XU, DA QIN MAO, LI LI FU, JIAN REN GU, JING DE ZHUThe State-Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ln 2200/25, Xie-Tu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，5： | 7 |
| 3 | Artificial immune systems as a novel soft computing paradigm显示文摘 | DE CASTRO LN TIMMIS JI | 2003 | Soft Computing2003，7，8： | 1 |
| 4 | Clinoid and paraclinoid aneurysms:surgical anatomy,operative techniques,andoutcome显示文摘 | De Jesus O Sekhar LN Riedel CJ | 1999 | Surg Neurol1999，51，4： | 1 |
| 5 | Learning and optimization using the clonal selection principle显示文摘 | DE CASTRO LN VON ZUBEN FJ | 2002 | IEEE Transactions on Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 6 | Elective resection of the internal carotid artery without reconstruction显示文摘 | de Vries EJ Sekhar LN Janecka IP | 1988 | Laryngoscope1988，98，9： | 1 |
| 7 | The use of liners under amalgam restorations: an vitro study on marginal leakage 显示文摘 | Marchiori S Baratieri LN de Andrada | 1998 | Quintessence Int1998，29，10： | 1 |
| 8 | A new method to prediet safe resection of the internal carotid显示文摘 | De Vries EJ Sekhar LN Horton JA | 1990 | Laryngoscope1990，100，： | 1 |
| 9 | Osseointegrated implant rehabilitation of irradiated oral cancer patients 显示文摘 | De la Plata M Gtas LN Dtez PM | 2012 | J Oral Maxillo- fac Surg2012，70，5： | 1 |
| 10 | PCR detection and typing of human papilloma virus DNA in squamous carcinoma of the cervix in a cohort of Sri Lankan women显示文摘 | de Silva R Karunaratne K Mendis LN | 2006 | Ceylon Med J2006，51，3： | 1 |
| 11 | Dental adhesion : present state of art and future prospectives 显示文摘 | Lopes GC Baratieri LN de Andrada MAC | 2002 | Quintessence lnt2002，33，7： | 1 |
| 12 | Inflammation in dysferlin myopathy:immunohistochemical characterization of 13 patients显示文摘 | Gallardo E Rojas-Garcia R de LN | 2001 | Neurology2001，57，： | 1 |
| 13 | Immune and Neural Network Models: Theoretical and Empirical Comparisons显示文摘 | DE CASTRO LN | 2001 | International Jnurn''al of Computational Intelligence and Applications2001，1，3： | 1 |
| 14 | cDNA cloning and heterologous expression of functional cysteine-rich autifugunal protein psdl in the yeast pichia pastoris 显示文摘 | Almeida MS Cabral KS de Medeiros LN | 2001 | Archives of Biochemistry & Biophysics2001，395，2： | 1 |
| 15 | Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression 显示文摘 | Byers DM Irwin LN Moss DE | 2005 | Brain Res Dev Brain Res2005，158，12： | 1 |
| 16 | Analysis of microsatellite instability and loss of heterozygosity in ovarian cancer : a study in the population of Espirito Santo, Brazil 显示文摘 | Alves LN Wolfgramm EV de Castro Neto AK | 2013 | Genet Mol Res2013，12，2： | 1 |
| 17 | Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrai(1 morphology and gene expression 显示文摘 | Byers DM Irwin LN Moss DE | 2005 | Brain Res Dev Brain Res2005，158，12： | 1 |
| 18 | Determination of arsenic compounds in beverages by high - performance liquid chromatography - inductively coupled plasma mass spectrometry 显示文摘 | NMM Coelho LN Coelho ES de Lima | 2005 | Talanta2005，66，： | 1 |
| 19 | I, Artificial Immune System: A New Computational Intelligence Approach显示文摘 | Leandro Nunes de Castro LN&Timmis J | 2002 | Springer- Verlay2002，，： | 1 |
| 20 | Influence of postplacement in the racture resistance of endodontically treated in-cisors veneered with direct composite 显示文摘 | Baratieri LN De Andrada MA Arcari GM | 2000 | J Prosthet Dent2000，84，2： | 1 |
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