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| 1 | Hepatocellular carcinoma: current management and recent advances显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a major health problem worldwide. It is the fifth most common cancer in the world, and the third most common cause of cancer-related death. Without specific treatment, the prognosis is very poor. The goal of management is 'cancer control' - a reduction in its incidence and mortality as well as an improvement in the quality of life of patients with HCC and their families. This article aims to review the current management of HCC and its recent advances. DATA SOURCES: A MEDLINE database search was performed to identify relevant article using the keyworks 'hepatocellular carcinoma', 'hepatectomy', 'liver transplantation', and 'local ablative therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Liver resection and liver transplantation remain the options that give the best chance of a cure. Recent evidence suggests that local ablative therapy may offer comparable survival results in patients with small HCC, and preserved liver function. Transarterial chemoembolization (TACE) is the most promising palliative modality for unresectable HCC, but other techniques, such as transarterial radioembolization (TARE), and local ablative therapy, have also shown comparable results. CONCLUSIONS: Early diagnosis of HCC remains a key goal in improving the prognosis of patients. During the last two decades, operative mortality and surgical outcome of liver resection and liver transplantation for HCC have improved. Progress also has been made in multi-modality therapy which can increase the chance of survival and improve the quality of life for patients with advanced HCC. | Wan-Yee Lau Eric C. H. Lai | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 100 |
| 2 | 资源发现系统功能分析及应用前景显示文摘介绍资源发现系统的产生背景、逻辑结构、功能特点及体系框架,指出当前资源发现系统需要引起关注的两个问题。结合清华大学的探索实践,阐述资源发现系统在图书馆应用的经验,提出数据驱动的知识服务新思路。 | 窦天芳 姜爱蓉 | 2012 | 图书情报工作2012，56，7： | 99 |
| 3 | Problems in Homoclinic Bifurcation with Higher Dimensions | Zhu Deming Department of Mathematics, East China Normal University. Shanghai 200062. China | 1998 | Acta Mathematica Sinica,English Series1998，14，3： | 30 |
| 4 | 东北森林带森林生态系统固碳服务空间特征及其影响因素显示文摘东北森林带作为国家主体生态区划'两屏三带'国家生态安全格局中的重要组成部分,在全球碳平衡中发挥着重要的碳汇作用。以东北森林带为研究区域,采用净生态系统生产力(NEP)评估其森林固碳服务,通过Anselin Local Moran's Ⅰ算法识别固碳服务的'热点'、'冷点'和'异常点',并分析探讨其空间格局与影响因素。结果表明:(1)东北森林带森林生态系统整体上是碳汇。2014年东北森林带森林固碳总量为36.41 Tg C/a,单位面积固碳量为89.57 g C m^(-2)a^(-1)。(2)固碳服务的热点区主要分布在大兴安岭北部和长白山中北部,冷点区主要分布在大兴安岭东部、小兴安岭和长白山南部,固碳服务的高值异常区域主要分布在森林边缘的农林交错带,低值异常区域主要分布在人为干扰严重的城市蔓延区。(3)东北森林带森林生态系统整体上受人为因素的影响小,其固碳服务与NDVI显著正相关。(4)城市扩张等人为干扰是固碳服务异常降低的根本原因,植被本身生长状况不佳和较高的温度是导致固碳服务的异常降低的重要影响因素。 | 孙滨峰 赵红 逯非 王效科 | 2018 | 生态学报2018，38，14： | 29 |
| 5 | Implementation of Envelope Analysis on a Wireless Condition Monitoring System for Bearing Fault Diagnosis显示文摘Envelope analysis is an effective method for characterizing impulsive vibrations in wired condition monitoring(CM)systems. This paper depicts the implementation of envelope analysis on a wireless sensor node for obtaining a more convenient and reliable CM system. To maintain CM performances under the constraints of resources available in the cost effective Zigbee based wireless sensor network(WSN), a low cost cortex-M4 F microcontroller is employed as the core processor to implement the envelope analysis algorithm on the sensor node. The on-chip 12 bit analog-to-digital converter(ADC) working at 10 k Hz sampling rate is adopted to acquire vibration signals measured by a wide frequency band piezoelectric accelerometer. The data processing flow inside the processor is optimized to satisfy the large memory usage in implementing fast Fourier transform(FFT) and Hilbert transform(HT). Thus, the envelope spectrum can be computed from a data frame of 2048 points to achieve a frequency resolution acceptable for identifying the characteristic frequencies of different bearing faults. Experimental evaluation results show that the embedded envelope analysis algorithm can successfully diagnose the simulated bearing faults and the data transmission throughput can be reduced by at least 95% per frame compared with that of the raw data, allowing a large number of sensor nodes to be deployed in the network for real time monitoring. | Guo-Jin Feng James Gu Dong Zhen Mustafa Aliwan Feng-Shou Gu Andrew D.Ball | 2015 | International Journal of Automation and computing2015，12，1： | 28 |
