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| 1 | Bone physiological microenvironment and healing mechanism:Basis for future bone-tissue engineering scaffolds显示文摘Bone-tissue defects affect millions of people worldwide.Despite being common treatment approaches,autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect.This has prompted researchers to explore novel bone-regeneration methods.In recent decades,the development of bone tissue engineering(BTE)scaffolds has been leading the forefront of this field.As researchers have provided deep insights into bone physiology and the bone-healing mechanism,various biomimicking and bioinspired BTE scaffolds have been reported.Now it is necessary to review the progress of natural bone physiology and bone healing mechanism,which will provide more valuable enlightenments for researchers in this field.This work details the physiological microenvironment of the natural bone tissue,bone-healing process,and various biomolecules involved therein.Next,according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism,it elaborates the biomimetic design of a scaffold,highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration. | Guanyin Zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao | 2021 | Bioactive Materials2021，6，11： | 11 |
| 2 | 3D打印PLLA/HA复合组织工程骨支架及性能表征显示文摘为了解决羟基磷灰石(HA)骨支架降解难的问题,本研究通过在HA骨支架中加入具有良好降解性能的聚左旋乳酸(PLLA)来调节其降解速度。采用3D打印挤出成型设备制备出PLLA/HA复合多孔骨支架,探究不同PLLA质量分数下复合组织工程骨支架抗压强度、亲水性、降解率以及细胞毒性的变化。实验结果表明:五组不同材料配比的复合骨支架中,PLLA质量分数为50%的支架亲水性及抗压强度最好,且抗压强度大于人体松质骨最低承载要求的2.5 MPa。体外模拟降解10周后,骨支架的降解失重率随PLLA质量分数的提高而加快,降解液的pH值为7.3~7.5,呈弱碱性;体外细胞毒性实验中细胞生长良好。表明通过改变骨支架中PLLA的质量分数,能够实现对支架降解速率的调节,当骨支架中PLLA质量分数为50%时,支架降解速率最快,且机械性能和生物安全性能良好,对改性组织工程骨支架的降解性能调节研究具有借鉴意义。 | 任泽宇 姜宏 石永芳 | 2022 | 燕山大学学报2022，46，2： | 3 |
| 3 | “补肾壮骨”中药应用于骨组织工程支架修复节段性骨缺损显示文摘背景:节段性骨缺损为骨科难题,现有治疗手段效果欠佳。新兴骨组织工程技术在节段性骨缺损修复方面展现出巨大的潜力,但仅使用人工支架进行骨缺损修复,成骨性能往往难以满足需求,负载活性因子又存在价格昂贵、不稳定等问题。中药取材广泛、价格低廉,“补肾壮骨”中药有效成分有充当外源性生物因子的潜力,中药复合支架展现出良好的骨组织修复效果。目的:介绍几种常用的骨组织工程支架材料,及骨碎补、淫羊藿、杜仲等“补肾壮骨”代表药物在支架材料上的复合应用,探讨“补肾壮骨”中药应用于骨组织工程支架修复节段性骨缺损的潜力。方法:由第一作者检索中国知网(CNKI)、万方、PubMed和Web of Science数据库,以“中药,补肾,骨碎补,淫羊藿,杜仲,骨缺损,骨修复,骨组织工程,支架”为中文检索词,以“Chinese medicine,Tonifying kidney,Drynariae,Epimedium,Eucommia,bone defects,Bone repair,Bone Tissue Engineering,Scaffold”为英文检索词,检索2007-2022年期间关于“补肾壮骨”中药应用于骨组织工程支架修复节段性骨缺损的文章。结果与结论:①现有骨组织工程支架材料包括生物陶瓷材料、医用金属材料及聚合物材料,因各材料的性能差异可复合使用以弥补单一材料的缺陷。②外源性生长因子结合骨组织工程支架修复节段性骨缺损疗效确切,但生长因子存在不稳定性、单价昂贵等问题。③现代药理学发现“补肾壮骨”中药对骨髓间充质干细胞有显著促进成骨分化作用,可替代生长因子在骨组织工程支架中的角色。④将“补肾壮骨”中药及其活性成分与支架材料融合,所制备复合支架在修复节段性骨缺损上展现出独特优势,应用前景广阔。 | 熊伟 袁灵梅 钱国文 黄锦阳 潘斌 郭灵 曾志奎 | 2023 | 中国组织工程研究2023，27，21： | 3 |
| 4 | Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration显示文摘The restoration of bone defects caused by osteoporosis remains a challenge for surgeons.Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model.The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility.Moreover,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in vitro.The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation.Furthermore,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting osteogenesis.This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis. | Qianju Wu Longwei Hu Ran Yan Junfeng Shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang | 2022 | Bone Research2022，10，4： | 1 |
