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| 1 | 机械泵驱动两相回路的储液器控温策略研究显示文摘本文阐述了一种机械泵驱动两相回路的储液器的控温原理,并对待选的两种控温策略进行了解释:一种是基于电压的PI控制,另一种是基于功率的PI控制。文中将它们作了近似等效转换,并用SINDA/FLUINT软件进行模拟。结果显示:当控温点上升时,两种不同控制策略的控温效果大体一致;但当控温点下降时,由于基于功率的PI控制策略包含有Peltier的制冷功能,可以比基于电压的PI控制策略更快到达控温点。另外,基于功率的PI控制策略在死区内的跳跃更少,其应当为优先选择的控制策略。 | 莫冬传 黄臻成 何振辉 Van Es Johannes 吕树申 Zwartbol Teun Pauw Aswin | 2012 | 工程热物理学报2012，33，1： | 5 |
| 2 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | 机械泵驱动两相回路的实时动态模型分析显示文摘在航空航天领域,为了加速系统设计及测试进度,通常需要进行半实物实时仿真,即控制器用实物,受控对象采用数学模型。本文开发出了基于Matlab/Simulink的两相传热模块,并用其搭建了某机械泵驱动两相回路的实时动态模型。通过与实验的对比,验证了模型的可靠性,表明该模型满足实时要求,可以在下一步用于半实物仿真。 | 莫冬传 黄臻成 Van Es Johannes Giuseppe Di Mauro 何振辉 吕树申 Teun Zwartbol Pauw Aswin | 2011 | 工程热物理学报2011，32，2： | 4 |
| 4 | Clinical End Points in Coronary Stent Trials: A Case for Standardized Definitions显示文摘 | Donald E. Cutlip Stephan Windecker Roxana Mehran Ashley Boam David J. Cohen Gerrit-Anne van Es P Gabriel Steg Marie-angèle Morel Laura Mauri Pascal Vranckx Eugene McFadden Alexandra Lansky Martial Hamon Mitchell W. Krucoff Patrick W. Serruys | 2007 | Circulation2007，，17： | 4 |
| 5 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 6 | Caught up in a Wnt storm: Wnt signaling in cancer显示文摘 | Rachel H. Giles Johan H. van Es Hans Clevers | 2003 | BBA - Reviews on Cancer2003，，1： | 2 |
| 7 | Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock显示文摘 | Van Amersfoort ES Van Berkel TJ Kuiper J | 2003 | Ctin Microbiol Rev2003，16，3： | 1 |
| 8 | Small cell cancer of the uterine cervix显示文摘 | Van Nagell JR Donaldson ES Wood EG | 1977 | Cancer1977，40，5： | 1 |
| 9 | Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol显示文摘 | ABUCHOWSKI A VAN ES T PALCZUK N C | 1977 | J Biol Chem1977，252，11： | 1 |
| 10 | The importance of cardiac MRI as a diagnostic tool in viral myocarditis-induced cardiomyopathy 显示文摘 | Olimulder MA Van Es J Galjee MA | 2009 | Neth Heart J2009，17，12： | 1 |
| 11 | Donor-Site morbidity of the radial forearm free flap versus the ulnar forearm free flap显示文摘 | Hekner DD Abbink JH van Es R J | 2013 | Plast Reconstr Surg2013，132，2： | 1 |
| 12 | Caught up in a Wnt storm~ Wnt signaling in cancer显示文摘 | Giles R H van Es J H Clevers H | 2003 | Biochim Biophys Acta2003，1653，： | 1 |
| 13 | Interpretation and precision of the Observer Scan Assessment Scale improved by a revised scoring显示文摘 | Lindeboom JA Bruijnesteijn van Coppenraet ES Kuijper E J | 2008 | J Clin Epidermiol2008，6，12： | 1 |
| 14 | TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling 显示文摘 | Brantjes H Barker N van Es J | 2002 | Biol Chem2002，383，2： | 1 |
| 15 | The unfolded protein response is activated in Alzheimer' s disease显示文摘 | Hoozemans J J Veerhuis R Van Haastert ES | 2005 | Acta Neuropathol2005，110，2： | 1 |
| 16 | The accuracy of D-dimertesting in suspected pulmonary embolism varies with the Wellsscore显示文摘 | van Es J Beenen LF Gerdes VE | 2012 | J Thromb Haemost2012，10，12： | 1 |
| 17 | Identification of stem cells in small intestine and colon by marker gene Lgr5显示文摘 | Barker N van Es J H Kuipers J | | Nature0，449，7165： | 1 |
| 18 | Miniature Rain Simulator for Measurement of Infiltration and Runoff显示文摘 | Ogden C B Van Es H M Schindelbeck R R | 1997 | Soil Science Society of American Journal1997，61，4： | 1 |
| 19 | Visible-near infrared reflectance spectroscopy for assessment of soil properties in a semi-arid area of Turkey显示文摘 | Volkan Bilgili A van Es H M Akbas F | 2010 | Journal of Arid Environments2010，74，2： | 1 |
| 20 | Receptors,mediators,and mechanisms involved in bacterial sepsis and septic shock显示文摘 | van Berkel TJ Kuiper J | 2003 | Clin Microbiol Rev2003，16，3： | 1 |
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