|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. | Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec | 2022 | Bone Research2022，10，2： | 6 |
| 2 | Immunohistochemical detection of estrogen receptor α in articular chondrocytes from cows, pigs and humans: in situ and in vitro results显示文摘 | Horst Claassen Joachim Hassenpflug Michael Schünke Walter Sierralta Hubert Thole Bodo Kurz | 2001 | Annals of Anatomy2001，，3： | 2 |
| 3 | C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins显示文摘 | MIZIELINSKA S GRC)NKE S NICCOLI T | 2014 | Science2014，345，6201： | 1 |
| 4 | Measurement of IgE antibodies using liquid allergens-an inter-method and inter laboratory quality assessment 显示文摘 | Aberer W Kr? nke B | 2002 | Wien Kiln Woehenschr2002，114，2122： | 1 |
| 5 | Fibrosis of the pancreas: the initial tissue damage and the resulting pattern显示文摘 | Günter Kl?ppel S?nke Detlefsen Bernd Feyerabend | 2004 | Virchows Archiv2004，，1： | 1 |
| 6 | Influence of various alginate brands on the redifferentiation of dedifferentiated bovine articular chondrocytes in alginate bead culture under high and low oxygen tension显示文摘 | Domm C Schünke M Steinhagen J | | 0，，11： | 1 |
| 7 | Etiologic and causative factors in perianal dermatitis: results of a prospective study in 126 patients显示文摘 | Birger Kr?nke Michaela Trummer Eva Brabek Peter Komericki Theo Dieter Turek Werner Aberer | 2006 | Wiener klinische Wochenschrift (-)2006，，3： | 1 |
| 8 | Predation risk induces changes in nest-site selection and clutch size in the Siberian jay显示文摘 | Eggers S? nke Griesser Michael Nystrand Magdalena Ekman Jan | 2005 | 2005 (1587)2005，，1587： | 1 |
| 9 | NO/c GMP signaling mole-cules in the rat epithelial rests of Malassez显示文摘 | Ybksel K Wilhelm B S?nke B | 2004 | Euro J Oral Scienc-es2004，112，1： | 1 |
| 10 | 银屑病、异位性皮炎、红斑患者和健康对照者中的葡萄球菌毒素 | Tomi N.S Krnke B. Aberer E 罗素菊 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，10： | 1 |
| 11 | Immunohistochemical detection of estrogen receptor alpha in articular chondrocytes from cows,pigs and humans:in situ and in vitro results显示文摘 | Claassen H Hassenpflug J Schünke M | 2001 | Ann Anat2001，183，3： | 1 |
| 12 | Strain differences in open-field and el- evated plus-maze behavior of rats without and with pretest handling显示文摘 | Schmitt U Hiei'nke C | 1998 | Pharmacol Biochem Behav1998，59，4： | 1 |
| 13 | Implicit consumer preferences and their influence on product choice显示文摘 | FRIESE M W NKE M PLESSNER H | 2006 | Psychology & Marketing2006，23，9： | 1 |
| 14 | Comparison of different constitutive and inducible promoters for the overexpression of transgenes in Arabidopsis thaliana显示文摘 | S?nke Holtorf Klaus Apel Holger Bohlmann | 1995 | Plant Molecular Biology1995，，4： | 1 |
| 15 | Efficacy and safety of paravertebral blocks in breast surgery:A meta- analysis of randomized controlled trials显示文摘 | Schnabel A Reichl SU Kra nke P | 2010 | Br J Anaesth2010，105，6： | 1 |
| 16 | 12/15-1ipoxygenase during the regulation of inflammation,immunity, and self-tolerance 显示文摘 | Uderhardt S Ki~nke G | 2012 | J Mol Med ( Bed )2012，90，11： | 1 |
| 17 | Etiologic and causativefactors in perianal dermatitis: results of a prospective study in 126 patients显示文摘 | Kr nke B Trummer M Brabek E | 2006 | Wien Klin Wochenschr2006，118，： | 1 |
| 18 | High secondary aerosol contribution to particulate pollution during haze events in China显示文摘 | Huang Ru-Jin Szidat Snke Haddad Imad El | 2014 | Nature2014，514，： | 1 |
| 19 | Induction of osteoclast-associated receptor,a key osteoclast costimulation molecule,in rheumatoid arthritis显示文摘 | Herman S Müller RB Kr(o)nke G | 2008 | Arthritis Rheum2008，58，10： | 1 |
| 20 | Clinical features and relapse rates after surgery in type 1 autoimmune pancreatitis differ from type 2: A study of 114 surgically treated European patients显示文摘 | S?nke Detlefsen Giuseppe Zamboni Luca Frulloni Bernd Feyerabend Felix Braun Oke Gerke Anna Melissa Schlitter Irene Esposito Günter Kl?ppel | 2012 | Pancreatology2012，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员