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| 1 | 急性缺血性与出血性卒中危险因素的对比研究显示文摘目的通过对1个大样本的医院脑卒中注册资料的分析,观察各种危险因素在脑卒中患者中的发生率,并对脑梗死与脑出血的危险因素,特别是心脏和动脉病变的因素进行比较。方法研究资料来自瑞士洛桑卒中注册的卒中患者共3901例,其中脑梗死3525例,脑出血376例,均预先对各项临床和辅助资料进行编码,输入计算机数据库。所有病例均进行系统的临床和辅助检查,心脏病变经心电图和超声心动图证实;颈内动脉和椎基底动脉的病变采用彩色超声多普勒、磁共振血管成像或常规脑血管造影确诊。结果高血压在脑出血和脑梗死患者中的发生率分别为53.7%和46.7%,两者相比差异有统计学意义(P<0.01)。高血压是本组脑卒中最突出的危险因素,其后依次是吸烟、轻度颈内动脉狭窄(≤50%)、高胆固醇血症、短暂性脑缺血发作、糖尿病以及心脏缺血。多因素分析研究发现,本组卒中患者无论是男性还是女性,吸烟、高胆固醇血症、短暂性脑缺血发作、心房纤颤、器质性心脏疾病以及动脉病变是脑梗死而非脑出血密切相关的危险因素。易患脑出血的惟一显著相关的危险因素是高血压(OR=0.64,P<0.01);心脏和动脉病变患者更容易发生脑梗死,但是,器质性心脏病和轻度颈内动脉狭窄在全体卒中患者中均特别常见。结论缺血性卒中和出血性卒中的危险因素并不一致,心脏和动脉病变是脑梗死而非脑出血的重要的危险因素,某些危险因素还存在性别差异。 | 刘新峰 徐格林 Guy van Melle Julien Bogousslavsky | 2005 | 中华神经科杂志2005，38，7： | 42 |
| 2 | 心肌梗死后抑郁的预测:来自心肌梗死和抑郁干预试验(MIND-IT)的数据显示文摘Background: Depression following myocardial infarction(MI) is associated with complicated cardiac rehabilitation, noncompliance and poor prognosis. Whether de pression following MI can be predicted from variables routinely assessed during hospitalization for MI is unknown. Methods: Using data from the Myocardial INfar ction and Depression-Intervention Trial(MIND-IT),we identified 2177 MI patient s(mean age 63 years; 23%female). Patients were randomly divided into a derivati on and a validation sample. In the derivation sample, we analyzed variables pote ntially associated with the development of post-MI depressive disorder, which w ere tested in the validation sample. Results: In the year following MI, 18.5%su ffered from depressive disorder(ICD-10 criteria). In a multivariate model, fact ors associated with depression were younger age(OR 1.94; CI 1.38-2.74), hyperch olesterolemia(OR 1.68; CI 1.08-2.61), the use of calcium channel blockers at di scharge(OR 1.80; CI 1.20-2.71), and left ventricular ejection fraction(LVEF)(OR 4.14 for patients with LVEF< 30%; CI 2.42-7.10). The derived predictors were tested in the validation sample. The final model yielded two clinical predictors , i.e., younger age and severe LV-dysfunction, which correctly predicted post- discharge depression status in 82.9%of the MI patients. The model yielded a hig h negative predictive value(89%). A positive depression questionnaire(BDI) duri ng hospitalization increased the positive predictive value of 23%to 52%. Concl usions: During hospitalization for MI and using a two-step strategy with common clinical variables, i.e., younger age, severe LV-dysfunction and BDI score dur ing hospitalization, it is possible to identify MI patients with a high risk for subsequent development of depression. | Van Melle J.P. De Jonge P. Kuyper A.M.G. 孙凯 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，9： | 3 |
| 3 | Diabetes,glycemic control,and new-onset heart failure in patients with stable coronary artery disease:data from the heart and soul study显示文摘 | Joost P van Melle Mariska Bot | 2010 | Diabetes Care2010，33，9： | 1 |
| 4 | The Lansanne Stroke Registry:Analysis of 1000 Eouseeutive Patients with First Stroke 显示文摘 | Bogousslavsky J Van melle G Regli F | 1988 | Stroke(S0039-2499)1988，19，9： | 1 |
| 5 | Different predictors of neurological worsening in different causes of stroke显示文摘 | Yamamoto H Bogousslavsky J Van melle G | 1998 | Arch Neurol1998，55，4： | 1 |
| 6 | Metformin improves cardiac function in a nondiabetic rat model ofpost-MI heart failure显示文摘 | Yin M van der Horst IC van Melle Jp | | 0，，02： | 1 |
| 7 | Efficacy of the Semont Maneuverin Benign Paroxysmal Positional Vertigo显示文摘 | Levrat E van Melle G MonnierP | 2003 | Arch Otolaryngol Head Neck Surg2003，129，6： | 1 |
| 8 | Preliminary clinical results of posterior lamellar keratoplasty through a sclerocorneal pocket incision显示文摘 | Melles GRJ Lander F van Dooren BTH | 2000 | Ophthalmology2000，107，： | 1 |
| 9 | Admission perfusion CT:prognostic value in patients with severe head trauma显示文摘 | Wintermark M Van Melle G Schnyder P | 2004 | Radiology2004，232，1： | 1 |
| 10 | Occlusion:a more severe disease than previously suggested显示文摘 | Ilhaud D De Freitas GR Van Melle G | 2002 | ArchNeurol2002，59，4： | 1 |
| 11 | Admission perfusion CT: prognostic value in patients with severe head trauma 显示文摘 | Wintermark M Van Melle GS chnyder P | 2004 | Radiology2004，232，1： | 1 |
| 12 | Different predictors of neurological worsening in different causes of stroke显示文摘 | Yamamoto H Bogousslavsky J van Melle G | 1998 | Arch Neurol1998，55，4： | 1 |
| 13 | Better outcome after stroke with higher serum cholesterol levels 显示文摘 | Vauthey C de Freitas GR van Melle G | 2000 | Neurology2000，54，5： | 1 |
| 14 | Chondrogenesis of mesenchymal stem ceils in an osteochondral environment is mediated by the suhehondrai bone 显示文摘 | de Vries -van Melle ML Narcisi R Kops N | 2014 | Tissue Eng Part A2014，20，12： | 1 |
| 15 | Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy显示文摘 | Feron EJ Veckcneer M Parys-Van Ginderdeuren R Van Lommei A Melles GR Stalmans P | 2002 | Arch Optholmol2002，120，2： | 1 |
| 16 | The laussanne stroke registry: analysis of 1,000 consecutive patients with first stroke显示文摘 | Bogousslavsky J Van Melle C Regli F | 1998 | Stroke1998，19，： | 1 |
| 17 | Prognostic factors in papillary Carcinoma of the thyroid显示文摘 | Schindler AM van Melle G Evequoi B | 1991 | Cancer1991，68，2： | 1 |
| 18 | Better outcome after stroke with higher serum cholesterol levels 显示文摘 | V authey C de Freitas GR van Melle G | 2000 | Neurology2000，54，： | 1 |
| 19 | Causes of primary donor failure in descemet membrane endothelial keratoplasty 显示文摘 | Ham L van der Wees J Melles GR | 2008 | Am J Ophthalmology2008，145，4： | 1 |
| 20 | Admissionperfusion CT:prognostic value in patients with severe headtrauma 显示文摘 | Wintermark M van Melle G Schnyder P | 2004 | Radioogy2004，232，1： | 1 |
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