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| 1 | Acupuncture-moxibustion in treating irritable bowel syndrome: How does it work?显示文摘Irritable bowel syndrome(IBS)is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits.It has drawn great attention because of its high prevalence,reoccurring symptoms,and severe influence on patients’lives.Many clinical studies have demonstrated the efficacy of acupuncturemoxibustion in treating IBS.Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS,and the adoption of modern techniques has achieved some progress.This article reviews the latest advances among actionmechanism studies from the perspectives of gastrointestinal motility,visceral hypersensitivity,the braingut axis,the neuroendocrine system,and the immune system.It is shown that acupuncture-moxibustion can effectively regulate the above items,and thus,this treatment should have a high efficacy in the treatment of IBS.This article also identifies existing problems in current mechanism research and raises several ideas for future studies.Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS. | Xiao-Peng Ma Jue Hong Cai-Ping An Dan Zhang Yan Huang Huan-Gan Wu Cui-Hong Zhang Sian Meeuwsen | 2014 | World Journal of Gastroenterology2014，20，20： | 30 |
| 2 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 3 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 4 | Clinical Observation on Electroacupuncture for Post-stroke Flaccid Paralysis显示文摘Objective:To observe the clinical efficacy of electroacupuncture (EA) in treating post-stroke flaccid paralysis. Methods:Forty patients with post-stroke flaccid paralysis were randomized by the random number table into a treatment group and a control group, 20 cases in each. The treatment group was intervened by acupuncture at Jiquan (HT 1), Tianquan (PC 2), Ququan (LR 8), Yinlingquan (SP 9), and Yongquan (KI 1), and the control group was treated by acupuncture with conventional acupoint selection. Barthel index (BI) was adopted for evaluating the activities of daily living (ADL), and therapeutic efficacy was analyzed. Results:The two groups both had marked increases of BI score after treatment. Compared to the control group after 1 treatment course and 2 treatment courses respectively, the treatment group had significant differences in BI score (P<0.01). The total effective rate was 100.0% in the treatment group versus 90.0% in the control group, and the difference was statistically significant (P<0.01). Conclusion:EA at Jiquan (HT 1), Tianquan (PC 2), Ququan (LR 8), Yinlingquan (SP 9), Yongquan (KI 1) is an effective approach in treating post-stroke flaccid paralysis. | Zhu Xian-min Hou Jing-yue Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，4： | 14 |
| 5 | Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats显示文摘AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response element binding protein(CREB) in spinal cord of rats with chronic inflammatory visceral pain(CIVP), and to explore the central mechanism of HPM in treating CIVP.METHODS Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide(DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic acid and ethanol. HPM was applied at bilateral Tianshu(ST25) and Qihai(CV6) acupoints in the HPM group, while in the sham-HPM group, moxa cones and herb cakes were only placed on the same points but not ignited. The MEK-inhibitor and DMSO groups received L5-L6 intrathecal injection of U0126 and 30% DMSO, respectively. Abdominal withdrawal reflex(AWR), mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were applied for the assessment of pain behavior. The colonic tissue was observed under an optical microscope after hematoxylin-eosin staining. Expression of phosphor(p)MEK1, p ERK1/2 and p CREB in rat spinal cord was detected using Western blotting. The levels of MEK, ERK and CREB m RNA in rat spinal cord were detected using real-time polymerase chain reaction. RESULTS Compared with the normal group, the AWR scores were increased significantly(P < 0.01) and the MWT and TWL scores were decreased significantly(P < 0.05) in the model, sham-HPM