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| 1 | Use of neuron-specific enolase to predict mild brain injury in motorcycle crash patients with maxillofacial fractures: A pilot study显示文摘Purpose: Mild traumatic brain injury (TBI) is common but accurate diagnosis and its clinical consequences have been a problem. Maxillofacial trauma does have an association with TBI. Neuron-specific enolase (NSE) has been developed to evaluate neuronl damage. The objective of this study was to investigate the accuracy of NSE serum levels to detect mild brain injury of patients with sustained maxillofacial fractures during motor vehicle accidents. Methods: Blood samples were drawn from 40 healthy people (control group) and 48 trauma patients who has sustained isolated maxillofacial fractures and mild brain injury in motor vehicle accidents. Brain injuries were graded by Glasgow Coma Scale. In the trauma group, correlations between the NSE serum value and different facial fracture sites were also assessed. Results: The NSE serum level (mean ± SD, ng/ml) in the 48 patients with maxillofacial fractures and mild TBI was 13.12 ± 9.68, significantly higher than that measured in the healthy control group (7.72 ± 1.82, p < 0.001). The mean NSE serum level (ng/ml) in the lower part of the facial skeleton (15.44 with SD 15.34) was higher than that in the upper facial part (12.42 with SD 7.68);and the mean NSE level (ng/ml) in the middle-and lower part (11.97 with SD 5.63) was higher than in the middle part (7.88 with SD 2.64). Conclusion: An increase in NSE serum levels can be observed in patients sustained maxillofacial fractures and mild brain injury. | Muhammad Ruslin Jan Wolff Harmas Yazid Yusuf Muhammad Zaifullah Arifin Paolo Boffano Tymour Forouzanfar | 2019 | Chinese Journal of Traumatology2019，22，1： | 17 |
| 2 | Fatal complications in a patient with severe multi-space infections in the oral and maxillofacial head and neck regions: A case report显示文摘BACKGROUND Odontogenic infection is one of the common infectious diseases in oral and maxillofacial head and neck regions.Clinically,if early odontogenic infections such as acute periapical periodontitis,alveolar abscess,and pericoronitis of wisdom teeth are not treated timely,effectively and correctly,the infected tissue may spread up to the skull and brain,down to the thoracic cavity,abdominal cavity and other areas through the natural potential fascial space in the oral and maxillofacial head and neck.Severe multi-space infections are formed and can eventually lead to life-threatening complications(LTCs),such as intracranial infection,pleural effusion,empyema,sepsis and even death.CASE SUMMARY We report a rare case of death in a 41-year-old man with severe odontogenic multi-space infections in the oral and maxillofacial head and neck regions.One week before admission,due to pain in the right lower posterior teeth,the patient placed a cigarette butt dipped in the pesticide'Miehailin'into the'dental cavity'to relieve the pain.Within a week,the infection gradually spread bilaterally to the floor of the mouth,submandibular space,neck,chest,waist,back,temporal and other areas.The patient had difficulty breathing,swallowing and eating,and was transferred to our hospital as an emergency admission.Following admission,oral and maxillofacial surgeons immediately organized consultations with doctors in otolaryngology,thoracic surgery,general surgery,hematology,anesthesia and the intensive care unit to assist with treatment.The patient was treated with the highest level of antibiotics(vancomycin)and extensive abscess incision and drainage in the oral,maxillofacial,head and neck,chest and back regions.Unfortunately,the patient died of septic shock and multiple organ failure on the third day after admission.CONCLUSION Odontogenic infection can cause serious multi-space infections in the oral and maxillofacial head and neck regions,which can result in multiple LTCs.The management and treatment of LTCs such as multi-space infections should be multidisciplinary led by oral and maxillofacial surgeons. | Tian-Guo Dai Hong-Bing Ran Yin-Xiu Qiu Bo Xu Jin-Qiang Cheng Ying-Kai Liu | 2019 | World Journal of Clinical Cases2019，7，23： | 14 |
