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| 1 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 2 | A study of pulmonary embolism after abdominal surgery in patients undergoing prophylaxis显示文摘AIM:To determine risk factors for pulmonary embolism and estimate effects and benefits of prophylaxis.METHODS:We included 78 patients who died subsequently to a pulmonary embolism after major abdomi nal surgery from 1985 to 2003.A first,retrospective analysis involved 41 patients who underwent elective surgery between 1985 and 1990 without receiving any prophylaxis.In the prospectively evaluated subgroup,37 patients undergoing major surgery between 1991 and 2003 were enrolled:all of them had received a prophylaxis consisting in low-molecular weight heparin,given subcutaneously at a dose of 2850 IU AXa/0.3 mL(body weight < 50 kg) or 5700 IU AXa/0.6 mL(body weight ≥ 50 kg).RESULTS:A higher incidence of thromboembolism(43.9% and 46.34% in the two groups,respectively) was found in older patients(> 60 years).The incidence of pulmonary embolism after major abdominal surgery in patients who had received the prophylaxis was signifi cantly lower compared to the subjects with the same condition who had not received any prophylaxis(P < 0.001,OR = 2.825;95% CI,1.811-4.408).Furthermore,the incidence of pulmonary embolism after colorectal cancer surgery was signifi cantly higher compared to incidence of pulmonary embolism after other abdominal surgical procedures.Finally,the incidence of pulmonary embolism after colorectal cancer surgery among the patients who had received the prophylaxis(11/4316,0.26%) was significantly lower compared to subjects undergoing a surgical procedure for the same indication but without prophylaxis(10/1562,0.64%)(P < 0.05,OR = 2.522;95% CI,1.069-5.949).CONCLUSION:Prophylaxis with low molecular weight heparin is highly recommended during the preoperative period in patients with diagnosis of colorectal cancer due to high risk of pulmonary embolism after elective surgery. | Mirko D Kerkez Dorde M ulafi Dragana D Mija Vitomir I Rankovi Nebja S Leki Dejan Z Stefanovi | 2009 | World Journal of Gastroenterology2009，15，3： | 14 |
| 3 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 4 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 5 | 无放疗史的成人ETV6-NTRK3易位甲状腺乳头状癌的临床和形态学特征显示文摘据报道,ETV6-NTRK3易位甲状腺乳头状癌(PTCs)通常与放疗相关且多发生在小儿。作者描述了12例无放疗史的成人ETV6-NTRK3易位PTCs的临床病理学特征,均为经二代测序技术证实的病例。患者平均年龄为37岁,以女性多见(女:男=10:2)。6例患者行术前细针穿刺,其中4例诊断为恶性,2例诊断为“性质未定的滤泡性病变”。术后病理证实1/3(4/12)的患者有甲状腺外浸润,1/2(5/10)有淋巴结转移,1例出现了脑转移。 | Seethala R R Chiosea S I Liu C Z 黄爱清 余英豪 | 2017 | 临床与实验病理学杂志2017，33，10： | 8 |
| 6 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 7 | Bulk nanostructured materials from severe plastic deformation显示文摘 | Valiev R Z Islamgaliev R K Alexandrov I V | 2000 | Progress in Material Science2000，45，2： | 2 |
| 8 | 运用远红外热像图观察针刺太溪穴的热效应(英文)显示文摘Objecive To observe the eventual thermic effects of stimulaing Tàixī (太溪 KI 3) by telethermography. Methods Nine individuals of both sexes, chosen randomly, paricipated in this study. The temperature of the room where the experiment was carried out was not above 21 ℃. At the start of the experiment the volunteer stayed for exactly ten minutes in the room for acclimaizaion, then the first thermographic image was recorded for standardizaion purposes. Following this, an acupuncture needle was inserted at KI 3 only in the right leg, whose depth was limited to obtain Deqi, only manual stimulation for 15 min permanence in the site. Ater this period, new images were recorded. Results Significant reduction of all the right leg temperatures, by about 1.1 ℃ in all the volunteers that received the acupuncture at the Kl 3 was noted, with a coefficient variaion of P<0.0001 that was staisically highly significant, while on the other not simulated leg the variaion that occurred was around 0.7 ℃, with no significant coefficient variation of P>0.05. Conclusion The results of this study demonstrate that manual simulaion of the Kl 3 influences significantly peripheral vascular circulation, by means of sympathetic stimulaion causing vasoconstricion. | Antonio JoséI pólito AffonsoLuíz Ferreira | 2013 | World Journal of Acupuncture-Moxibustion2013，23，2： | 2 |
| 9 | Blue-light electroluminescence from p-phenylene vinylene-based copolymers显示文摘 | Sokolik I Yang Z Karasz F E | 1993 | J Appl Phys1993，74，： | 2 |
| 10 | A Note on the stability of large-scale system with delay显示文摘 | SUH I H BIEN Z | 1982 | on automat Contr1982，27，： | 2 |
| 11 | His-His-Leu,an angiotensinⅠconverting enzyme inhibitory peptide derived from Korean soybean paste,exerts antihypertensive activity in vivo显示文摘 | Shin Z I Yu R Park S A | 2001 | J Agric Food Chem2001，49，6： | 2 |
| 12 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 13 | Graft copolymerization of methyl methacrylate onto sago starch using ceric ammonium nitrate and potassium persulfate as redox initiator systems显示文摘 | Qudsieh I Y M Yunus W M Z W Fakhrul-Razi A | 2002 | J Appl Polym Sci2002，83，10： | 2 |
| 14 | Graft copolymerization of methyl methacrylate onto sago starch using ceric ammonium nitrate and potassium persulfate as redox initiator systems显示文摘 | Fakhrul-Razi A Qudsieh I Y M Yunus W M Z W | 2001 | J Appl Polym Sci2001，82，6： | 2 |
| 15 | Bulk nano structured materials from severe plastic deformation显示文摘 | Valiev R Z Islamgaliev R K Alexandrov I V | 2000 | Process in Materials Science2000，45，： | 1 |
| 16 | Sealing furcation perforations with silver glass ionomer cement: an in titro evaluation 显示文摘 | Fuss Z Abramovitz I Metzger Z | 2000 | J Endod2000，26，8： | 1 |
| 17 | Material balance studies on animal cell metabolism using a stoichiometrically based reaction network显示文摘 | XIE L Z WANG D I C | 1996 | Biotechnology Bioengineering1996，52，5： | 1 |
| 18 | Early activation of microglia as antigen presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system显示文摘 | Shaked I Porat Z Gersner R etal | 2004 | J Neuroimmunol2004，146，12： | 1 |
| 19 | Influence of particle size and dissolution conditions on the degradation properties of polylactideco-glycolide particles 显示文摘 | Dunne M Corrigan O I Ramtoola Z | 2000 | Biomaterials2000，21，： | 1 |
| 20 | Assessing the alignment between business strategy and use of multiple performance using interaction approach 显示文摘 | Ruzita J N I Daing Z Yuserrie | 2006 | The Business Review2006，5，1： | 1 |
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