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| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | Effect of grain refinement induced by wire and arc additive manufacture (WAAM) on the corrosion behaviors of AZ31 magnesium alloy in NaCl solution显示文摘Additive manufacturing(AM)of Mg alloys has become a promising strategy for producing complex structures,but the corrosion performance of AM Mg components remains unexploited.In this study,wire and arc additive manufacturing(WAAM)was employed to produce single AZ31 layer.The results revealed that the WAAM AZ31 was characterized by significant grain refinement with non-textured crystallographic orientation,similar phase composition and stabilized corrosion performance comparing to the cast AZ31.These varied corrosion behaviors were principally ascribed to the size of grain,where cast AZ31 and WAAM AZ31 were featured by micro galvanic corrosion and intergranular corrosion,respectively. | Jianwei LI Youmin QIU Junjie YANG Yinying SHENG Yanliang YI Xun ZENG Lianxi CHEN Fengliang YIN Jiangzhou SU Tiejun ZHANG Xin TONG Bin GUO | 2023 | Journal of Magnesium and Alloys2023，11，1： | 6 |
| 3 | Curing Reaction Kinetics of Epoxy Resin Using Dicyandiamide Modified by Aromatic Amines显示文摘The curing reaction and reaction mechanism of epoxy resin E-44, for which aromatic amine modified dicyandiamide was used as a curing reagent, were investigated by means of differen-tial scanning calorimetry (DSC). The results showed that the modified dicyandiamide had better curing characteristic than un-modified dicyandiamide for epoxy resin E-44, and the curing reac-tion could be carried out at moderate temperature. Apparent acti-vation energy of the curing reaction was decreased appreciably from 123.829 kJ/mol to 61.550-64.405 kJ/mol, and reaction order was decreased from 0.941 to 0.896-0.900. Curing reaction mecha-nism also was discussed. | CHEN Lianxi TIAN Hua LIU Quanwen Wang Jun | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 6 |
| 4 | Measurement and Scaling of Mercury on Soil and Air in a Historical Artisanal Gold Mining Area in Northeastern China显示文摘The Jiapigou gold mine area, located in the upper reaches of the Songhua River, was the first and largest artisanal gold mine once in China, and it used to be prominent in two marking years(1870 and 1974). Jiapigou area had a gold mining history of more than 190 years, which was first opened in 1820. Gold extraction with algamation was applied as the dominant method of excavation from 1940 to 2008, and a total of more than 100 t of gold were extracted from the mine using this method and it was estimated that 100–200 t Hg were released, thus causing severe mercury environmental pollution in the mining area. In the experimental campaigns of this study, in situ air and soil Hg concentrations and air-soil Hg fluxes were measured from April 2009 to December 2011. The results showed that in the study area the total gaseous mercury(TGM) concentration exhibited remarkable spatial and temporal distribution patterns, i.e. the TGM gradually decreased following the increase in distance to gold mining sites in space, and the values in spring, summer and autumn were elevated by 1–2 orders of magnitude in comparison with those in winter. Furthermore, at other sampling sites the total soil mercury(TSM) concentration in spring was higher than that in autumn, except for the contrary laws demonstrated at the Erdaogou mining site. However, in spring and winter the Hg flux between air and soil was under the control of different environmental factors, and the characteristics were clear and distinct. In spring the Hg flux between air and soil was directly under the control of solar irradiation, and the releasing process was predominant with a remarkable positive correlation to solar irradiation. Nevertheless, in winter the Hg fluxes were indirectly under the control of solar irradiation, which caused thermal inversion due to the thick snow cover. The depositing process was predominant and the correlations between Hg flux and air temperature was remarkably negative, and there was a positive correlation between Hg flux and solar irradiation. | WANG Zhaojun ZHANG Gang CHEN Xiaobing ZHAO Qiaojing WANG Weiying SHENG Lianxi BIAN Hongfeng LI Zhenxin WANG Deli | 2019 | Chinese Geographical Science2019，29，2： | 3 |
