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| 1 | Perinatal complications and live-birth outcomes following assisted reproductive technology: a retrospective cohort study显示文摘Background:With the development of assisted reproductive technology(ART)and its increasing success rate in the mainland of China,more attention has been paid to the safety of ART.In this study,we explored the associations between conception by ART and pregnancy/perinatal complications,and neonatal outcomes compared with similar outcomes following spontaneous conception.Methods:This retrospective cohort study of pregnancies over a 3-year period(2013-2015)was performed at Beijing Obstetrics and Gynecology Hospital,Beijing,China.Subjects were divided into two groups:conception by ART(n=2256)or spontaneous conception(n=6768).According to different fertilization modes,the ART group was divided into in vitro fertilization(IVF,n=1873)and intracytoplasmic sperm injection(ICSI,n=383)subgroups.The ART group was also divided into two different embryo transfer methods;fresh embryo transfer(ET,n=1583)and frozen embryo transfer(FET,n=673)subgroups.Pregnancy complications,perinatal complications,and neonatal outcomes of the enrolled subjects were investigated and analyzed by univariate analysis and multivariate logistic regression.Results:After adjustment for maternal age,gravidity,parity,maternal education,smoking,alcohol consumption,and body mass index(BMI),pregnancies conceived by ART were associated with a significantly increased incidence of gestational diabetes mellitus(GDM;OR 1.88,95%CI 1.56-2.27),gestational hypertension(OR 2.18,95%CI 1.83-2.60),and intrahepatic cholestasis of pregnancy(ICP)(OR 2.79,95%CI 2.15-3.64),compared with spontaneous conception.These associations were similar for the singleton group.In the twin group,only the incidence of ICP was significantly higher than in controls.We found that pregnancies conceived by ART were associated with perinatal complications,including placental abruption(OR 2.14,95%CI 1.33-3.45),premature rupture of membranes(PROM;OR 1.24,95%CI 1.06-1.45),postpartum hemorrhage(OR 2.89,95%CI 2.33-3.59)and polyhydramnios(OR 2.01,95%CI 1.29-3.16).The singleton group had a similar result with placental abruption,but not with fetal membranes ruptures before labor and polyhydramnios.There were no significant differences in the incidence of these perinatal complications in the twin group.Some neonatal outcomes,including preterm labor(OR 4.29,95%CI 3.84-4.80)and low birth weight(OR 1.72,95%CI 1.42-2.08),were more likely to occur with singleton births after ART.However,there were no significant differences for these outcomes from twin pregnancies.Perinatal complications and neonatal outcomes were consistent between the IVF and ICSI subgroups.The FET and ET subgroups showed a similar increase in complications,except for the incidence of placental abruption.After taking into account the effects of parity,birth plurality and maternal age,the ART group still exhibited increased maternal and neonatal complications,although some differences narrowed or disappeared.Conclusions:This retrospective cohort study demonstrated that patients who underwent ART were at increased risk of several adverse pregnancy outcomes compared with women who conceived spontaneously.These complications may be attributed in part to the relatively high multiple pregnancy rate after ART.Elective single embryo transfer should be promoted in China to reduce the obstetrical risks of ART pregnancy.Singletons of ART pregnancy exhibited increased maternal and neonatal complications as well,suggesting that underlying infertility or other maternal or parental factors may contribute to the adverse outcomes. | Ling-Ling Lei Yong-Lian Lan Shu-Yu Wang Wei Feng Zhi-Jin Zhai | 2019 | Chinese Medical Journal2019，，20： | 24 |
| 2 | The oldest angiosperm--a tricarpous female reproductive fossil from western Liaoning Province, NE China显示文摘The fossil plant female reproductive organs each with a tricarpous were collected from the Yixian Formation, Chaoyang district, western Liaoning Province. The geological age of the Yixian Formation here is believed to be Late Jurassic, which places this fossil as the oldest angiosperm currently known. Its morphological characters are distinct from other known angiosperm reproductive organs as it has 3 ovaries, each with a terminal style and an apical stigma. 9 such organs compose a cyme. As this morphological arrangement is unique to this plant, a new genus and species has been established, named Chaoyangia liangii gen. et sp. nov. | 段淑英 | 1998 | Science China Earth Sciences1998，41，1： | 15 |
