|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 急性脑梗死早期进展相关危险因素的临床研究显示文摘进展性脑梗死(progressive cerebral infarction,PCI)是急性脑梗死的一种特殊类型和过程,临床症状逐渐加重或经及时治疗仍不能阻止病情进展,其预后较差,增加了脑卒中患者的致残率和死亡率。PCI按照进展时间分为早期进展(发病72 h以内)和晚期进展(发病48 h~7 d),据报道发病率高达20%~30%。 | 徐耀铭 齐晓飞 王姝瑶 张国锋 李莹 郑哲龙 山花 韩树海 吴占福 | 2018 | 中风与神经疾病杂志2018，35，6： | 70 |
| 2 | Angiogenesis and neuronal remodeling after ischemic stroke显示文摘Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal models.This raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic stroke.Blood vessels and neuronal cells communicate with each other using various mediators and contribute to the pathophysiology of cerebral ischemia as a unit.In this mini-review,we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional recovery after cerebral ischemia.Angiogenesis occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and periphery.Post-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional recovery.First,new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin signaling.Second,blood vessels are thought to enhance neurogenesis in three stages:1)Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals,2)microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen,nutrients,and soluble factors as well as serving as a scaffold for migration,and 3)oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature neurons.Thus,the regions of angiogenesis and surrounding tissue may be coupled,representing novel treatment targets. | Masahiro Hatakeyama Itaru Ninomiya Masato Kanazawa | 2020 | Neural Regeneration Research2020，15，1： | 63 |
| 3 | Update on cerebral small vessel disease: a dynamic whole-brain disease显示文摘Cerebral small vessel disease(CSVD)is a very common neurological disease in older people.It causes stroke and dementia,mood disturbance and gait problems.Since it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on imaging findings including white matter hyperintensities,lacunar ischaemic stroke,lacunes,microbleeds,visible perivascular spaces and many haemorrhagic strokes.However,variations in the use of definition and terms of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of terms should be encouraged in CSVD research.These CSVD features have long been regarded as different lesions,but emerging evidence has indicated that they might share some common intrinsic microvascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaemic stroke)and management of traditional risk factors still remain the most important therapeutic and preventive approach,due to limited understanding of pathophysiology in CSVD.Increasing evidence suggests that new studies should consider drugs that target endothelium and blood–brain barrier to prevent and treat CSVD.Epidemiology of CSVD might differ in Asian compared with Western populations(where most results and guidelines about CSVD and stroke originate),but more community-based data and clear stratification of stroke types are required to address this. | Yulu Shi Joanna M Wardlaw | 2016 | Stroke & Vascular Neurology2016，1，3： | 74 |
| 4 | Hyperbaric oxygen preconditioning induces neuroprotection against ischemia in transient not permanent middle cerebral artery occlusion rat model显示文摘This study was designed to determine if repeated hyperbaric oxygen (HBO) exposure induces ischemic tolerance in focal cerebral ischemia Methods Sixty male SD rats were used in this study Thirty animals underwent transient middle cerebral artery occlusion (MCAO) and the other thirty permanent MCAO model The rats were randomly allocated to 3 sub-groups: control group (n=10), HBO-3 group (n=10), and HBO-5 group (n=10) The animals in HBO-3 and HBO-5 groups received 1*!hour hyperbaric oxygenation at 2 5 atmosphere absolute (ATA) in 100% oxygen every day for 3 and 5 days, respectively The animals in the control group received sham treatments 