|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 2 | 合适的链接 最佳的服务——SFX与CrossRef/DOI交互作用探讨显示文摘介绍基于OpenURL的SFX Context Sensitive Linking和基于DOI的CrossRef这两种目前主流的动态链接系统。指出SFX具有本地化、互操作性强和可定制的特点,能够针对用户对资源的可获得性给出合适的链接;CrossRef链接直接指向出版社文献信息网页,链接准确稳定,但不适合用户获取最终文献。讨论CrossRef链接存在的问题,分析SFX的特点,并在此基础上提出将SFX与CrossRef/DOI结合使用的方法,指出这将增强和完善SFX的链接功能,同时解决CrossRef/DOI合适链接的问题。 | 黄美君 姜爱蓉 | 2006 | 图书情报工作2006，50，3： | 8 |
| 3 | THE MORSE INDEX OF A SADDLE POINT显示文摘This paper is devoted to clarifying the relationship between the classical Morse theory andthe Mountain Pass Lemma via the local linking concept.It is shown that for a C^1-function f with alocal linking,the m-thcritical group is nontrivial,where m is the Morse index.Combined with thebehavior of f at infinity,this result can be used to offer the existence of nontrivial critical points. | 刘嘉荃 | 1989 | Systems Science and Mathematical Sciences1989，2，1： | 7 |
| 4 | 网络半结构化信息资源的描述显示文摘要对网络信息资源进行更好的管理和查询,首先要建立一种合理的信息资源描述机制。metadata是描述网络信息资源的有力工具,但新的信息描述机制——linking机制不仅能表述metadata的内容,而且可以表达比metada更丰富的语义,弥补metadata自身不能克服的一些缺陷。 | 黄奇 李伟 接晓莉 | 2002 | 图书情报工作2002，46，2： | 4 |
| 5 | Sleep apnoea and stroke显示文摘Sleep disorders have been known to physicians for a long time.In his famous aphorisms,Hippocrates said“Sleep or watchfulness exceeding that which is customary,augurs unfavorably”.Modern medicine has been able to disentangle some of the phenomena that disturb sleep.Among the most notable offenders is sleep apnoea that has gained prominence in the past few decades.It is being proposed as one of the potentially modifiable risk factors for vascular diseases including stroke.The pathological mechanisms linking sleep apnoea to vascular risk factors include hypoxia,cardiac arrhythmias,dysautonomia,impaired glucose tolerance,hypertension,dyslipidaemia and inflammation.In this article,we review literature linking sleep apnoea and stroke,including sleep apnoea as a risk factor for primary prevention with the potential to improve outcome after acute stroke and as a secondary risk factor,amenable to modification and hence vascular risk reduction. | Sameer Sharma Antonio Culebras | 2016 | Stroke & Vascular Neurology2016，1，4： | 4 |
| 6 | Telomere-to-telomere and gap-free reference genome assembly of the kiwifruit Actinidia chinensis显示文摘Kiwifruit is an economically and nutritionally important fruit crop with extremely high contents of vitamin C.However,the previously released versions of kiwifruit genomes all have a mass of unanchored or missing regions.Here,we report a highly continuous and completely gap-free reference genome of Actinidia chinensis cv.‘Hongyang’,named Hongyang v4.0,which is the first to achieve two de novo haploid-resolved haplotypes,HY4P and HY4A.HY4P and HY4A have a total length of 606.1 and 599.6 Mb,respectively,with almost the entire telomeres and centromeres assembled in each haplotype.In comparison with Hongyang v3.0,the integrity and contiguity of Hongyang v4.0 is markedly improved by filling all unclosed gaps and correcting some misoriented regions,resulting in∼38.6–39.5 Mb extra sequences,which might affect 4263 and 4244 protein-coding genes in HY4P and HY4A,respectively.Furthermore,our gap-free genome assembly provides the first clue for inspecting the structure and function of centromeres.Globally,centromeric regions are characterized by higher-order repeats that mainly consist of a 153-bp conserved centromere-specific monomer(Ach-CEN153)with different copy numbers among chromosomes.Functional enrichment analysis of the genes located within centromeric regions demonstrates that chromosome centromeres may not only play physical roles for linking a pair of sister chromatids,but also have genetic features for participation in the regulation of cell division.The availability of the telomere-to-telomere and gap-free Hongyang v4.0 reference genome lays a solid foundation not only for illustrating genome structure and functional genomics studies but also for facilitating kiwifruit breeding and improvement. | Junyang Yue Qinyao Chen Yingzhen Wang Lei Zhang Chen Ye Xu Wang Shuo Cao Yunzhi Lin Wei Huang He Xian Hongyan Qin Yanli Wang Sijia Zhang Ying Wu Songhu Wang Yi Yue Yongsheng Liu | 2023 | Horticulture Research2023，10，2： | 4 |
