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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Information-guided genetic algorithm approach to the solution of MINLP problems显示文摘 | Young, CT Zheng, Y Yeh, CW Jang, SS | 2007 | 中国生物学文摘2007，21，10： | 2 |
| 3 | The characteristics of a hydroxyapatite-chitosan-PMMA bone cement显示文摘 | SEOK B K YOUNG J K TAEK L Y | 2004 | Biomaterials2004，25，26： | 1 |
| 4 | Characteristic of acoustic emission during stress corrosion cracking of inconel 600 alloy显示文摘 | Key Y S In S K Young K Y | 1997 | Scripta Materialia1997，37，： | 1 |
| 5 | Reconstruction for renal artery aneurysm: Operative techniques and long-term results显示文摘 | Jong A H Young K W | 2003 | J Vas Surg2003，37，2： | 1 |
| 6 | Finite Horizon Stochastic Knapsacks with Applications to Yield Management 显示文摘 | Van Slyke R Young Y | 2000 | Operations Research2000，48，： | 1 |
| 7 | Observations of triad coupling of finite depth wind waves显示文摘 | Young I R Eldeberky Y | 1998 | Coastal Eng1998，33，： | 1 |
| 8 | Binding of herbicides by water-soluble organic materials from soil显示文摘 | Maduhun Y A Young J L Free V H | 1986 | J Environ Qual1986，15，： | 1 |
| 9 | Comparison of a-amylase activities from different assay methods 显示文摘 | YOUNG J Y JUAN H RANDOLPH T H | 1987 | Biotechnol Bioeng1987，30，： | 1 |
| 10 | Formation acquisition sensor for the terrestrial planet finder(TPF) mission显示文摘 | TIEN J Y SRINICASAN J M YOUNG J E | 2004 | IEEE Aerospace Conference Proceedings2004，6，2： | 1 |
| 11 | Disruption of microbial cells for intracellular products 显示文摘 | CHISTI Y YOUNG M M | 1986 | Enzyme and Microbial Technol- ogy1986，8，： | 1 |
| 12 | Vertical vibration analysis of vehicle/imperfect track systems 显示文摘 | YOUNG T H LI C Y | 2003 | Vehicle System Dynamics2003，40，5： | 1 |
| 13 | Survival,migration and differentiation of retinal progenitor cellstransplanted on micro-machined poly (methyl methacrylate)scaffolds to the subretinal space显示文摘 | Tao S Young C Redenti S Zhang Y Klassen H Desai T | | 0，，06： | 1 |
| 14 | Propofol neuroproteetion in a rat model of ischaemia reperfusion injury 显示文摘 | Young Y Menon DK Tisavipat N | 1997 | Eur J Anaesthesiol1997，14，3： | 1 |
| 15 | Effect of rice bran dietary fiber on flour rheolo-gy and quality of wet noodles 显示文摘 | Young S K Tea Y H SANG H L | 1997 | KoreanJournal of Food Science and Technology1997，29，1： | 1 |
| 16 | Information- guided genetic algorithm approach to the solution of MINLP problems显示文摘 | Young C T Zheng Y Yeh C W | 2007 | Industrial & Engineering Chemistry Research2007，46，5： | 1 |
| 17 | Satellite Selection Scheme for Reducing Handover Attempts in LEO Satellite Communication Systems显示文摘 | KWON Y YOUNG Y J SUNG D | 1998 | International Journal of Satellite Communications1998，16，4： | 1 |
| 18 | Expression of interferon-γby stromal cells inhibits murine long-term repopulatiny hematopoietic stem cell actirity显示文摘 | Hanazono Y Sellers S Young NS | 1999 | Exp Hematol1999，27，5： | 1 |
| 19 | Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique 显示文摘 | Zhao H Kassama Y Young M | 2004 | Appl Environ Microbiol2004，70，11： | 1 |
| 20 | Egg yolk peptides up-regulate glu-tathione synthesis and antioxidant enzyme activities in a porcinemodel of intestinal oxidative stress显示文摘 | Young D Fan M Z Mine Y | 2010 | J Agr Food Chem2010，58，13： | 1 |
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