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| 1 | Acupuncture for ischemic stroke:cerebellar activation may be a central mechanism following Deqi显示文摘The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magnetic resonance imaging(f MRI)on the effects of acupuncture at Waiguan(SJ5)in pathological and physiological states is controversial.In this study,12 patients with ischemic stroke received acupuncture at Waiguan(SJ5)and simultaneously underwent f MRI scanning of the brain,with imaging data of the activated areas obtained.Based on the patient’s sensation,imaging data were allocated to either the Deqi group or non-Deqi group.In the Deqi group,the activated/deactivated areas were the left superior temporal gyrus(BA39)/right anterior lobe of the cerebellum and left thalamus.In the non-Deqi group,the activated areas included the medial frontal gyrus of the right frontal lobe(BA11),right limbic lobe(BA30,35),and left frontal lobe(BA47),while the only deactivated area was the right parietal lobe(BA40).Compared with the non-Deqi group,the Deqi group exhibited marked activation of the right anterior lobe of the cerebellum and right limbic lobe(BA30).These findings confirm that the clinical effect of Deqi during acupuncture is based on brain functional changes.Cerebellar activation may be one of the central mechanisms of acupuncture in the treatment of ischemic stroke. | Miao-keng Li Yu-jie Li Gui-feng Zhang Jun-qi Chen Ji-ping Zhang Ji Qi Yong Huang Xin-sheng Lai Chun-zhi Tang | 2015 | Neural Regeneration Research2015，10，12： | 24 |
| 2 | Acupuncture at Waiguan(SJ5) and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study显示文摘Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group(true acupuncture at right Waiguan(SJ5)) and sham point group(sham acupuncture). Results of functional magnetic resonance imaging revealed activation in right parietal lobe(Brodmann areas 7 and 19), the right temporal lobe(Brodmann area 39), the right limbic lobe(Brodmann area 23) and bilateral occipital lobes(Brodmann area 18). Furthermore, inhibition of bilateral frontal lobes(Brodmann area 4, 6, and 45), right parietal lobe(Brodmann areas 1 and 5) and left temporal lobe(Brodmann area 21) were observed in the true point group. Activation in the precuneus of right parietal lobe(Brodmann area 7) and inhibition of the left superior frontal gyrus(Brodmann area 10) was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex(Brodmann area 5) is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients. | Ji Qi Junqi Chen Yong Huang Xinsheng Lai Chunzhi Tang Junjun Yang Hua Chen Shanshan Qu | 2014 | Neural Regeneration Research2014，9，3： | 19 |