and DMSO groups. Compared with the model group, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly in the HPM and MEK-inhibitor groups(P < 0.05). Compared with the sham-HPM and DMSO groups, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly(P < 0.05) in the HPM and MEK-inhibitor groups. Compared with the normal group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were increased significantly in the model, sham-HPM and DMSO groups(P < 0.01 or < 0.05). Compared with the model group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). Compared with the sham-HPM and DMSO groups, expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). CONCLUSION HPM down-regulates protein phosphorylation of MEK1, ERK1/2 and CREB, and m RNA expression of MEK, ERK and CREB, inhibiting activation of the MEK/ERK/CREB signaling pathway in the spinal cord of CIVP rats, which is possibly a critical central mechanism of the analgesic effect of HPM. | Zhi-Yuan Li Yan Huang Yan-Ting Yang Dan Zhang Yan Zhao Jue Hong Jie Liu Li-Jie Wu Cui-Hong Zhang Huan-Gan Wu Ji Zhang Xiao-Peng Ma | 2017 | World Journal of Gastroenterology2017，23，34： | 12 |
| 6 | Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats显示文摘AIM To observe the effect of herb-partitioned moxibustion(HPM) on expression of colonic cytokines in ulcerative colitis(UC) rats.METHODS A UC rat model was established by protein immunization in combination with topical chemical stimulation.Rats in the HPM group(n = 8) received HPM at bilateral Tianshu(ST25) points.The gross injury and pathological scores of the colon were recorded.The expression profile of colonic cytokines was assayed using the protein microarray technique.Specific differential cytokines were selected and verified by ELISA.The corresponding Uni Prot Accessions of the differentially expressed cytokines were retrieved in the Uni Prot database.The pathways involved were analyzed with the help of the KEGG PATHWAY database.The DAVID database was used for functional cluster and pathway analysis.RESULTS HPM improved colon injuries in UC rats,manifested by accelerated repair of ulcers and alleviation of inflammation,and the gross injury and pathological scores both significantly decreased(P < 0.01).Fold change > 1.3 or < 0.77 was taken as the screening standard.There were 77 down-regulated and 9 up-regulated differentially expressed colonic cytokines in the HPM group compared with the model group,and expression of 20 differed significantly(P < 0.05).Twelve of the 20 significantly differentially expressed cytokines [β-catenin,interleukin-1 receptor 6(IL-1 R6),IL-1β,B7-1,nerve growth factor receptor,AMP-activated protein kinase-α1,neuropilin-2,orexin A,adipocyte differentiation-related protein,IL-2,Fas and Fas L] were up-regulated in the model group(n = 3,compared with the normal group) but downregulated in the HPM group(n = 3,compared with the model group).Functional cluster analysis showed that the differentially expressed colonic cytokines in the HPM group regulated apoptosis and protein phosphorylation.KEGG pathway analysis showed that 52 down-regulated and 7 up-regulated differentially expressed colonic cytokines in the HPM group had pathways.The pathways that interacted between the cytokines and their receptors accounted for the largest proportion(28 of the downregulated and 5 of the up-regulated cytokines).CONCLUSION HPM promotes the repair of colon injuries in UC rats,which is related to the regulation of several abnormally expressed cytokines. | Dan Zhang Yan-Bo Ren Kai Wei Jue Hong Yan-Ting Yang Li-Jie Wu Ji Zhang Zheng Shi Huan-Gan Wu Xiao-Peng Ma | 2018 | World Journal of Gastroenterology2018，24，30： | 11 |
| 7 | Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion显示文摘Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5% trinitrobenzenesulfonic acid and 50% ethanol. Bilateral Tianshu(ST25) and Qihai(CV6) points were selected for herb-partitioned moxibustion. Our results showed that herb-partitioned moxibustion improved visceral pain and down-regulated extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and m RNA expression in dorsal root ganglia. These results indicate that down-regulation of extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and m RNA may be a central mechanism for the analgesic effect of herb-partitioned moxibustion. | Zhi-yuan Li Yan-ting Yang Jue Hong Dan Zhang Xiao-fei Huang Li-jie Wu Huan-gan Wu Zheng Shi Jie Liu Yi Zhu Xiao-peng Ma | 2017 | Neural Regeneration Research2017，12，9： | 7 |
