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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | The effectiveness of functional electrical stimulation for the treatment of shoulder subluxation and shoulder pain in hemiplegic patients:A randomized controlled trial显示文摘 | Koyuncu E Nakipo lu-Yüzer GF Do an A | | 0，，07： | 1 |
| 3 | Quantification of scattering from fiber surface irregularities显示文摘 | Avram E Mahmood W e zer M | 2002 | Journal of Lightwave Technology2002，20，4： | 1 |
| 4 | Prognostic signifieance of microvascular obstruction by magnetic imaging in patients with acute myocardial infarction显示文摘 | WU K C ZER HOUNI E A JUDD R M | 1998 | Circulation1998，97，8： | 1 |
| 5 | LIN28 alters cell fate succession and acts independently of the let-7 mi- eroRNA during neurogliogenesis in vitro显示文摘 | Ba!zer E Heine C Jiang Q | 2010 | Devel- opment2010，137，6： | 1 |
| 6 | Serum leptin level can be a negative marker of hepatocyte damage in nonalco- holic fatty liver显示文摘 | Serin E ~zer B Gtimtirdtilii Y | 2003 | J Gastroenterol2003，38，5： | 1 |
| 7 | Foodbome viruses: an emerging problem 显示文摘 | KOOPMANS M DU/ZER E | 2004 | Int J Food Microbiol2004，90，1： | 1 |
| 8 | Modeling of the classification behavior of the diaphragms used in multi-chamber cement mills显示文摘 | (OI) ZER C E ERG (U) N S L BENZER A H | | 0，，： | 1 |
| 9 | I nter na rderangement of the wrist:indirect MR arthrography versusunenhanced MR imaging显示文摘 | Hai ms A H Schweit zer M E Mor r ison W B | 2003 | Radiology2003，227，3： | 1 |
| 10 | Lea kage of teet h root-f illed wit h Gutta Floe and a single GP cone compared to lateral condensation and warm vertical condensation显示文摘 | Pitout E Oberhol zer TG | 2009 | SADJ2009，64，3： | 1 |
| 11 | Investigations on the activation of recombinant microbial pro-transglutaminase: in contrast to proteinase K, dispase removes the histidine- tag 显示文摘 | Sommer C Hertel T C Schme|zer C E H et a/ | 2012 | Amino Acids2012，42，2： | 1 |
| 12 | Selective spectrophotometric determination of trinitrotoluene,trinitrophenol,dinitrophenol and mononitrophenol显示文摘 | ERCA(g) E APAK R | 2004 | Analytica Chimica Acta2004，505，： | 1 |
| 13 | Chemical composition of the essential oil of Teucrium multicaule montbret et Aucher ex Bentham from Turkey显示文摘 | Polat T ?zer H ?ztürk E | 2010 | J Essent Oil Res2010，22，5： | 1 |
| 14 | Perceptual audio hashing functions显示文摘 | MEMON N ANARIM E (O)ZER H | 2005 | EURASIP Journal on Applied Signal Processing2005，12，： | 1 |
| 15 | Efficacy and safety of serial glycol- ic acid peels and a topical regimen in the treatment of recalcitrant melasma显示文摘 | Erbil H Se zer E Tastan B | 2007 | J De rmatol2007，34，： | 1 |
| 16 | Analysis of TNF-α(-308)polymorphism and gingival crevicular fluid TNF-αlevels in aggressive and chronic periodontitis:a preliminary report显示文摘 | zer Yücel Berker E Mesci L | 2015 | Cytokine2015，72，2： | 1 |
| 17 | Relationships between epidural fibrosis,pain,disability,and psychological factors after lumbar disc surgery 显示文摘 | Coskun E Süzer T Topuz O | 2000 | Eur Spine J2000，9，2： | 1 |
| 18 | Quantification of scattering from fiber surface irregularities显示文摘 | Avram E Mahmood W zer M | 2002 | Journal of Lightwave Technology2002，20，4： | 1 |
| 19 | A rapid HPLC method for determination of Sudan dyes and Para Red in red chilli pepper显示文摘 | Ertas E Zer H Alasalvar C | 2007 | Food Chemistry2007，105，2： | 1 |
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