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| 1 | GPS PPP技术用于滑坡监测的试验与结果分析显示文摘为了研究全球定位系统(GPS)精密单点定位(PPP)技术用于滑坡等地质灾害监测时可能达到的精度和可靠性等问题,结合某类滑坡的大型物理模型试验,在滑坡体上布设了若干GPS监测点进行连续实时动态监测,利用PPP技术对该滑坡从稳定、开始滑动直至产生破坏的全过程监测数据进行了处理与分析,并与GPS单历元差分定位、载波相位实时差分定位技术监测结果进行了对比。结果表明:GPS PPP技术监测结果的内符合精度约为10 mm,外符合精度约为40 mm,且GPS PPP技术具有一些差分GPS无法比拟的优势,如无需基准站支持、作业成本低、效率高、可直接获取监测点在国际地球参考框架下的绝对坐标等。该技术完全可用于滑坡等地质灾害的实时动态监测和预警。 | 王利 张勤 黄观文 涂锐 张双成 | 2014 | 岩土力学2014，35，7： | 31 |
| 2 | Comprehensive application of modern technologies in precise liver resection显示文摘BACKGROUND: Liver surgery has gone through the phases of wedge liver resection, regular resection of hepatic lobes, irregular and local resection, extracorporeal hepatectomy, hemi-extracorporeal hepatectomy and Da Vinci surgical system-assisted hepatectomy. Taking advantage of modern technologies, liver surgery is stepping into an age of precise liver resection. This review aimed to analyze the comprehensive application of modern technologies in precise liver resection. DATA SOURCE: PubMed search was carried out for English-language articles relevant to precise liver resection, liver anatomy, hepatic blood inflow blockage, parenchyma transection, and down-staging treatment. RESULTS: The 3D image system can imitate the liver operation procedures, conduct risk assessment, help to identify the operation feasibility and confirm the operation scheme. In addition, some techniques including puncture and injection of methylene blue into the target Glisson sheath help to precisely determine the resection. Alternative methods such as Pringle maneuver are helpful for hepatic blood inflow blockage in precise liver resection. Moreover, the use of exquisite equipment for liver parenchyma transection, such as cavitron ultrasonic surgical aspirator, ultrasonic scalpel, Ligasure and Tissue Link is also helpful to reduce hemorrhage in liver resection, or even operate exsanguinous liver resection without blocking hepatic blood flow. Furthermore, various down-staging therapies including transcatheter arterial chemoembolization and radio-frequency ablation were appropriate for unresectable cancer, which reverse the advanced tumor back to early phase by local or systemic treatment so that hepatectomy or liver transplantation is possible.CONCLUSIONS: Modern technologies mentioned in this paper are the key tool for achieving precise liver resection and can effectively lead to maximum preservation of anatomical structural integrity and functions of the remnant liver. In addition, large randomized trials are needed to evaluate the usefulness of these technologies in patients with hepatocellular carcinoma who have undergone precise liver resection. | Nian-Song Qian Yong-Hui Liao Shou-Wang Cai Vikram Raut Jia-Hong Dong | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 27 |
| 3 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 4 | Progression in translational research on spinal cord injury based on microenvironment imbalance显示文摘Spinal cord injury(SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years.Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction. | Baoyou Fan Zhijian Wei Shiqing Feng | 2022 | Bone Research2022，10，2： | 17 |
| 5 | PRECISE FUNDAMENTAL INEQUALITIES AND SUM OF DEFICIENCIES显示文摘In the present paper, some precise fundamental inequalities are introduced. Applying them,we obtain the precise estimate for the sum of deficiencies. Let f(z) be transcendental mero-morphic in the finite plane and k be a positive integer. If ε is an arbitrary positive numberand a and b are two distinct finite complex numbers, then we have T(r,f)<(1+1/k)N (r,1/f)+(1+1/k)N (r,1/(fk-1)) -N (r,1/(f(k+1))+εT(r,f)+S(r,f)and δ(a,fk)+δ(b,fk)≤1+1/(2k+1). | 杨乐 | 1991 | Science China Mathematics1991，34，2： | 15 |
| 6 | Precise orbit determination of a maneuvered GEO satellite using CAPS ranging data显示文摘Wheel-off-loadings and orbital maneuvers of the GEO satellite result in additional accelerations to the satellite itself. Complex and difficult to model, these time varying accelerations are an important error source of precise orbit determination (POD). In most POD practices, only non-maneuver orbital arcs are treated. However, for some applications such as satellite navigation RDSS services, uninterrupted orbital ephemeris is demanded, requiring the development of POD strategies to be processed both during and after an orbital maneuver. We in this paper study the POD for a maneuvered GEO satellite, using