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| 1 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 2 | Ocular involvement in Adamantiades-Behcet's disease in Berlin,Germany显示文摘 | Krause L K(o)hler AK Altenburg A | | 0，，： | 1 |
| 3 | NF-显示文摘 | Fagerlund R Kinnunen L K?hler M | 2005 | J Biol Chem2005，280，15： | 1 |
| 4 | Brain Research显示文摘 | Kφhler L B Berezin Vladimir Bock Elisabeth Milena Penkowa | 2003 | 992(1): 1282003，992，1： | 1 |
| 5 | Effect of ettringite on thaumasite formation显示文摘 | KHLER S HEINZ D URBONAS L | 2006 | Cement and Concrete Research2006，36，4： | 1 |
| 6 | Diagnosis,pathology,and treatment of fractures of the oscalcis显示文摘 | Bhler L | 1931 | Bone Joint Surg1931，，31： | 1 |
| 7 | Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein显示文摘 | Hendershot L Bole D K(o)hler G | | 0，，03： | 1 |
| 8 | Integration of biocatalyst and process engineering for sustainable and efficient n-butanol production显示文摘 | Khler K A Rühl J Blank L M | 2015 | Eng Life Sci2015，15，： | 1 |
| 9 | Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis显示文摘 | S T. Engelter M Reichhart L Sekoranja D Georgiadis A Baumann B Weder F Müller R Lüthy M Arnold P Michel H P. Mattle B Tettenborn H J. Hungerbühler R W. Baumgartner R Sztajzel J Bogousslavsky P A. Lyrer | 2005 | Neurology2005，，11： | 1 |
| 10 | Long-term expression of the hepatitis B virus core-e-and X-proteins does not cause pathologic changes in transgenic mice显示文摘 | Reifenberg K Lhler J Pudollek H P | 1997 | J Hepatol1997，26，1： | 1 |
| 11 | The temperature dependent anisotropy constants of epitaxially grown PrCo5+z显示文摘 | Patra A.K Eisterer M Biele R F(a)hler S Schultz L and Nen V | | 0，，07： | 1 |
| 12 | Formulation and integration of the standard linear viscoelastic solid with fractional order rate laws显示文摘 | Enelund M Mhler L Runesson K | 1999 | International Journal of Solids and Structures1999，36，16： | 1 |
| 13 | Segregated mathematical model for growth of anchorage-dependent MDCK cells in microcarrier culture 显示文摘 | M?hler L Bock A Reich U | 2008 | Biotechnol Proc2008，24，1： | 1 |
| 14 | Crystal growth of rare earth-transition metal borocarbides and silicides显示文摘 | Günter Behr Wolfgang L?ser Dmitri Souptel Günter Fuchs Irina Mazilu Chongde Cao Anke K?hler Ludwig Schultz Bernd Büchner | 2008 | Journal of Crystal Growth2008，，7： | 1 |
| 15 | Paraganglioma of the ampulla of Vater:a potentially malignant neoplasm显示文摘 | Bucher P Mathe Z Bühler L | 2004 | Scand J Gastroenterol2004，39，3： | 1 |
| 16 | Phase formation,texture,and magnetic properties of epitaxial Pr-Co films grown on MgO(100)显示文摘 | Patra A.K Neu V F(a)hler S Wendrock H and Schultz L | | 0，，04： | 1 |
| 17 | Detection of nucleotide variability in rpoB in both rifampin-sensitive and rifampin-resistant strains of Chlangrdia traehomatis 显示文摘 | Dreses-Werringloer U Padubrin I K hler L | 2003 | Antilnicrob Agents Chemother2003，47，7： | 1 |
| 18 | Proteomic profiling in an animal model of acute pancreatitis显示文摘 | VanessaFétaud Jean‐LouisFrossard AnnaritaFarina Catherine M.Pastor LéoBühler Jean‐MarcDumonceau AntoineHadengue Denis F.Hochstrasser PierreLescuyer | 2008 | Proteomics2008，，17： | 1 |
| 19 | Crystal structure and its correlation to intrinsic and extrinsic magnetic properties of epitaxial hard magnetic Pr-Co films显示文摘 | Parra A.K Neu V F(a)hler S Groetzschel R Bedanta S Kleemann W and Schultz L | | 0，，18： | 1 |
| 20 | Self-assembly of proximity probes for flexible and modular proximity ligation assays显示文摘 | Darmanis S K hler A Sp ngberg L | 2007 | Biotechniques2007，43，44： | 1 |
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