| 3 | Robotic surgical systems in maxillofacial surgery:a review显示文摘Throughout the twenty-first century, robotic surgery has been used in multiple oral surgical procedures for the treatment of head and neck tumors and non-malignant diseases. With the assistance of robotic surgical systems, maxillofacial surgery is performed with less blood loss, fewer complications, shorter hospitalization and better cosmetic results than standard open surgery.However, the application of robotic surgery techniques to the treatment of head and neck diseases remains in an experimental stage, and the long-lasting effects on surgical morbidity, oncologic control and quality of life are yet to be established. More well-designed studies are needed before this approach can be recommended as a standard treatment paradigm. Nonetheless,robotic surgical systems will inevitably be extended to maxillofacial surgery. This article reviews the current clinical applications of robotic surgery in the head and neck region and highlights the benefits and limitations of current robotic surgical systems. | Hang-Hang Liu Long-Jiang Li Bin Shi Chun-Wei Xu En Luo | 2017 | International Journal of Oral Science2017，9，2： | 11 |
| 4 | Biomaterial-based strategies for maxillofacial tumour therapy and bone defect regeneration显示文摘Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects.In traditional tumour therapy,the systemic toxicity of chemotherapeutic drugs,invasive surgical resection,intractable tumour recurrence,and metastasis are major threats to the patients’lives in the clinic.Fortunately,biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis,suggesting new promising antitumour therapies.In addition,maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients,and investment in treatment can result in a multitude of burdens to society.Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration.More interestingly,an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option.Herein,we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair.Furthermore,we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future. | Bowen Tan Quan Tang Yongjin Zhong Yali Wei Linfeng He Yanting Wu Jiabao Wu Jinfeng Liao | 2021 | International Journal of Oral Science2021，13，1： | 9 |
| 5 | Development and application of rapid rehabilitation system for reconstruction of maxillofacial soft-tissue defects related to war and traumatic injuries显示文摘Background: Maxillofacial war injuries usually cause severe facial organ defects and deformities, handicapping the patient's daily activities, even result in a tendency to commit suicide. The application of maxillofacial prosthesis is an alternative to surgery in functional–aesthetic facial reconstruction. Computer aided design and computer aided manufacturing has opened up a new approach to the fabrication of maxillofacial prosthesis. An intelligentized rapid simulative design and manufacture system for prosthesis was developed to facilitate the prosthesis fabrication procedure.Methods: Maxillofacial prosthesis rapid simulation design and rapid fabrication system consists of three components: digital impression, intelligentized prosthesis designing, and rapid manufacturing. The patients' maxillofacial digital impressions were taken with Structured-light 3D scanner; and then the 3D model of prostheses and their negative molds could be designed in specific software; finally, with the resin molds fabricated by rapid prototyping machine, the prostheses could be produced directly and quickly.Results: Fifteen patients of maxillofacial defect caused by traumatic injuries received prosthesis rehabilitation provided by the established system. The contour of the prostheses coordinated properly with the appearance of the patients, and the uniform-thickness border sealed well to adjacent tissues. All the patients were satisfied with their prostheses.Conclusions: The rapid simulative rehabilitation system of maxillofacial defects has been approaching completion. It could provide advanced technological reservation for the Army in the issue of maxillofacial defect rehabilitation. | Shi-Zhu Bai Zhi-Hong Feng Rui Gao Yan Dong Yun-Peng Bi Guo-Feng Wu Xi Chen | 2014 | Journal of Medical Colleges of PLA(China)2014，29，1： | 5 |
