|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances in coatings on magnesium alloys for cardiovascular stents-A review显示文摘Magnesium(Mg)and its alloys,as potential biodegradable materials,have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility.Nevertheless,the occurrence of thrombosis,inflammation,and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications.Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality.This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade,regarding preparation strategies for metal oxide,metal hydroxide,inorganic nonmetallic,polymer,and their composite coatings;and the performance of these strategies in regulating degradation behavior and biofunction.Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations.It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field. | Zhao-Qi Zhang Yong-Xin Yang Jing-An Li Rong-Chang Zeng Shao-Kang Guan | 2021 | Bioactive Materials2021，6，12： | 8 |
| 2 | Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg显示文摘Layered double hydroxides(LDHs)are widely studied to enhance corrosion resistance and biocompatibility of Mg alloys,which are promising bone implants.However,the influence of LDH coating on the osteointegration of Mg implants lacks of a systematic study.In this work,Mg-Al LDH coating was prepared on pure Mg via hydrothermal treatment.The as-prepared Mg-Al LDH coated Mg exhibited better in vitro and in vivo corrosion resistance than bare Mg and Mg(OH)2 coated Mg.In vitro culture of mouse osteoblast cell line(MC3T3-E1)suggested that Mg-Al LDH coated Mg was more favorable for its osteogenic differentiation.In vitro culture of HUVECs revealed that cells cultured in the extract of Mg-Al LDH coated Mg showed superior angiogenic behaviors.More importantly,the immune response of Mg-Al LDH coated Mg was studied by in vitro culturing murine-derived macrophage cell line(RAW264.7).The results verified that Mg-Al LDH coated Mg could induce macrophage polarize to M2 phenotype(anti-inflammatory).Furthermore,the secreted factor in the macrophageconditioned culture medium of Mg-Al LDH group was more suitable for the bone differentiation of rat bone marrow stem cells(rBMSCs)and the angiogenic behavior of human umbilical vein endothelial cells(HUVECs).Finally,the result of femoral implantation suggested that Mg-Al LDH coated Mg exhibited better osteointegration than bare Mg and Mg(OH)2 coated Mg.With favorable in vitro and in vivo performances,Mg-Al LDH is promising as protective coating on Mg for orthopedic applications. | Shi Cheng Dongdong Zhang Mei Li Xuanyong Liu Yu Zhang Shi Qian Feng Peng | 2021 | Bioactive Materials2021，6，1： | 7 |
