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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | The Unscen- ted Kalman Fil- ter for Nonlinear Estimation显示文摘 | Eric A W Rudolph van der M | 2000 | ASSP- CC2000，，： | 1 |
| 4 | ADMET in silico modeling:towards prediction paradise?显示文摘 | Han van de W Eric G | 2003 | Nat Rev Drug Discov2003，2，： | 1 |
| 5 | Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials显示文摘 | Eric Boersma Robert A Harrington David J Moliterno Harvey White Pierre Théroux Frans Van de Werf Anneke de Torbal Paul W Armstrong Lars C Wallentin Robert G Wilcox John Simes Robert M Califf Eric J Topol Maarten L Simoons | 2002 | The Lancet2002，，9302： | 1 |
| 6 | Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience显示文摘 | Matthias Pfisterer Jafna L Cox Christopher B Granger Sorin J Brener C.David Naylor Robert M Califf Frans van de Werf Amanda L Stebbins Kerry L Lee Eric J Topol Paul W Armstrong | 1998 | Journal of the American College of Cardiology1998，，3： | 1 |
| 7 | Patient outcome after aortic valve replacement with a mechanical or biological prosthesis: weighing lifetime anticoagulant-related e- vent risk against reoperation risk显示文摘 | VAN GELDORP M W A ERIC JAMIESON W R KAPPETEIN A P | 2009 | J Thoracic Card- iovasc Surg2009，137，： | 1 |
| 8 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | 2008 | The Lancet2008，，9617： | 1 |
| 9 | Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study显示文摘 | Joost Daemen Peter Wenaweser Keiichi Tsuchida Linda Abrecht Sophia Vaina Cyrill Morger Neville Kukreja Peter Jüni Georgios Sianos Gerrit Hellige Ron T van Domburg Otto M Hess Eric Boersma Bernhard Meier Stephan Windecker Patrick W Serruys | 2007 | The Lancet2007，，9562： | 1 |
| 10 | International differences in evolution of early discharge after acute myocardial infarction显示文摘 | Padma Kaul L Kristin Newby Yuling Fu Daniel B Mark Robert M Califf Eric J Topol Phil Aylward Christopher B Granger Frans Van de Werf Paul W Armstrong | 2004 | The Lancet . 2004 (9408)2004，，： | 1 |
| 11 | Obesity in the dog显示文摘 | Markwell P J van Eric W Parkin G D | 1990 | Journal of Small Animal Practice1990，31，： | 1 |
| 12 | Nanotribological Properties of Unsymmetrical n-Dialkyl Sulfide Monolayers on Gold: Effect of Chain Length on Adhesion, Friction, and Imaging 显示文摘 | Vegte Eric W van der Subbotin Andrei Hadziioannou Georges | 2000 | Langmuir2000，16，： | 1 |
| 13 | 显示文摘 | Ren X B Eric Van Stryland W | 2000 | J Aml Chem Soc2000，122，： | 1 |
| 14 | Social dilemmas as strong versus weak situations: Social value orientations and tacit coordination under resource size uncertainty 显示文摘 | Erik W de Kwaadsteniet Eric van Dijk Arjaan Wit | 2006 | Journal of Experimental Social Psychology2006，42，： | 1 |
| 15 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | 2008 | The Lancet2008，，9617： | 1 |
| 16 | Can Information Heterogeneity Explain The Exchange Rate Determination Puzzle?显示文摘 | Philippe B Eric van W | 2006 | The American Economic Re- view2006，，3： | 1 |
| 17 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | 2008 | The Lancet2008，，9617： | 1 |
| 18 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | | The Lancet0，，： | 1 |
| 19 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial显示文摘 | Bernard Nordlinger Halfdan Sorbye Bengt Glimelius Graeme J Poston Peter M Schlag Philippe Rougier Wolf O Bechstein John N Primrose Euan T Walpole Meg Finch-Jones Daniel Jaeck Darius Mirza Rowan W Parks Laurence Collette Michel Praet Ullrich Bethe Eric Van | 2008 | The Lancet2008，，9617： | 1 |
| 20 | Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials显示文摘 | Eric Boersma Robert A Harrington David J Moliterno Harvey White Pierre Théroux Frans Van de Werf Anneke de Torbal Paul W Armstrong Lars C Wallentin Robert G Wilcox John Simes Robert M Califf Eric J Topol Maarten L Simoons | 2002 | The Lancet . 2002 (9302)2002，，9302： | 1 |
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