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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Interval mapping for red/green skin color in Asian pears using a modified QTL-seq method显示文摘Pears with red skin are attractive to consumers and provide additional health benefits.Identification of the gene(s)responsible for skin coloration can benefit cultivar selection and breeding.The use of QTL-seq,a bulked segregant analysis method,can be problematic when heterozygous parents are involved.The present study modified the QTL-seq method by introducing a|Δ(SNP-index)|parameter to improve the accuracy of mapping the red skin trait in a group of highly heterozygous Asian pears.The analyses were based on mixed DNA pools composed of 28 red-skinned and 27 green-skinned pear lines derived from a cross between the‘Mantianhong’and‘Hongxiangsu’red-skinned cultivars.The‘Dangshansuli’cultivar genome was used as reference for sequence alignment.An average single-nucleotide polymorphism(SNP)index was calculated using a sliding window approach(200-kb windows,20-kb increments).Nine scaffolds within the candidate QTL interval were in the fifth linkage group from 111.9 to 177.1 cM.There was a significant linkage between the insertions/deletions and simple sequence repeat markers designed from the candidate intervals and the red/green skin(R/G)locus,which was in a 582.5-kb candidate interval that contained 81 predicted protein-coding gene models and was composed of two subintervals at the bottom of the fifth chromosome.The ZFRI 130-16,In2130-12 and In2130-16 markers located near the R/G locus could potentially be used to identify the red skin trait in Asian pear populations.This study provides new insights into the genetics controlling the red skin phenotype in this fruit. | Huabai Xue Ting Shi Fangfang Wang Huangkai Zhou Jian Yang Long Wang Suke Wang Yanli Su Zhen Zhang Yushan Qiao Xiugen Li | 2017 | Horticulture Research2017，4，1： | 5 |
| 3 | Nitriding of steel surface by spraying pulsed-arc plasma jet under at- mospheric pressure 显示文摘 | Ryuta Ichiki Hirokazu Nagamatsu Yuta Yasumatsu Tada- suke Iwao Shuichi Akamine Seiji Kanazawa | 2012 | Materials Letters2012，，71： | 1 |
| 4 | Identification and Pharmacological Characterization of a Novel Human Melanin-concentrating Hormone Receptor, MCH-R2显示文摘 | Suke W Jiang B Kim O | 2001 | J Biol Chem2001，276，34： | 1 |
| 5 | Laboratory experiments and numerical simulation of sediment-wave formation by turbidity currents显示文摘 | Yu'suke Kubo Takeshi Nakajima | 2002 | Marine Geology2002，192，： | 1 |
| 6 | Practical multi- processor scheduling algorithms for efficient parallel processing 显示文摘 | Hironori Kasahara Seino suke Narita | 1984 | IEEE Trans on Computers1984，233，11： | 1 |
| 7 | Endosuffan and other organochlorine pesticide residues in maternal and cord blood in north Indian population显示文摘 | PATHAK R SUKE S G AHMED R S | | 0，，02： | 1 |
| 8 | Effects of water stress on sorbitol production and anatomical changes in the nuclei of leaf and root cells of young loquat tress显示文摘 | Cui S M Chen G L Nao suke Nii | 2003 | J Japan Soc Hort Sci2003，72，： | 1 |
| 9 | Sixty three cases of traumatic injury of the diaphragm显示文摘 | Suke DM | 1991 | Injury1991，22，： | 1 |
| 10 | Semi-volatile and particulate emissions from the combustion of alternative fuels显示文摘 | Suke Sidhu John Graham Richard Striebich | 2001 | Chemosphere2001，，42： | 1 |
| 11 | Clinical features and characteristics of paranasal sinus effusion in allergic sinusitis显示文摘 | SuZuki M Suke T Sakamoto N | 1998 | Nippon Jibiinkoka Gakkai Kaiho1998，101，6： | 1 |
| 12 | Analysis of quazepam and its metabolites in hu man urine by gas chromatography-mass spectrometry: Appli- cation to a forensic case显示文摘 | Masaru Terada Tatsuo Shinozuka Chika Hasegawa Eino- suke Tanaka Makiko Hayashida Youkichi Ohno and Kunihi- ko Kuosaki | 2013 | Forensic Science Interflational2013，227，： | 1 |
| 13 | Epidemiology of breast cancer in Japan显示文摘 | Tetsuo Kuroishi | 1995 | Cancer Letters1995，90，： | 1 |
| 14 | Protective effect ofmelatonin against propoxur-induced oxidative stress andsuppression of humoral immune response in rats显示文摘 | Suke S Kumar A Ahmed R | 2006 | Indian J Exp Biol2006，44，4： | 1 |
| 15 | Eumelanin and p haeo mel2anin content s of human epider mis and cult ured melanocytes显示文摘 | Gillan H Sylvia K Sho suke I | | 0，，04： | 1 |
| 16 | Photol Shigeki, Miyajima Shinfrom silicon quantum dots in Si quantum dots/amorphous SiC superlattice 显示文摘 | Kurokawa Yasuyoshi Tomita suke | 2007 | Japanese Journal of Applied Physics2007，46，35： | 1 |
| 17 | Clinical features and characteristics of paranasal sinus effusion in allergic sinusitis显示文摘 | SuZuki M Suke T Sakamoto N | 1998 | Nippon Jibiinkoka Gakkai Kaiho1998，101，6： | 1 |
| 18 | The Sp-family of transcription factors显示文摘 | Suke G | 1999 | Gene1999，238，： | 1 |
| 19 | Inverse modeling of post Last Glacial Maximum transgressive sedimentation using 2D-SedFlux : Application to the northern Adriatic Sea显示文摘 | Yu’suke Kubo James P.M. Syvitski Eric W.H. Hutton Albert J. Kettner | 2006 | Marine Geology2006，，1： | 1 |
| 20 | Clinical eval- uation o{ cinepazide in the treatment of cerebrovascular disor- ders-multicenter double-blind study in comparison with p la- cebo显示文摘 | A TARASH I JONO SUKE A RAK I GO RO | 2002 | Therapie2002，，7： | 1 |
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