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| 1 | NK cells in liver homeostasis and viral hepatitis显示文摘As an important member of the innate immune system, natural killer(NK) cells are well known for their rapid and efficient immune responses against infectious agents and tumors. NK cells are widely distributed throughout the body and are particularly enriched within the liver, where they display unique phenotypic and functional properties, playing important roles in various liver diseases. Herein, we present an overview of liver NK cell properties with regard to phenotype, function, and subset composition at steady state, and we also summarize the complex reciprocal interactions between liver NK cells and other cell types within the local environment of the liver. We also provide an overview of recent advances demonstrating the roles of NK cells in viral hepatitis, including a discussion of NK cell altered states and their beneficial versus harmful effects during hepatitis B virus and hepatitis C virus infection. | Hui Peng Zhigang Tian | 2018 | Science China(Life Sciences)2018，61，12： | 7 |
| 2 | NK细胞相关免疫检查位点的研究进展显示文摘自然杀伤(NK)细胞是机体内重要的免疫细胞。NK细胞的多种受体(PD-1、NKG2A、TIGIT、TIM-3等)具有充当抗肿瘤免疫检查位点的潜力;通过对这些受体的活性进行激活或抑制,使NK细胞正常发挥免疫调控作用,为肿瘤的免疫治疗提供了新的研究方向。文章主要就NK细胞受体作为肿瘤免疫治疗的免疫检查位点以及检查位点相关抑制剂的研究现状进行综述。 | 唐家优(综述) 彭艳(审校) | 2020 | 东南国防医药2020，22，2： | 3 |
| 3 | CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus显示文摘Influenza epidemics and pandemics are constant threats to global public health.Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection,the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains.Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections.However,one notable drawback ofγδ-T cell-based immunotherapy is the rapid exhaustion of proliferation and effector responses due to repeated treatments with phosphoantigens.Here,we found that the expression of CD137 was inducible in Vγ9Vδ2-T cells following antigenic stimulation.CD137^(+)Vγ9Vδ2-T cells displayed more potent antiviral activity against influenza virus than their CD137−counterparts in vitro and in Rag2^(-/-)γc^(-/-)mice.We further demonstrated that CD137 costimulation was essential for Vγ9Vδ2-T cell activation,proliferation,survival and effector functions.In humanized mice reconstituted with human peripheral blood mononuclear cells,CD137 costimulation with a recombinant human CD137L protein boosted the therapeutic effects of pamidronate against influenza virus.Our study provides a novel strategy of targeting CD137 to improve the efficacy of Vγ9Vδ2-T cell-based immunotherapy. | Yujun Pei Kun Wen Zheng Xiang Chunyu Huang Xiwei Wang Xiaofeng Mu Liyan Wen Yinping Liu Wenwei Tu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 4 | 自然杀伤(NK)细胞治疗新型冠状病毒感染肺炎方案的探讨和展望显示文摘探讨自然杀伤(NK)细胞治疗严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新冠病毒感染肺炎(COVID-19)的可行性和潜力。通过回顾性分析已有NK细胞的抗病毒研究和应用成果,并依据该细胞的特点和性质,设计NK细胞治疗SARS-CoV-2感染肺炎的研究方案。NK细胞作为免疫系统的重要组成部分,抗病毒生理特点明确,也起着免疫防御、免疫监视和免疫调节功能,临床应用已证明具有安全性和有效性。现在,SARS-CoV-2传染性强、危害大,易造成不可逆性的肺损伤,虽然通过隔离能有效防控,但鉴于尚无特效的治疗药物,为了未雨绸缪,避免可能造成的更大损失,研究一套有效的治疗方案仍非常必要。 | 范晓乐 王水平 吴炳义 蔡程程 张军一 李妍妍 孟玉茹 | 2020 | 细胞与分子免疫学杂志2020，36，5： | 1 |
| 5 | 不同类型免疫细胞在流感病毒感染中的作用显示文摘流行性感冒是由流感病毒引起的严重危害人类健康的一种急性呼吸道传染病,目前仍缺乏有效的治疗手段。流感病毒经呼吸道侵袭人体后,呼吸道上皮细胞首先做出反应,产生多种细胞因子诱导机体发挥免疫应答。对流感病毒引起的机体免疫反应深入了解,将有助于了解流感病毒的致病机制及机体的免疫机制,以采取更有效的治疗措施。本文将就流感病毒感染过程中各类免疫细胞在固有免疫和特异性免疫应答等方面发挥的不同功能进行综述。 | 张善语 王文静 刘子铭 朱锦璐 王晓龙 | 2022 | 中华医院感染学杂志2022，32，23： | 1 |
| 6 | Technical advances in NK cell-based cellular immunotherapy显示文摘Natural killer(NK)cells represent a promising future for tumor immunotherapy because of their unique biological functions and characteristics.This review focuses on technical advances in NK cell-based cellular immunotherapy and summarizes the developments of recent years in cell sources,genetic modification,manufacturing systems,clinical programs,and outcomes.Future prospects and challenges in NK cell immunotherapy are also discussed,including off-the-shelf NK cell exploitation,automatic and closed manufacturing systems,cryopreservation,and therapies involving regulatory checkpoints. | Fang Fang Wei Wang Minhua Chen Zhigang Tian Weihua Xiao | 2019 | Cancer Biology & Medicine2019，16，4： | 0 |
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