| 3 | Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV) infection is the leading cause of economic casualty in swine industry worldwide. The virus can cause reproductive failure, respiratory disease, and growth retardation in the pigs. This review deals with current status of commercial PRRS vaccines presently used to control PRRS. The review focuses on the immunogenicity, protective efficacy and safety aspects of the vaccines. Commercial PRRS modified-live virus(MLV) vaccine elicits delayed humoral and cell-mediated immune responses following vaccination. The vaccine confers late but effective protection against genetically homologous PRRSV, and partial protection against genetically heterologous virus. The MLV vaccine is of concern for its safety as the vaccine virus can revert to virulence and cause diseases. PRRS killed virus(KV) vaccine, on the other hand, is safe but confers limited protection against either homologous or heterologous virus. The KV vaccine yet helps reduce disease severity when administered to the PRRSV-infected pigs. Although efforts have been made to improve the immunogenicity, ef-ficacy and safety of PRRS vaccines, a better vaccine is still needed in order to protect against PRRSV. | Wasin Charerntantanakul | 2012 | World Journal of Virology2012，1，1： | 13 |
| 4 | Fish germ cells显示文摘Fish, like many other animals, have two major cell lineages, namely the germline and soma. The germ-soma separation is one of the earliest events of embryonic development. Germ cells can be specifically labeled and isolated for culture and transplan-tation, providing tools for reproduction of endangered species in close relatives, such as surrogate production of trout in salmon. Haploid cell cultures, such as medaka haploid embryonic stem cells have recently been obtained, which are capable of mimicking sperm to produce fertile offspring, upon nuclear being directly transferred into normal eggs. Such fish originated from a mosaic oocyte that had a haploid meiotic nucleus and a transplanted haploid mitotic cell culture nucleus. The first semi-cloned fish is Holly. Here we review the current status and future directions of understanding and manipulating fish germ cells in basic research and reproductive technology. | XU HongYan1, LI MingYou1, GUI JianFang2 & HONG YunHan1,2 1Department of Biological Sciences, National University of Singapore, Singapore 119260, Singapore 2 State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China | 2010 | Science China(Life Sciences)2010，53，4： | 12 |
| 5 | 两种不同EL ISA法在检测猪繁殖与呼吸综合征抗体中的选择与应用显示文摘猪繁殖与呼吸综合征(简称猪蓝耳病)是引起母猪繁殖障碍和仔猪、育成猪呼吸道症状的一种高度接触性传染病。本文比较了两种常用的检测猪繁殖与呼吸综合征抗体的ELISA方法,确定IDEXX猪蓝耳病抗体ELISA检测试剂盒适合蓝耳病感染抗体的检测和早期诊断;LSI猪蓝耳病抗体ELISA检测试剂盒适合蓝耳病免疫抗体的监测。两种ELISA方法在应用范围和诊断意义方面完全不同,因此在日常监测中,应根据监测目的合理选择猪蓝耳病抗体检测试剂盒。 | 王宏燕 | 2014 | 现代畜牧兽医2014，，4： | 12 |
| 6 | Physiological Responses of Contrasting Rice Genotypes to Salt Stress at Reproductive Stage显示文摘Salinity is a major abiotic stress affecting plant growth and productivity. Considerable genetic variation is present in rice in response to salt stress, with higher sensitivity during early seedling and reproductive stage. In this study, physiological changes in leaves and developing panicles of rice genotypes (IR686, Sadri, Rc222, CSR28, IR670 and Pokkali) contrasting in salt tolerance at the reproductive stage were evaluated in greenhouse experiment under salt stress. The results showed that IR670 and the tolerant-check Pokkali maintained lower Na^+/K^+ ratio, less reduction in chlorophyll concentration, lower malondialdehyde (MDA) production, higher concentrations of reduced ascorbate (reduced AsA), higher proline accumulation and lower percentage reduction in pollen viability than the salt-sensitive genotypes under salt stress. The higher concentration of reduced AsA suggests an efficient ROS-scavenging system. Physiological measurements and pollen viability analysis revealed that Sadri (moderately tolerant at the seedling stage) is sensitive to salt stress at the flowering stage. The findings will be useful in breeding salt tolerant varieties at both seedling and reproductive stages by selecting appropriate genotypes and phenotypes. | Maria Elisa B.GERONA Marjorie P. DEOCAMPO James A.EGDANE Abdelbagi M.ISMAIL Maribel L. DIONISIO-SESE | 2019 | Rice science2019，26，4： | 9 |
| 7 | The molecular and evolutionary basis of reproductive isolation in plants显示文摘Reproductive isolation is defined as processes that prevent individuals of different populations from mating, survival or producing fertile offspring. Reproductive isolation is critical for driving speciation and maintaining species identity, which has been a fundamental concern in evolutionary biology. In plants,reproductive isolation can be divided into prezygotic and postzygotic reproductive barriers, according to its occurrence at different developmental stages. Postzygotic reproductive isolation caused by reduced fitness in hybrids is frequently observed in plants, which hinders gene flow between divergent populations and has substantial effects on genetic differentiation and speciation, and thus is a major obstacle for utilization of heterosis in hybrid crops. During the past decade, China has made tremendous progress in molecular and evolutionary basis of prezygotic and postzygotic reproductive barriers in plants. Present understandings in reproductive isolation especially with new data in the last several years well support three evolutionary genetic models, which represent a general mechanism underlying genomic differentiation and speciation. The updated understanding will offer new approaches for the development of wide-compatibility or neutral varieties, which facilitate breeding of hybrid rice as well as other hybrid crops. | Yidan Ouyang Qifa Zhang | 2018 | Journal of Genetics and Genomics2018，45，11： | 9 |