| 8 | Long-term prognosis in patients continuing taking antithrombotics after peptic ulcer bleeding显示文摘AIM To investigate the long-term prognosis in peptic ulcer patients continuing taking antithrombotics after ulcer bleeding, and to determine the risk factors that influence the prognosis. METHODS All clinical data of peptic ulcer patients treated from January 1, 2009 to January 1, 2014 were retrospectively collected and analyzed. Patients were divided into either a continuing group to continue taking antithrombotic drugs after ulcer bleeding or a discontinuing group to discontinue antithrombotic drugs. The primary outcome of follow-up in peptic ulcer bleeding patients was recurrent bleeding, and secondary outcome was death or acute cardiovascular disease occurrence. The final date of follow-up was December 31, 2014. Basic demographic data, complications, and disease classifications were analyzed and compared by t- or χ2-test. The number of patients that achieved various outcomes was counted and analyzed statistically. A survival curve was drawn using the Kaplan-Meier method, and the differencewas compared using the log-rank test. COX regression multivariate analysis was applied to analyze risk factors for the prognosis of peptic ulcer patients. RESULTS A total of 167 patients were enrolled into this study. As for the baseline information, differences in age, smoking, alcohol abuse, and acute cardiovascular diseases were statistically significant between the continuing and discontinuing groups(70.8 ± 11.4 vs 62.4 ± 12.0, P < 0.001; 8(8.2%) vs 15(21.7%), P < 0.05; 65(66.3%) vs 13(18.8%), P < 0.001). At the end of the study, 18 patients had recurrent bleeding and three patients died or had acute cardiovascular disease in the continuing group, while four patients had recurrent bleeding and 15 patients died or had acute cardiovascular disease in the discontinuing group. The differences in these results were statistically significant(P = 0.022, P = 0.000). The Kaplan-Meier survival curve indicated that the incidence of recurrent bleeding was higher in patients in the continuing group, and the risk of death and developing acute cardiovascular disease was higher in patients in the discontinuing group(log-rank test, P = 0.000 for both). Furthermore, COX regression multivariate analysis revealed that the hazard ratio(HR) for recurrent bleeding was 2.986(95%CI: 067-8.356, P = 0.015) in the continuing group, while HR for death or acute cardiovascular disease was 5.216(95%CI: 1.035-26.278, P = 0.028).CONCLUSION After the occurrence of peptic ulcer bleeding, continuing antithrombotics increases the risk of recurrent bleeding events, while discontinuing antithrombotics would increase the risk of death and developing cardiovascular disease. This suggests that clinicians should comprehensively consider the use of antithrombotics after peptic ulcer bleeding. | Xi-Xu Wang Bo Dong Biao Hong Yi-Qun Gong Wei Wang Jue Wang Zhen-Yu Zhou Wei-Jun Jiang | 2017 | World Journal of Gastroenterology2017，23，4： | 7 |
| 9 | Therapeutic Observation on Swift Needling with Fire Needle plus Medication for Herpes Zoster显示文摘Objective:To discuss the effectiveness and safety of swift needling with fire needle plus medication in treating herpes zoster and the change of substance P.Methods:Seventy-nine patients with herpes zoster were selected and randomized into a fire-acupuncture group(41 cases)and a Westernmedication group(38 cases).The fire-acupuncture group was intervened by swift needling with fire needle,and simultaneously prescribed with Valaciclovir Hydrochloride tablets and Vitamin B1;the Western-medication group was by the same oral medicines alone.The therapeutic efficacies were evaluated