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| 1 | Influence of the nasal mucociliary system on intranasal drug administration显示文摘To study the influence of the nasal mucociliary system on intranasal drug administration and ways of reducing its influence on nasal absorption Methods Rabbit nasopharynx was closed to stop mucociliary function in one group In the other group, rabbits maintained their mucociliary function Both groups were given a nasal drip of gentamycin and the serum levels were measured from 0 to 180 minutes after drug administration To reduce the undesirable effects of the nasal mucociliary system, acetylcysteine was mixed into the gentamycin drops In addition, nasal nebulization was evaluated in human volunteers as a means of increasing absorption of the drug in the non ciliary area of the nasal cavity Results Nasal mucociliary function reduced intranasal absorption of drug and made the highest absorbing rate and area under the curve (AUC) decrease by 25 1% and 18 2%, respectively Both the nasal drip containing acetylcysteine and the nebulizer could promote drug absorption in the nasal mucosa The former made the highest intranasal absorption and AUC increase by 18 0% and 10 7%, respectively The latter made the absorption increase 1 5-1 6 times Conclusion The mucociliary system can decrease intranasal drug absorption Application of acetylcysteine or the use of nebulizer can increase drug | 王静清 卜国铉 | 2000 | Chinese Medical Journal2000，，7： | 2 |
| 2 | Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function显示文摘Cystic fibrosis(CF) is a multisystem disorder with significantly shortened life expectancy. The major cause of mortality and morbidity is lung disease with increasing pulmonary exacerbations and decline in lung function predicting significantly poorer outcomes. The pathogenesis of lung disease in CF is characterised in part by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. This leads to accumulation of viscous mucus in the CF airway, providing an ideal environment for bacterial pathogens to grow and colonise, propagating airway inflammation in CF. The use of nebulised hypertonic saline(HTS) treatments has been shown to improve mucus clearance in CF and impact positively upon exacerbations, quality of life, and lung function. Several mechanisms of HTS likely improve outcome, resulting in clinically relevant enhancement in disease parameters related to increase in mucociliary clearance. There is increasing evidence to suggest that HTS is also beneficial through its anti-inflammatory properties and its ability to reduce bacterial activity and biofilm formation. This review will first describe the use of HTS in treatment of CF focusing on its efficacy and tolerability. The emphasis will then change to the potential benefits of aerosolized HTS for the attenuation of receptor mediated neutrophil functions, including down-regulation of oxidative burst activity, adhesion molecule expression, and the suppression of neutrophil degranulation of proteolytic enzymes. | Emer P Reeves Cormac McCarthy Oliver J McElvaney Maya Sakthi N Vijayan Michelle M White Danielle M Dunlea Kerstin Pohl Noreen Lacey Noel G McElvaney | 2015 | World Journal of Critical Care Medicine2015，4，3： | 0 |
| 3 | Nasal Irrigation Effects towards Nasal Mucociliary Transport Time in Active Smokers显示文摘Nasal irrigation is often recommended as an adjuctive therapy for treating many sinonasal conditions.It provides mechanical cleansing of mucus,crust,cell debris and various air contaminants.The study was done to analyze the effect of nasal irrigation on change of nasal mucociliary transport time,in active smokers.This study was experimental using pre and post test controlled group design.Samples were divided into two groups;treatment and control group.The mucociliary transport time were tested with saccharin method for two times;before and fourteen days after treatment.On the day fourteen after nasal irrigation there was a significant decreased of the mucociliary transport time than before(p=0,000).In the control group on second measurement was significantly longer compared to the first measurement(p=0,003).In the comparison of mucociliary transport time change between treatment group and control group was found significant differences(p=0,000). | Trikaya Cuddhi Dwi Marliyawati Anna Mailasari K.D | 2020 | Journal of Pharmacy and Pharmacology2020，8，2： | 0 |
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