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| 1 | Re-isolation of Wuxiang Virus from Wild Sandflies Collected from Yangquan County, China显示文摘We previously isolated a new species of the genus Phlebovirus from wild sandflies collected from Wuxiang County in central China,which named the Wuxiang virus(WUXV).In this study,we re-isolated the WUXV from wild sandflies collected from two villages in Yangquan County,China in 2019.Four virus isolates that caused cytopathic effects in BHK-21 cells were successfully isolated from sandfly specimens collected from chicken pens and sheep pens.Phylogenetic analyses of the L,M and S gene segments of the viruses revealed that the four virus strains represented the previously isolated WUXV.The minimum infection rate(MIR)of the virus isolated from the sheep pen was 3.21,and the MIR of the virus isolated from the chicken pen was 3.45.The positive rates of Wuxiang virus neutralizing antibodies in serum samples of local healthy people and domestic chickens were 8.7%(4/46)and 100%(4/4),respectively,suggesting that Wuxiang virus can infect human and animal.In view of the fact that Wuxiang virus is infectious to humans and animals and has a relatively wide geographical distribution in China,it is of great public health significance to strengthen the investigation and study on the infection status of Wuxiang virus in humans and animals. | Qinyan Wang Shihong Fu Jingxia Cheng Xiuyan Xu Jing Wang Bin Wu Xiaodong Tian Yan Li Ying He Fan Li Kai Nie Songtao Xu Bin Wang Huanyu Wang Xiaoqing Lu Guodong Liang | 2021 | Virologica Sinica2021，36，5： | 4 |
| 2 | A comprehensive overview on sandfly fever显示文摘Sandfly fever is a febrile emerging arboviral illness which is a huge threat posed to public health.Sandfly fever viruses(Sicilian,Naples,and Toscana)are endemic to the Mediterranean region.Evidence suggests an increase in the activity of sandfly-borne phleboviruses and their extension to other places.The infection is relatively benign but may cause severe clinical manifestations and complications.Sandfly fever viruses belongs to the genus Phlebovirus(family Bunyaviridae),and the four main serotypes include sandfly fever Sicilian virus,sandfly fever Naples virus,sandfly fever Cyprus virus,and Toscana virus.Sandfly fever has flu-like symptoms such as fever,headache,photophobia,malaise,myalgia,and retro-orbital pain.The incubation period of the disease is 4-8 days,and the patient usually recovers within a week.The first infection provides the host with immunity.Sandfly fever viruses are transmitted through the bites of infected female sandflies,thus,the epidemiology of sandfly fever is closely related to the presence and activity of sandfly species that act as the vectors for transmission.Cases and outbreaks of the disease have been reported worldwide for more than 100 years.All in all,this disease is important for non-endemic countries because it is a travel-related and/or imported illness. | Rouhullah Dehghani Hamid Kassiri Iman Khodkar Saina Karami | 2021 | Journal of Acute Disease2021，10，3： | 0 |
| 3 | Emergence of Toscana virus in the mediterranean area显示文摘Toscana virus(TOSV) is an arthropod-borne virus, identified in 1971, from Phlebotomus perniciosus and Phlebotomus perfiliewi in central Italy. TOSV belongs to the Phlebovirus genus within the Bunyaviridae family. As other bunyaviruses, the genome of TOSV consists of 3 segments(S for small, M for Medium, and L for Large) respectively encoding non structural and capsid proteins, envelope structural proteins, and the viral RNA-dependant RNA-polymerase. It is transmitted by sand flies. Therefore its distribution is dictated by that of the arthropod vectors, and virus circulation peaks during summertime when sandfly populations are active. Here, we reviewed the epidemiology of TOSV in the old world. First evidence of its pathogenicity for humans, specifically its propensity to cause central nervous system(CNS) infections such as meningitis and encephalitis, was reported in central Italy. After 2000, it was recognized that TOSV had a much larger geographic distribution than initially believed, and was present in most of the Western European countries located on the northern border of the Mediterranean Sea(Portugal, Spain, France, Greece, Croatia) as well as eastern countries such as Cyprus and Turkey. In the countries where TOSV is present, it is among the three most prevalent viruses in meningitis during the warm seasons, together with enteroviruses and herpesviruses. Up to now, epidemiological data concerning Northern Africa and other countries located south of the Mediterranean are scarce. TOSV must be considered an emerging pathogen. Despite the important role played by TOSV in CNS infections, it remains a neglected agent and is rarely considered by physicians in diagnostic algorithms of CNS infections and febrile illness during the warm season, probably because of the lack of information. | Remi N Charrel Laurence Bichaud Xavier de Lamballerie | 2012 | World Journal of Virology2012，1，5： | 0 |
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