| 7 | Graph-ranking collective Chinese entity linking algorithm显示文摘Entity linking(EL)systems aim to link entity mentions in the document to their corresponding entity records in a reference knowledge base.Existing EL approaches usually ignore the semantic correlation between the mentions in the text,and are limited to the scale of the local knowledge base.In this paper,we propose a novel graphranking collective Chinese entity linking(GRCCEL)algorithm,which can take advantage of both the structured relationship between entities in the local knowledge base and the additional background information offered by external knowledge sources.By improved weighted word2vec textual similarity and improved PageRank algorithm,more semantic information and structural information can be captured in the document.With an incremental evidence mining process,more powerful discrimination capability for similar entities can be obtained.We evaluate the performance of our algorithm on some open domain corpus.Experimental results show the effectiveness of our method in Chinese entity linking task and demonstrate the superiority of our method over state-of-the-art methods. | Tao XIE Bin WU Bingjing JIA Bai WANG | 2020 | Frontiers of Computer Science2020，14，2： | 3 |
| 8 | Editing the Shape Morphing of Monocomponent Natural Polysaccharide Hydrogel Films显示文摘Shape-morphing hydrogels can be widely used to develop artificial muscles,reconfigurable biodevices,and soft robotics.However,conventional approaches for developing shape-morphing hydrogels highly rely on composite materials or complex manufacturing techniques,which limit their practical applications.Herein,we develop an unprecedented strategy to edit the shape morphing of monocomponent natural polysaccharide hydrogel films via integrating gradient cross-linking density and geometry effect.Owing to the synergistic effect,the shape morphing of chitosan(CS)hydrogel films with gradient cross-linking density can be facilely edited by changing their geometries(length-to-width ratios or thicknesses).Therefore,helix,short-side rolling,and longside rolling can be easily customized.Furthermore,various complex artificial 3D deformations such as artificial claw,horn,and flower can also be obtained by combining various flat CS hydrogel films with different geometries into one system,which can further demonstrate various shape transformations as triggered by pH.This work offers a simple strategy to construct a monocomponent hydrogel with geometry-directing programmable deformations,which provides universal insights into the design of shape-morphing polymers and will promote their applications in biodevices and soft robotics. | Hao Hu Chao Huang Massimiliano Galluzzi Qiang Ye Rui Xiao Xuefeng Yu Xuemin Du | 2021 | Research2021，，1： | 3 |
| 9 | Human regulatory γδT cells and their functional plasticity in the tumor microenvironment显示文摘γδT cells were first identified as a novel T-cell subset in the 1980s.1 Whereas the vast majority of T cells express a T-cell receptor(TCR)composed of αβ heterodimers,a smaller population expresses a γδT CR.Unlike conventional αβ T cells,γδT cells are considered to be a unique and conserved subset of T cells cross-linking innate immunity and adaptive immunity.2 Therefore,γδT cells are usually categorized as innate immune T cells. | Hui Chen Wei He | 2018 | Cellular & Molecular Immunology2018，15，4： | 3 |
| 10 | Methionine metabolism in chronic liver diseases:an update on molecular mechanism and therapeutic implication显示文摘As one of the bicyclic metabolic pathways of one-carbon metabolism,methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway.In addition to being a precursor for glutathione synthesis,and the principal methyl donor for nucleic acid,phospholipid,histone,biogenic amine,and protein methylation,methionine metabolites can participate in polyamine synthesis.Methionine metabolism disorder can aggravate the damage in the pathological state of a disease.In the occurrence and development of chronic liver diseases(CLDs),changes in various components involved in methionine metabolism can affect the pathological state through various mechanisms.A methionine-deficient diet is commonly used for building CLD models.The conversion of key enzymes of methionine metabolism methionine adenosyltransferase(MAT)1 A and MAT2A/MAT2B is closely related to fibrosis and hepatocellular carcinoma.In vivo and in vitro experiments have shown that by intervening related enzymes or downstream metabolites to interfere with methionine metabolism,the liver injuries could be reduced.Recently,methionine supplementation has gradually attracted the attention of many clinical researchers.Most researchers agree that adequate methionine supplementation can help reduce liver damage.Retrospective analysis of recently conducted relevant studies is of profound significance.This paper reviews the latest achievements related to methionine metabolism and CLD,from molecular mechanisms to clinical research,and provides some insights into the future direction of basic and clinical research. | Zhanghao Li Feixia Wang Baoyu Liang Ying Su Sumin Sun Siwei Xia Jiangjuan Shao Zili Zhang Min Hong Feng Zhang Shizhong Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 11 | 基于IFIX的半潜式钻井平台集成监控系统显示文摘针对目前海洋钻井平台中集成能力、可操作性和可扩展性存在的问题,分析了平台监控的设计思想和主要功能。应用OPC技术设计客户端实现了平台钻井系统集成监控的网络结构。研究了半潜式钻井平台各子系统集成监控技术;并以压载监控子系统的人机界面为例,采用IFIX工控组态软件进行了制作。此钻井平台集成监控系统具有独立性、可扩展性强等特点。 | 赵莉 陈红卫 | 2012 | 科学技术与工程2012，20，5： | 3 |
