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| 1 | 基于脑肠轴理论探讨胃肠调理在针灸治疗脑病中的应用显示文摘胃肠道与脑关系密切,脑肠轴理论的提出把对脑与胃肠道相互作用的认识提升到新的高度。对胃肠道影响脑功能的免疫、神经、内分泌、肠道菌群通路进行梳理,结合胃肠道疾病与脑病发生密切相关的机理、针灸调节胃肠道的效应及针刺调理胃肠道治疗脑病的理论基础,全面剖析和探讨针灸通过胃肠调理治疗脑病的可行性。提出针灸治疗脑病过程中应当重视对胃肠道的调节,加强胃经、大肠经及腹部腧穴的使用。 | 黄凯裕 梁爽 傅淑平 于美玲 卢圣锋 | 2016 | 中医杂志2016，57，13： | 81 |
| 2 | 艾灸对机体免疫调节的研究进展显示文摘艾灸是我国传统中医药的治疗方法之一,可促进人体的新陈代谢,提高机体的免疫功能。笔者通过查阅国内外大量文献,从免疫分子、免疫细胞和免疫器官3个层面论述了艾灸对机体免疫调节作用的进展,为进一步揭示艾灸对机体免疫调节的作用机理奠定基础。 | 杨杰 闫晓 张玲莉 宋忆楠 邹军 | 2013 | 中国中医基础医学杂志2013，19，9： | 35 |
| 3 | 艾灸对溃疡性结肠炎大鼠结肠TLR4和TNF-α蛋白及其mRNA表达影响的研究显示文摘目的:观察艾灸对溃疡性结肠炎大鼠结肠Toll样受体4(TLR4)和肿瘤坏死因子α(TNF-α)蛋白及其m RNA表达的影响,进一步探讨艾灸治疗溃疡性结肠炎的作用机制。方法:将40只SD大鼠随机分为正常组、模型组、隔药灸组和柳氮磺胺吡啶(Sulfasalazine,SASP)组。采用隔药灸天枢和气海穴及SASP灌胃进行干预。干预结束后,应用HE染色光镜下观察各组大鼠结肠病理学变化,分别采用Western blot法和FQ-PCR法检测大鼠结肠TLR4和TNF-α蛋白及其m RNA表达。结果:造模大鼠存在结肠组织病理学损伤,隔药灸组和SASP组大鼠结肠病理学与模型组相比均有一定的改善;与正常组比较,模型组大鼠结肠TLR4和TNF-α蛋白及其m RNA表达均显著增加(P<0.05);经隔药灸和SASP干预后,大鼠结肠TLR4和TNF-α蛋白及其m RNA表达均显著降低(P<0.05)。结论:TLR4、TNF-α可能在溃疡性结肠炎中发挥炎症损伤作用,隔药灸能下调溃疡性结肠炎大鼠结肠TLR4和TNF-α的表达,提示其机制可能是通过下调TLR4和TNF-α表达介导的级联反应达到艾灸治疗溃疡性结肠炎的目的。 | 王晓梅 黄艳 王圆圆 刘雅楠 祁琴 金凤 华雪桂 吴焕淦 | 2016 | 世界科学技术-中医药现代化2016，18，3： | 29 |
| 4 | Acupuncture-moxibustion in treating irritable bowel syndrome: How does it work?显示文摘Irritable bowel syndrome(IBS)is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits.It has drawn great attention because of its high prevalence,reoccurring symptoms,and severe influence on patients’lives.Many clinical studies have demonstrated the efficacy of acupuncturemoxibustion in treating IBS.Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS,and the adoption of modern techniques has achieved some progress.This article reviews the latest advances among actionmechanism studies from the perspectives of gastrointestinal motility,visceral hypersensitivity,the braingut axis,the neuroendocrine system,and the immune system.It is shown that acupuncture-moxibustion can effectively regulate the above items,and thus,this treatment should have a high efficacy in the treatment of IBS.This article also identifies existing problems in current mechanism research and raises several ideas for future studies.Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS. | Xiao-Peng Ma Jue Hong Cai-Ping An Dan Zhang Yan Huang Huan-Gan Wu Cui-Hong Zhang Sian Meeuwsen | 2014 | World Journal of Gastroenterology2014，20，20： | 30 |