24*!hours after the last HBO, transient MCAO (120 min) and permanent MCAO were induced by introducing a 3-0 nylon monofilament suture through internal carotid artery based on the Koizumi technique The neurological outcome was evaluated until 24*!hours after reperfusion in transient MCAO rats and ischemia in permanent MCAO rats The infarct volume was then assessed by TTC staining Results In transient MCAO rats, the neurological outcome in both the HBO-3 and HBO-5 groups was better than that of the control group ( P <0 05 and 0 001) The infarct volume decreased from 171 5±113*!mm 3 to 40 6±49 9*!mm 3 ( P <0 05) in the HBO-3 group and 16 2±28 8*!mm 3 ( P <0 01) in the HBO-5 group There were no significant differences in neurological outcome and infarct volume among the three groups in permanent MCAO rats Conclusions The present study demonstrated that HBO preconditioning can induce ischemic tolerance in transient not permanent MCAO rats in a “dose-dependent' | 熊利泽 朱正华 董海龙 胡文能 候立朝 陈绍洋 | 2000 | Chinese Medical Journal2000，，9： | 60 |
| 5 | Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients显示文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C. | Gang Lv Guo-Qiang Wang Zhen-Xi Xia Hai-Xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang | 2019 | Military Medical Research2019，6，3： | 60 |
| 6 | 凯力康对大鼠局灶性脑缺血的实验研究显示文摘以电烧灼法阻断大鼠大脑中动脉(middle cerebral artery occlusion,MCAO)造成局灶 性脑缺血模型,观察凯力康(kallidinogenase)对缺血脑组织的保护作用。结果表明,凯力康8.75× 10-3、17.5×10-3 PNAU/kg于术后30 min静脉注射,能显著缩小MCAO 24h造成的脑梗死面积,改 善神经症状,并能减少脑含水量。 | 屈志炜 苏丹 张丽英 吴俊芳 巫锦娣 王晓岩 谢永立 | 2005 | 中国处方药2005，4，11： | 43 |
| 7 | 慢性脑缺血中西医结合诊疗专家共识显示文摘1前言慢性脑缺血(chronic cerebral hypoperfusion,CCH)是一组由于慢性脑灌注下降导致脑功能障碍的临床综合征,既往又称为"脑动脉硬化症"、"慢性脑供血不足"、"慢性脑低灌注"、"慢性脑血管机能不全"等,相对于急性或亚急性脑缺血,其具有较长的可干预时间窗,如能早期识别及干预,将能有效阻断病程进展、预防脑血管相关事件的发生。 | 无 高利 | 2018 | 中国中西医结合杂志2018，38，10： | 45 |
| 8 | 提升希望感的心理护理干预对脑梗死介入治疗患者负性情绪和希望水平的影响分析显示文摘急性脑梗死(acute cerebral infarction,ACI)是临床发病率和致残率均较高的疾病类型,发病率占到脑血管疾病的60%~80%[1],约20%~50%ACI患者会发生抑郁,尤其存在肢体残疾的后遗症患者抑郁等负性情绪更为严重.负性情绪不仅影响患者认知功能,导致认识损伤加重;而且会影响患者治疗依从性[2].希望感是心理学研究的一个新领域,属于一种积极的心理品质.关于希望感与疾病治疗效果间的关联性研究在国外进行的较多,且结果显示,提升希望感能更好提高患者战胜病魔的信心和勇气,改善患者预后[3].鉴于此,笔者将提升希望感的心理干预模式应用到ACI介入治疗患者中,期待该模式能对ACI患者临床疗效产生影响. | 崔琼 杨文华 | 2019 | 山西医药杂志2019，48，14： | 50 |
| 9 | The efficacy and safety of endovascular recanalization of occluded large cerebral arteries during the subacute phase of cerebral infarction:a case series report显示文摘background Intravenous tissue plasminogen activator with or without mechanical thrombectomy during the acute phase are approved therapies for ischaemic stroke.Due to the short treatment time window(<6 hours)and often treatment failure,these patients would still have an intracranial arterial occlusion(IAO).It is unclear whether these patients can benefit from subsequent interventional recanalizationof their occluded artery in the subacute phase.In this retrospective study,we have examined the efficacy and safety in patients who have received either percutaneous transluminal angioplasty(PTA)or percutaneous transluminal angioplasty and stenting(PTAS)for IAO in the subacute phase of their stroke.Methods Patients with subacute symptomatic ischaemic stroke caused by IAO were assessed to identify the responsible artery and low perfusion areas by CT angiography,MR angiography or digital subtraction angiography.In eligible patients,a PTA or PTAS was performed to reopen the occluded artery.Regular antithrombotic therapy,use of statins,control of risk factors and rehabilitation therapy were prescribed after the procedure.All patients had regular follow-up up to 12 months.results PTA or PTAS was performed in 16 patients with cerebral infarction caused by IAO in the subacute phase.After the procedure,12 cases were recanalized,two were partially recanalized and two failed to open.One patient with left C6 segment occlusion of the