| 3 | A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants:Current status,challenges,and future prospects显示文摘Mg and its alloys are drawing huge attention since the last two decades as a viable option for temporary implants applications.A commendable progress has already been made in the development of these alloys.The biodegradable nature of Mg,appreciable biocompatibility of elemental Mg,and its close resemblance to natural bone in terms of density and elastic modulus make them highly preferable option amongst other available alternatives in this field.This review article presents an overview covering the recent advancements made in the field of Mg-based biodegradable implants for orthopaedic implant applications.The paper focuses on alloy development and fabrication techniques,the state of the art of important Mg-based alloy systems in terms of their mechanical properties,in-vitro and in-vivo degradation behaviour and cytotoxicity.Further,the paper reviews the current progress achieved in the clinical transition of Mg-based alloys for orthopaedic fixtures.The review also includes the degradation mechanisms of the alloys in physiological environment and highlights the mismatch existing between the rate of bone healing and alloy degradation due to rapid corrosion of the alloys in such environment,which has still restricted their widespread application.Finally,the surface coating techniques available for the alloys as an effective way to reduce the degradation rate are reviewed,followed by a discussion on the future research prospects. | Darothi Bairagi Sumantra Mandal | 2022 | Journal of Magnesium and Alloys2022，10，3： | 5 |
| 4 | Magnesium based implants for functional bone tissue regeneration–A review显示文摘Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone tissue.Mg is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue recovery.It also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and Zinc.Most importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to infection.Despite its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is complete.Mechanical properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology optimization.To reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone tissue.The present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic implants.In addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been highlighted.Further,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores. | Gavish Uppal Amit Thakur Amit Chauhan Saroj Bala | 2022 | Journal of Magnesium and Alloys2022，10，2： | 4 |
| 5 | Insights into self-healing behavior and mechanism of dicalcium phosphate dihydrate coating on biomedical Mg显示文摘Self-healing coatings have been developed as smart surface coatings for Mg and its alloys to retain local corrosion from the coating damages.In this study,we prepared dicalcium phosphate dihydrate(DCPD)coating on biomedical Mg,and found that the artificial scratches in DCPD coating can be efficiently sealed by anti-corrosive products in both Hank's and normal saline(NS)solutions.Besides,the in-depth study revealed that DCPD was served as not only a physical barrier but also a self-healing agent,demonstrating an autonomous self-healing coating without embedded extra corrosion inhibitors.Moreover,Hank's solution provided foreign-aid filmforming ions to promote self-healing behavior.The findings might offer new opportunities for further studies and applications of efficient self-healing coatings on biodegradable Mg implants. | Qiangsheng Dong Xingxing Zhou Yuanjia Feng Kun Qian Huan Liu Mengmeng Lu Chenglin Chu Feng Xue Jing Bai | 2021 | Bioactive Materials2021，6，1： | 4 |