high precision and high sampling rate ranging data obtained with Chinese Area Positioning System (CAPS). The strategy of long arc POD including maneuver arcs is studied by using telemetry data to model the maneuver thrust process. Combining the thrust and other orbital perturbations, a long arc of 6 days’ CAPS ranging data is analyzed. If the telemetry data are not available or contain significant errors, attempts are made to estimate thrusting parameters using CAPS ranging data in the POD as an alternative to properly account for the maneuver. Two strategies achieve reasonably good data fitting level in the tested arc with the maximal position difference being about 20 m. | HUANG Yong HU XiaoGong HUANG Cheng YANG QiangWen JIAO WenHai | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 13 |
| 7 | Orbit determination for geostationary satellites with the combination of transfer ranging and pseudorange data显示文摘Geostationary satellites(GEOs) play a significant role in the regional satellite navigation system.Simulation experiments show that the clock corrections could be mitigated through a single strategy or double differencing strategies for a navigation constellation,but for the mode of individual GEO orbit determination,high precision orbit and clock correction could not be obtained in the orbit determination based on the pseudorange data.A new GEO combined precise orbit determination(POD) strategy is studied in this paper,which combines pseudorange data and C-band transfer ranging data.This strategy overcomes the deficiency of C-band transfer ranging caused by limited stations and tracking time available.With the combination of transfer ranging and pseudorange data,clock corrections between the GEO and the stations can be estimated simultaneously along with orbital parameters,maintaining self-consistency between the satellite ephemeris and clock correction parameters.The error covariance analysis is conducted to illuminate the contributions from the transfer ranging data and the psudoranging data.Using data collected for a Chinese GEO satellite with 3 C-band transfer ranging stations and 4 L-band pseudorange tracking stations,POD experiments indicate that a meter-level accuracy is achievable.The root-mean-square(RMS) of the post-fit C-band ranging data is about 0.203 m,and the RMS of the post-fit pseudorange is 0.408 m.Radial component errors of the POD experiments are independently evaluated with the satellite laser ranging(SLR) data from a station in Beijing,with the residual RMS of 0.076 m.The SLR evaluation also suggests that for 2-h orbital predication,the predicted radial error is about 0.404 m,and the clock correction error is about 1.38 ns.Even for the combination of one C-band transfer ranging station and 4 pseudorange stations,POD is able to achieve a reasonable accuracy with the radial error of 0.280 m and the 2-h predicted radial error of 0.888 m.Clock synchronization between the GEO and tracking stations is achieved with an estimated accuracy of about 1.55 ns,meeting the navigation service requirements. | GUO Rui1,2,3,4,HU XiaoGong2,4,LIU Li1,WU XiaoLi1,HUANG Yong2,4 & HE Feng1 1 Beijing Global Information Application and Development Center,Beijing 100094,China 2 Shanghai Astronomical Observatory,Chinese Academy of Sciences,Shanghai 200030,China 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 4 Space Navigation and Positioning Technology,Laboratory of Shanghai Municipal,Shanghai 200030,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 13 |
| 8 | 医科达Precise直线加速器iViewGT系统故障分析及维修显示文摘瑞典医科达公司的Precise直线加速器是一款设计精细、全数字化控制的加速器,配备40对MLC(多叶光阑)[1]。其中利用i View GT电子影像验证系统,可开展普通放射治疗、立体定向放射治疗及适形调强放射治疗(intensity modulated radiation therapy,IMRT),高分辨率的影像质量保证了投照剂量得到实时验证,以满足不同患者的治疗需要[2]。 | 陈浩 林丹凤 李玉琼 严潭 | 2015 | 中国医学装备2015，12，9： | 13 |
| 9 | High-accuracy same-beam VLBI observations using Shanghai and Urumqi telescopes显示文摘The same-beam VLBI observations of Rstar and Vstar,which were two small satellites of Japanese lunar mission,SELENE,were successfully performed by using Shanghai and Urumqi 25-m telescopes. When the separation angle between Rstar and Vstar was less than 0.1 deg,the differential phase delay of the X-band signals between Rstar and Vstar on Shanghai-Urumqi baseline was obtained with a very small error of 0.15 mm rms,which was reduced by 1-2 order compared with the former VLBI results. When the separation angle was less than 0.56 deg,the differential phase delay of the S-band signals was also obtained with a very small error of several mm rms. The orbit determination for Rstar and Vstar was performed,and the accuracy was improved to a level of several meters by using VLBI and Doppler data. The high-accuracy same-beam differential VLBI technique is very useful in orbit determination for a spacecraft,and will be used in orbit determination for Mars missions of China Yinghuo-1 and Russia Phobos-grunt. | KIKUCHI Fuyuhiko KAMATA Shun'ichi MATSUMOTO Koji HANADA Hideo | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 11 |