| 6 | Clinical evaluation of implants in patients with maxillofacial defects显示文摘AIM: To show the efficacy of reconstruction and rehabilitation of large acquired maxillofacial defects due to tumor resections and firearm injuries. METHODS: The study group comprised of 16 patients(10 men and 6 women) who were operated on because of their maxillofacial defects under local and general anesthesia between June 2007 and June 2011. Prosthetic treatment with the aid of dental implants was performed for all of the patients. Eight patients received an implant supported fixed prosthesis; six patients received implant supported overdentures and two patients received both. Patients were followed up postoperatively for 1 to 4 years. Implant success and survival rates were recorded. Panoramic radiographs were taken preoperatively, immediately after surgery, immediately after loading and at every recall session. Peri-implant and prosthetic complications were recorded. Subjects were asked to grade their oral health satisfaction after treatment according to 100 mm visual analog scale(VAS) and the oral health related quality oflife of the patients was measured with the short-form Oral Health Impact Profile. RESULTS: Five implants(3 in the mandible, 2 in the maxilla) in five patients were lost, while the other 53 survived, which brings an overall survival rate of 91.37% on the implant basis, but 68.75% on patient basis. All the failed implants were lost before abutment connection and were therefore regarded as early failures. For all failed implants, new implants were placed after a 2 mo period and the planning was maintained. The mean marginal bone loss(MBL) was 1.4 mm on the mesial side and 1.6 mm on the distal side of the implants. Five of the implants showed MBL > 2 mm(mean MBL = 2.3 mm) but less than 1/2 of the implant bodies and therefore were regarded as not successful but surviving implants. The VAS General Comfort mean score was 85.07, the VAS Speech mean score was 75.25 and the VAS Esthetics mean score was 82.74. No patient reported low scores(score lower than 50) of satisfaction in any of the evaluated factors. The mean of OHIP-14 scores was 5.5. CONCLUSION: Although further follow up and larger case numbers will give more information about the success of dental implants as a treatment modality in maxillofacial defects patients, the actual results are encouraging and can be recommended for similar cases. | Belir Atalay Hakan Bilhan Onur Geckili Caglar Bilmenoglu Ugur Meric | 2013 | World Journal of Stomatology2013，2，3： | 3 |
| 7 | Temporary Cavity Effects of High Velocity Spherical Steel Bullet Wounds in Maxillofacial Region of Dogs显示文摘Maxillofacial region wounds of dogs were inflicted by spherical steel bullets,0.7 g weight,with the muzzle velocity of 1.3 km/s.The photographs of the temporarycavity were taken with a high speed x-ray cine-camera,and local wounding conditionswere observed with the naked eye.The experimental results proved that a temporary ca-vity was formed in the maxillofacial region wound.The contusion zone of the maxillofa-cial soft tissue was smaller than that of the extremities.The contusion zone of the skinand oral mucous membrane was 1-2 mm,and that of muscle was 5-8 mm in thickness.In clinical situation,the tissues of the contusion zones should always be excised since itconsists of devitalized tissue.The temporary cavitation is an important factor in causingstructural injuries of tissues around the local wound track. | 华泽权 周树夏 刘荫秋 刘志斌 | 1990 | Journal of Medical Colleges of PLA(China)1990，5，2： | 0 |
| 8 | Pathological Changes of Small Blood Vessels in Maxillofacial Region Following High Velocity Missile Wound:an Experimental Study in Dogs显示文摘In order to provide an experimental foundation and pathological base for earlyreconstruction of maxillofacial tissues defects after firearms wound using microsurgicalmethods,an experiment,was made to study the microvascular pathological changesthrough light and electron microscopy observation.In the experiment we found somepathological changes of small vessels in wounded region,such as mierothrombi forma-tion,endothelial loss,internal elastic membrane break and some degenerations,necrosis within endothelial and smooth muscle cells of vessel.The nearer the woundededge was,the more evident injury was.The microvascular injurous range was 3 cm dis-tant from wounded edge,which recovered in 7 days later after wounding.The experi-ment indicated that if we used the vascularized free tissue transfer to repair defects ofmaxillofacial firearms wounds,the pedicles of flap should be anastomosed to distant re-cipient vesseles which could be chosen beyond 3 cm from wounded edge.Thereconstructive operation should be done 7 days later after wound. | 谭颖徽 周树夏 刘宝林 刘荫秋 程学明 赖西南 | 1990 | Journal of Medical Colleges of PLA(China)1990，5，3： | 0 |