| 5 | Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats显示文摘AIM: To observe the efficacy and mechanism of grainsized moxibustion at different acupoints in a rat model of ulcerative colitis(UC). METHODS: Sprague-Dawley rats were randomly divided into control, UC model, grain-sized moxibustion at a single acupoint(CV 12), grain-sized moxibustion at two acupoints(CV 12 and CV 4), grain-sized moxibustion at three acupoints(CV 12, CV 4, and ST 36), and medication groups(n = 8/group). The UC model was established by enema of trinitrobenzene sulfonic acid. Direct moxibustion was used once a day for 7 d. Disease activity index(DAI) was evaluated before and after the treatment. Morphologic changes of intestinal tissue were observed under an optical microscope. The expression of tumor necrosis factor(TNF)-α and p38 mitogen-activated protein kinase(p38MAPK) in colonic tissue was detected using Western blot, and the levels of occludin and zonula occludens-1(ZO-1) m RNAs were detected using reverse transcription PCR. RESULTS: Compared with the control group, the intestinal mucosae were incomplete in the model group, glandular structures were irregular, and submucosae were edematous, hyperemic, and infiltrated with inflammatory cells. The DAI scores and expression ofTNF-α and p38 MAPK were increased significantly in the model group compared to controls(P s < 0.01), while the m RNA levels of occludin and ZO-1 were reduced significantly(P s < 0.01). Compared with the model group, colonic mucosa and the arrangement of glands were complete and regular in the treatment groups. DAI scores and the expression of TNF-α and p38 MAPK were reduced significantly in moxibustion groups compared to controls(P s < 0.01), while the m RNA levels of occludin and ZO-1 were increased significantly(P s < 0.01). The improvements in the above indices in the three acupoints group and the medication group were superior to those in the single and two acupoints groups(all P < 0.05). CONCLUSION: Reduction of TNF-α and p38 MAPK and increased expression of occludin and ZO-1 in colonic tissue represent a potential mechanism for improved intestinal mucosal tissue repair with grain-sized moxibustion. | Tie-Ming Ma Na Xu Xian-De Ma Zeng-Hua Bai Xing Tao Hong-Chi Yan | 2016 | World Journal of Gastroenterology2016，22，8： | 30 |