| 6 | Advances in bioorganic molecules inspired degradation and surface modifications on Mg and its alloys显示文摘Mg alloys possess biodegradability,suitable mechanical properties,and biocompatibility,which make them possible to be used as biodegradable implants.However,the uncontrollable degradation of Mg alloys limits their general applications.In addition to the factors from the metallic materials themselves,like alloy compositions,heat treatment process and microstructure,some external factors,relating to the test/service environment,also affect the degradation rate of Mg alloys,such as inorganic salts,bioorganic small molecules,bioorganic macromolecules.The influence of bioorganic molecules on Mg corrosion and its protection has attracted more and more attentions.In this work,the cutting-edge advances in the influence of bioorganic molecules(i.e.,protein,glucose,amino acids,vitamins and polypeptide)and their coupling effect on Mg degradation and the formation of protection coatings were reviewed.The research orientations of biomedical Mg alloys in exploring degradation mechanisms in vitro were proposed,and the impact of bioorganic molecules on the protective approaches were also explored. | Lei Cai Di Mei Zhao-Qi Zhang Yuan-ding Huang Lan-Yue Cui Shao-Kang Guan Dong-Chu Chen M.Bobby Kannan Yu-feng Zheng Rong-Chang Zeng | 2022 | Journal of Magnesium and Alloys2022，10，3： | 3 |
| 7 | PEO/Mg-Al LDH涂层增强金属镁的生物相容性和成骨作用:体内外研究显示文摘镁(Mg)及其合金因具有生物可降解和促成骨效应而成为理想的骨内固定材料,但其抗腐蚀能力差、体内降解快的缺点限制了其临床应用.开发稳定的防腐涂层是镁基金属临床应用的主要挑战.本研究首先通过等离子体电解氧化法(PEO)在Mg表面形成多孔的PEO涂层,然后通过水热处理制备Mg-Al层状双氢氧化物(LDH)层来封闭MgO层的多孔结构(根据处理时间不同分为LDH-2h和LDH-12h组).体外实验结果表明,与其他涂层相比,LDH-12h组在磷酸盐缓冲液(PBS)中可以有效减少Mg^2+释放并抑制p H值变化.另外,LDH-12h组促进了大鼠骨髓干细胞(rBMSC)的生物活性、增殖速率以及成骨活性.大鼠皮下植入试验表明,经过改性的纯镁金属在体内的耐蚀性和组织相容性增加,尤其是LDH-12h组.此外,LDH-12h组植入大鼠股骨12周后降解率最低、与新生骨结合最紧密,并且未发现主要器官功能障碍.本研究所制备的PEO/Mg-Al LDH复合涂层能够明显改善Mg的耐蚀性和生物相容性,增强体内成骨活性,具有良好的临床应用前景. | 王洁 彭峰 吴晓琳 王东辉 郑奥 曹玲燕 郁春华 刘宣勇 蒋欣泉 | 2021 | Science China Materials2021，64，2： | 3 |
| 8 | 骨植入镁合金表面缓蚀剂覆载的微弧氧化/PLGA 复合涂层的制备与表征显示文摘目的在可降解镁合金表面制备缓蚀剂覆载的微弧氧化/聚乳酸-羟基乙酸(PLGA)复合涂层,提高其耐蚀性。方法首先利用微弧氧化技术在镁合金表面制备出适合复合缓蚀剂涂层的微弧氧化(Micro-Arc Oxidation,MAO)涂层,之后在微弧氧化多孔涂层上浸涂PLGA-缓蚀剂涂层,得到复合涂层,缓蚀剂选择天然植物提取物姜黄素(Curcumin,Cur)。利用SEM&EDS、FTIR和AFM等实验对涂层形貌、成分及结构进行分析,通过电化学测试、体外浸泡实验评价涂层的耐蚀性能。结果FTIR结果表明Cur可成功覆载在涂层中,且不与PLGA发生反应。电化学测试和体外浸泡实验表明MAO/PLGA-Cur涂层能有效提高镁合金的耐蚀性。动电位极化曲线显示MAO/PLGA-Cur涂覆样品的腐蚀电流密度比基体下降了3个数量级,浸泡14 d的质量损失比基体下降62.04%,比未覆载的样品减少26.63%。结论MAO时间为10 min为最合适复合缓蚀剂涂层的参数。Cur作为缓蚀剂的最佳添加量为0.12%,PLGA的最佳添加量为12%,最佳浸涂角度为0°。 | 石梦佳 李伟杰 马小爽 朱世杰 关绍康 | 2021 | 表面技术2021，50，2： | 2 |