| 9 | An experimental study of early anastomosis of injured microvessels of maxillofacial region in dogs显示文摘This study was designed to evaluate whether the microvascularanastomosis of small arteries and veins in the wound area was possible after gun-shot wound was inflicted to the maxillofacial region of a dog.It was found thatsmall vessels could be connected with subsequent patency of their lumen if theoperation was performed on the 3rd day after the debridment of the gunshotWound,which provides a basis for microvascular anastomosis to repairmaxillofacial defect due to gunshot wound with free vascularized flap grafting.Inaddition the best time to have a defect repaired and the healing features of thewounds after vascular anastomosis are discussed. | 谭颖徽 周树夏 刘荫秋 刘宝林 李忠禹 程学明 | 1991 | Journal of Medical Colleges of PLA(China)1991，6，2： | 0 |
| 10 | Review of cost and surgical time implications using virtual patient specific planning and patient specific implants in midface reconstruction显示文摘Aim:Summarize the available data on midfacial virtual patient specific planning and patient specific implants,highlighting the financial costs and savings,and additionally emphasize the potential cost implications of transitioning to“in-house”virtual 3D modeling and printing.Methods:Review of current literature.Results:Current literature suggests cost benefits of virtual patient specific planning and patient specific implants in the form of improved ischemia time,better boney apposition between flaps,and reduced patient complications.This reduction of complications includes a reduction in blood loss and time spent in the intensive care unit from flap failure.Improved boney apposition results in a higher likelihood of boney union and a further reduction in failure and complications.Subjective benefits of virtual patient specific planning and patient specific implants are shown in the form of improved reconstructive surgeon mental energy.In-house production of 3D models and presurgical planning provides additional cost benefits for providers as they can produce viable models at a fraction of the price of that which is produced by industrial companies.Providers can also construct and use models in an expedient manner compared to industrial models,allowing for the opportunity to be utilized in more acute settings.The foundation of developing an in-house workflow is adequate funding,resources,and clinical volume.Facilities also must focus on appropriate quality and safety measures,as well as appropriate workflow development for adequate production of models.Conclusion:Virtual patient specific planning and patient specific implants show benefits in midfacial reconstructive outcomes,resulting in realized financial and temporal gains for both patient and provider.These gains may be enhanced by moving to in-house planning and printing. | Michael Lawless Brian Swendseid Natalia von Windheim Kyle VanKoevering Nolan Seim Matthew Old | 2022 | Plastic and Aesthetic Research2022，9，1： | 0 |
| 11 | Early débridement of the maxillofacial missile wound:an experimental study显示文摘Rapid debridement and 1% chlorhexidine iodine complex (CIC)wereused for treating badly cdntaminated and/or infected missile wounds 72 h after in-jury.The result showed that the combined use of the two methods proved to behighly effective in clearing out the necrotic tissues,bony debris and pathogenicbacteria,and in achieving primary healing.The problems about the extent andthe method of debridement in the early débridement of the fire-arm injury are dis-cussed in this paper. | 李伟忠 孙弘 陈必胜 姜晓钟 | 1991 | Journal of Medical Colleges of PLA(China)1991，6，1： | 0 |
