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| 1 | 心力衰竭研究的组学视角显示文摘心力衰竭是多种心血管疾病的终末阶段,严重影响了全世界近4000万人的生活质量及生命安全。目前还有部分类型心力衰竭的临床特征、病理生理特点不清楚,无有效的诊断及治疗方法。近年来,基因组学、转录组学、表观基因组学、蛋白质组学、代谢组学等组学技术在疾病研究中的广泛应用,为心力衰竭的预防、诊断及治疗提供了新的策略,同时也为降低心力衰竭死亡率带来了希望。本文针对心力衰竭临床治疗现状,对各组学及其相互间的联合在心力衰竭发病机制、临床诊断治疗、相关药物药效和作用机制等方面研究中的作用及应用潜力进行了综述。 | 张金月 刘启凤 杨柳 吕雪琪 王映红 | 2020 | 药学学报2020，55，5： | 5 |
| 2 | Concentration of circulating microparticles:a new biomarker of acute heart failure after cardiac surgery with cardiopulmonary bypass显示文摘Acute heart failure(AHF)is a severe complication after cardiac surgery with cardiopulmonary bypass(CPB).Although some AHF biomarkers have been used in clinic,they have limitations when applied in the prediction and diagnosis of AHF after cardiac surgery with CPB,and there are still no effective and specific biomarkers.We and other researchers have shown that circulating microparticles(MPs)increased in a variety of cardiovascular diseases.However,whether the concentration of circulating MPs could be a new biomarker for AHF after cardiac surgery remains unknown.Here,90 patients undergoing cardiac surgery with CPB and 45 healthy subjects were enrolled.Patients were assigned into AHF(n=14)or non-AHF(n=76)group according to the diagnosis criteria of AHF.The concentrations of circulating MPs were determined before,as well as 12 h and 3 days after operation with nanoparticle tracking analysis technique.MPs concentrations in patients before surgery were significantly higher than those of healthy subjects.Plasma levels of MPs were significantly elevated at 12 h after surgery in patients with AHF,but not in those without AHF,and the circulating MPs concentrations at 12 h after surgery were higher in AHF group compared with non-AHF group.Logistic regression analysis indicated that MPs concentration at postoperative 12 h was an independent risk factor for AHF.The area under receiver operating characteristic curve for MPs concentration at postoperative 12 h was 0.87 and the best cut-off value is 5.20×10~8 particles mL~(–1)with a sensitivity of 93%and a specificity of 70%.These data suggested that the concentration of circulating MPs might be a new biomarker for the occurrence of AHF after cardiac surgery with CPB. | Yuquan Li Haoxiang Yuan Caiyun Chen Chao Chen Jian Ma Yating Chen Yan Li Yupeng Jian Donghong Liu Zhijun Ou Jingsong Ou | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 3 | 心血管衰老的机制和干预综述显示文摘随着老龄化进程的逐年加速,我国已正式迈入老龄化社会。随着年龄的增长,心血管系统可发生结构和功能的改变,使老年人心血管事件的发生率和严重程度增加。目前,心血管疾病已成为我国居民死亡的首要原因。深入阐释心血管衰老及相关疾病的分子细胞调控网络,寻找心血管衰老及相关疾病的应对策略,积极推动心血管衰老及相关疾病研究的深入开展和临床转化,对于我国心血管病的主动防治具有重要意义。本文回顾心血管衰老及相关疾病研究的发展简史,综述近期我国心血管衰老及相关疾病的机制和临床转化的研究进展,并简要探讨心血管衰老研究领域的发展趋势和未来前景。 | 刘聘选 张嘉禾 毕金淼 王语涵 宋默识 | 2021 | 中国基础科学2021，，6： | 1 |
| 4 | 代谢组学在心肌梗死及心衰方面研究的进展显示文摘心血管疾病是代谢组学的主要研究靶点,代谢改变在其发病和进展中起着重要作用。寻找心肌梗死后发生心衰期间不同阶段疾病的代谢标志物,可以准确地对疾病发展进程进行诊断,并有助于采取准确的治疗措施。本文就代谢组学及其在心肌梗死及心衰方面研究的进。 | 刘东坤 吕勃 | 2023 | 心血管康复医学杂志2023，32，2： | 0 |
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