afterwards.Results:The total effective rate was 95.1%in the fire-acupuncture group versus 89.5%in the Western-medication group,and the difference was statistically significant(P<0.05).After treatment,the concentration of substance P and visual analogue scale(VAS)score dropped significantly in both groups(both P<0.05);the inter-group differences were statistically significant(both P<0.05).Conclusion:Swift needling with fire needle plus medication has better therapeutic efficacy than medication alone in treating herpes zoster. | Fan Yu-jiang Liu Qing-guo Yin Gai-zhen Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，6： | 6 |
| 10 | Efficacy of herb-partitioned moxibustion at Qihai(CV 6) and bilateral Tianshu(ST 25) on colonic damage and the TLR4/NF-κB signaling pathway in rats with Crohn's disease显示文摘OBJECTIVE: To observe the effect of stimulating Qihai(CV 6) and bilateral Tianshu(ST 25) with herb-partitioned moxibustion(HPM) in rats with Crohn's disease(CD), and to investigate the possible anti-inflammatory mechanism of HPM.METHODS: Forty rats were randomly divided into four groups(n = 10 rats per group): normal control(NC), model control(MC), mesalamine(MES), and HPM. The CD rat model was established in the MC,MES, and HPM groups by administering a mixture of trinitrobenzenesulfonic acid and alcohol via enema. The HPM group received HPM on Qihai(CV 6)and bilateral Tianshu(ST 25), while the MES group received intragastric mesalamine. Colonic histomorphological scores, and serum concentrations of tumor necrosis factor α(TNF-α) and interleukin 1β(IL-1β) were assessed to evaluate the effects of HPM on colonic reparation and anti-inflammation.The expressions of Toll-like receptor 4(TLR-4), nuclear factor κB inhibitor α(IκB-α), IκB kinase α/β(IKKα/β), and NF-κB p65 were further analyzed to investigate the regulatory effects of the interventions on the TLR4/NF-κB pathway.RESULTS: CD rats showed inflammatory colonic damage and increased serum concentrations of TNF-α and IL-1β. The expressions of TLR4, IKKα/β,and NF-κB p65 in the colons of CD rats were significantly increased compared with the NC group,while the expression of IκBα(a key negative regulator of NF-κB p65) was decreased. HPM significantly mitigated colonic damage and reduced the serum concentrations of TNF-α and IL-1β. HPM downregulated the expressions of TLR4, IKKα/β, and NF-κB p65 in the colon, and upregulated the expression of IκBα. The effects of HPM in CD rats were similar to those of mesalamine.CONCLUSION: HPM alleviates colonic inflammation in CD rats. This may be achieved through regulation of TLR4, which induces NF-κB signal transduction. | Zhang Dan Wei Kai Ma Xiaopeng Wu Huangan Hong Jue Zhang Cuihong Wu Lingxiang Yan Huang Liu Jie Zhu Yi Yang Ling | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 6 |
| 11 | Clinical Study on Acupoint Injection for Primary Osteoporosis显示文摘Objective:To observe the therapeutic efficacy of acupoint injection in treating primary osteoporosis. Methods:A hundred and fourteen eligible subjects were randomized at 2:1 into two groups. Seventy-six subjects in the observation group were intervened by acupoint injection, and 38 subjects in the control group were intervened by oral medication. Symptom and signs scores were observed before and after treatment. A two-year follow-up study was conducted to compare the long-term therapeutic efficacy between the two groups. Results:The recovery and markedly effective rate was 68.4% in the observation group versus 47.4% in the control group, and the difference was statistically significant (P<0.05). During the 2-year follow up study, 5 subjects in the observation group and 8 in the control group had new fracture, occupying 6.6% and 21.1% respectively, and the difference was statistically significant (P<0.05). Conclusion:In treating primary osteoporosis, acupoint injection has better short and long term therapeutic efficacies compared to oral medication, and it's convenient with high security evaluation. | Xia Shu-shu Qu Qun-wei Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，4： | 6 |