| 6 | Influences of local factors on permafrost occurrence and their implications for Qinghai-Xizang Railway design显示文摘The construction of the Qinghai-Xizang Railway is facing some challenges posed by the presence of warm and ice-rich permafrost and predicted climate warming. To resolve these issues and ensure the railway a success, adjustments will have to be made in design strategies and principles. This paper presents several examples of permafrost-distribution anomaly caused by site-specific conditions. It analyzes the mechanism through which these local factors influence the occurrence and preservation of permafrost by modifying the heat convection and conduction patterns, and the amount of solar radiation received by the ground surface. A good understanding of these anomalies in permafrost occurrence is significant as it may provide some hints on the techniques and measures we can use to artificially simulate similar effects. A number of measures can be taken to lower ground temperature and to counter the effect of cli-mate warming. These measures include use of proper roadbed material and configuration, in order to adjust solar radiation, heat convection and conduction patterns. It is recommended that a new proactive approach be adopted in the railway design. This approach emphasizes the use of all the above-mentioned measures to cool down the roadbed. This is different from previous methods of preventing permafrost from thawing by utilizing more thermal resistant materials. | CHENG Guodong | 2004 | Science China Earth Sciences2004，47，8： | 26 |
| 7 | Evolution of Intraseasonal Oscillation over the Tropica lWestern Pacific/South China Sea and Its Effect to the Summer Precipitation in Southern China显示文摘EvolutionofIntraseasonalOscilationovertheTropicalWesternPacific/SouthChinaSeaandItsEfecttotheSummerPrecipitationinSouthernChi... | 李崇银 李桂龙 | 1997 | Advances in Atmospheric Sciences1997，14，2： | 26 |
| 8 | Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy显示文摘AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.METHODS A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after surgery.Mean arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two groups.Surgical stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two groups.Significantly lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P<0.05 for all).MAP was significantly lower at 6,12,and 24 h(P<0.05 for all);HR was significantly lower at 0,6,12,and 24 h(P<0.05 for all);time to bowel recovery and length of hospitalization after surgery(P<0.05 for both)were significantly shortened;and cumulative sufentanil consumption was significantly lower at 6,12,24,and 36 h(P<0.05 for all)in the ropivacaine group than in the control group,although the incidence of nausea and vomiting showed no significant difference between the two groups.The levels of epinephrine,norepinephrine,and cortisol were significantly lower in the ropivacaine group than in the control group at 24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery. | Jing-Xian Sun Ke-Yun Bai Yan-Feng Liu Gang Du Zhi-Hao Fu Hao Zhang Jin-Huan Yang Ben Wang Xiu-Yu Wang Bin Jin | 2017 | World Journal of Gastroenterology2017，23，36： | 25 |
| 9 | 地方坐标系向2000国家大地坐标系转换方法的研究显示文摘针对地方坐标系存在着多样性和复杂性,将地方坐标系根据建立方法概括为三种类型,提出地方坐标向2000国家大地坐标系转换的两种技术路线,通过具体实例分析,表明该方法坐标转换精度较高,并具有实用性、通用性。同时给出根据重合点情况,如何选择转换模型,并通过检验点误差和转换残差全面来衡量坐标转换精度。 | 李东 毛之琳 | 2010 | 测绘与空间地理信息2010，33，6： | 24 |