| 10 | Chiral Phosphoric Acid Creates Promising Opportunities for Enantioselective Photoredox Catalysis显示文摘In recent years,visible light driven enantioselective chemical transformations have emerged as new additions to the toolkit of synthetic chemists to accomplish more efficient assembly of chiral molecules.Nonetheless,implementing precise stereocontrol on photoinduced intermolecular radical coupling process remai ns arduous. | Shaoyu Li Shao-Hua Xiang Bin Tan | 2020 | Chinese Journal of Chemistry2020，38，2： | 10 |
| 11 | Results and Analyses of BDS Precise Orbit Determination with the Enhancement of Fengyun-3C显示文摘Global navigation satellite system occultation sounder (GNOS) Fengyun-3C was launched successfully on September 23, 2013, which carried GPS/BDS receiver for the first time. This provides the convenience to study the enhancement results of low earth orbiter satellite (LEO) to BDS precise orbit determination (POD). First the data characteristic and code observation noise of GNOS are analyzed. Then the enhancement experiments in the case of global and regional ground observation stations layout are processed with four POD schemes: BDS single system, GPS/BDS double system, BDS single system with GNOS observations, GPS/BDS double system with GNOS observations. The precision of BDS orbits and clocks are compared via overlapping arcs. Results show that in the case of global station layout the along directional precision of GEO satellite has the biggest improvement, with the improvement percentage 60%. Then the precision of cross direction and the along direction of remaining satellites shows the second biggest improvement. The orbit precision of BDS-only POD in part of observation arcs some satellite even suffers a slight decline. The root mean square (RMS) of overlapping clock difference of visible arcs in GPS/BDS POD experiments improves by 0.1 ns level. As to the experiments of regional station layout with 7 ground stations, the orbit and clock overlapping precision and orbit predicting precision are analyzed. Results show that the predicting precision of BDS GEO satellites in the along direction improves by 85%. The remaining also has a substantial improvement, with the average percentage 21.7%. RMS of overlapping clock difference of visible arcs improves by 0.5 ns level. | Tian ZENG Lifen SUI Xiaolin JIA Guofeng JI Qinghua ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 9 |
| 12 | Dual-comb spectroscopy resolved three-degreeof-freedom sensing显示文摘Precise and fast determination of position and orientation, which is normally achieved by distance and angle measurements, has broad applications in academia and industry. We propose a dynamic three-degree-of-freedom measurement technique based on dual-comb interferometry and a self-designed grating-corner-cube(GCC) combined sensor. Benefiting from its unique combination of diffraction and reflection characteristics, the absolute distance, pitch, and yaw of the GCC sensor can be determined simultaneously by resolving the phase spectra of the corresponding diffracted beams. We experimentally demonstrate that the method exhibits a ranging precision(Allan deviation) of 13.7 nm and an angular precision of 0.088 arcsec, alongside a 1 ms reaction time. The proposed technique is capable of precise and fast measurement of distances and two-dimensional angles over long stand-off distances. A system with such an overall performance may be potentially applied to space missions,including in tight formation-flying satellites, for spacecraft rendezvous and docking, and for antenna measurement as well as the precise manufacture of components including lithography machines and aircraftmanufacturing devices. | SIYU ZHOU VUNAM LE SHILIN XIONG YUETANG YANG KAI NI QIAN ZHOU GUANHAO WU | 2021 | Photonics Research2021，9，2： | 8 |
