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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | A pilot study of functional magnetic resonance imaging brain correlates of deception in healthy young men 显示文摘 | KOZEL F A REVELL L J LORBERBAUM J P | 2004 | The Journal of neuropsychiatry and clinical neuroscienc- es2004，16，3： | 1 |
| 3 | Defciency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced bearing loss in mice显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，164，12： | 1 |
| 4 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced heating loss in mice 显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，164，12： | 1 |
| 5 | Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule显示文摘 | Kozel TR Thorkildson P Brandt S | 2007 | Infect Immun2007，75，1： | 1 |
| 6 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noiseinduced heating loss in mice 显示文摘 | KOZEL P J DAVIS R R KRIEG E F | 2002 | Hear Res2002，164，1： | 1 |
| 7 | Deficiency in plasma membrane calcium atpase isoform 2 increases susceptibility to noise-induced hearing loss in mice显示文摘 | KOZEL P J | 2002 | Hear Res2002，164，12： | 1 |
| 8 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise- induced hearing loss in mice 显示文摘 | KOZEL P J DAVIS R R KRIEG E F | 2002 | Hear Res2002，164，12： | 1 |
| 9 | Molecular architecture of the Cryptococcus neoformans capsule显示文摘 | Gates MA Thorkildson P Kozel TR | | 0，，01： | 1 |
| 10 | Genetic influences susce in individual susceptibility to noise: a review 显示文摘 | Davis R R Kozel P Erway L C | 2003 | Noise Health2003，5，20： | 1 |
| 11 | Balance and hearing deficits in mice with a null mutation in the gene encoding plasma mem- brance Ca^2+-ATPase isoform 2 显示文摘 | Kozel P J Friedman R A Erway L C | 1998 | Biol Chem1998，273，18： | 1 |
| 12 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，12，164： | 1 |
| 13 | Deficiency in plasma membrane calcium ATPase isofonn 2 increases susceptibility to noise induced hearing lossinmice 显示文摘 | Kozel P J Davis R R Krieq E F | 2002 | Hear Res2002，164，12： | 1 |
| 14 | Molecular architecture of the Cryptococcus neoformans capsule 显示文摘 | Gates MA Thorkildson P Kozel TR | 2004 | Mol Microbiol2004，52，1： | 1 |
| 15 | Deficiency in plasma membrance calcuim ATPase isoform 2 increases susceptibility to noise-induced heating loss in mice 显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，164，12： | 1 |
| 16 | Genetic influences in individual susceptibility to noise: a review 显示文摘 | Davis R R kozel P Erway L C | 2003 | Noise Health2003，5，20： | 1 |
| 17 | Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule显示文摘 | Kozel T R Thorkildson P Brandt S | 2007 | Infect Immun2007，75，1： | 1 |
| 18 | Molecular architecture of the Cryptococcus neoformans capsule显示文摘 | Gates M A Thorkildson P Kozel T R | 2004 | Mol Microbiol2004，52，： | 1 |
| 19 | Genetic influences in individual susceptibility to noise:a review显示文摘 | Davis RR Kozel P Erway LC | | 0，，20： | 1 |
| 20 | Genetic influences in individual susceptibility to noise:a review显示文摘 | Davis RR Kozel P Erway LC | 2003 | Noise Health2003，5，： | 1 |
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