| 9 | AZ31镁合金表面苯丙氨酸、甲硫氨酸和天冬酰胺诱导Ca-P涂层耐蚀性能比较显示文摘为澄清氨基酸基团对成膜的影响,采用苯丙氨酸(Phenylalanine,Phe)、甲硫氨酸(Methionine,Met)和天冬酰胺(Asparagine,Asn)3种氨基酸调控AZ31镁合金的降解速率,采用恒温水浴法(60℃)在其表面制备了3种氨基酸Ca-P涂层(Ca-P_(Phe)、Ca-P_(Met)和Ca-P_(Asn)),并使用SEM、EDS、XRD、FTIR及XPS对涂层的形貌、成分分布和物相结构进行分析,利用电化学极化和交流阻抗及析氢腐蚀实验对涂层在模拟人体体液(Hank��s)中的耐蚀性能进行研究。探讨了氨基酸添加剂在AZ31镁合金表面诱导Ca-P涂层成膜的作用机制。Ca-P、Ca-P_(Phe)、Ca-P_(Met)和Ca-P_(Asn)涂层的厚度分别为(3.47±0.47)、(6.06±0.77)、(7.63±1.70)和(8.23±1.37)μm。涂层主要组成物相为CaHPO_(4)及Ca_(10)(PO_(4))_(6)(OH)_(2)(HA)。电化学和析氢实验结果表明,氨基酸提高了Ca-P涂层耐蚀性能。这主要归因于氨基酸分子的缓蚀作用,并在AZ31镁合金表面发生化学吸附。氨基酸中的氨基吸附主要是通过N原子的孤对电子与镁合金表面耦合来实现的;羧基是通过羰基中的O原子与Mg^(2+)结合。此外,氨基酸中的杂原子亦能与镁合金的空位分子轨道共享其孤对电子。最后,提出了氨基酸诱导Ca-P涂层的成膜机理。 | 王雪梅 殷正正 于晓彤 邹玉红 曾荣昌 | 2021 | 金属学报2021，57，10： | 2 |
| 10 | 使用可降解金属材料制备定向骨再生膜的可行性与挑战显示文摘定向骨再生手术是一种用于增加牙槽骨体积的治疗手段.目前,商用的不吸收薄膜(钛膜等)需要二次手术去除,而可吸收薄膜(胶原膜等),由于强度较低,在覆盖大部分病变骨骼时可能会失效.理想的定向骨再生薄膜仍处于发展中.近年来,生物可降解金属被认为是潜在的骨再生薄膜候选材料.因此,本文主要从力学和生物学角度评估了可降解金属作为定向骨再生薄膜的可行性.结果表明,可降解金属具有良好的生物相容性、足够的机械强度、可控的降解速率、良好的成骨性能、广谱抗菌能力和较好的创面愈合能力等优点,能够被用于制备定向骨再生薄膜.然而,对于镁合金来说,其较快的降解速率、析氢行为和应力腐蚀现象制约了其应用.对于锌合金而言,其降解速率适中且无氢气产生,似乎具有更好的应用前景.目前,可降解金属的发展已经为其在口腔临床中的应用奠定了一定的基础. | 陈凯 赵莉 孙洁 顾雪楠 黄晨阳 苏皓然 樊瑜波 | 2022 | Science China Materials2022，65，10： | 0 |
| 11 | 医用镁合金微弧氧化/有机复合涂层的研究现状及演进方向显示文摘医用镁及镁合金过快的降解速率严重缩短了其有效服役时间,过高的析氢速率引发局部炎症,束缚了其临床应用前景。微弧氧化(MAO)/有机复合涂层良好的抑蚀降析性能,在医用镁及镁合金表面改性领域展现出巨大的应用潜力。首先,从有机材料(植酸(PA)、壳聚糖(CS)、硬脂酸(SA)、多巴胺(DA)、聚乳酸-乙醇酸共聚物(PLGA)、聚乳酸(PLA)、聚已内酯(PCL))自身的组织及性能特征入手,分析了单一有机涂层提高镁及镁合金耐蚀性的作用机理,并指出单一涂层自身的性能弱点(单一MAO涂层微孔和裂纹的不可避免,单一有机涂层与镁合金结合强度低,易于剥落)限制了对镁合金降解保护效能。其次,从结合强度、耐蚀性、多功能性(生物安全性、生物相容性、诱导再生性、抑菌抗菌性、载药缓释性等)的角度,详细阐述了各MAO/有机复合涂层的结构特点、优势特征。在此基础上,明确指出以MAO/PCL(MAO/CS)复合涂层为基底涂层,通过PCL(CS)涂层与其他涂层的交叉组合,是实现医用镁合金植入材料的生物活性及多功能性的最佳路径。最后,对镁合金MAO/有机复合涂层的演进方向进行了科学展望。 | 冀盛亚 常成 常帅兵 倪艳荣 李承斌 | 2023 | 表面技术2023，52，12： | 0 |
| 12 | 可生物降解金属支架修复长骨严重骨缺损显示文摘长骨严重骨缺损的治疗仍是骨科医师亟待解决的难题。随着生物材料及骨组织工程技术的发展,生物活性支架为修复长骨严重骨缺损提供了新思路。用于修复长骨严重骨缺损的生物活性支架,除提供骨再生需要的稳定框架外,还需具备成骨诱导性和可降解性。可生物降解金属支架通过微结构合金化、离子成分改性及生物涂层等技术,集合良好的力学支撑、骨诱导、生物相容性等优势于一体,加速骨缺损部位血管化成骨及矿化。为促进可生物降解金属支架的临床转化,该文对铁、镁、锌、钙、猛、锶等可生物降解金属支架的理化性质、促成骨转导力学性能的研究进展进行综述。 | 刘凯(综述) 艾合买提江·玉素甫(审校) | 2024 | 临床骨科杂志2024，27，1： | 0 |
| 13 | Evaluation of the biodegradation product layer on Mg-1Zn alloy during dynamical strain显示文摘Magnesium(Mg)alloys are attractive biodegradable implant materials.The degradation products on Mg alloys play a critical role in the stability of the interface between implant and surrounding tissue.In the present study,the effects of dynamic deformation on the interface layer of biomedical Mg-1Zn alloy were investigated using the constant extension rate tensile tests(CERT)coupled with electrochemical impedance spectroscopy(EIS).The deformation of the Mg-1Zn alloy had an adverse influence on the impedance of the surface degradation layer formed in simulated body fluid that only containing inorganic compounds.However,the surface degradation layer with improved corrosion resistance was obtained for the strained samples tested in protein-containing simulated body fluid.The spontaneous or enhanced adsorption of protein into the degradation product led to a flexible and stable hybrid anti-corrosive layer.A relationship between the dynamic deformation of Mg alloy and the impendence of the degradation layer was established,which demonstrates the necessity for in situ characterisation of the evolution of the surface layer under dynamic condition. | Lianxi Chen Cheng Guo Carsten Blawert Junjie Yang Dongchu Chen Xiaojian Wang Zhentao Yu Mikhail L.Zheludkevich Wei Li | 2021 | Journal of Magnesium and Alloys2021，9，5： | 0 |
