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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | PNPLA3 rs738409-G in Recipients of Liver Transplants is a Risk Factor for Graft Steatosis显示文摘 | Armin Finkenstedt Claudia Auer Bernhard Glodny Ursula Posch Hansjoerg Steitzer Gerhard Lanzer Johann Pratschke Matthias Biebl Michael Steurer Ivo Graziadei Wolfgang Vogel Heinz Zoller | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 3 | WONCA研究论文摘要汇编——非心血管胸痛的诊断指标:系统性综述和荟萃分析显示文摘背景虽然非心血管胸痛(NCCP)具有较高的医疗费用,但还是缺乏针对其诊断研究的指导。当前工作旨在识别重要的诊断指标及其在诊断特定和非特定情况中潜在NCCP的准确性。方法 2012年5月进行系统评价和荟萃分析,对6个数据库进行检索,并进行手动检索和参考书目检索。纳入评估NCCP患者的诊断试验研究。排除每组患者<30例,评估急性心血管疾病的诊断试验。采用似然比表示诊断精确度,采用分层贝叶斯模型进行诊断灵敏度和特异度的联合荟萃分析。结果在6 316个研究中,对260个回顾了全文,最终纳入28个[包括20个胃食管反流病(GERD)研究、3个肌肉骨骼疼痛研究和5个精神疾病研究]。15个研究质量良好,13个研究质量中等。典型的GERD症状诊断GERD的阳性似然比分别为2.70、2.75,阴性似然比分别为0.42、0.78;非典型GERD症状诊断GERD的阳性似然比为0.49,阴性似然比为2.71。质子泵抑制剂(PPI)测试阳性反应诊断GERD的阳性似然比分别为5.48、7.13、8.56,阴性似然比分别为0.24、0.25、0.28;6个研究的平均灵敏度和特异度分别为0.89[95%CI(0.28,1.00)]、0.88[95%CI(0.26,1.00)]。恐惧和焦虑筛查得分可以进一步识别需要检测焦虑或恐慌异常的个体。通过临床表现诊断肌肉骨骼疼痛要么阳性似然比是一般到中等和阴性似然比是较差,要么反之亦然。结论对NCCP患者的病史、症状和临床表现彻底的临床评估可以确定最合适的诊断试验。对大剂量PPI疗法的治疗反应提供了关于GERD的重要信息,应该及早考虑到。恐慌和焦虑症通常是未确诊的,应在胸痛的鉴别诊断中予以考虑。 | WERTLI M M RUCHTI K B STEURER J 本刊编辑部 | 2017 | 中国全科医学2017，20，10： | 2 |
| 4 | A nitrogen gas cooled, hybrid, high temperature superconducting fault currem limiter 显示文摘 | STEURER M BRECHNA H FROHLICH K | 2000 | IEEE Transactions on Applied Superconductivity2000，10，1： | 1 |
| 5 | Increase of regulatory T cells in the peripheral blood of cancer patients显示文摘 | Wolf AM Wolf D Steurer M | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 6 | An effective method for evaluating the accuracy of power hardware in-the-loop simulations显示文摘 | WEI R STEURER M BALDWIN T L | 2009 | IEEE Trans on Industry Applications2009，45，4： | 1 |
| 7 | Increase of regulatory T cells in the peripheral blood of cancer patients显示文摘 | WOLF D STEURER M | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 8 | In crease of regulatory T cells in the peripheral blood of cancer patients显示文摘 | Wolf AM Wolf D Steurer M | 2003 | Clin Cancer Res2003，9，： | 1 |
| 9 | A novel hybrid current-limiting cirecuit breaker for medium voltage: principle and test results显示文摘 | STEURER M HOLAUS W KALTENEGGER K | 2003 | IEEE Trans on Power Delivery2003，18，2： | 1 |
| 10 | Increase of regulatory T cells in the peripheral blood of cancer patients显示文摘 | Wolf AM Wolf D Steurer M | 2003 | ClinCancer Res2003，9，2： | 1 |
| 11 | Interfacing issues in real-time digital simulators 显示文摘 | REN W SLODERBECK M STEURER M | 2011 | IEEE Trans on Power Delivery2011，26，2： | 1 |
| 12 | The effect of oralN-acetylcysteine in chronic bronchitis:a quantitative systematic review显示文摘 | Stey C Steurer J Bachrnarm S | 2000 | Eur Respir2000，16，： | 1 |
| 13 | A novel hybrid currentlimiting circuit breaker for medium voltage:principle and test results显示文摘 | STEURER M FROHLICH K HOLAUS W | 2003 | IEEE Trans on Power Delivery2003，18，2： | 1 |
| 14 | Cytokines and thd Th1/Th2 paradigm in transplantstion显示文摘 | Nickerson P Steurer W Stejger J | 1994 | Curr Opin Immunol1994，6，： | 1 |
| 15 | A Megawatt- Scale Power Hardware-in-the-Loop Simulation Setup for Mo- tor Drivers显示文摘 | Steurer M Edrington C S Sloderbeck M | 2010 | IEEE Transactions on Industrial Electronics2010，57，4： | 1 |
| 16 | Interleukin-6 stimulates thrombopoiesis through thrombopoietin:Role in inflammatory throm- bocytosis显示文摘 | Kaser A Brandacher G Steurer W | 2001 | Blood2001，98，： | 1 |
| 17 | Cardiac depolarization and repolarization in Wolff-Parkinson- White syndrome显示文摘 | Frey B Gursoy S | 1994 | Am Heart J1994，128，5： | 1 |
| 18 | The effects of oral N- acetylcysteine in chronic bronchitis: a quantitative systematic review显示文摘 | Stey C Steurer J Bachmann S | 2000 | Eur Respir J2000，16，2： | 1 |
| 19 | Increase of regulatory T cells in the peripheral blood of cancer patients显示文摘 | Wolf AM Wolf D Steurer M | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 20 | Increase of regulatory T cells in the peripheral blood of cancer patients显示文摘 | Wolf AM Wolf D Steurer M | 2003 | Clin Cancer Res2003，9，2： | 1 |
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