| 12 | Acupuncture plus Chinese Medicinal Fumigation and Washing for Edema of the Stroke-affected Limb显示文摘Objective: To evaluate the therapeutic efficacy of acupuncture plus Chinese medicinal fumigation and washing in treating edema of the affected limb in post-stroke hemiplegia. Methods: Two hundred patients with edema of the stroke-affected limb from our hospital were randomized into two groups according to their visiting sequence. In the observation group, 100 subjects were intervened by acupuncture plus Chinese medicinal fumigation and washing in addition to oral administration of diuretics, while the other 100 subjects in the control group were only given diuretics. The therapeutic efficacy was evaluated after successive 2-week treatments. Results: The total effective rate was 90.0% in the observation group, significantly higher than 66.0% in the control group, indicating that there was a significant difference in comparing the overall therapeutic effect(P<0.01). Conclusion: Acupuncture plus Chinese medicinal fumigation and washing in addition to oral administration of diuretics is effective in treating edema of the affected limb in post-stroke hemiplegia. | Wu Bin Hong Jue | 2014 | Journal of Acupuncture and Tuina Science2014，12，5： | 6 |
| 13 | Systematic Review of Acupuncture for Functional Constipation显示文摘Objective: To systematically analyze the therapeutic efficacy and safety of acupuncture in treating functional constipation(FC). Methods: By searching the Cochrane Library, PubMed, Web of Science, Embase, CBM, CNKI, WanFang databases, the randomized controlled trials(RCTs) comparing acupuncture with Western medication in treating FC were retrieved, from the inception of the databases to September 2013. When the literatures were arranged according to the inclusion and exclusion criteria, and the methodological qualities were evaluated, RevMan 5.2 was adopted for meta-analysis. Results: Ten RCTs were included, covering 1 041 cases of FC. The meta-analysis showed that there was no significant difference in comparing spontaneous bowel movements per week between shallow acupuncture at Tianshu(ST 25) and Western medication [MD=-0.47, 95% CI(-1.28, 0.34)]; there was a significant difference in comparing the spontaneous bowel movements per week between deep acupuncture at Tianshu(ST 25) and Western medication [MD = 0.53, 95% CI(0.13, 0.92)], but the difference was insignificant according to the sensitivity analysis [MD=0.38, 95% CI(-0.03, 0.80)], indicating the low reliability of the conclusion. Regarding the Cleveland clinic score(CCS), the difference between shallow acupuncture at Tianshu(ST 25) and Western medication was insignificant [MD = 0.39, 95% CI(- 1.13, 1.91)]; the difference between deep acupuncture at Tianshu(ST 25) and Western medication was significant [MD=2.64, 95% CI(1.32, 3.97)]. In the evaluation of security, the incidence rate of adverse events in acupuncture treatment(0.31%) was significantly lower than that in Western medication treatment(3.4%). Conclusion: Although the present systematic review showed that deep acupuncture at Tianshu(ST 25) should have better therapeutic efficacy than Western medication, the reliability and quality of the evidences were poor, and thus the above results require proving by more RCTs of higher quality. | Zhang Wei Sun Jian-hua Pei Li-xia Wu Xiao-liang Chen Lu Jiao Dai-yan Hong Jue | 2014 | Journal of Acupuncture and Tuina Science2014，12，2： | 5 |
| 14 | Electroacupuncture in Treating Depression:A Randomized Controlled Study显示文摘Objective: To observe the clinical efficacy of electroacupuncture in treating depression. Methods: By a randomized controlled study method, sixty patients with depression were randomized into an electroacupuncture group and a medication group, 30 in each. The electroacupuncture group was treated with electroacupuncture, and the medication group was orally administrated Paroxetine tablets. They were evaluated by using Hamilton Depression Scale (HAMD) before and after treatments and the safety was also assessed. Results: The total effective rate was 83.3% in the electroacupuncture group versus 60.0% in the medication group, and the difference was statistically significant (P<0.05). The electroacupuncture group was superior to the medication group in comparing the improvement of HAMD scores after treatment (P<0.05). Conclusion: Electroacupuncture is an effective approach in treating depression. | Chen Xiu-ling Xu Kai Luo Ren-han Lin Miao-jun Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，1： | 5 |