carotid artery had a central retinal artery embolism after PTAS.The perioperative adverse events were 6.25%.At 3 months,the distribution of modified Rankin scale scores was 0(seven cases),1(three cases),2(five cases)and 3(one case).conclusion Selective PTA or PTAS could be performed in ischaemic stroke patients with a small infarct size and large area of hypoperfusion from an occluded large cerebral artery after the acute phase.It may improve neurological dysfunction and reduce the incidence of disability. | Kangning Chen Xianhua Hou Zhenhua Zhou Guangjian Li Qu Liu Li Gui Jun Hu Shugui Shi | 2017 | Stroke & Vascular Neurology2017，2，3： | 41 |
| 10 | 缺血性卒中基层诊疗指南(实践版·2021)显示文摘一、概述(一)定义缺血性卒中(ischemic stroke)又称脑梗死(cerebral infarction),指脑血循环障碍病因导致脑血管堵塞或严重狭窄,使脑血流灌注不足,进而缺血、缺氧导致脑血管供血区脑组织死亡,临床上表现为突发局灶或弥散性的神经功能缺损,头部电子计算机断层扫描(CT)或磁共振成像(MRI)上形成新的局灶性脑梗死病灶,24 h之后往往留有后遗症(包括症状、体征、新的脑梗死病灶)。 | 无 龚涛 蔡业峰 王拥军(审校) 陈海波(审校) 鞠奕(审校) | 2021 | 中华全科医师杂志2021，20，9： | 48 |
| 11 | 慢性脑供血不足的基础及临床研究显示文摘 | 孙强 吕晓红 | 2009 | 中风与神经疾病杂志2009，26，6： | 37 |
| 12 | Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury显示文摘Electroacupuncture is known as an effective adjuvant therapy in ischemic cerebrovascular disease. However, its underlying mechanisms remain unclear. Studies suggest that autophagy, which is essential for cell survival and cell death, is involved in cerebral ischemia reperfusion injury and might be modulate by electroacupuncture therapy in key ways. This paper aims to provide novel insights into a therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury from the perspective of autophagy. Here we review recent studies on electroacupuncture regulation of autophagy-related markers such as UNC-51-like kinase-1 complex, Beclin1, microtubule-associated protein-1 light chain 3, p62, and autophagosomes for treating cerebral ischemia/reperfusion injury. The results of these studies show that electroacupuncture may affect the initiation of autophagy, vesicle nucleation, expansion and maturation of autophagosomes, as well as fusion and degradation of autophagolysosomes. Moreover, studies indicate that electroacupuncture probably modulates autophagy by activating the mammalian target of the rapamycin signaling pathway.This review thus indicates that autophagy is a therapeutic target of electroacupuncture treatment against ischemic cerebrovascular diseases. | Ya-Guang Huang Wei Tao Song-Bai Yang Jin-Feng Wang Zhi-Gang Mei Zhi-Tao Feng | 2019 | Neural Regeneration Research2019，14，6： | 39 |
| 13 | 急性脑梗死溶栓治疗的研究与展望显示文摘急性脑梗死(acute cerebral infarction,ACI)是神经系统常见病,致死率和致残率高,已成为严重的医学和公共卫生课题,所以寻找有效的治疗方法特别重要。溶栓疗法是当今治疗急性脑梗死最有前途、最有希望的方法之一,可迅速恢复梗死区脑血流量,获得脑血管早期再灌注,使局部脑缺血造成的神经功能缺损症状和体征得以缓解。文献报道溶栓治疗的溶通率为21%~93%。但由于溶栓疗法引起的颅内出血、再灌注损伤和再闭塞等严重并发症,所以选择最佳溶栓方案,最适宜的溶栓时机和最佳给药途径以及理想的溶栓剂成为当今世界溶栓疗法研究的主题。现就急性脑梗死溶栓治疗的时间窗、方法、药物的选择及应用以及并发症等方面综述如下。 | 姚敏 吴江 | 2007 | 中风与神经疾病杂志2007，24，1： | 33 |
| 14 | Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage显示文摘Intracerebral haemorrhage (ICH) is a devastating type of stroke with high mortality and morbidity. However, we have few options for ICH therapy and limited knowledge about post-ICH neuronal death and related mechanisms. In the aftermath of ICH, iron overload within the perihaematomal region can induce lethal reactive oxygen species (ROS) production and lipid peroxidation, which contribute to secondary brain injury. Indeed, iron chelation therapy has shown efficacy in preclinical ICH studies. Recently, an iron-dependent form of non-apoptotic cell death known as ferroptosis was identified. It is characterised by an accumulation of iron-induced lipid ROS, which leads to intracellular oxidative stress. The ROS cause damage to nucleic acids, proteins and lipid membranes, and eventually cell death. Recently, we and others discovered that ferroptosis does occur after haemorrhagic stroke in vitro and in vivo and contributes to neuronal death. Inhibition of ferroptosis is beneficial in several in vivo and in vitro ICH conditions. This minireview summarises current research on iron toxicity, lipid peroxidation and ferroptosis in the pathomechanisms of ICH, the underlying molecular mechanisms of ferroptosis and the potential for combined therapeutic strategies. Understanding the role of ferroptosis after ICH will provide a vital foundation for cell death-based ICH treatment and prevention. | Jieru Wan Honglei Ren Jian Wang | 2019 | Stroke & Vascular Neurology2019，4，2： | 32 |
