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42篇 您的检索式：作者名="de Mulder M"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Economicgrowth and technological change : a comparison of insightsfrom a neoclassical and an evolutionary perspective 显示文摘	MULDER P DE GROOT H HOFKES M	2001	Technological Forecasting & Social Change2001，，68：	1
3	Environmental impact assessment on land reclamation projects in the Netherlands: a case history显示文摘	De Mulder E F J van Bruchem A J Claessen F A M	1994	Engineering Geology1994，37，1：	1
4	Elevated adalission glucose is associated with in- creased long-term mortality in myocardial infarction pa- tients, irrespective of the initially applied reperfusion strategy显示文摘	DE MULDER M CORNEL J H VAN DER PLOEG T	2010	Am Heart J2010，160，41：	1
5	The use of remote sensing in soil and terrain mapping-A review 显示文摘	Mulder V L de Bruin S Schaepman M E	2011	Geoderma2011，162，：	1
6	The outer wall of small airways is a major site of remodeling in fatal asthma 显示文摘	Dolhnikoff M da Silva LF de Araujo BB Gomes HA Fernezlian S Mulder A	2009	Allergy Clin Immunol2009，123，5：	1
7	Hydrogen atom abstraction kinetics from intramolecularly hydrogen bonded ubiquinol-O and other(Poly)methoxyphenols显示文摘	De Heer M I Mulder P Korth H G	2000	J Am Chem Soc2000，122，10：	1
8	Experimental quantification of transmission of genetically engineered pseudorabies virus显示文摘	Mulder W A M De Jong M C M Priem J	1995	Vaccine1995，13，18：	1
9	Mental fatigue and task control:Planning and preparation显示文摘	Lorist M.M Klein M Nieuwenhuis S De Jong R Mulder G & Meijman T.F		0，，：	1
10	The use of remote sensing in soil and terrain mapping - A review 显示文摘	Mulder V L de Bruin S Schaepman M E	2011	Geoderma2011，162，12：	1
11	Lack of ef-ficacy of two consecutive treatments of radioimmunotherapywith 131l-cG250 in patients with metastasized clear cell renalcell carcinoma显示文摘	Brouwers A H Mulders P F A de Mulder P H M et ai	2005	Journal of Clinical Oncology : official journal ofthe American Society of Clinical Oncology2005，23，27：	1
12	Prognostic Value of Renal Vein and Inferior Vena Cava Involvement in Renal Cell Carcinoma显示文摘	Bernd Wagner Jean-Jacques Patard Arnaud Méjean Karim Bensalah Grégory Verhoest Richard Zigeuner Vincenzo Ficarra Jacques Tostain Peter Mulders Denis Chautard Jean-Luc Descotes Alexandre de la Taille Laurent Salomon Tommaso Prayer-Galetti Luca Cindolo Anto	2008	European Urology2008，，2：	1
13	Long-term outcomes of isolated aortic valve replacement and concomitant AVR and coronary artery bypass grafting显示文摘	de Waard GA Jansen EK de Mulder M		0，，03：	1
14	Modeling aluminum and organic matter solubility in the forest floor using WHAM显示文摘	De Wit H A Kotowski M Mulder J	1999	Soil Science Society of America Journal1999，63，：	1
15	Properties of nisin Z and distribution of its gene, nisZ, in Lactococcus lactis显示文摘	de VOS W M MULDERS J W SIEZEN R J	1993	Appl Environ Microbiol1993，59，：	1
16	Local Deposition of High-Purity Pt Nanostructures by Combining Electron Beam Induced Deposition and Atomic Layer Deposition 显示文摘	Mackus A J M Mulders J J L Van De Sanden M C M	2010	JApplPhys2010，，11：	1
17	Tidal variations in suspended sediment concentration in the Ems estuary: origin and resulting sediment flux显示文摘	Van de Kreeke J Day C M Mulder H P J	1997	Journal of Sea Research1997，38，1：	1
18	EuroHeart score for the evaluation of in-hospital mortality in patients undergoing percutaneous coronary intervention显示文摘	de Mulder M Gitt A van Domburg R	2011	Eur Heart J2011，32，11：	1
19	Randomized study of a short course of weekly cisplatin with or without amifostine in advanced head and neck cancer显示文摘	Planting A S T Catimel G de Mulder P H M	1999	Annals of Oncology1999，10，3：	1
20	Environmental impact assessmem on land reclamation projects in the northerlands: a case histoay显示文摘	De Mulder E F J VanBruchem A J Claessen F A M	1994	Eng Geo1994，17，2：	1

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