| 13 | AN ADAPTIVE ALGORITHM OF PRECISE INTEGRATION FOR TRANSIENT ANALYSIS显示文摘This paper present an improved precise integration algorithm for transient analysis of heattransfer and some other problems.The original precise integration method is improved by mean of the inve-rse accuracy analysis so that the parameter N,which has been taken as a constant and an independent pa-rameter without consideration of the problems in the original method,can be generated automatically by thealgorithm itself.Thus,the improvde algorithm is adaptive and the accucacy of the algorithm is not dependenton the length of the time step in the integration process.It is shown that the numerical results obtained by themethod proposed are more accurate than those obtained by the conventional time integration methods such asthe difference method and others.Four examples are given to demonstrate the validity,accuracy and effi-ciency of the new method. | Zhang Hongwu Chen Biaosong gu Yuanxian | 2001 | Acta Mechanica Solida Sinica2001，14，3： | 8 |
| 14 | Performing optical logic operations by a diffractive neural network显示文摘Optical logic operations lie at the heart of optical computing,and they enable many applications such as ultrahighspeed information processing.However,the reported optical logic gates rely heavily on the precise control of input light signals,including their phase difference,polarization,and intensity and the size of the incident beams.Due to the complexity and difficulty in these precise controls,the two output optical logic states may suffer from an inherent instability and a low contrast ratio of intensity.Moreover,the miniaturization of optical logic gates becomes difficult if the extra bulky apparatus for these controls is considered.As such,it is desirable to get rid of these complicated controls and to achieve full logic functionality in a compact photonic system.Such a goal remains challenging.Here,we introduce a simple yet universal design strategy,capable of using plane waves as the incident signal,to perform optical logic operations via a diffractive neural network.Physically,the incident plane wave is first spatially encoded by a specific logic operation at the input layer and further decoded through the hidden layers,namely,a compound Huygens’metasurface.That is,the judiciously designed metasurface scatters the encoded light into one of two small designated areas at the output layer,which provides the information of output logic states.Importantly,after training of the diffractive neural network,all seven basic types of optical logic operations can be realized by the same metasurface.As a conceptual illustration,three logic operations(NOT,OR,and AND)are experimentally demonstrated at microwave frequencies. | Chao Qian Xiao Lin Xiaobin Lin Jian Xu Yang Sun Erping Li Baile Zhang Hongsheng Chen | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 15 | Matrix Interference in Serum Total Thyroxin (T_4) Time-resolved Fluorescence Immunoassay (TRFIA) and Its Elimination With the Use of Streptavidin-biotin Separation Technique显示文摘In development of serum total thyroxin TRFIA using the surface second-antibody (S-Ab) as separation agent, a significant bias of measurement caused by matrix interference when the surface S-Ab shows a relatively low binding capacity for primary anti-T4 monoclonal antibody (McAb) is studied. The bias ranges from 10% to 78%, depending on the matrix of individual samples and the binding capacity of the surface S-Ab prepared. So, a new separation system based on the use of a highly active surface streptavidin and biotinylated anti-T4 McAb is employed. The results | WU Feng-bo, HE You-feng, HAN Shi-quan | 2001 | Annual Report of China Institute of Atomic Energy2001，，0： | 7 |
| 16 | Structural Engineering of Eu^2+-Doped Silicates Phosphors for LED Applications显示文摘CONSPECTUS:Phosphor-converted light-emitting diodes(pc-LEDs)are of great importance for their applications in solid-state lighting,backlit display,and near-infrared detection light source.Herein,the main challenges for these emergent pc-LEDs are to achieve full-spectrum lighting,wide color gamut display and broadband high efficiency near-infrared emission,respectively,which depends on the luminescence properties of phosphors used.Owing to the unique 4f-5d transition,Eu^2+is one of the most commonly used activators in luminescent materials for pc-LEDs,and Eu^2+-doped earth-abundant silicates phosphors exhibit outstanding luminescence properties,including multicolor emission,adjustable bandwidth,excellent