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| 1 | Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases显示文摘The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system. Abnormal expression of CMTM is associated with the development of various diseases. This article summarizes the relevant research on the role of the CMTM family in immune disorders. This information will increase our understanding of pathogenesis and identify promising targets for the diagnosis and treatment of autoimmune diseases. The CMTM family is highly expressed in peripheral blood mononuclear cells. CKLF1 may be involved in the development of arthritis through its interaction with C-C chemokine receptor 4. CKLF1 is associated with the pathogenesis of lupus nephritis and psoriasis. Both CMTM4 and CMTM5 are associated with the pathogenesis of systemic lupus erythematosus. CMTM1, CMTM2, CMTM3, and CMTM6 play a role in rheumatoid arthritis, systemic sclerosis, Sj?gren syndrome, and anti-phospholipid syndrome, respectively. The CMTM family has been implicated in various autoimmune diseases. Further research on the mechanism of the action of CMTM family members may lead to the development of new treatment strategies for autoimmune diseases. | Hong-Ji Duan Xin-Yi Li Chang Liu Xiao-Li Deng | 2020 | Chinese Medical Journal2020，，8： | 8 |
| 2 | 睾酮对雄性精子发生障碍大鼠CMTM家族表达的影响显示文摘研究睾酮对生精功能障碍大鼠的作用,以及对CMTM家族各蛋白表达的影响。采用棉酚(50mg·kg-1)和环磷酰胺(20mg·kg-1)建立大鼠精子发生障碍模型,给予丙酸睾酮(5mg·kg-1,隔日给药,共6次)后取左侧附睾尾,收集精子。采用CASA图像分析系统对精子进行数量和活力分析,取睾丸组织采用HE染色进行形态学检查,采用蛋白印记方法(Western blotting)对CMTM家族各成员进行蛋白水平表达研究。研究发现,棉酚和环磷酰胺均可使睾丸组织发生明显的病理改变,降低精子数量和活力,而睾酮(5mg·kg-1)具有一定的改善作用。研究CMTM家族表达情况发现,棉酚和环磷酰胺均可降低雄性大鼠睾丸组织中CMTM4的表达,睾酮(5mg·kg-1)可显著提高CMTM4表达;棉酚可显著增加睾丸中CMTM2的表达,给予睾酮后CMTM2表达量显著下降,而环磷酰胺对于CMTM2影响不显著;棉酚和环磷酰胺对于CKLF1、CMTM3和CMTM5的表达影响不显著,睾丸组织中未检测到CMTM6、CMTM7和CMTM8的表达。研究结果表明,睾酮(5mg·kg-1)的生精作用可能与影响CMTM家族个别成员表达有关,趋化因子CMTM2和CMTM4可能在精子发生过程具有作用。 | 李刚 李光艳 吉海杰 赵文杰 楚世峰 陈乃宏 | 2010 | 药学学报2010，45，8： | 4 |
| 3 | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome显示文摘Antiphospholipid syndrome(APS)is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies(aPLs).Chemokine-like factor-like MARVEL transmembrane domain-containing family(CMTM)is widely expressed in the immune system and may closely related to APS.This review aimed to systematically summarize the possible effects of CMTM on APS.Publications were collected from PubMed and Web of Science databases up to August 2020.CKLF,CKLFSF,CMTM,antiphospholipid syndrome,immune cells,and immune molecules were used as search criteria.Immune cells,including neutrophil,dendritic cells(DCs),T-cells,B-cells,and inflammatory cytokines,play an important role in the development of APS.Chemokine-like factor 1(CKLF1)has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB(NF-kB)pathway or mitogen-activated protein kinase(MARK)pathway.CKLF1 can participate in the maturation of DCs,T lymphocyte activation,and the activation of neutrophils through the MAPK pathway.CMTM1 may act on Annexin A2 by regulating Ca^(2+) signaling.CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients.Some CMTM family members influence the activation and accumulation of platelets.CMTM3 and CMTM7 are binding partners of B-cell linker protein(BLNK),thereby linking B cell receptor(BCR)and activating BLNK-mediated signal transduction in B cells.Moreover,CMTM3 and CMTM7 can act on DCs and B-1a cell development,respectively.CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules.Thus,CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS. | Ying-Ying Ge Hong-Ji Duan Xiao-Li Deng | 2021 | Chinese Medical Journal2021，，14： | 2 |
| 4 | CMTM中国药物治疗管理标准案例高血压病1例显示文摘近年来,我国药学服务的现状不断发生变化,逐渐从以药品调剂为主发展到以患者为中心的药学监护阶段。通过药物治疗管理,建立药师和患者之间的联系,使患者最终能够实现自我管理。运用中国药物治疗管理(CMTM)的方法学,药师和患者通过预约,进行门诊访谈及文件记录,并定期随访的一种长期管理的模式。 | 钟悦华 韩伟民 | 2021 | 中国社区医师2021，37，9： | 2 |
| 5 | Analysis of CMTM6 and CMTM4 expression as potential regulators of the PD-L1 protein and its association with prognosis in glioma cancer显示文摘Chemokine-like factor super family(CKLFSF)is a gene family reported in 2003.In humans,the family is composed of nine members,namely chemokine-like factor(CKLF)and CKLF-like MARVEL transmembrane domain-containing member 1-8(CMTM1-8)[1].Genes in the CMTM family have different spliceosomes,which code for MAL-related proteins for vesicle trafficking and membrane link domain(MARVEL).Studies have shown that molecules containing this domain play important physiological and pathological roles in protein transport[2]. | Hui Xue Bin Qiu Hao Wang Ping Jiang Weiwei Zhang Lixiang Xue Junjie Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 1 |
| 6 | 趋化素样因子超家族成员在肿瘤中的研究进展显示文摘趋化素样因子超家族成员(chemokine-like factor-like MARVEL transmembrane domain containing member/chemokine-like factor superfamily member,CMTM/CKLFSF)是连接趋化因子和跨膜超家族的一组新的蛋白家族,包括CKLF和CMTM1-CMTM8。CMTM除了具有广泛的趋化活性外,还与造血系统、免疫系统以及肿瘤的发生、发展和转移密切相关。CMTM蛋白参与癌症发展中的关键生物学过程,包括生长因子受体的激活和循环、细胞的增殖与转移以及肿瘤免疫微环境的调节。随着研究发现CMTM4、CMTM6可作为程序性死亡配体1(programmed cell death ligand 1,PD-L1)的调控器,关于CMTM与肿瘤之间的关系重新成为研究热点。本文对CMTM家族成员在癌症中作用进行综述,特别是在肿瘤生长、转移和免疫逃逸中的研究进展,并总结CMTM与非小细胞肺癌之间关系的最新研究结果,探讨CMTM作为新型药物靶点或生物标志物的潜在临床价值。 | 谢刚 成婧 张俊萍 | 2023 | 中国肺癌杂志2023，26，1： | 1 |
| 7 | 试论CMTM在小学美术教学中的应用策略显示文摘现代社会,科技飞速发展,多媒体技术逐渐渗透于各个领域。在小学美术教学过程中,CMTM的应用优化了教学过程,提高了教学效率,但同时我们也应该清楚地意识到,它存在一定的弊端。所以,小学美术老师在教学过程中,应该灵活地应用CMTM,充分发挥其优势,扬长避短,最大限度地优化小学美术的教学效果。 | 王红梅 | 2015 | 小学生(教学实践)2015，，10： | 0 |
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