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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘 | Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J | 2013 | International Journal of Environmental Research and Public Health2013，，12： | 1 |
| 3 | Design and syn- thesis of tricyclic cores for kinase inhibition 显示文摘 | Epps S V Fiamengo B Edmunds J | 2013 | Bioorganic & Medicinal Chemistry Letters2013，23，3： | 1 |
| 4 | Optimizing dispersal and corridor models using landscape genetics显示文摘 | Epps C W Wehausen J D Bleich V C | 2007 | Journal of Applied Ecology2007，44，4： | 1 |
| 5 | Correlation between myocar- lial enzyme serum levels and markers of inflammation with severity of oronary artery disease and Gensini score :a hospital-based,prospective tudy in Greek patients显示文摘 | eppes V Rammos G Manios E | 2008 | Clin Interv Aging2008，3，4： | 1 |
| 6 | Swimming performance of a biomimetic compliant fish-like robot显示文摘 | Epps B P Alvarado P V Y Youcef-Toumi K | 2009 | Ex- periments in Fluids2009，47，6： | 1 |
| 7 | Optimizing dispersal and corridor models using landscape genetics显示文摘 | EPPS C W WEHAUSEN J D BLEICH V C | | Ap plied Ecology0，44，4： | 1 |
| 8 | Characterization of the steady-state and dynamic fluorescence properties of the poten-tia-l sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol(Dibac4(3))in model systems and cells显示文摘 | Epps D E Wolfe M L Groppi V | 1994 | Chem Phys Lipids1994，69，2： | 1 |
| 9 | Social learning and sustainable development 显示文摘 | Kristjanson P Harvery B Epp M V | 2014 | Nature Cli- mate Change2014，，4： | 1 |
| 10 | Characterization of the steadystate and dynamic fluorescence properties of the potential - sensitive dye his-( 1,3-dibutylbarbituric acid ) trimethine oxonol ( Dibae4( 3 ) in model systems and cells 显示文摘 | Epps D E Wolfe M L Groppi V | 1995 | Chem Phys Lipids1995，69，： | 1 |
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