| 12 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 13 | Characterization of Modified Tapioca Starch in Atmospheric Argon Plasma under Diverse Humidity by FTIR Spectroscopy显示文摘Tapioca is economical crop grown in Thailand and continues to be one of the major sources of starch.Nowadays,tapioca starch has been widely used in industrial applications,however the native form of starch has limited the applications.Thus scientists try to modify the properties of starch for increasing the stability of the granules,pastes to low pH,heat,and shear during the food process.We modify the tapioca starch by plasma treatment under an argon atmosphere.The degree of modification is determined by following water content in the starch granules.The tablet samples of native starch are also prepared and compared with the plasma treated starch.Before plasma treatment,the starch tablets are stored under three different relative humilities(RH)including 11%,68%,and 78%RH,respectively.The samples are characterized using FTIR spectroscopy associated with the degree of cross-linking.The results show that the water molecules are engulfed into the starch structure in two ways,a tight bond and a weak absorption of water molecules which is represented at two wave number of 1630 cm^(-1) and 3272 cm^(-1),respectively.The degree of cross-linking can be identified from the relative intensity of these two peaks with the C–O–H peak at 993 cm^(-1).The results show that the degree of cross-linking increase in the plasma treated starch.The degree of cross-linking of the treated starch with high relative humidity is less than that of the treated starch with low relative humidity. | P.Deeyai M.Suphantharika R.Wongsagonsup S.Dangtip | 2013 | Chinese Physics Letters2013，30，1： | 2 |
| 14 | Action mechanisms and research methods of tRNA-derived small RNAs显示文摘tRNA-derived small RNAs(tsRNAs),including tRNA-derived fragments(tRFs)and tRNA halves(tiRNAs),are small regulatory RNAs processed from mature tRNAs or precursor tRNAs.tRFs and tiRNAs play biological roles through a variety of mechanisms by interacting with proteins or mRNA,inhibiting translation,and regulating gene expression,the cell cycle,and chromatin and epigenetic modifications.The establishment and application of research technologies are important in understanding the biological roles of tRFs and tiRNAs.To study the molecular mechanisms of tRFs and tiRNAs,researchers have used a variety of bioinformatics and molecular biology methods,such as microarray analysis,real-time quantitative reverse transcription-polymerase chain reaction(qRT-PCR);Northern blotting;RNA sequencing(RNA-seq);cross-linking,ligation and sequencing of hybrids(CLASH);and photoactivatable-ribonucleoside-enhanced cross-linking and immunoprecipitation(PAR-CLIP).This paper summarizes the classification,action mechanisms,and roles of tRFs and tiRNAs in human diseases and the related signal transduction pathways,targeted therapies,databases,and research methods associated with them. | Yaoyao Xie Lipeng Yao Xiuchong Yu Yao Ruan Zhe Li Junming Guo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 15 | Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System显示文摘Photosynthetic biohybrid systems exhibit promising performance in biosynthesis;however,these systems can only produce a single metabolite and cannot further transform carbon sources into highly valuable chemical production.Herein,a photosynthetic biohybrid system integrating biological and chemical cascade synthesis was developed for solar-driven conversion of glucose to value-added chemicals.A new ternary cooperative biohybrid system,namely bacterial factory,was constructed by self-assembling of enzyme-modified light-harvesting donor-acceptor conjugated polymer nanoparticles(D-A CPNs)and genetically engineered Escherichia coli(E.coli).The D-A CPNs coating on E.coli could effectively generate electrons under light irradiation,which were transferred into E.coli to promote the 37%increment of threonine production by increasing the ratio of nicotinamide adenine dinucleotide phosphate(NADPH).Subsequently,the metabolized threonine was catalyzed by threonine deaminase covalently linking with D-A CPNs to obtain 2-oxobutyrate,which is an important precursor of drugs and chemicals.The 2-oxobutyrate yield under light irradiation is increased by 58%in comparison to that in dark.This work provides a new organic semiconductor-microorganism photosynthetic biohybrid system for biological and chemical cascade synthesis of highly valuable chemicals by taking advantage of renewable carbon sources and solar energy. | Wen Yu Haotian Bai Yue Zeng Hao Zhao Shengpeng Xia Yiming Huang Fengting Lv Shu Wang | 2022 | Research2022，，3： | 2 |