| 6 | 基于“肠道菌群-免疫反应”探讨针灸治疗缺血性脑卒中的作用机制显示文摘当前,肠道菌群受到越来越多国内外学者们的关注,其与缺血性脑卒中(IS)的相关性研究也逐渐成为脑卒中领域的新兴热点。研究表明,肠道菌群可能是一类新的危险因子,其通过细菌代谢产物或免疫机制可直接或间接影响IS的发生发展。而针灸对于IS、肠道菌群及免疫炎性反应均有一定的正向调节作用。因此,本文围绕三者的相关性展开讨论,并基于'肠道菌群-免疫反应'探讨针灸在治疗IS中的应用,推测针灸或许可以通过纠正紊乱的肠道菌群,降低免疫炎性反应,进而促进卒中损伤后的脑组织及神经功能恢复。 | 马继红 彭拥军 孙建华 朱冰梅 | 2019 | 针刺研究2019，44，7： | 26 |
| 7 | 针灸对肠道菌群影响的研究进展显示文摘本文总结近10年来针灸干预对肠道菌群的影响与作用机制,并加以归纳分析,为针灸对肠道菌群相关疾病的治疗提供更多依据。发现针灸对肠道菌群具有调节作用,能明显改善肠道菌群的多样性及有益菌群的含量,从而达到调整机体功能的目的。针灸治疗的方法、选穴和治疗时间等不同,对菌群的影响不同。同时指出肠道菌群失调与诸多疾病有密切关系,尤其是胃肠道疾病,而针灸对于这类疾病都有良好的治疗作用,但目前对于针灸干预肠道菌群的研究较少,机制不清,文献缺乏,所以提出针灸治疗疾病有效性的机制研究可以从肠道菌群入手。 | 孙路强 张微 魏韬 罗芳丽 李瑛 | 2018 | 湖南中医杂志2018，34，1： | 24 |
| 8 | 基于阴阳平衡理论探讨针灸与肠道微生态的关系显示文摘肠道微生态平衡具有维系人体正常的生命活动的重要作用,肠道微生态失衡会导致疾患的发生或促使病情进一步恶化。针灸治疗疾病在于调和阴阳,促进机体向阴阳平衡的状态发展。针灸可有效改善肠道微生物的多样性,增加机体的免疫功能,从而达到改善疾病状况、恢复肠道微生态平衡的目的。针灸维持机体阴阳平衡与针灸维系肠道微生态平衡从本质上讲是相通的,以阴阳平衡理论为切入点探讨针灸与肠道微生态的关系,为针灸从阴阳平衡论治肠道微生态失衡相关病症提供理论基础。 | 袁伟渠 杨卓欣 周玉梅 卓缘圆 曾旭梅 于海波 | 2020 | 世界科学技术-中医药现代化2020，22，11： | 20 |
| 9 | Randomized controlled trial: Moxibustion and acupuncture for the treatment of Crohn's disease显示文摘AIM: To evaluate the clinical efficacy and safety of acupuncture and moxibustion for the treatment of active Crohn's disease(CD).METHODS: Ninety-two patients were equally and randomly divided into the treatment group and received herb-partitioned moxibustion combined with acupuncture, and the control group received wheat bran-partitioned moxibustion combined with superficial acupuncture. The patients received three treatment sessions per week for 12 wk and were followed up for 24 wk. The main outcome was evaluated using the CD Activity Index(CDAI) score, and the secondary outcomes were evaluated using laboratory indicators such as hemoglobin(HGB), C-reactive protein(CRP), erythrocyte sedimentation rate, quality-of-life, endoscopic ratings, and intestinal histology scores.RESULTS: The CDAI scores of both the treatment and control groups were significantly reduced after treatment compared with those measured before treatment. However, the degree of improvement in the treatment group was significantly greater than that of the control group. The improvement in symptoms in patients of the treatment group was sustained at follow-up, whereas that of the control group was not. The overall efficacy of the treatment was significantly greater than that of the control. Both groups demonstrated significant improvements in quality-of-life ratings after treatment, but the improvement