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| 1 | Laparoscopic surgery for benign and malign diseases of the digestive system:Indications,limitations,and evidence显示文摘The laparoscopic technique was introduced in gastrointestinal surgery in the mid 1980s.Since then,the development of this technique has been extraordinary.Triggered by technical innovations(stapling devices or coagulation/dissecting devices),nowadays any type of gastrointestinal resection has been successfully performed laparoscopically and can be performed laparoscopically dependent on the patient’s condition.This summary gives an overview over 30 years of laparoscopic surgery with focus on today’s indications and evidence.Main indications remain the more common procedures,e.g.,appendectomy,cholecystectomy,bariatric procedures or colorectal resections.For all these indications,the laparoscopic approach has become the gold standard with less perioperative morbidity.Regarding oncological outcome there have been several highquality randomized controlled trials which demonstrated equivalency between laparoscopic and open colorectal resections.Less common procedures like esophagectomy,oncological gastrectomy,liver and pancreatic resections can be performed successfully as well by anexperienced surgeon.However,the evidence for these special indications is poor and a general recommendation cannot be given.In conclusion,laparoscopic surgery has revolutionized the field of gastrointestinal surgery by reducing perioperative morbidity without disregarding surgical principles especially in oncological surgery. | Markus Alexander Küper Friederike Eisner Alfred K?nigsrainer J?rg Glatzle | 2014 | World Journal of Gastroenterology2014，20，17： | 9 |
| 2 | Risk factors for recurrence following complete cytoreductive surgery and HIPEC in colorectal cancer-derived peritoneal surface malignancies显示文摘 | Ingmar K?nigsrainer Philipp Horvath Florian Struller Viola Forkl Alfred K?nigsrainer Stefan Beckert | 2013 | Langenbeck’s Archives of Surgery2013，，： | 1 |
| 3 | Histidine–tryptophan–ketoglutarate solution for organ preservation in human liver transplantation—a prospective multi-centre observation study显示文摘 | Herwig Pokorny Susanne Rasoul-Rockenschaub Felix Langer Thomas Windhager Andreas Rosenstingl Reinhard Lange Alfred K?nigsrainer Burckhardt Ringe Ferdinand Mühlbacher Rudolf Steininger | 2004 | Transplant International2004，，5： | 1 |
| 4 | Contributors to individual quality of life after liver transplantation显示文摘 | Christian Thiel Kerstin Landgrebe Evelyn Knubben Silvio Nadalin Ruth Ladurner Christian Grasshoff Alfred K?nigsrainer Martin Schenk Karolin Thiel | 2012 | European Journal of Clinical Investigation2012，，1： | 1 |
| 5 | SJWD15012600002617显示文摘 | Giridhar Kanuri Ruth Ladurner Julia Skibovskaya Astrid Spruss Alfred K?nigsrainer Stephan C. Bischoff Ina Bergheim | 2015 | Liver Int2015，，2： | 1 |
| 6 | Transient Lower Esophageal Sphincter Relaxation in Morbid Obesity显示文摘 | J. H. Schneider M. Küper A. K?nigsrainer B. Brücher | 2009 | Obesity Surgery2009，，5： | 1 |
| 7 | Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score:is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)?显示文摘Background:Preoperative patient selection in Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)is not always reliable with currently available scores,particularly in patients with primary liver tumor.This study aims to(I)to determine whether comorbidities and patients characteristics are a risk factor in ALPPS and(II)to create a score predicting 90-day mortality preoperatively.Methods:Thirteen high-volume centers participated in this retrospective multicentric study.A risk analysis based on patient characteristics,underlying disease and procedure type was performed to identify risk factors and model the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score.A nonparametric receiver operating characteristic analysis was performed to estimate the predictive ability of our score against the Charlson Comorbidity Index(CCI),the age-adjusted CCI(aCCI),the ALPPS risk score before Stage 1(ALPPS-RS1)and Stage 2(ALPPS-RS2).The model was internally validated applying bootstrapping.Results:A total of 451 patients were included.Mortality was 14.4%.The CAPRA score is calculated based on the following formula:(0.1×age)−(2×BSA)+1(in the presence of primary liver tumor)+1(in