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| 1 | Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients显示文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C. | Gang Lv Guo-Qiang Wang Zhen-Xi Xia Hai-Xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang | 2019 | Military Medical Research2019，6，3： | 60 |
| 2 | Disposable circumcision suture device: clinical effect and patient satisfaction显示文摘根据我们的经验,经历割礼的病人主要关于疼痛和阴茎外观被担心。我们进行了未来的使随机化的试用估计一台新可处理的割礼缝术设备(DCSD ) 的好处。942 个病人的一个总数同等地被划分成三个组(常规割礼,商戒指和可处理的缝术设备组) 。在 DCSD 组的病人是有化合物 5% lidocaine 乳脂的 anesthetized,其它与 2% lidocaine 阴茎块。操作时间, intra 起作用的血损失,切口愈合时间, intra 起作用、手术后的疼痛,阴茎外观和全面满足度被测量。操作时间和 intra 起作用的血损失与传统的组相比在商戒指和缝术设备组是显著地更低的(P <0.001 ) 。Intra 起作用的疼痛与另外的二个组相比是在缝术设备组的更少(P <0.001 ) ;而手术后的疼痛在与另外的二个组相比的传统的组是更高的(P <0.001 ) 。设备(80.57%) 和商戒指(73.57%) 组织的在缝术的病人是与常规割礼组相比对阴茎外观满意的更多(20.06% , P <0.05 ) 。在缝术设备组的病人也比传统的组快显著地愈合了(P <0.01 ) 。全面满足率在缝术设备组(78.66%) 更好与相比常规(47.13%) 并且商戒指(50.00%) 组(P <0.05 ) 。DCSD 和 lidocaine 乳脂的联合导致了更短的操作和切口愈合时间,减少了 intra 起作用、手术后的疼痛并且改进了对化妆外观的耐心的满足。 | Bo-Dong Lv Shi-Geng Zhang Xuan-Wen Zhu Jie Zhang Gang Chen Min-Fu Chen Hong-Liang Shen Zai-Jun Pei Zhao-Dian Chen | 2014 | Asian Journal of Andrology2014，16，3： | 49 |
| 3 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 4 | Fibroblast growth factor 21 as a possible endogenous factor inhibits apoptosis in cardiac endothelial cells显示文摘(FGF21 ) 背景成纤维细胞生长因素 21 是是为全身的葡萄糖和类脂化合物新陈代谢的一个重要内长的管理者的 FGF 超级家庭的一个新成员。这研究试图探索 FGF21 是否减少动脉粥样硬化患者损害并且作为独立保护 factor.Methods 阻止 endothelial 机能障碍现在的学习被设计调查氧化低的密度脂蛋白(ox-LDL ) 导致的 FGF21 层次的变化,并且 apoptosis 的变化由调整 FGF21 表示影响了。有教养的心脏的 microvascular endothelial 房间(CMEC ) 的 FGF21 mRNA 层次被真实 time-PCR 决定,在文化媒介的蛋白质集中被连接酶的 immunosorbent 试金检测。我们分析了与 ox-LDL 孵化的未经治疗的控制和 CMFC 的不同表示层次,并且 CMEC apoptosis 的变化由分泌物 FGF21 mRNA 铺平的 FGF21 levels.Results 的改进或抑制开始了,蛋白质是显著地,在 CMEC 的 upregulated 与 ox-LDL 孵化了。而且, 200 mol/L bezafibrate 增加的 FGF21 层次能减少 CMEC apoptosis ,并且由导致的 shRNA 禁止 FGF21 表示 apoptosis ( P 0.05 ) .Conclusions FGF21 可以是受伤目标织物的一个信号,并且可以在在动脉粥样硬化并且在停止冠的心疾病的开发的一个早阶段改进 endothelial 函数起生理的作用。 | Lv Yun LIU Jing-hua ZHANG Li-ke DU Jie ZENG Xiang-jun HAO Gang HUANG Ji ZHAO Dong-hui WANG Guo-zhong ZHANG Ying-chuan | 2010 | Chinese Medical Journal2010，，23： | 25 |
| 5 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 6 | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord显示文摘Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury. | Changwei Song Shiqiang Fang Gang Lv Xifan Mei | 2013 | Neural Regeneration Research2013，8，15： | 16 |
| 7 | Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus显示文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT. | Xi Cao Qing-Hua Shang Xiao-Ling Chi Wei Zhang Huan-Ming Xiao Mi-Mi Sun Gang Chen Yong An Chun-Lei Lv Lin Wang Yue-Min Nan Cui-Ying Chen Zong-Nan Tan Xue-En Liu Hui Zhuang | 2020 | World Journal of Gastroenterology2020，26，10： | 12 |
| 8 | Time representation of mitochondrial morphology and function after acute spinal cord injury显示文摘Changes in mitochondrial morphology and function play an important role in secondary damage after acute spinal cord injury. We recorded the time representation of mitochondrial morphology and function in rats with acute spinal cord injury. Results showed that mitochondria had an irregular shape, and increased in size. Mitochondrial cristae were disordered and mitochondrial membrane rupture was visible at 2–24 hours after injury. Fusion protein mitofusin 1 expression gradually increased, peaked at 8 hours after injury, and then decreased to its lowest level at 24 hours. Expression of dynamin-related protein 1, amitochondrial fission protein, showed the opposite kinetics. At 2–24 hours after acute spinal cord injury, malondialdehyde content, cytochrome c levels and caspase-3 expression were increased, but glutathione content, adenosine triphosphate content, Na+-K+-ATPase activity and mitochondrial membrane potential were gradually reduced. Furthermore, mitochondrial morphology altered during the acute stage of spinal cord injury. Fusion was important within the first 8 hours, but fission played a key role at 24 hours. Oxidative stress was inhibited, biological productivity was diminished, and mitochondrial membrane potential and permeability were reduced in the acute stage of injury. In summary, mitochondrial apoptosis is activated when the time of spinal cord injury is prolonged. | Zhi-qiang Jia Gang Li Zhen-yu Zhang Hao-tian Li Ji-quan Wang Zhong-kai Fan Gang Lv | 2016 | Neural Regeneration Research2016，11，1： | 8 |