was significantly greater in the treatment group than in the control group. In addition, the patients in the treatment group showed significantly increased HGB and significantly decreasedCRP levels and histopathological scores at the end of treatment, whereas the control group did not exhibit significant changes.CONCLUSION: Moxibustion with acupuncture provided significant therapeutic benefits in patients with active CD beyond the placebo effect and is therefore an effective and safe treatment for active CD. | Chun-Hui Bao Ji-Meng Zhao Hui-Rong Liu Yuan Lu Yi-Fang Zhu Yin Shi Zhi-Jun Weng Hui Feng Xin Guan Jing Li Wei-Feng Chen Lu-Yi Wu Xiao-Ming Jin Chuan-Zi Dou Huan-Gan Wu | 2014 | World Journal of Gastroenterology2014，20，31： | 19 |
| 10 | 艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望显示文摘背景:肠道菌群在宿主肠道内寄生,与肠黏膜免疫屏障相互作用,相互影响,在机体内肠道内环境稳态的调解中起着重要作用。目的:从肠道菌群失调和黏膜免疫激活角度,探讨肠道菌群在肠易激综合征发病环节中的作用及其艾灸治疗肠易激综合征的作用机制。方法:以'肠易激综合征,肠道菌群,肠道黏膜免疫,艾灸'为中文检索词,以'irritable bowel syndrome,intestinal flora,intestinal immune,moxibustion'为英文检索词,应用计算机在中国知网、维普和Pub Med数据库检索2001年10月至2014年10月的相关文献,并进行筛选、归纳和总结。结果与结论:共纳入37篇符合标准文献,其中中文文献15篇,英文文献22篇。文章阐述了肠道菌群失调和肠黏膜免疫在肠易激综合征发病的病理生理过程中发挥的重要作用,肠道菌群失调可影响机体对直肠扩张刺激的感觉阈值、内脏敏感性等。艾灸可从多环节、多靶点调节机体生理平衡,在改善肠易激综合征各项症状,尤其是内脏高敏感性腹痛方面凸显优势。 | 赵继梦 黄艳 窦传字 王硕硕 王晓梅 李垠和 包春辉 周次利 翁志军 陆嫄 吴焕淦 | 2015 | 中国组织工程研究2015，19，2： | 19 |
| 11 | 艾灸治疗脾肾阳虚型溃疡性结肠炎30例临床体会显示文摘目的:研究艾灸治疗脾肾阳虚型溃疡性结肠炎的临床效果。方法:将60例脾肾阳虚型溃疡性结肠炎患者随机分为治疗组和对照组各30例,治疗组患者采用艾灸治疗,对照组口服柳氮磺胺吡啶肠溶片治疗,比较两组患者的治疗效果。结果:经过治疗,治疗组患者总有效率为93.3%;对照组患者总有效率为50.0%,组间临床疗效比较差异具有统计学意义(P<0.05)。结论:艾灸治疗脾肾阳虚型溃疡性结肠炎临床疗效显著,可有效缓解腹痛、腹泻症状,操作简单,值得临床推广应用。 | 宋宸宇 刘丽爽 | 2015 | 亚太传统医药2015，11，18： | 17 |
| 12 | 肠道菌群对中枢神经系统疾病影响的研究进展显示文摘肠道菌群在人体健康和疾病转换过程中扮演重要角色。它不仅参与宿主的多项生理过程,还可通过菌群-肠-脑轴的活动影响中枢神经系统(CNS)功能,可能与神经递质、免疫、内分泌以及代谢产物等途径密切相关。当肠道菌群失调时,可对脑缺血、帕金森病、阿尔茨海默病、多发性硬化、肝性脑病以及精神障碍等CNS疾病的发生发展产生影响。粪便微生物移植、运动训练、针灸推拿等疗法可改善肠道菌群失调,有望成为治疗和预防一些神经系统疾病的有效措施。 | 吴孝军 朱路文 叶涛 李宏玉 陈玉宏 唐强 | 2018 | 中国康复理论与实践2018，24，5： | 17 |
| 13 | 针灸对慢性疲劳综合征及肠道菌群的作用研究显示文摘慢性疲劳综合症(CFS)病因病机尚未明确,现代研究发现其可能与肠道菌群失调密切相关,调节肠道菌群对于CFS具有明显的改善作用。研究证实针灸能够防治CFS,同时也能调节肠道菌群,对于由CFS导致的菌群紊乱可发挥调控与保护作用。本研究拟从针灸对CFS与肠道菌群的影响入手,就三者间的相关性进行探讨,为从肠道菌群角度探讨针灸防治CFS提供新思路。 | 李超然 刘德柱 杨燕 王德龙 郭静 石天宇 屈媛媛 杨添淞 | 2018 | 针灸临床杂志2018，34，7： | 16 |
