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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Au nanoparticles target cancer显示文摘 | Jain P K El - Sayed I H and El - Sayed M A | 2007 | Nano Today2007，2，1： | 1 |
| 3 | Limonoids from Citrus reticulate显示文摘 | KHALILA A T MAATOOQ G T El SAYED K A | 2003 | Z Naturforsch2003，58，34： | 1 |
| 4 | Marine natural products as antituberculosis agents显示文摘 | El Sayed K A Bartyzel P Shen X Y | 2000 | Tetrahedron2000，56，7： | 1 |
| 5 | Review of some in- teresting surface plasmon resonance - enhanced properties of noble met- al nanoparticles and their applications to biosystems 显示文摘 | JAIN P K HUANG X H EL - SAYED I H | 2007 | Plasmonics2007，，2： | 1 |
| 6 | Single‐ versus double‐layer hysterotomy closure at primary caesarean delivery and bladder adhesions显示文摘 | YJ Blumenfeld AB Caughey YY El‐Sayed K Daniels DJ Lyell | 2010 | BJOG: An International Journal of Obstetrics & Gy2010，，6： | 1 |
| 7 | New quinoline alkaloids from Rutachalepensis显示文摘 | El Sayed K Al-Said MS El-Feraly FS | 2000 | J Nat Prod2000，63，7： | 1 |
| 8 | Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata显示文摘 | MUHAMMAD I SAYED EL K A MOSSA J S | 2000 | J Nat Prod2000，63，5： | 1 |
| 9 | Au Nanoparticles target cancer显示文摘 | JAIN P K EI-SAYED I H EL SAYED M A | 2007 | Nano Today2007，2，1： | 1 |
| 10 | New quinoline alkaloids from Ruta chalepensis显示文摘 | El Sayed K Al-Said MS El-Feraly FS | 2000 | Nat Prod2000，63，7： | 1 |
| 11 | Marine Natural Products as Antituberculosis Agents显示文摘 | EL SAYED K A BARTYZEL P SHEN X Y | | 0，，： | 1 |
| 12 | CXCL16 and oxLDL are induced in the onset of diabetic nephropathy显示文摘 | Paul Gutwein Mohamed Sadek Abdel‐Bakky Kai Doberstein Anja Schramme Janet Beckmann Liliana Schaefer Kerstin Amann Anke Doller Nicole K?mpfer‐Kolb Abdel‐Aziz H. Abdel‐Aziz El Sayed M. El Sayed Josef Pfeilschifter | 2009 | Journal of Cellular and Molecular Medicine (b)2009，，9： | 1 |
| 13 | Plasmon coupling in nanorod assemblies:optical absorption,discrete dipole approximation simulation,and exciton coupling model显示文摘 | JAIN P K EUSTIS S EL -SAYED M A | 2006 | J Phys Chem B2006，110，18： | 1 |
| 14 | Synthesis, Charavterization and catalytic oxidalion of carbon monoxid~ ow~r cobalt oxide 显示文摘 | Lin Chin H C 'l'sai H C el al | 2003 | Catal Leli2003，88，： | 1 |
| 15 | Heterotopic and orthotopac autologous chondrocyte implantation using a minipig chondral defect model显示文摘 | Lohan A Marzahn U el Sayed K | 2013 | Ann Anat2013，195，5： | 1 |
| 16 | Evolution of Treatment of High-risk Metastatic Gestational Trophoblastic Tumors: Ain Shams University Experience显示文摘 | El Lamie I K El Sayed H M Badawie A G | 2006 | Int J Gynecol Cancer2006，16，2： | 1 |
| 17 | CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein显示文摘 | Paul Gutwein Mohamed Sadek Abdel-Bakky Anja Schramme Kai Doberstein Nicole K?mpfer-Kolb Kerstin Amann Ingeborg A. Hauser Nicholas Obermüller Christine Bartel Abdel-Aziz H. Abdel-Aziz El Sayed M. El Sayed Josef Pfeilschifter | 2009 | The American Journal of Pathology2009，，6： | 1 |
| 18 | Development of the Flame Atomic Absorption Spectroscopic Method for Beryllium Determination显示文摘 | El Saied F A Farag N M Fouad H K | 2009 | Journal of Applied Sciences Research2009，5，5： | 1 |
| 19 | Current status on marine products with reversal effect on cancer multidrug resistance显示文摘 | Abraham I El Sayed K Chen ZS | 2012 | Mar Drugs2012，10，10： | 1 |
| 20 | Automatic Building of New Field Association Word Candidates Using Search Engine显示文摘 | Sayed El Elmarhomy G Morita K | 2006 | Information Processing and Management2006，，42： | 1 |
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