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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 3 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | Soil pollution by petroleum products ( Ⅲ ) : Kerosene stability in soil column as affected by volatilization 显示文摘 | Galin T S Gerstl Z Yaron B | 1990 | Journal of Contaminant Hydrology1990，5，： | 1 |
| 5 | Changes in steroid concentrations during sexual ontogenesis in tilapia显示文摘 | ROTHBARD S MOAV B YARON Z | 1987 | Aquacul- ture1987，61，： | 1 |
| 6 | First trimester embryosize discordance a predictor of premature birth followingmultifetal pregnancy reduction 显示文摘 | Carreno CA Yaron Y Feldman B | 2001 | Fertil Steril2001，75，2： | 1 |
| 7 | Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo controlled trial : the Diacerein Study Group 显示文摘 | Pelletier JP Yaron M Haraoui B | 2000 | Ar- thritis Rhum2000，43，10： | 1 |
| 8 | Efficacy and safety of diacerein in osteoarthritis of the knee:a double-blind,placebo-controlled trial显示文摘 | Pelletier JP Yaron M Haraoui B | 2000 | Arthritis Rheum2000，43，： | 1 |
| 9 | Navigating their way to the clinic:emerging roles for axon guidance molecules in neuroles in neurological disorders and injury显示文摘 | Yaron A Zheng B | 2007 | Dev Neurobiol2007，67，： | 1 |
| 10 | Ef- ficacy and safety of diacercin in os- teoarthritis of the knee: a double-blind, placebo controlled trial: the Diacerein Study Group 显示文摘 | Pelletier JP Yaron M Haraoui B | 2000 | Arthritis Rhum2000，43，10： | 1 |
| 11 | First-trimester embryo size discordance: a predictor of premature birth following multifetal pregnancy reduction显示文摘 | Carreno CA Yaron Y Feldman B | 2001 | Fertil Steril2001，75，2： | 1 |
| 12 | Effect of soil and water salinity on tomato growth显示文摘 | SHALHEVET J YARON B | 1973 | Plant and Soil1973，39，2： | 1 |
| 13 | Use of modified clays for controlling soil environmental quality 显示文摘 | Prost R Yaron B | 2001 | Soil Science2001，166，12： | 1 |
| 14 | Transmission of Escherichia coli O157:H7 from contaminated manure and irrigation water to lettuce plant tissue and its subsequent internalization显示文摘 | Solomon E B Yaron S Matthews K R | 2002 | App Environ Micro2002，68，1： | 1 |
| 15 | Retention and volatilization of kerosene: Laboratory experiments on glacial and post-glacial soils 显示文摘 | Jaesjo J Destouni G Yaron B | 1994 | Journal of Contaminant Hydrology1994，17，： | 1 |
| 16 | Efficacy and safety of diacerein in osteoarthritis of the knee:a double blind,placebo controlled trial显示文摘 | Pelletier JP Yaron M Haraoui B | 2000 | Arthritis Rheum2000，43，： | 1 |
| 17 | Outdoor experiments on enhanced volatilization by venting of kerosene component from soil显示文摘 | Fine P yaron B | 1993 | Journal of Contaminant Hydrology1993，12，： | 1 |
| 18 | Organo-clay formulations of pesticides: Reduced leaching and photo degradation显示文摘 | YARON B SALTMAN S | 2000 | Applied Clay Science2000，18，： | 1 |
| 19 | Efficacy and safety of diacerein in osteoarthritis of the knee:a double-blind,p lacebo-controlledtrial显示文摘 | Pelletier J P Yaron M Haraoui B | 2000 | Arthritis Rheum2000，43，： | 1 |
| 20 | Soil interactions with petroleum hydrocarbons: Abiotic processes 显示文摘 | Fine P Graber E R Yaron B | 1997 | Soil Technol1997，10，： | 1 |
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