| 10 | Local conjugacy theorem, rank theorems in advanced calculus and a generalized principle for constructing Banach manifolds显示文摘Applications of locally fine property for operators are further developed. Let E and F be Banach spaces and f: U( x0) E—→F be C1 nonlinear map, where U (x0) is an open set containing point x0∈ E. With the locally fine property for Frechet derivatives f’ (x) and generalized rank theorem for f ’( x), a local conjugacy theorem, i. e. a characteristic condition for f being conjugate to f (x0) near x0,is proved. This theorem gives a complete answer to the local conjugacy problem. Consequently, several rank theorems in advanced calculus are established, including a theorem for C1 Fredholm map which has been so far unknown. Also with this property the concept of regular value is extended, which gives rise to a generalized principle for constructing Banach submanifolds. | 马吉溥 | 2000 | Science China Mathematics2000，43，12： | 23 |
| 11 | 结合GLWT和LBP提取纹理特征的图像分割显示文摘提出一种提取图像纹理特征的新方法:结合广义局部沃尔什变换(GLWT)和局部二值模式(LBP)。首先说明广义局部沃尔什变换的定义,然后计算并分析广义局部沃尔什变换系数,并选取识别性能较好的2阶矩作为纹理特征。结合LBP空间纹理特征和灰度特征,然后根据纹理特征采用模糊C均值算法对像素进行聚类。实验结果表明,结合广义局部沃尔什变换和LBP的纹理特征具有更好的鉴别性能,且计算简单。 | 詹曙 胡德凤 蒋建国 | 2014 | 电子测量与仪器学报2014，28，2： | 23 |
| 12 | Immunometabolism:A novel perspective of liver cancer microenvironment and its influence on tumor progression显示文摘The initiation and progression of liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are dependent on its tumor microenvironment. Immune cells are key players in the liver cancer microenvironment and show complicated crosstalk with cancer cells. Emerging evidence has shown that the functions of immune cells are closely related to cell metabolism. However, the effects of metabolic changes of immune cells on liver cancer progression are largely undefined. In this review, we summarize the recent findings of immunometabolism and relate these findings to liver cancer progression. We also explore the translation of the understanding of immunometabolism for clinical use. | Qi Zhang Yu Lou Xue-Li Bai Ting-Bo Liang | 2018 | World Journal of Gastroenterology2018，24，31： | 23 |
| 13 | 广义加性模型及其应用显示文摘目的探讨广义加性模型在医学研究领域中的应用。方法通过研究低出生体重与年龄、先兆流产、妊高症之间关系的实例分析说明模型的实际应用。结果该模型可以揭示出发病与年龄的复杂非线性关系。结论广义加性模型不需要对模型的线性假设,应用起来灵活性强,是探索变量间复杂关系的有力工具。 | 李丽霞 郜艳晖 周舒冬 邹宗峰 张瑛 | 2007 | 中国卫生统计2007，24，3： | 20 |
| 14 | Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis显示文摘Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration and metastasis. Additionally, there is growing evidence for the prognostic significance of PVTT classification according to the location of tumor thrombosis. Favorable outcomes can be obtained by applying local modalities, including surgery or transarterial chemoembolization, especially in second-order or distal branch PVTT. Rapid control of PVTT could maintain or improve liver function and reduce intrahepatic as well as distant metastasis. Radiotherapy(RT) is one of the main locoregional treatment modalities in oncologic fields, but has rarely been used in HCC because of concerns regarding hepatic toxicity. However, with the development of advanced techniques, RT has been increasingly applied in HCC management. Randomized studies have yet to definitively prove the benefit of RT, but several comparative studies have justified the application of RT in HCC. The value of RT is especially noticeable in HCC with PVTT; several prospective and retrospective studies have reported favorable outcomes, including a 40% to 60% objective response rate and median overall survival of 15 mo to 20 mo in responders. In this review, we evaluate the role of RT as an alternative local modality in HCC with PVTT. | Jeong Il Yu Hee Chul Park | 2016 | World Journal of Gastroenterology2016，22，30： | 20 |