| 12 | Influence of Carcinogenic Factors in the Maxillofacial Region显示文摘Objective To study the influence of carcinogenic factors on tissues and organs of the maxillofacial region(MFR)by measuring the expression of biomarkers in the oral fluid.Methods We recruited 421 patients who were divided into 2 groups:356 patients with a tumour of the MFR and 65 healthy people without somatic pathology in medical history.Results The effects of carcinogenic factors on the expression of biomarkers in the oral fluid in patients with a tumour of the MFR revealed a significant increase in the levels of biomarkers of tobacco use-MMP-8,TIMP-1,TIMP-2,and CA 72-4,CEA and CA 125;frequent use or abuse of alcohol-MMP-8,TIMP-1,TIMP-2,AFP and NSE;use of narcotics-TIMP-1 and TIMP-2;presence of occupational hazards in the medical history-MMP-8,MMP-9,TIMP-1 and TIMP-2;with a diagnostic sensitivity(DS)of over 60%.Also our analysis showed that the use of tobacco was significantly affecting the expression of TIMP-1and CA 125;frequent use or abuse of alcohol-CA 19-9,AFP and CEA;use of drugs had an impact on MMP-8expression.However,the occupational hazards in the medical history did not show a statistically significant effect.Conclusion Factors of carcinogenesis affect the expression of biomarkers in the oral fluid.The expression of the biomarkers of the MFR should be compared with that in the control group of patients with no carcinogenic factors. | Vladimir N.Nikolenko Ekaterina V.Kochurova | 2015 | 哈尔滨医科大学学报2015，49，5： | 0 |
| 13 | Surgical obturator duplicating original tissue-form restores esthetics and function in oral cancer显示文摘Oral cancer treatment primarily focused on the surgical removal of cancer tissues followed by surgical/prosthetic reconstruction.Restoration of the missing structures immediately after surgery shortens recovery time and allows patient to return to community as a functioning member.The most practiced surgical obturators are simple resin prosthetic bases without incorporation of the teeth.This article highlights a technique to fabricate a surgical obturator that duplicates patient’s original tissue form including teeth,alveolus and palatal tissues.The obturator is placed immediately after surgery and make patient feel unaware of surgical deformity.The obturator prosthesis fabricated with this technique supports soft tissues and minimizes the scar contracture.We have clinically tried this technique in 11 patients.Patients’satisfaction level was recorded on visual analogue scale(VAS)and it ranges between 74%and 94%(with average of 87%).Four different prosthodontists have visually evaluated facial asymmetry of patients at6 mo recall and their average perception on VAS varies between 71%and 93%(with average of 84%). | Pravinkumar G Patil | 2013 | World Journal of Stomatology2013，2，4： | 0 |
| 14 | Management of missile injuries to the maxillofacial region: A case series显示文摘AIM: To assess our management of patients suffering from missile injuries to the maxillofacial region.METHODS: From December 2009 to September 2012, 40 patients with missile injuries(high velocity gunshot and bullet wounds, explosive injuries and shrapnel etc.) affecting the maxillofacial region were treated. All except for 2 patients were males. All had soft tissue injuries with or without bone injuries. These patients were referred to the plastic and maxillofacial surgery ward of our hospital. The patients were 19 to 65 years of age(mean 45 years). In 19 cases, there were missile injuries to other parts of the body, especially the lower extremities. All of the patients were managed by early soft tissue debridement, comprehensive reconstruction and antibiotics. This retrospective study was approved by the IRB and ethical committees.RESULTS: The majority of injuries were caused by high velocity projectiles(88%) and the remaining by car explosions or dynamite blasts(12%). 