| 3 | 针刺联合低频疗法治疗缺血性脑卒中后失眠显示文摘目的观察针刺联合低频治疗缺血性脑卒中后失眠的临床疗效。方法选取缺血性脑卒中患者病例60例,随机分为治疗组与对照组,各30例,治疗组在常规治疗基础上予针刺联合低频治疗,对照组在常规治疗基础上给予艾司唑仑片治疗。2组均连续治疗4周,并在3个月后随访。观察PSQI量表、AIS量表、SDS量表、5-HT、DA浓度的变化。结果治疗组临床疗效结果总有效率为86.67%,优于对照组的70.00%(P<0.05);2组治疗前后患者血浆5-HT、DA浓度的差异有统计学意义(P<0.05),2组患者血浆5-HT浓度均有不同程度的升高,DA浓度均有不同程度的降低,治疗组患者血浆5-HT升高的程度较对照组更为明显(P<0.05),DA浓度下降的程度较对照组更为明显(P<0.05)。结论针刺联合低频治疗缺血性脑卒中后失眠,疗效优于艾司唑仑片,其作用机制可能与调节血浆5-HT和DA浓度有关。 | 游毅 陈卉 李土明 谢安劼 王长德 | 2019 | 吉林中医药2019，39，11： | 14 |
| 4 | 基于体素的静息态fMRI观察原发性失眠患者针刺治疗后全脑度中心度的改变显示文摘【目的】利用度中心度(DC)的方法探讨原发性失眠(PI)患者针灸治疗后静息态下脑功能网络连接属性的改变。【方法】对29例PI患者及22例年龄、性别、受教育程度均匹配的健康对照组进行百会、四神聪、神门、三阴交等穴位行两周针灸治疗后,行静息状态下的功能磁共振成像扫描,经预处理和后处理计算出全脑DC值图,采用双样本t检验进行组间比较,分别检测PI组与NC组间DC分布图间的统计学差异。【结果】与NC组相比,PI患者DC值减低的脑区主要分布在右侧颞中回、右侧海马、右侧豆状核、双侧海马旁回及左侧楔叶等区域。【结论】基于静息态功能MRI数据的DC分析观察到PI患者在脑区间功能连接改变,DC作为一种新的基于体素水平描述脑网络属性的方法,可能对理解PI神经机制及观察其脑网络属性的改变提供了一个新视角。 | 许晓跃 王水 陆儒 马晓芬 江桂华 傅世舜 詹文峰 方金 | 2017 | 中山大学学报(医学科学版)2017，38，2： | 13 |
| 5 | 功能磁共振成像对针刺联合中医药治疗脑梗死疗效评价显示文摘目的:观察针刺联合中医药干预治疗前后脑梗死患者功能磁共振成像(f MRI)相应检测数据的变化,探讨其与临床疗效评价之间关系。方法:选取40例脑梗死患者,采用随机数表法将脑梗死患者分为常规治疗的对照组和针刺中药联合治疗的观察组,每组20例,两组患者于治疗前后分别进行病情评测及f MRI检查,使用美国国立卫生研究所脑卒中(NIHSS)评分对神经功能缺损程度进行评价,分析基底节脑梗死患者针刺联合药物治疗前后f MRI影像学表现,利用血氧水平依赖(BOLD)、f MRI及弥散张量成像(DTI)等脑功能成像技术了解患者在治疗中和治疗后相应机体功能区及其功能连接的不同脑区间在脑梗死患者针刺治疗前后的变化。结果:观察组的NIHSS评分明显少于对照组,差异有统计学意义(t=5.450,P<0.05);观察组治疗总有效率为95.0%明显高于对照组的75.0%,两组比较差异有统计学意义(x2=4.329,P<0.05);观察组激活频率、激活体积、平均表观弥散系数(ADCavg)值和各向异性分数(FA)值与对照组存在明显差异,具有统计学意义(t=5.425,t=2.760,t=3.453,t=5.513;P<0.05)。结论:针刺中药联合治疗可以有效的改善脑梗死患者的神经功能缺损,而且f MRI检查可以更好地观察患者治疗前后的临床疗效。 | 赵波沣 胡元明 陈树平 | 2017 | 中国医学装备2017，14，7： | 13 |
| 6 | 基于Citespace针灸近5年研究热点及趋势可视化分析显示文摘目的:探索针灸近5年研究现状、热点及趋势。方法:计算机检索Web of Science(SCI-EXPANDED)数据库,获取针刺、艾灸以及穴位相关的研究,应用Citespace Ⅴ软件分析纳入结果。结果:共纳入4666篇文献针灸相关文献。可视化分析显示:研究最多的学科是综合补充医学(37.7%),试验类型以随机对照试验最多(69.1%),国家科学自然基金是支持针灸研究最多的基金(11.9%),发文最多的机构是韩国庆熙大学(5.2%),所有疾病中以痛症、脑卒中以及情感障碍等疾病为热点,突显词检测显示大脑、神经痛、焦虑、预防、老年痴呆等为最新研究。结论:针灸研究类型以随机对照试验最多,痛症是研究最多的症状,近5年的研究热点是脑病,神经系统疾病、癌症以及慢性病。 | 徐桂兴 李惠菁 李雨谿 付亚男 李涓 银子涵 陈姣 梁繁荣 | 2019 | 中药与临床2019，10，3： | 5 |
| 7 | 针刺治疗脑卒中后偏瘫的功能性磁共振机制研究进展显示文摘针刺被广泛应用于脑卒中后偏瘫的康复治疗,基于功能性磁共振成像(fMRI)技术的研究观察到针刺阳陵泉、外关、足三里等脑卒中康复常用穴后,出现运动皮质重塑、脑区连接改变和神经网络变化等,提示针刺能够通过调节脑皮质活性,促进脑功能重组,影响患者运动功能的恢复。针刺调节脑皮质功能活性受到多种因素影响,患者病灶部位、健侧和患侧的选取以及不同取穴方案均能引起神经影像上的差异。众多研究结果在体现针刺辨证论治的个性化疗法特点的同时,也提示了基于“神经调控”开展针刺治疗的难度。 | 张建忠 齐瑞 李昭缘 卞跃峰 周茜 | 2022 | 世界中医药2022，17，8： | 1 |
| 8 | Retraction Notice显示文摘The following article from Neural Regeneration Research,‘Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia’by Shu et al.,published on Volume 8,Issue25,Pages 2370-2378 has been retracted by agreement between the authors and the journal.The retraction has | | 2014 | Neural Regeneration Research2014，9，8： | 0 |
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