thermal stability as well as high luminescence efficiency.These attributes motivate scientists to find Eu^2+-doped silicates phosphors that can practically meet the various LED application requirements.Since the traditional trial and error exploration is time-consuming and not necessarily successful,it is necessary to find reliable structural engineering strategies to discover new phosphor systems and also realize purposeful photoluminescence tuning.The adjustable 4f-5d electronic transitions of Eu^2+,the variable crystal structures of the silicate hosts and their coupling effect simultaneously account for the targeted luminescence behaviors and their precise emission color tuning.Thus,we aim at developing Eu^2+-doped silicate phosphors that can solve the application challenges through a comprehensive understanding of Eu^2+photoluminescence mechanism and the structure−property relationships.In this Account,we first illustrate the luminescence theory of Eu^2+in inorganic solids and summarize the research results of the effect originated from centroid shift,crystal field splitting,Stokes shift,and emission bandwidth.On the basis of the factors dominating the variation of luminescence characteristics,several structural strategies to manipulate Eu^2+emission in silicates are proposed,including(1)modify the chemical composition and crystal structure by various substitutions,(2)choose or change a suitable crystallographic site for Eu^2+and(3)control crystalline phase transition by external factors.Meanwhile,we briefly introduce the photoluminescence behaviors of Eu^2+in different silicates controlled by these structural engineering strategies.Second,we outline our recent research progress on blue LED pumped Eu^2+-doped silicate phosphors with emphasis on the design principle and the relationship between the structure and luminescence.The state-of-the-art LED application including full spectrum solid-state lighting,wide color gamut display and near-infrared night-vision technologies are introduced.Finally,we proposed the future research opportunities and challenges.The development of these Eu^2+-doped silicate phosphors exhibiting excellent luminescence performance is highly inspiring,and we expect this Account can be helpful for controlling the photoluminescence by theory-structure−property relationships and guide scientists discover the next generation of Eu^2+-doped phosphors for emerging applications. | Ming Zhao Qinyuan Zhang Zhiguo Xia | 2020 | Accounts of Materials Research2020，1，2： | 7 |
| 17 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 18 | CRISPR/Cas9-Mediated Adenine Base Editing in Rice Genome显示文摘Precise base editing is highly desired in plant functional genomic research and crop molecular breeding. In this study, we constructed a rice-codon optimized adenine base editor(ABE)-nC as9 tool that induced targeted A·T to G·C point mutation of a key single nucleotide polymorphism site in an important agricultural gene. Combined with the modified single-guide RNA variant, our plant ABE tool can efficiently achieve adenine base editing in the rice genome. | LI Hao QIN Ruiying LIU Xiaoshuang LIAO Shengxiang XU Rongfang YANG Jianbo WEI Pengcheng | 2019 | Rice science2019，26，2： | 7 |
| 19 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 20 | Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin显示文摘Dear Editor,Similar to higher-order folding of polypeptide chains into functional proteins,linear DNA molecules are spatially folded in a hierarchical and dynamic manner into three-dimensional(3D)functional chromatin structures in eukaryotic nuclei(Huang and Wu,2016;Rowley and Corces,2018).This dynamic folding is closely related to many nuclear processes such as DNA replication and repair,chromosomal translocation,recombination,and segregation,as well as RNA transcription,splicing,and transport.In particular,dynamic long-distance chromatin looping interactions,which result in close spatial contacts between distal enhancers and target promoters,are thought to play a role in controlling precise spatiotemporal as well as cell-type specific gene expression during animal development(Rowley and Corces,2018).Mammalian genomes contain numerous noncoding regulatory elements that regulate these dynamic long-distance chromatin looping interactions. | Yujia Lu Jia Shou Zhilian Jia Yonghu Wu Jinhuan Li Ya Guo Qiang Wu | 2019 | Protein & Cell2019，10，12： | 7 |
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