| 16 | A computational model for feature binding显示文摘The 'Binding Problem' is an important problem across many disciplines, including psychology, neuroscience, computational modeling, and even philosophy. In this work, we proposed a novel computational model, Bayesian Linking Field Model, for feature binding in visual perception, by combining the idea of noisy neuron model, Bayesian method, Linking Field Network and competitive mechanism. Simulation Experiments demonstrated that our model perfectly fulfilled the task of feature binding in visual perception and provided us some enlightening idea for future research. | SHI ZhiWei1,2, SHI ZhongZhi1, LIU Xi1,2 & SHI ZhiPing1 1 Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China | 2008 | Science China(Life Sciences)2008，51，5： | 2 |
| 17 | Explaining the lack of FDI in western China:an industrial perspective显示文摘It is difficult to attract FDI into western China.This situation might not be explained by traditional geographical factors,because the gap of inward FDI between the western and the eastern regions of China has increased.This paper attempts to explain the situation from an industrial perspective by exploring the industrial differences in the two regions and analyzing their effects in terms of industrial development level,industrial structure and industrial linking capability.The results reveal that industrial factors are important barriers to the inflow of FDI to western China. | 杨先明 袁帆 刘岩 | 2009 | China Economist2009，4，3： | 1 |
| 18 | Introduction to special topic on exercise and oxidative stress显示文摘The discovery that endurance exercise is associated with oxidative stress was first reported in 1978.In the ensuing 4 decades,many studies confirmed this original observation.Recent investigations provided mechanistic insight into the sites of reactive oxygen species(ROS)production during exercise and the cellular consequences of an increase in ROS production.In this special topic of the Journal of Sport and Health Science,we feature 4 state-of-the-art reviews on key topics linking exercise and oxidative stress. | Zsolt Radak Scott K.Powers | 2020 | Journal of Sport and Health Science2020，9，5： | 1 |
| 19 | Linking China's emissions trading pilot schemes显示文摘All seven emissions trading pilots in China operate independently.One challenge facing most of them is the low inclusion thresholds for enterprises and the few total covered emissions,which negatively influences the effects of the emissions trading systems(ETSs).Some pilot sites,such as Guangdong,Hubei,Tianjin and Beijing,have indicated their willingness to link their schemes with others.ETS linking could expand scheme coverages and therefore help to reduce the overall costs of achieving the linked schemes' emissions control targets.Linking could also help to address the issues of carbon leakage and reduce price fluctuations.The potential benefits and feasibility of linking different pilot systems are analyzed in this article.The seven pilot regions are at different stages of social and economic development,with significant differences in total emissions and emissions structures as well as carbon abatement potentials and costs.Through linking,more-developed regions such as Beijing,Shanghai and Shenzhen,which are typically considered to face higher mitigation costs,will have the opportunity to achieve their emissions control targets by purchasing carbon units from less-developed regions,which will earn financial revenues from selling the units.To realize this win-win result,a series of policy and technical barriers at both the central government and pilot government levels needs to be overcome.Establishing a unified national emissions trading market would appear to be the ideal solution to these challenges,but it will take considerable time and will not be the short-term solution.In the absence of a unified national scheme,it is recommended that the central government encourage pilot schemes to link,that it develops corresponding national policies to support the linking efforts and that the pilot schemes that are intended to be linked coordinate on certain design elements.Based on the coordinating need,the major elements of an ETS can be divided into four categories:elements that need mutual recognition(cap setting and allowance allocation methods);elements that should be completely identical(compliance mechanisms,price containment measures,banking and borrowing rules,and offset mechanisms);technical elements that are preferably identical and easy to coordinate(MRV standards,technical registry standards);and elements that require no coordination(coverages and scopes). | Tao Pang Li Zhou Maosheng Duan | 2015 | Chinese Journal of Population,Resources and Environment2015，13，3： | 1 |
| 20 | MetaLib资源导航页面的本地化实践显示文摘基于MetaLib系统提供的Type字段、分类/子类模块、深度链接(Deep Linking)和自定义字段等关键技术,文章讨论了在MetaLib资源导航设计中资源类型和学科分类等方面的页面本地化实践。 | 关富英 李书宁 李松玲 | 2010 | 图书馆学研究(应用版)2010，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员