| 15 | Clinical Study on Puncturing Houxi (SI 3) Toward Hegu (LI 4) plus Lumbar Movement for Acute Lumbar Sprain显示文摘Objective: To observe the therapeutic efficacy of puncturing Houxi (SI 3) toward Hegu (LI 4) plus lumbar movement in treating acute lumbar sprain. Methods: A total of 212 patients with acute lumbar sprain were randomized into two groups. There were 106 subjects in the observation group who were treated with puncturing Houxi (SI 3) toward Hegu (LI 4) plus lumbar movement; the other 106 patients in the control group were treated with puncturing Houxi (SI 3) toward Hegu (LI 4) alone. Therapeutic efficacy was evaluated after 2 treatment courses. Results: The total effective rate was 95.3% in the observation group versus 88.7% in the control group, and the difference was statistically insignificant between the two groups (P>0.05). However, in comparing the treatment times for achieving recovery and effectiveness, differences between the two groups were statistically significant (both P<0.05), indicating that integrated use of acupuncture and exercise is faster in realizing therapeutic effectiveness. Conclusion: By selecting fewer acupoints, puncturing Houxi (SI 3) toward Hegu (LI 4) is effective in treating acute lumbar sprain, and with the help of lumbar movement, it can achieve even better treatment effect. | Zhou Jing-hui Wu Yao-chi SunYi-jun Zhang Jun-feng Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，1： | 5 |
| 16 | Aligned Acupuncture at Muscle Regions plus Cutaneous Needle for Upper Limb Spasticity After Stroke: A Multicenter Randomized Controlled Trial显示文摘Objective: To evaluate the clinical efficacy of aligned acupuncture at the muscle regions plus cutaneous needle for post-stroke upper limb spasticity.Methods: By adopting a design of multicenter randomized controlled clinical trial, 488 patients with post-stroke upper limb spasticity were randomized into a treatment group and a control group, 244 in each group. In addition to rehabilitation training, the treatment group received aligned acupuncture at the muscle regions plus cutaneous needle therapy and the control group received conventional Western medicine. After successive 3-week treatments, the clinical efficacy, spasticity degree of the upper limb, joint function, and neurological defect degree were evaluated in the two groups. Results: The total effective rate was 93.4% in the treatment group versus 61.5% in the control group, and the difference was statistically significant(P < 0.05). The upper-limb spasticity degree, joint function, and neurological defect degree were improved significantly in both groups after intervention(P<0.05), and the improvements in the treatment group were more significant than those in the control group(P<0.05 or P<0.01). Conclusion: Aligned acupuncture at the muscle regions plus cutaneous needle therapy is effective in treating post-stroke upper limb spasticity. | Hou Li-jun Han Shu-kai Gao Wei-na Xu Yu-na Yang Xin-wei Yang Wei-hong Hong Jue | 2014 | Journal of Acupuncture and Tuina Science2014，12，3： | 5 |
| 17 | Clinical and angiographic characteristics of premenopausal women with coronary artery disease显示文摘当中年的 men.It 的疾病广泛地被接受,背景冠的动脉疾病( CAD )通常被考虑因为荷尔蒙 protection.Based ,为绝经前的女人的 CAD 的风险是低的,没有足够的 concern.Even nowthere ,更绝经前的女人受不了咽峡炎和心肌的梗塞,这仍然是有限的详细数据为了描述绝经前的 CAD patients.This 的 characteristicsmechanism 和预后,文章瞄准了到分析临床所有 P < 0.05 )我们在绝经前的 CAD 发现了单个容器的更多的经常的参与的 .Although (43.2%对 26.9%P=0 ),并且三倍的容器在绝经后( 56-60 岁) CAD 病人(33.8%对 20.4%P=0 )更严重的损害(90%)在留给主要(2.9%对1.1%, P=0.048 )并且近似左前面的下降动脉(男孩)(28.2%对 16.6%P=0 )在绝经前的 CAD ,组是有胸不快的绝经前的女人总是被发现把明显的 atherosclerosismore 使倾向了被定位的 found. | DOU Ke-fei XU Bo YANG Yue-jin Lü Rong QIU Hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun | 2008 | Chinese Medical Journal2008，，23： | 5 |