| 15 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 16 | TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro显示文摘Both TLR4 and TLR2 participated in the mediation of the inflammatory injury in the process of partial cerebral ischemia/reperfusion.However,it still remains unclear whether a crosstalk exists between TLR2 and TLR4 in ischemic cerebral damage.In the present study,we investigated the effect of TLR4 signaling on TLR2 expression during mimic cerebral I/R in vitro.BV-2 cells were cultured and treated with ischemia/reperfusion,then transfected with the plasmid pEGFP-H1/TLR4-siRNA,the plasmid pEGFP-H1/control sequence-siRNA and the blank plasmid,respectively.Interestingly,the expression of TLR2 and TLR4 mRNA and protein,NF-κB p65 mRNA and supernatant TNF-α level were significantly higher in ischemia/reperfusion treated cells than those lack of ischemia/reperfusion treatment,and as compared with those in ischemia/reperfusion treated cells without transfection,no significant differences about the above mentioned gene and protein expression were found in the blank plasmid tranfected cells and the plasmid pEGFP-H1/control sequence-siRNA transfected cells respectively,while the expression levels in the plasmid pEGFP-H1/TLR4-siRNA transfected cells were significantly lower.Additionally,in order to determine the effects of pyrrolidinediethyldithiocarbamate (PDTC),an NF-κB inhibitor,on the TLR4-induced TLR2 expression in BV-2 cells treated with ischemia/reperfusion,it was found that TLR4 and TLR2 mRNA expressions in PDTC pretreated cells were significantly lower in comparison with normal saline pretreated cells and non-pretreated cells.The data suggested that TLR2 activation,signaled by TLR4 and regulated by NF-κB,might be directly involved play an important role in ischemia/reperfusion induced brain damage. | SUN Peng1,ZHANG Qing2,HAN JiYuan1,TIAN Yuan3 & ZHANG JingHui3 1Department of Emergency,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China 2Department of Anesthesia,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China 3Department of General Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China | 2010 | Science China(Life Sciences)2010，53，2： | 30 |
| 17 | 强制性运动疗法在偏瘫型脑性瘫痪中的应用及机制研究进展显示文摘脑性瘫痪(以下简称脑瘫)是儿童肢体残疾最常见的原因,患病率为1.5%。—4%[1]。近年来随着产科技术的提高及围产医学和新生儿医学的发展,高危儿和极低体重儿生存率大幅度提高,脑瘫的发生率呈现稳中有升的趋势。据不完全统计目前中国现有脑瘫患者约530万,其中0—6岁患儿约占50%,且以每年约5万的速率递增。在所有类型脑瘫患儿当中,偏瘫型脑瘫(hemiplegic cerebral palsy,HCP)在临床中最为常见,约占44%[2],主要表现为偏侧肢体功能障碍,尤以手功能障碍最为显著。研究发现,HCP患儿的粗大运动功能(gross motor function classification system)水平绝大多数可达I级或Ⅱ级,其社会生活能力可接近正常人的82%[3],单侧肢体功能障碍最为突出;其中单侧上肢功能障碍比下肢功能障碍较为明显。此外患儿上肢肌力、感觉也会有不同程度减退,并伴手部精细活动功能及协调障碍。 | 唐红梅 刘力茹 徐开寿 | 2018 | 中国康复医学杂志2018，33，10： | 29 |
| 18 | 早产儿脑损伤的诊治进展显示文摘 | 周丛乐 | 2006 | 中国实用儿科杂志2006，21，9： | 28 |
| 19 | 中、重型颅脑损伤患者并发外伤性脑梗死相关因素分析显示文摘外伤性脑梗死(posttraumatic cerebral infarction,PTCI)是颅脑损伤的常见并发症之一,PTCI的发生影响患者预后[1],但对其发病率、病因及对患者预后影响的研究较少。笔者回顾分析310例中、重型颅脑损伤患者的临床资料,探讨PTCI发生相关因素及其对患者预后的影响。 | 柯尊华 张毅 方永军 周锋 胡珍渊 王更新 柏鲁宁 周振国 畅涛 周雄波 于勇 郑运松 赵晓平 罗卫 | 2011 | 中华创伤杂志2011，27，10： | 28 |
| 20 | 颈动脉粥样硬化性缺血性脑血管病的超声检测与应用显示文摘随着国人生活水平、工作节奏的不断改变,老龄化问题日趋严重,脑血管疾病(cerebral vascular disease,CVD)的发病率呈明显上升趋势。脑血管疾病的发生是造成人类死亡和病残的重要原因,是我国的常见病、多发病,居国内死因调查中的首位。 | 华扬 | 2006 | 中国现代神经疾病杂志2006，6，5： | 25 |
您所在的机构暂未开通此部分的功能，请联系管理员