| 15 | Local and non-local sources of airborne particulate pollution at Beijing——The ratio of Mg/Al as an element tracer for estimating the contributions of mineral aerosols from outside Beijing显示文摘A new element tracer technique has firstly been established to estimate the contributions of mineral aerosols from both inside and outside Beijing. The ratio of Mg/Al in aerosol is a feasible element tracer to distinguish between the sources of inside and outside Beijing. Mineral aerosol, inorganic pollution aerosol mainly as sulfate and nitrate, and organic aerosol are the major components of airborne particulates in Beijing, of which mineral aerosol accounted for 32%―67% of total suspended particles (TSP), 10%―70% of fine particles (PM2.5), and as high as 74% and 90% of TSP and PM2.5, respectively, in dust storm. The sources from outside Beijing contributed 62% (38%―86%) of the total mineral aerosols in TSP, 69% (52%―90%) in PM10, and 76% (59%―93%) in PM2.5 in spring, and 69% (52%―83%), 79% (52%―93%), and 45% (7%―79%) in TSP, PM10, and PM2.5, respectively, in winter, while only ~20% in summer and autumn. The sources from outside Beijing contributed as high as 97% during dust storm and were the dominant source of airborne particulates in Beijing. The contributions from outside Beijing in spring and winter are higher than those in summer, indicating clearly that it was related to the various meteorological factors. | HAN Lihui1, ZHUANG Guoshun1,2,3, SUN Yele1 & WANG Zifa3 1. The Center for Atmospheric Environmental Study, Department of Chemistry, Beijing Normal University, Beijing 100875, China 2. Center for Atmospheric Chemistry Study, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China 3. LAPC/NZC, Institute of Atmospheric Physics, CAS, Beijing 100029, China | 2005 | Science China Chemistry2005，48，3： | 18 |
| 16 | Adjuvants to local anesthetics: Current understanding and future trends显示文摘Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by itsduration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action. A large array of opioids ranging from morphine, fentanyl and sufentanyl to hydromorphone, buprenorphine and tramadol has been used with varying success. However, their use has been limited by their adverse effect like respiratory depression, nausea, vomiting and pruritus, especially with its neuraxial use. Epinephrine potentiates the local anesthetics by its antinociceptive properties mediated by alpha-2 adrenoreceptor activation along with its vasoconstrictive properties limiting the systemic absorption of local anesthetics. Alpha 2 adrenoreceptor antagonists like clonidine and dexmedetomidine are one of the most widely used class of local anesthetic adjuvants. Other drugs like steroids(dexamethasone), anti-inflammatory agents(parecoxib and lornoxicam), midazolam, ketamine, magnesium sulfate and neostigmine have also been used with mixed success. The concern regarding the safety profile of these adjuvants is due to its potential neurotoxicity and neurological complications which necessitate further research in this direction. Current research is directed towards a search for agents and techniques which would prolong local anaesthetic action without its deleterious effects. This includes novel approaches like use of charged molecules to produce local anaesthetic action(tonicaine and n butyl tetracaine), new age delivery mechanisms for prolonged bioavailability(liposomal, microspheres and cyclodextrin systems) and further studies with other drugs(adenosine, neuromuscular blockers, dextrans). | Amlan Swain Deb Sanjay Nag Seelora Sahu Devi Prasad Samaddar | 2017 | World Journal of Clinical Cases2017，5，8： | 18 |
| 17 | Genetic Diversity and Structure of Tunisian Local Pear Germplasm as Revealed by SSR Markers显示文摘Growing pear has a long tradition in Tunisia, and numerous local cultivars possessing an excellent adaptability and resilience potential to climatic variation are present. This large adaptability is associated with an important genetic diversity, which is threatened to erosion.Appropriate measures have to be taken in order to properly evaluate and conserve this local material. Microsatellite markers were used to assess the level of genetic diversity among Tunisian pear germplasm, and compare it with some European varieties and wild pear species. 