40 patients were treated surgically. Thirty patients had soft tissue loss(75%) and 20 patients(50%) had bone loss; there was combined soft tissue and bone loss in 10(25%) patients. Facial fractures were in the orbital bones in 10 cases, maxillary in 7, nasal in 5 and the mandible in 3 cases. We used primary repair in the majority of soft tissue defects(25 of 40 cases). Bone repair was done primarily at the same stage using miniplates, titanium screws or wires. In some cases with a bone defect, iliac bone grafts were used simultaneously or in the later stages(mandibular defects). There was no failure of bone reconstruction in our cases. Infections occurred in two cases and were treated with systemic antibiotics and dressing changes, without any long term sequelae.CONCLUSION: Our principles for soft tissue reconstructions were according to the reconstructive ladder and included primary repair, local flaps, skin grafts and regional flaps depending on the extent of damage. Primary repair in facial missile defects was not associated with increased morbidity or complications in this series. We recommend this approach when feasible. | Ali Ebrahimi Mohammad Hosein Kalantar Motamedi Nasrin Nejadsarvari Hossein Mohammad Kazemi | 2013 | World Journal of Stomatology2013，2，3： | 0 |
| 15 | CLINICAL EFFECTIVENESS OF ELECTRO-ACUPUNCTURE THERAPY IN TREATING MAXILLOFACIAL TUMOURS显示文摘Electrochemical therapy, ECT, has been used to treat 122 cases of various kinds of tu-mour, among them, 81 cases were malignant tumours (32 cases facial, 18 cases subaural, 16 cases labial, 15 cases tongue), and the other 41 cases were bening tumours (cavermous hemangioma at facial region 23 cases and in oral cavity 18 cases). Pathological examination of malignant tumours revealed that there were 63 cases of squamous epithelial cancers and 18 cases of adenocarcinoma. Cavermous he-mangioma is benign tumour and congenital. Special designed and made platinum needles were inserted into the tumours and the needles were connected to an instrument protucing a direct current for treat-ment. Voltage used was usually 8 volts with current 60 - 80 mA. The quantity elecricity applied was 100 coulombs per 1 cm in diameter of the tumour. The effectiveness of treating 81 cases malignant tu-mours was: CR 42 cases (51. 8% ), PR 31 cases (38. 3% ), NC 5 cases (6. 2% ) and PD 3 cases (3.7 % ). CR + PR was 73 cases (90. 1 % ). The effectiveness of treating 41 cases of benign hemangioma was: CR 38 cases (92. 7 % ) and PR 3 cases (7. 3 % ). One, three and five year survival rates of malig-nant tumour patients were 95 %, 65. 4 % and 37 %, respectively. While all the 41 patients with he-mangioma survived over five years after treatment. | 辛育龄 | 1997 | World Journal of Acupuncture-Moxibustion1997，7，4： | 0 |
| 16 | STUDY ON INHIBITORY EFFECTS OF Na_2SeO_3 ON TRANSPLANTABLE TUMORS WITH Tca8113 CELLS显示文摘Some aspects of current research have focused on its relationship with malignant diseases and on its chemothearapeutic role. An attempt was made to determine the inhibitory effects of selenium on Tca8113 cells in vivo. In the experimental study, Na2SeO3 effectively limited the growth and proliferation of Tca8113 cell in vivo. The response was dependent on the dose, the starting administered time, exposed length of selenium and the concentration of inoculated Tca8113 cells. The morbidity of transplanted tumors was remarkably decreased with enhancing dose of selenium. At 60μg ip dose, the weight of nude mice were not remarkably reduced, and the pathological changes in liver and kidney had not been found in this experiment. | 步荣发 邱蔚六 | 1991 | Medical Bulletin of Shanghai Jiaotong University1991，14，2： | 0 |
| 17 | A NEW FLAP CLINICAL EXPERIENCE OF ACROMIOTHORACIC CUTANEOUS FREE FLAP FOR REPAIR OF DEFECTS IN THE ORAL AND MAXILLOFACIAL REGION显示文摘Since December 1986, acromiothoracic cutaneous flap (with its blood supply from the cutaneous perforators of deltoid muscular branches of thoracoacromial vessels) has been used for repair of the defects in the oral and maxillofacial region on 7 cases. All falps in this group survived. This skin flap must be very promising with advantages of an unexposed donor site, soft in texture and color matching the face. Moreover, the operation is less traumatic. The design and essential points of preparing the flap are introduced. The indication of operation is also discussed. | 唐友盛 邱蔚六 袁文化 | 1991 | Medical Bulletin of Shanghai Jiaotong University1991，14，2： | 0 |
| 18 | 成人高等医学教育初探 | 孙爱琴 | 1995 | 城市研究1995，，3X： | 0 |
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