| 18 | Clinical Observation of Acupuncture-moxibustion for Alzheimer’s Disease显示文摘Objective: To observe the clinical efficacy of acupuncture-moxibustion in treating Alzheimer's disease(AD). Methods: Forty-eight eligible AD patients were enrolled to receive acupuncture plus herb-partitioned moxibustion. Mini-mental state examination(MMSE) was adopted for evaluation before and after intervention, and the therapeutic efficacy was observed. Results: After intervention, the MMSE score changed significantly(P<0.01), and the total effective rate was 83.3%. Conclusion: Acupuncture-moxibustion can significantly improve the cognitive function of AD patients, beneficial to the general promotion of the quality of life. | Cui Li Hong Jue | 2014 | Journal of Acupuncture and Tuina Science2014，12，6： | 4 |
| 19 | Diverse Needling Methods for Dry Eye Syndrome:A Randomized Controlled Study显示文摘Objective:To explore a proper acupuncture treatment protocol for dry eye syndrome(DES),by comparing the therapeutic effects between ordinary acupuncture and electroacupuncture(EA).Methods:Forty-seven eligible subjects with DES were randomized into an acupuncture group(n=23)and an EA group(n=24).With the same acupoint formula,the acupuncture group was treated with ordinary acupuncture,and the EA group was treated with ordinary acupuncture plus electrical stimulation.After a treatment course,eye symptom score,Schirmer I test(SIT),Break-up Time(BUT)of tear film,Corneal Fluorescein Staining(CFS),and Visual Analogue Scale(VAS)were adopted in evaluation and comparison of the two groups.Results:The total effective rate was 79.2%in the EA group versus 56.5%in the acupuncture group,and the difference was statistically significant(P<0.05).After treatment,both groups had marked improvements in eye symptom score,SIT,BUT,CFS,and VAS values(P<0.001);the EA group was better than acupuncture group in improving eye symptom score and SIT value(both P<0.05);the differences were insignificant in comparing VAS,BUT and CFS results between the two groups(P>0.05).Conclusion:Both EA and ordinary acupuncture are effective in treating DES,but EA is better than ordinary acupuncture in improving eye symptom and SIT score. | Guo Meng-hu Cui En-cao Li Xin-yuan Zong Lei Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，2： | 4 |
| 20 | High performance octahedral PtNi/C catalysts investigated from rotating disk electrode to membrane electrode assembly显示文摘Octahedral PtNi/C catalysts have demonstrated superior catalytic performance in oxyge n reduction reacti on (ORR) over commercial Pt/C with rotating disk electrode (RDE). However, it is not trivial to translate such promising results to real-world membrane-electrode assembly (MEA). In this work, we have synthesized octahedral PtNi/C catalysts using poly(diallyldimethylammonium chloride)(PDDA) as a capping age nt and in vestigated their performance from RDE to MEA. In RDE, mass activity and specific activity of the optimized octahedral PtNi/C catalyst for oxygen reduction reaction (ORR) are nearly 19 and 28 times high of the state-of-the-art commercial Pt/C, respectively. At MEA level, the octahedral PtNi/C catalyst exhibits excelle nt power generation performa nee and durability paired with commercial Pt/C ano de. Its cell voltage at 1,000mA·cm^-2 reaches 0.712 V, and maximum power density is 881.6 mW·cm^-2 and its performance attenuation is also less, around 11.8% and 7% under galvanostatic condition of 1,000 mA·cm^-2 for 100 h. Such results are investiaged by thermodynamic analysis and fundametal performance modeling, which indicate the single cell performance can be further improved by reducing the size of PtNi/C catalyst agglomerates. Such encouraging results have demonstrated the feasibility to convey the superior performance of octahedral PtNi/C from RDE to MEA. | Bing Li Jue Wang Xin Gao Congwei Qin Daijun Yang Hong Lv Qiangfeng Xiao Cunman Zhang | 2019 | Nano Research2019，12，2： | 3 |
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