| 5 | 氧阻聚层调控原理及其对陶瓷光固化成型精度的影响显示文摘利用自由基树脂材料进行光固化3D打印时出现的“氧阻聚层”,为其连续制造和表面质量的提升提供了可能,但因对打印件的结构精度的调控机理不清,打印具有复杂外形的多孔结构件难以控制其成型精度。利用自制自由基生物陶瓷浆料经光固化3D打印制造多孔生物骨陶瓷支架,研究并提出了光固化过程中的3阶段的固化区间和氧阻聚层调控成型精度原理;建立了寻找合理的氧阻聚调控打印工艺参数的方法;发现了氧阻聚层不仅能够提升陶瓷制件的成型精度,也会影响其力学性能。由此建立起的氧阻聚层厚度对生物骨陶瓷支架的多孔结构成型精度和力学性能的作用机制,为多功能陶瓷打印技术及其陶瓷基骨替代物应用提供了高精度制造基础理论与方法。 | 连芩 王永辉 李涤尘 何晓宁 | 2021 | 硅酸盐学报2021，49，9： | 1 |
| 6 | A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration显示文摘We demonstrate a simple,effective and feasible method to address the shrinkage of Poly(lactic-co-glycolic acid)(PLGA)through a core-shell structure fiber strategy.The results revealed that introducing size-stable poly-caprolactone(PCL)as the core fiber significantly improved the PLGA-based fibrous scaffold’s dimensional maintenance.We further utilized fish collagen to modify the PLGA shell layer(PFC)of coaxial fibers and loaded baicalin(BA)into the PCL core layer(PCL-BA)to endow fibrous scaffold with more functional biological cues.The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype.Importantly,the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation,favor neovascularization and bone formation.This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration. | Shue Jin Jing Gao Renli Yang Chen Yuan Ruili Wang Qin Zou Yi Zuo Meifang Zhu Yubao Li Yi Man Jidong Li | 2022 | Bioactive Materials2022，7，2： | 1 |
| 7 | Milestones and current achievements in development of multifunctional bioscaffolds for medical application显示文摘Tissue engineering(TE)is a rapidly growing interdisciplinary field,which aims to restore or improve lost tissue function.Despite that TE was introduced more than 20 years ago,innovative and more sophisticated trends and technologies point to new challenges and development.Current challenges involve the demand for multifunctional bioscaffolds which can stimulate tissue regrowth by biochemical curves,biomimetic patterns,active agents and proper cell types.For those purposes especially promising are carefully chosen primary cells or stem cells due to its high proliferative and differentiation potential.This review summarized a variety of recently reported advanced bioscaffolds which present new functions by combining polymers,nanomaterials,bioactive agents and cells depending on its desired application.In particular necessity of study biomaterial-cell interactions with in vitro cell culture models,and studies using animals with in vivo systems were discuss to permit the analysis of full material biocompatibility.Although these bioscaffolds have shown a significant therapeutic effect in nervous,cardiovascular and muscle,tissue engineering,there are still many remaining unsolved challenges for scaffolds improvement. | Jagoda Litowczenko Marta J.Wózniak-Budych Katarzyna Staszak Karolina Wieszczycka Stefan Jurga Bartosz Tylkowski | 2021 | Bioactive Materials2021，6，8： | 1 |
| 8 | 人工软骨支架材料、结构设计与制备技术研究进展显示文摘骨软骨是一种半透明状组织,主要功能是传递、吸收应力和减少摩擦。由于结构和功能复杂性,软骨一旦受损很难修复和再生,软骨缺损治疗仍是一大临床难题。随着再生医学蓬勃发展,组织工程人工软骨技术有望在软骨修复和治疗领域发挥重要作用。首先介绍了天然关节软骨不同分层的解剖结构和功能特征,然后重点从人工软骨支架构建材料、结构设计和制备技术等方面系统地综述了人工软骨组织工程技术的最新进展,最后讨论了人工软骨支架当前面临主要问题和未来发展方向,以期为相关研究提供参考。 | 刘天 王臻 储彬 陈昌盛 赵小文 邢璐 左佳盛 王松 刘伟强 | 2023 | 功能材料2023，54，3： | 1 |
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