| 5 | Foraging areas of Rousettus leschenaulti on the Hainan Island of China显示文摘We investigated the foraging area of three individuals (1 female and 2 males) of Rousettus leschenaulti (Chiroptera,Pteropodidae) in suburban Haikou City, Hainan Province, South China from November 2005 to January 2006 using radio telemetry.These animals left the daytime roosting sites about 90 min after sunset with no significant difference in departure time betweenthe male and female bats. The average active times were 391.8 min for males and 533.7 min for the female, respectively.By reconstructing 93 radio-telemetry recording positions, we found that the long axis of foraging area of the bats ranged from7.45 to 11.70 km. The foraging area of the female (3867 ha) was larger than that of the males (1138 ha), and there was overlapbetween the foraging areas of different individuals. These bats usually kept the same flight routes across a few successive daysfrom the daytime roosting site to the foraging areas. Our findings suggested that female R. leschenaulti may explore a larger foragingarea than males. No obvious territorial behaviors were observed in our studied area. | Zhanhui TANG Zhong CHEN Jie MA Guangjian ZHU Xunfeng MA Lianxi SHENG Yuchun LI | 2010 | Current Zoology2010，56，4： | 2 |
| 6 | The Syntheses of Benzofuran Derivatives 显示文摘 | Yan Yuhua Chen Xiaoming | 2000 | J of Wuhan University of Technology (Materials Science)2000，15，4： | 1 |
| 7 | The Ring-Opening Polymerization of D,L- Lactide Initiated with Stannous Octoate 显示文摘 | Chen Lianxi Jiang Xin Yan Yuhua | 2001 | J of Wuhan University of Technology (Material Science)2001，，4： | 1 |
| 8 | The Ring-opening Polymerization of D,L-lactide Initiated with Stannous Octoate显示文摘 | Chen Lianxi Jiang Xin Yan Yuhua | 2001 | J of Wuhan University of Technology (Material Science)2001，，4： | 1 |
| 9 | Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes显示文摘 | Guoyue Yuan Jue Jia Liangliang Di Libin Zhou Sijing Dong Jingjing Ye Dong Wang Ling Yang Jifang Wang Lianxi Li Ying Yang Chaoming Mao Mingdao Chen | 2012 | Biochemical and Biophysical Research Communications2012，，3： | 1 |
| 10 | Microstructure refi- ning and property improvement of ZK60 magnesium alloy by hot rolling显示文摘 | Wang Xin Chen Wenzhen Hu Lianxi | 2011 | Trans Nonferrous Metals Soc China2011，21，242： | 1 |
| 11 | The Ring-opening Polymerization of D, L-Lactide Initiated with Stannous Octoate显示文摘 | Chen Lianxi Jing Xin Yan Yuhua | 2001 | Journal of Wuhan University of Technology2001，，4： | 1 |
| 12 | Evaluation of the biodegradation product layer on Mg-1Zn alloy during dynamical strain显示文摘Magnesium(Mg)alloys are attractive biodegradable implant materials.The degradation products on Mg alloys play a critical role in the stability of the interface between implant and surrounding tissue.In the present study,the effects of dynamic deformation on the interface layer of biomedical Mg-1Zn alloy were investigated using the constant extension rate tensile tests(CERT)coupled with electrochemical impedance spectroscopy(EIS).The deformation of the Mg-1Zn alloy had an adverse influence on the impedance of the surface degradation layer formed in simulated body fluid that only containing inorganic compounds.However,the surface degradation layer with improved corrosion resistance was obtained for the strained samples tested in protein-containing simulated body fluid.The spontaneous or enhanced adsorption of protein into the degradation product led to a flexible and stable hybrid anti-corrosive layer.A relationship between the dynamic deformation of Mg alloy and the impendence of the degradation layer was established,which demonstrates the necessity for in situ characterisation of the evolution of the surface layer under dynamic condition. | Lianxi Chen Cheng Guo Carsten Blawert Junjie Yang Dongchu Chen Xiaojian Wang Zhentao Yu Mikhail L.Zheludkevich Wei Li | 2021 | Journal of Magnesium and Alloys2021，9，5： | 0 |
| 13 | A facile method for preparing thiocyanato-functionalized porous silica nanospheres显示文摘 | Jie Li Lianxi Chen Xi Li Chaocan Zhang Zhenhui Liu | 2016 | Particuology2016，14，1： | 0 |
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