| 14 | 医用镁合金表面氟化改性的研究现状及演进方向显示文摘表面改性处理已成为当前破解医用镁合金临床应用瓶颈的有效手段。MgF_(2)复合涂层凭借其成本低廉、工艺简单、生物安全、生物相容等特点在医用镁合金表面改性处理领域展现出巨大的应用前景。首先,阐述了制备工艺参数对单一MgF_(2)涂层的影响规律,分析了单一MgF_(2)涂层提高镁合金耐蚀性的作用机理,并指出单一MgF_(2)涂层的弱点(涂层微孔的不可避免及较薄的厚度决定了其对镁合金有效保护时间的短暂性,涂层成分的单一性也决定了涂层功能的单调性)。其次,结合各涂层材料(CaF_(2)、羟基磷灰石(HA)、聚多巴胺(PDA)、植酸(PA)、聚乳酸(PLA))自身的组织及性能特征,从涂层形貌、结合强度、耐蚀性、多功能性(抗凝血功能、细胞相容性)等角度,详细阐述了各MgF_(2)复合涂层的结构特点、优势特征。最后,明确指出镁合金MgF_(2)复合涂层的演进发展方向:一方面,积极探索MgF_(2)与一些性能优异的涂层材料(壳聚糖(CS),聚乳酸-乙醇酸共聚物(PLGA),聚己内酯(PCL),胶原蛋白(Collagen)等)组合与交互,并尝试通过多重涂层的交互组合来实现镁合金植入材料的生物功能多样性(药物输送及缓释给药性、可控降解性、广谱抑菌性等);另一方面,开发能满足不同植入部位功能性需求差异的MgF_(2)复合涂层,并积极开展相关的动物体内实验,以期加快医用镁合金临床应用进程。 | 冀盛亚 常成 常帅兵 倪艳荣 王雷 | 2023 | 河南工学院学报2023，31，6： | 0 |
| 15 | 医用镁合金植入材料的发展策略及演进趋势显示文摘镁合金凭借其优异的生物安全性、生物诱导性、生物相容性及可贵的自降解性能,在骨植入及心血管支架领域具有广泛的临床应用前景。本文从合金化、制备方法、热处理及表面改性这四方面系统综述了近年来医用镁合金的研究进展,重点分析了各种工艺及表面改性方法的基本原理、技术优劣势,总结了它们对镁合金组织、性能的影响。针对镁合金临床应用的瓶颈,提出医用镁合金植入材料的最佳发展策略:一方面,通过合金化、制备方法及热处理三种工艺的协同耦合实现与自然骨组织力学行为的有效匹配;另一方面,通过表面改性处理实现对镁合金降解速率的精准调控。通过两种或多种表面改性技术的组合与交互来实现多功能性需求将成为未来镁合金表面改性技术的主要演进趋势。 | 冀盛亚 常成 常帅兵 倪艳荣 李承斌 | 2023 | 材料工程2023，51，7： | 0 |
| 16 | 有机官能团离子注入对ZK60镁合金力学性能和耐蚀性的影响显示文摘生物可降解镁合金因其优异的生物性能和力学性能,在医学领域表现出巨大的应用潜力。然而,过快的腐蚀速率阻碍了其临床应用。采用有机官能团(羟基(OH^(-))和羧基(COOH^(+)))离子注入对ZK60镁合金进行表面改性,采用X射线光电子能谱(XPS)技术、纳米压痕仪和电化学腐蚀试验等研究了离子注入对ZK60合金的表面结构、力学性能和耐蚀性的影响,并使用等效电路对电化学阻抗谱(EIS)进行拟合,进一步探讨其腐蚀机理。结果表明:羟基和羧基离子注入后,在ZK60镁合金表面分别形成了富含各种化合物的改性层,致使其力学性能和耐蚀性均得到显著增强,此外,羧基注入的试样在力学性能和耐蚀性方面优于羟基注入的试样。 | 韦仙 冯中营 杨文锦 | 2022 | 材料热处理学报2022，43，8： | 0 |
| 17 | Corrosion resistance of Ca-P coating induced by layer-by-layer assembled polyvinylpyrrolidone/DNA multilayer on magnesium AZ31 alloy显示文摘A hydrothermal deposition method was utilized to fabricate Ca-P composite coating induced by the layer-by-layer(LbL)assembled polyvinylpyrrolidone/deoxyribonucleic acid(PVP/DNA)_(20) multilayer on AZ31 alloy.The surface morphology and compositions were characterized by SEM,EDS,FTIR and XRD.Besides,the corrosion resistance and degradation behavior of the coating were tested via electrochemical polarization,impedance spectroscopy and immersion measurements.Results show that the main components of Ca-P coatings are hydroxyapatite,Ca_(3)(PO_(4))_(2) and Mg_(3)(PO_(4))_(2)·nH_(2)O.The LbL-assembled DNA and PVP promote the adsorption of Ca-P deposits on the sample surface,and structures and functional groups of the polyelectrolyte in the outermost layer are the primary influencing factor for the induction of the Ca-P coating.Carboxyl groups have the best biomineralization effect among all related functional groups.The enhanced corrosion resistance and adhesion highlight a promising use of(PVP/DNA)_(20)-induced Ca-P coatings in the field of biomedical magnesium alloys. | Zhen-Yu ZHANG Duo WANG Lu-Xian LIANG Shen-Cong CHENG Lan-Yue CUI Shuo-Qi LI Zhen-Lin WANG Rong-Chang ZENG | 2021 | Frontiers of Materials Science2021，15，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员