| 14 | Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial显示文摘Background: Insomnia is a common complaint that is closely related to gastrointestinal symptoms, which is consistent with the traditional Chinese medicine classical theory of ‘‘stomach disharmony leading to restless sleep.' Acupuncture is an effective complementary and alternative medicine therapy to improve gastrointestinal function and restore the normal sleep-wake cycle. However, studies on the effectiveness of acupuncture for insomnia due to spleen-stomach disharmony syndrome are limited to case reports and few randomized controlled trials; deeper research on its mechanism is still lacking. This randomized controlled trial aims to assess the treatment efficacy of ‘‘harmonizing stomach to tranquilize mind'acupuncture for insomnia and its influence on the intestinal microbiome.Methods/design: This is a randomized, single-blind, parallel-group study. Sixty eligible patients with insomnia due to spleen-stomach disharmony syndrome will be randomly divided into two groups(1:1 allocation ratio). The intervention group will use ‘‘harmonizing stomach to tranquilize mind'acupuncture, and the control group will receive sham acupuncture. Participants will receive 5 acupuncture treatment sessions per week for 4 consecutive weeks. The Pittsburgh Sleep Quality Index will be used to evaluate the clinical efficacy of acupuncture treatment by making assessments at baseline, the end of treatment and the end of the follow-up. High-throughput 16 S ribosomal ribonucleic acid gene sequencing will be performed to detect changes in the intestinal microbial composition before and after treatment.Discussion: The results of this trial are expected to confirm that ‘‘harmonizing stomach to tranquilize mind' acupuncture can effectively relieve insomnia and alter the intestinal microbiome. | Ya-ru Huangfu Wei Peng Bao-jun Guo Zhi-fu Shen Li Li Shi-wei Liu Hui Zheng You-ping Hu | 2019 | Journal of Integrative Medicine2019，17，3： | 15 |
| 15 | 长蛇灸治疗脾肾阳虚型功能性腹泻的临床研究显示文摘【目的】观察长蛇灸疗法对脾肾阳虚型功能性腹泻患者的临床疗效及对肠道菌群的影响。【方法】将60例脾肾阳虚型功能性腹泻患者随机分为观察组和对照组,每组各30例。观察组给予长蛇灸治疗,每周1次,连续治疗4周。对照组给予四神丸合附子理中丸治疗,每次各9 g,每日2次,7 d为1个疗程,共治疗4个疗程。评价2组临床疗效,比较2组患者治疗前后各项中医症状积分及症状总积分的变化情况,以及观察组患者肠道菌群物种丰度、Alpha多样性指数、优势菌群、菌群分布及治疗前后群落差异等指标。【结果】(1)观察组总有效率为73.33%,对照组为56.67%。观察组疗效优于对照组(P<0.05)。(2)治疗后,2组患者的各项临床症状积分均明显改善,但差异无统计学意义(P>0.05);治疗后,2组患者症状总积分明显改善(P<0.05),且观察组优于对照组(P<0.05)。2组患者治疗前后症状总积分差值比较,观察组优于对照组(P<0.05)。(3)治疗前后能够检测到的比例在1%以上的肠道菌群共有5个门,即拟杆菌门、厚壁菌门、变形菌门、放线菌门、梭杆菌门。其中长蛇灸疗法治疗后梭杆菌门的相对丰度明显高于治疗前(P<0.05),其他菌门相对丰度值治疗前后比较,差异无统计学意义(P>0.05)。