61 pear accessions representing eight groups(six groups from Tunisia, one from Northern Europe and another group composed of wild pear) have been genotyped using SSR markers derived from apple and pear. The pear accessions showed a significant polymorphism and 95 polymorphic alleles were found. The number of alleles per locus varied from 5 for CH04e03 locus to 14 for CH01d09 locus with an average of 9.4 alleles per locus.Moreover, the mean gene diversity(H_e) per locus ranged from 0.192 to 0.752. Genetic distance values and cluster analyses revealed high genetic similarities among the Tunisian groups. Factorial correspondence analysis(FCA) categorized the accessions into three independent groups where Tunisian local accessions agglomerated together distantly from European and wild pear accessions. Additionally, UPGMA dendrogram grouped accessions into two clusters, confirmed thereafter by the Bayesian model-based Structure analysis. The results showed 16 putative triploid accessions found in the local germplasm. This study provides valuable information to develop strategies of local pear conservation and use. | Rim Ouni Anna Zborowska Jasna Sehic Sarra Choulak JInaki Hormaza Larisa Garkava-Gustavsson Messaoud Mars | 2020 | Horticultural Plant Journal2020，6，2： | 18 |
| 18 | Interventional treatments for hepatocellular carcinoma显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most frequent primary malignant tumors in the world. Hepatic resection and liver transplantation are considered optimal for potential treatment of HCC. However, only 20% of HCCs can be surgically treated. And most of surgically-noneligible patients have to receive interventional managements including local ablation and transarterial chemoembolization (TACE). In this paper, we review the interventional treatments of HCC. DATA SOURCES: A literature search of PubMed database was conducted and research articles were reviewed. RESULTS: Percutaneous ethanol injection (PEI) is usually applied to small HCC for a complete necrosis. Radiofrequency ablation, an alternative to PEI, also causes tumor necrosis and needs fewer times of ablation. Other methods such as acetic acid injection, laser, microwave, etc have enriched local ablation for HCC. High intensity focus ultrasound (HIFU) is thought to be promising. TACE, another common modality, can improve the survival rate of patients with HCC. The newly developed embolic agents and adjuvant rAd-p53 gene therapy are well reported. CONCLUSIONS: Surgically-noneligible HCC can be treated with interventional procedures. Each method has its advantages and disadvantages. However, it is still pressing to develop ablative methods as well as new embolic agents for a better prognosis of HCC. | Yong-Song Guan and Yuan Liu Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 17 |
| 19 | Disclosure of government financial information and the cost of local government's debt financing——Empirical evidence from provincial investment bonds for urban construction显示文摘China's slowing economic growth and rapid urbanization have made local government debt financing a significant issue.This study uses a sample of China's provincial government data for the 2006–2012 period to examine the effect of the disclosure of financial information by local governments on their debt financing costs.The results show that financial information disclosure is conducive to public supervision and enhances government credibility,leading to a decrease in the cost of debt financing.Furthermore,increased government economic intervention increases the strength of the association between financial information disclosure and the cost of debt financing.Increased government audit prevention function weakens the strength of the association between financial information disclosure and the cost of debt financing. | Zhibin Chen Jun Pan Liangliang Wang Xiaofeng Shen | 2016 | China Journal of Accounting Research2016，，3： | 15 |
| 20 | Bifurcations of Rough Heteroclinic Loops with Three Saddle Points | JIN Yin Lai ZHU De Ming Department of Mathematics. Linyi Teachers University. Shandong 276005. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 13 |
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