| 9 | Repair of sciatic nerve defects using tissue engineered nerves显示文摘In this study, we constructed tissue-engineered nerves with acellular nerve allografts in Sprague-Dawley rats, which were prepared using chemical detergents-enzymatic digestion and mechanical methods, in combination with bone marrow mesenchymal stem cells of Wistar rats cultured in vitro, to repair 15 mm sciatic bone defects in Wistar rats. At postoperative 12 weeks, electrophysiological detection results showed that the conduction velocity of regenerated nerve after repair with tissue-engineered nerves was similar to that after autologous nerve grafting, and was higher than that after repair with acellular nerve allografts. Immunohistochemical staining revealed that motor endplates with acetylcholinesterase-positive nerve fibers were orderly arranged in the middle and superior parts of the gastrocnemius muscle; regenerated nerve tracts and sprouted branches were connected with motor endplates, as shown by acetylcholinesterase histochemistry combined with silver staining. The wet weight ratio of the tibialis anterior muscle at the affected contralateral hind limb was similar to the sciatic nerve after repair with autologous nerve grafts, and higher than that after repair with acellular nerve allografts. The hind limb motor function at the affected side was significantly improved, indicating that acellular nerve allografts combined with bone marrow mesenchymal stem cell bridging could promote functional recovery of rats with sciatic nerve defects. | Caishun Zhang Gang Lv | 2013 | Neural Regeneration Research2013，8，21： | 8 |
| 10 | Analysis on Dam-Breaking Mode of Tangjiashan Barrier Dam in Beichuan County显示文摘Tangjiashan landslide is a typical high-speed consequent landslide of medium-steep dip angle. This landslide triggered by earthquake took place in about semi-minute. The relative sliding displacement is 900 meters, so average sliding speed is about 30 meters per second. The longitudinal length of barrier dam which is formed by high-speed landslide along river is 803.4 meters; and maximum width crossing river is 611.8 meters. And its volume is estimated about 20.37 million steres. Through detailed geological investigation of the barrier dam, together with early geological information before earthquake, geological structures of the barrier dam and its stability of upstream and downstream slopes are studied when water level reaches different elevations in condition of continual after shocks with seismic intensity of 7 or 8 Richter scale. On this basis, dam-breaking mode of barrier dam is discussed deeply. Thereby, analytic results provide significant guidance and advices to front headquarters of Tangjiashan barrier dam, so that some proper engineering measures can be implemented and flood discharge can be carried out well. | HU Xiewen LUO Gang LV Xiaoping HUANG Runqiu SHI Yubin | 2011 | Journal of Mountain Science2011，8，2： | 6 |
| 11 | Gingerol activates noxious cold ion channel TRPA1 in gastrointestinal tract显示文摘TRPA1 channels are non-selective cation channels that could be activated by plant-derived pungent products, including gingerol, a main active constituent of ginger. Ginger could improve the digestive function; however whether ginger improves the digestive function through activating TRPA1 receptor in gastrointestinal tract has not been investigated. In the present study, gingerol was used to stimulate cell lines(RIN14B or STC-1) while depletion of extracellular calcium.TRPA1 inhibitor(rethenium red) and TRPA1 gene silencing via TRPA1-specific si RNA were also used for mechanistic studies. The intracellular calcium and secretion of serotonin or cholecystokinin were measured by fura-2/AM and ELISA. Stimulation of those cells with gingerol increased intracellular calcium levels and the serotonin or cholecystokinin secretion. The gingerol-induced intracellular calcium increase and secretion(serotonin or cholecystokinin) release were completely blocked by ruthenium red, EGTA, and TRPA1-specific si RNA. In summary, our results suggested that gingerol derived from ginger might improve the digestive function through secretion releasing from endocrine cells of the gut by inducing TRPA1-mediated calcium influx. | YANG Meng-Qi YE Lin-Lan LIU Xiao-Ling QI Xiao-Ming LV Jia-Di WANG Gang FARHAN Ulah-Khan WAQAS Nawaz CHEN Ding-Ding HAN Lei ZHOU Xiao-Hui | 2016 | Chinese Journal of Natural Medicines2016，14，6： | 6 |
