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	题名	作者	年代	出处	被引量
1	Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.	Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels	2010	World Journal of Gastroenterology2010，16，6：	11
2	Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘	Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta	2012	The Lancet . 2012 (9829)2012，，：	3
3	Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘	Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta	2012	The Lancet2012，，9829：	1
4	Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘	Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland	2004	Journal of Steroid Biochemistry and Molecular Biology2004，，3：	1
5	Trehalose metabolism in plants显示文摘	John Edward Lunn Ines Delorge Carlos María Figueroa Patrick Van Dijck Mark Stitt	2014	Plant J2014，，4：	1
6	Potentials of biological oxidation processes for the treatment of spent sulfidic caustics containing thiols 显示文摘	Sipma J Svitelskaya A van der Mark B	2004	Water Res2004，38，20：	1
7	Low-dose aspirin dose not prevent thrombovascular accidents in low-risk hemodialysis patients during treatment with recombinant human erythropoietin 显示文摘	Kooistra MP Van Es A Mark JJ	1994	Nephrol Dial Trans Plant1994，9，8：	1
8	Gene-expression profiling of White spot syndrome virus in vivo显示文摘	Marks H Vorst O van Houwelingen A M	2005	J Gen Virol2005，86，：	1
9	Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘	Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J	2011	Diabetes Care2011，，5：	1
10	The anaerobic oxidation of ammonium显示文摘	Mike S.M Jetten Marc Strous Katinka T van de Pas-Schoonen Jos Schalk Udo G.J.M van Dongen Astrid A van de Graaf Susanne Logemann Gerard Muyzer Mark C.M van Loosdrecht J.Gijs Kuenen	1999	FEMS Microbiology Reviews1999，，5：	1
11	Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain显示文摘	Mark A Lovell Hartmut Geiger Gary E Van Zant	2006	Neurobiology of Aging2006，27，7：	1
12	Formulation of waterborne epoxy显示文摘	Michael Van De Mark Kurt A Kirby	1997	American Paint and Coating1997，，1：	1
13	A social dilemma analysis of commuting prefer- ences:the roles of social value orientation and trust显示文摘	Van Lange Paul A M Van Vugt Mark Meertens Ree M Ruiter Rob A C	1998	Journal of Applied Social Psychology1998，，9：	1
14	Capabilitiesfor managing framework显示文摘	Pim den H Wietze van der A Mark W	2010	(4):490-514 service innovation Journal of Service Towards a conceptual Management2010，21，：	1
15	Formulation of water-borne epoxy 显示文摘	MICHAEL VAN DE MARK KURT A KIRBY	1997	American Paint and Coating1997，，1：	1
16	The anaerobic oxidation of ammonium显示文摘	Mike S.M Jetten Marc Strous Katinka T van de Pas-Schoonen Jos Schalk Udo G.J.M van Dongen Astrid A van de Graaf Susanne Logemann Gerard Muyzer Mark C.M van Loosdrecht J.Gijs Kuenen	1999	FEMS Microbiology Reviews1999，，5：	1
17	Yard stick for knowledge man- agement 显示文摘	Van buren Mark E A	1999	Training and Development1999，，3：	1
18	The anaerobic oxidation of ammonium显示文摘	Mike S.M Jetten Marc Strous Katinka T van de Pas-Schoonen Jos Schalk Udo G.J.M van Dongen Astrid A van de Graaf Susanne Logemann Gerard Muyzer Mark C.M van Loosdrecht J.Gijs Kuenen	1999	FEMS Microbiology Reviews1999，，5：	1
19	Pa- rametrization of aliphatic CHn united atoms of GRO- MOS96 force field 显示文摘	DAURA X MARK A E van GUNSTERN W F	1998	J Comput Chem1998，19，5：	1
20	Cerebral microbleeds: a guide to detection and interpretation显示文摘	Steven M Greenberg Meike W Vernooij Charlotte Cordonnier Anand Viswanathan Rustam Al-Shahi Salman Steven Warach Lenore J Launer Mark A Van Buchem Monique MB Breteler	2009	Lancet Neurology2009，，2：	1

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