the presence of severe cardiovascular disease)+2(in the presence of moderate or severe diabetes)+2(in the presence of renal disease)+2(if classic ALPPS is planned).The predictive ability was 0.837 for the CAPRA score,0.443 for CCI,0.519 for aCCI,0.693 for ALPPS-RS1 and 0.807 for ALPPS-RS2.After 1,000 cycles of bootstrapping the C statistic was 0.793.The accuracy plot revealed a cut-off for optimal prediction of postoperative mortality of 4.70.Conclusions:Comorbidities play an important role in ALPPS and should be carefully considered when planning the procedure.By assessing the patient’s preoperative condition in relation to ALPPS,the CAPRA score has a very good ability to predict postoperative mortality. | Ivan Capobianco Karl J.Oldhafer Mohammed-Hossein Fard-Aghaie Ricardo Robles-Campos Roberto Brusadin Henrik Petrowsky Michael Linecker Arianeb Mehrabi Katrin Hoffmann Jun Li Asmus Heumann Roberto Hernandez-Alejandro Mauro Enrique Tun-Abraham Elio Jovine Matteo Serenari Bergthor Bjornsson Per Sandström Ruslan Alikhanov Mikhail Efanov Paolo Muiesan Andrea Schlegel Thomas M.van Gulik Pim B.Olthof Gregor Alexander Stavrou Lina Maria Serna-Higuita Alfred Königsrainer Silvio Nadalin | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 1 |
| 8 | Inhibitors ofindoleamine-2,3-dioxygenase for cancer therapy:can we see thewood for the trees?显示文摘 | Lob S Knigsrainer A Rammensee HG | 2009 | Nat Rev Cancer2009，9，6： | 1 |
| 9 | ALPPS in right trisectionectomy:a safe procedure to avoid postoperative liver failure?显示文摘 | Li J Girotti P K(o)nigsrainer I | 2013 | J Gastrointest Surg2013，17，5： | 1 |
| 10 | IDO1 and IDO2 areexpressed in human tumors:levo-but not dextro-1-methyl trypto-phan inhibits tryptophan catabolism显示文摘 | Lb S Knigsrainer A Zieker D | 2009 | Cancer Immunol Immu-nothe2009，58，1： | 1 |
| 11 | Complete versus selective portal triad clamping for minor liver resections显示文摘 | Kǒnigsrainer I Ledurner R Steurer W | 2006 | Ann surg2006，243，1： | 1 |
| 12 | Effects of Surgical and Dietary Weight Loss Therapy for Obesity on Gut Microbiota Composition and Nutrient Absorption显示文摘 | Antje Damms-Machado Suparna Mitra Asja E. Schollenberger Klaus Michael Kramer Tobias Meile Alfred K?nigsrainer Daniel H. Huson Stephan C. Bischoff Kuo-Sheng Hung | 2015 | BioMed Research International2015，，： | 1 |
| 13 | Effort, safety, and findings of routine preoperative endoscopic evaluation of morbidly obese patients undergoing bariatric surgery显示文摘 | M. A. Küper T. Kratt K. M. Kramer M. Zdichavsky J. H. Schneider J. Glatzle D. Stüker A. K?nigsrainer B. L. D. M. Brücher | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 14 | Die Behandlung der Hepatitis-C-Genotyp-1-Reinfektion nach Lebertransplantation: Tübinger Erfahrungen mit der Telaprevir-Triple-Therapie显示文摘 | C. Werner D. Egetemeyr S. Nadalin A. K?nigsrainer N. Malek U. Lauer C. Berg | 2014 | Z Gastroenterol2014，，01： | 1 |
| 15 | Simultaneous adrenal and extra-adrenal myelolipoma-an uncommon incident:case report and review of the literature显示文摘 | Zieker D K(o)nigsrainer I Miller S | 2008 | World J Surg Oncol2008，6，4： | 1 |
| 16 | Liver Transplantation for Hilar Cholangiocarcinoma: A German Survey显示文摘 | G.M. Kaiser G.C. Sotiropoulos K.W. Jauch F. L?he A. Hirner J.C. Kalff A. K?nigsrainer W. Steurer N. Senninger J.G. Brockmann H.J. Schlitt C. Zülke M.W. Büchler P. Schemmer U. Settmacher J. Hauss H. Lippert U.T. Hopt G. Otto M.M. Heiss W.O. Bechstein S. Ti | 2008 | Transplantation Proceedings2008，，9： | 1 |
| 17 | Laparoscopic Sleeve Gastrectomy: Standardized Technique of a Potential Stand-alone Bariatric Procedure in Morbidly Obese Patients显示文摘 | Markus A. Kueper Klaus M. Kramer Andreas Kirschniak Alfred K?nigsrainer Rudolph Pointner Frank A. Granderath | 2008 | World Journal of Surgery2008，，7： | 1 |
| 18 | Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancerdetected in a tumor mouse model using positron emission tomography/magnetic resonance imaging显示文摘 | Zieker D K(o)nigsrainer I Weinreich J | | 0，，02： | 1 |
| 19 | Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer显示文摘 | Zieker D K(o)nigsrainer I Tritschler I | | 0，，06： | 1 |
| 20 | The gut is not only the target but a source of inflammatory mediators inhibiting gastrointestinal motility during sepsis显示文摘 | K(o)nigsrainer I Türck MH Eisner F | | 0，，04： | 1 |
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