| 12 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 13 | Treatment of Post-traumatic Pediatric Ankle Varus Deformity with Physeal Bar Resection and Hemi-Epiphysiodesis显示文摘Children presenting with partial physeal arrest and significant remaining growth may benefit from physeal bar resection,although the operation is a technique demanding procedure.This study evaluates the treatment of post-traumatic pediatric ankle varus deformity using physeal bar resection and hemi-epiphysiodesis with the assistance of two operative methods.Forty-five patients presenting with a distal tibial medial physeal bridge as well as ankle varus deformity following traumatic ankle physeal injury between 2009 and 2017 were followed.These patients were treated w让h physeal bar resection and hemi-epiphysiodesis,with the assistance of either fluoroscopy (10 cases) or intraoperative three-dimensional navigation (35 cases).Of the 45 cases,the median age was 9.0 years (range:3-14 years) with 28 male and 17 female patients.The median of pre-operation ankle varus angle was 20 degrees (IQR 15-25) and 5 degrees (IQR 0-20) at the time of final follow up,representing a statistically significant difference (P<0.05).No differences were observed with regards to age,gender,and surgical history between effective group and ineffective group (P>0.05).The median of pre-operative ankle varus angles of the navigation and fluoroscopy groups were both 20 degrees (P>0.05).The median correction angle of the navigation and fluoroscopy groups was 10 and 15 degrees,respectively (P>0.05).Our results indicate that physeal bar resection and hemiepiphysiodesis are effective treatments for correcting ankle varus deformity due to traumatic medial physeal arrest of the distal tibia.We observe no difference in outcome between fluoroscopy group and three-dimensional navigation group during the procedures. | Gang FU Wang WANG Yi-fei DONG Xue-min LV Zheng YANG | 2019 | Current Medical Science2019，39，4： | 5 |
| 14 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 15 | Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type,but not in dopamine D3 receptor knockout mice显示文摘Increasing preclinical evidence demonstrates that dopamine D3 receptor (D3R) antagonists are a potential option for the treatment of drug addiction. The reinstatement of the addiction can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug’s effects. YQA14 is a novel D3R antagonist that has exhibited pharmacotherapeutic efficacy in reducing cocaine and amphetamine reward and relapse to drug seeking in mice. In this study we investigated the effects of YQA14 on morphine-induced context-specific locomotor sensitization in mice. We showed that repeated injection of YQA14 (6.25–25mg/kg every day ip) prior to morphine (10mg/kg every day sc) not only inhibited the acquisition, but also significantly attenuated the expression of morphine-induced locomotor sensitization. Furthermore, in the expression phase, one single injection of YQA14 (6.25-25mg/kg, ip) dose-dependently inhibited the expression of morphine-induced behavioral sensitization. Moreover, YQA14 inhibited the expression of morphine-induced behavioral sensitization in wild mice (WT), but not in D3R knockout (D3R^-/-) mice in the expression phase. In addition, D3R^-/- mice also displayed the reduction in the expression phase compared with WT mice. In summary, this study demonstrates that blockade or knockout of the D3R inhibits morphine-induced behavior sensitization, suggesting that D3R plays an important role in the pathogenesis and etiology of morphine addiction, and it might be a potential target for clinical management of opioid addiction. | Yang Lv Rong-rong Hu Manyi Jing Tai-yun Zhao Ning Wu Rui Song Jin Li Gang Hu | 2019 | Acta Pharmacologica Sinica2019，40，5： | 4 |