(4)治疗后观察组毛螺菌属、嗜血杆菌属、萨特氏菌属相对丰度值明显低于治疗前,而梭杆菌属相对丰度值明显高于治疗前(P<0.05)。(5)观察组属分类水平物种丰度聚类热图结果显示:普雷沃氏菌属、拟杆菌属、栖粪杆菌属在各样本中丰度较高;患者治疗前后样本肠道菌群的优势菌群存在明显区别。(6)观察组患者治疗后Observed species指数较治疗前下降(P<0.05),治疗前后Chao1指数、Shannon指数、Simpson指数和PD whole tree指数变化无统计学意义(P>0.05)。(7)Beta多样性检测显示,治疗前5个样本分布比较集中;治疗后3个样本较集中、2个样本分布离散,可能是由于个体差异的存在,治疗对不同个体的肠道菌群结构的作用也存在一定差异。(8)观察组治疗后毛螺菌科梭菌属较治疗前显著升高,梭菌科梭菌属、毛螺菌属以及厚壁菌门梭菌目菌属均较治疗前显著下降。(9)2组患者中仅有1例患者在长蛇灸治疗后出现了少量局部的水泡,其余患者均无不良反应发生。【结论】长蛇灸疗法治疗脾肾阳虚型功能性腹泻具有良好的临床疗效,其疗效可能是通过改善肠道菌群结构来实现的。 | 唐舒婷 易曲 胡雪莹 侯江涛 陈斌 刘凤斌 | 2020 | 广州中医药大学学报2020，37，1： | 15 |
| 16 | 基于“脾胃”学说探讨针灸调节肠道菌群的研究概述显示文摘肠道菌群是一个复杂多样的肠道微生态系统,其平衡影响着宿主的平衡和健康。近年来,越来越多学者关注到针灸对肠道菌群的影响。本文从理论、机制、应用三方面对针灸调节肠道菌群的现状进行综述。整理发现'脾胃'学说是针灸调节肠道菌群的理论基础,针灸调节肠道菌群多用于治疗肥胖、胃肠道、心血管系统、中枢神经系统疾病。微生物-脑-肠轴理论可能是针刺调节肠道菌群的重要机制。基于中医'脾胃'学说理论,针灸调节肠道菌群是否能运用于更多疾病领域有待于进一步研究。 | 郑雅玲 金荣疆 黄依杰 蔡继希 李涓 | 2020 | 世界科学技术-中医药现代化2020，22，3： | 15 |
| 17 | 中医药治疗溃疡性结肠炎机制研究进展显示文摘越来越多的临床证据提示中医药可能有效防治溃疡性结肠炎。近年来,中医药治疗UC的机制研究成为UC研究的热点之一。其中发现中医药可通过抗炎、减轻氧化应激、改善肠上皮和微血管通透性、调节免疫、调控肠道微生态等多方面在治疗UC中发挥积极有效的作用。探讨中医药治疗UC的作用机制对指导中医临床用药,提高临床疗效,以及对进一步探明UC发病机制以及新药开发具有重要指导意义。 | 王师英 胡鸿毅 林江 | 2016 | 辽宁中医杂志2016，43，11： | 15 |
| 18 | 针灸治疗溃疡性结肠炎的作用机理研究进展显示文摘近年来针灸疗法在溃疡性结肠炎(ulcerative colitis,UC)的临床应用中逐步增多,在UC的治疗中占据重要地位。笔者对近二十年针灸治疗UC的作用机制研究文献进行归纳、概括、分析,总结出针灸治疗UC的作用机理主要集中在以下五个方面:保护UC结肠黏膜、纠正UC免疫功能失常及缓解炎症、防治UC结肠纤维化、调控UC神经系统、调节UC肠道微生态。针灸可通过多环节、多靶点调控机体生理功能,以促使机体恢复免疫稳态、促进结肠黏膜修复、阻止结肠纤维化进程从而有效控制肠炎。目前针灸治疗UC的作用机制研究取得了一定成果,后期可进行多种作用靶点的综合性研究及针灸治疗不同UC证型的作用机制研究,为针灸疗法在UC临床治疗中的应用推广提供科学依据。 | 贾文睿 刘清国 魏玮 苏晓兰 杨俭勤 王欣 甄建华 冯玉音 蒋海旭 黄光瑞 | 2021 | 环球中医药2021，14，10： | 14 |
| 19 | 黄酮类天然产物调控肠道微生物改善炎症性肠病的研究进展显示文摘炎症性肠病(IBD)是一种肠道的慢性炎症病变,主要表现为肠道炎症性细胞的浸润和肠黏膜的受损,并且在亚洲国家的发病率逐渐升高。IBD的常规治疗包括抗生素和免疫抑制剂等,但是毒副作用大,会产生超级致病菌,甚至会对免疫系统造成一定的损伤。黄酮类化合物是一类具有可变酚结构的天然物质,具有抗氧化、抗炎等特性。黄酮类天然产物广泛存在于自然界中,已被证明可以预防和治疗肠道炎症,但具体的作用机制仍不清楚。综述了肠道菌群与炎症性肠病发病机制的相互关系,以及黄酮类天然产物如何通过调节肠道菌群减轻IBD患者中普遍的菌群失衡和促炎因子的增加进而改善IBD患者的严重程度。以期以调节肠道菌群为切入点,通过深入了解黄酮类天然产物的抑菌和免疫调节作用,探讨其改善炎症性肠病的机理,进一步为黄酮类化合物在改善炎症性肠病中的运用和探究其作用的机制提供一定的理论指导。 | 李明 卢慧 徐振江 | 2020 | 河南工业大学学报(自然科学版)2020，41，3： | 14 |
| 20 | Role of gut microbiota via the gut-liver-brain axis in digestive diseases显示文摘The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis. | Jian-Hong Ding Zhe Jin Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao Rui Xie Jing-Yu Xu | 2020 | World Journal of Gastroenterology2020，26，40： | 13 |
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