| 16 | AST-to-ALT ratio and coronary artery lesions among patients with Kawasaki disease显示文摘Background The aim of this study was to explore the associations between the aspartate aminotransferase-to-alanine aminotransferase ratio(AST/ALT)and coronary artery lesions(CALs)among patients with Kawasaki disease(KD).Methods Medical records of KD patients presenting to a single center between January 2019 and December 2020 were retrospectively collected and analyzed.Univariate,multivariable-adjusted analyses,subgroup analyses,restricted cubic spline test,and fitted curves were used to evaluate the associations between AST/ALT and CALs.Results A total of 831 patients were enrolled,of which 201(24.2%)had CALs on admission and 21(2.5%)developed CALs de novo after intravenous immunoglobulin(IVIG).Multivariable-adjusted analyses models revealed that a lower AST/ALT was associated with an increased risk of CALs on admission when AST/ALT was a continuous variable(P=0.007)and when it was a categorical variable(P for trend=0.004).Each unit increase in AST/ALT was associated with a 22%lower risk of CALs on admission(odds ratio=0.78,95%confidence interval 0.65-0.94).A negative linear relationship was noted between AST/ALT and the risk of CALs on admission in both observed and fitted models.However,such associations were not observed in AST/ALT and CALs de novo after IVIG.None of the variables significantly modified the association between AST/ALT and CALs on admission and CALs de novo after IVIG(P>0.05).Conclusion Our findings suggested that AST/ALT was a risk factor of CALs,but was not associated with progressive CALs. | Lei Cao Yun-Jia Tang Miao Gang Jin Ma Wei-Guo Qian Qiu-Qin Xu Hai-Tao Lv | 2021 | World Journal of Pediatrics2021，17，6： | 4 |
| 17 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 18 | DRUCKER-PRAGER YIELD CRITERIA IN VISCOELASTIC-PLASTIC CONSTITUTIVE MODEL FOR THE STUDY OF SEA ICE DYNAMICS显示文摘Based on the characteristics of sea ice drifting and ridging at meso-small scale, the Drucker-Prager (D-P) yield criteria was introduced into the Viscoelastic-Plastic (VEP) constitutive model for the study of sea ice dynamics. In this model, the Kelvin–Vogit viscoelastic model was adopted in the elastic stage, and the associated normal flow rule was used in the plastic stage. Using the VEP model, the sea ice ridging process was simulated in an idealized rectangular basin, and the simulation results show that the simulated ice ridge thickness is consistent with the analytical solution. Moreover, the VEP model with the D-P yield criteria was also applied for the sea ice simulation of Bohai Sea, and the ice thickness, concentration, velocity, and ice stress were obtained in 48 h. The simulated thickness distributions agree well with the satellite images. The singular problem in the Mohr–Coulomb (M-C) yield criteria was overcome by the D-P yield criteria, and the computational efficiency was also improved. In the numerical simulations described above, the smoothed particle hydrodynamics was applied. | WANG Gang JI Shun-ying LV He-xiang YUE Qian-jin | 2006 | Journal of Hydrodynamics2006，18，6： | 3 |
| 19 | 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury显示文摘Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature. | Zhenli Mao Zhenquan Song Gang Li Wei Lv Xu Zhao Bin Li Xinli Feng Youli Chen | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 20 | An optimal dose of tea polyphenols protects against global cerebral ischemia/reperfusion injury显示文摘Previous studies addressing the protection of tea polyphenols against cerebral ischemia/ reperfusion injury often use focal cerebral ischemia models, and the optimal dose is not unified. In this experiment, a cerebral ischemia/reperfusion injury rat model was established using a modified four-vessel occlusion method. Rats were treated with different doses of tea polyphenols (25, 50, 100, 150, 200 mg/kg) via intraperitoneal injection. Results showed that after 2, 6, 12, 24, 48 and 72 hours of reperfusion, peroxide dismutase activity and total antioxidant capacity in brain tissue gradually increased, while malondialdehyde content gradually decreased after tea polyphenol intervention. Tea polyphenols at 200 mg/kg resulted in the most apparent changes. Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotic cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury. The open field test and elevated plus maze experiments showed that tea polyphenols at 200 mg/kg strengthened exploratory behavior and reduced anxiety of cerebral ischemia/reperfusion injured rats. Experimental findings indicate that tea polyphenols protected rats against cerebral ischemia/ reperfusion injury and 200 mg/kg is regarded as the optimal dose. | Jianrui Lv Rongliang Xue Jing Zhao Xin Wei Hui Gao Rongguo Fu Gang Wu Wei Li Xiaoming Lei Junbin Tian | 2013 | Neural Regeneration Research2013，8，9： | 3 |
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