| 8 | Molecular mechanisms of hybrid sterility in rice显示文摘Hybrid sterility presents a major bottleneck in hybrid crop breeding and causes postzygotic reproductive isolation in speciation.Here, we summarize the current understanding of the genetics of rice hybrid sterility and highlight new advances in deciphering the molecular basis of the major genetic loci for hybrid sterility in rice. We also discuss practical strategies for overcoming reproductive barriers to utilize hybrid vigor in inter-specific and inter-subspecific hybrid rice breeding. | Yongyao Xie Rongxin Shen Letian Chen Yao-Guang Liu | 2019 | Science China(Life Sciences)2019，62，6： | 8 |
| 9 | Changes of Cytokines Levels in Peritoneal Fluids of Patients with Endometriosis and Its Effect on Reproductive Activity显示文摘To study the changes of cytokines in peritoneal fluids of patients with endometriosis and their effects on reproductive activity, levels of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in peritoneal fluids and peritoneal macrophages’ culture supernatant were studied by using enzyme linked immunoassay (ELISA) in 14 infertile patients with endometriosis (EMT group) and 11 infertile women with normal pelvis (control group). The effects of peritoneal fluids in patients with endometriosis in vitro on sperm motility and development of 2-cell mouse embryos were also studied. The results showed that the levels of TNF and IL-6 in peritoneal fluids and peritoneal macrophages’ supernatant in EMT group were elevated significantly as cohipared with thai in the control group (P <0. 01). The percent of sperm straight line movement and total sperm motility were decreased significantly in EMT group (P<0. 01 ). The percent of 2-cell mouse embryos developing to 16-cells was 32. 5 % in EMT group, while 47. 6 % in control group after 48 h co-culture with peritoneal fluid (P <0. 01). It is likely that the elevation of peritoneal fluid cytokines in patients with endometriosis may play a role in infertility associated with endometriosis. | 刘义 罗丽兰 赵海波 | 2000 | Journal of Huazhong University of Science and Technology(Medical Sciences)2000，20，2： | 8 |
| 10 | Discovery of Two Different Reproductive Development Modes of the Eggs of Artificial Multiple Tetraploid Allogynogenetic Silver Crucian Carp显示文摘Introduction Artificial multiple tetraploid allogynogenetic silver crucian carp possesses the reproductive function of gynogenesis in spite of incorporating one genome of common carp, because all chromosomes of silver crucian carp are maintained. This was first confirmed in the artificial propagation experiments in which the eggs of the multiple tetraploid fish were respectively inseminated with normal and UV-irradiated sperms of red common carp. Recently, | 桂建芳 梁绍昌 朱蓝菲 蒋一珪 | 1993 | Chinese Science Bulletin1993，38，4： | 7 |
| 11 | 规模猪场猪繁殖与呼吸综合征(PRRS)风险评估系统的构建显示文摘为建立适用于现代规模猪场的猪繁殖与呼吸综合征(PRRS)风险评估方法,以猪繁殖与呼吸综合征病毒(PRRSV)传入猪场和场内循环传播的相关风险因素组成的总体风险为建模系统,将其按层次建成由2个Ⅰ级、8个Ⅱ级和29个Ⅲ级风险指标变量组成的评估指标体系,并以此为基础构建了计算各级指标变量风险值的评估系统。该评估系统通过调查问卷、实地收集和工具辅助3种指标数据采集方法获取猪场PRRS风险相关数据,并计算输出各级指标风险值,提示猪场高风险指标和单一高风险因子,为规模猪场PRRS风险管理决策提供支持。 | 谭业平 陆昌华 胡肄农 何孔旺 黄小国 | 2014 | 江苏农业学报2014，30，3： | 6 |
| 12 | Molecular mechanism of endocrine-disruptive effects induced by Bisphenol A:The role of transmembrane G-protein estrogen receptor 1 and integrin αvβ3显示文摘Bisphenol A(BPA) is one of the highest volume industrial products worldwide and has been widely used to make various products as the intermediates of polycarbonate plastics and epoxy resins.Inevitably, general population has been widely exposed to BPA due to extensive use of BPAcontaining products. BPA has similar chemical structure with the natural estrogen and has been shown to induce a variety of estrogen-like endocrine effects on organism in vivo or in vitro. High doses of BPA tend to act as antagonist of estrogen receptors(ERs) by directly regulating the genomic transcription. However, BPA at environmentally relevant low-dose always disrupt the biological function via a non-genomic manner mediated by membrane receptors, rather than ERs. Although some studies had investigated the non-genomic effects of low-dose BPA, the exact molecular mechanism still remains unclear. Recently, we found that membrane G protein-coupled estrogen receptor 1 and integrin αvβ3 and its relative signal pathways participate in the induction of male germ cell proliferation and thyroid transcription disruption by the low-dose BPA. A profound understanding for the mechanism of action of the environmentally relevant BPA exposure not only contributes to objectively evaluate and predict the potential influence to human health, but also provides theoretical basis and methodological support for assessing health effects trigged by other estrogen-like environmental endocrine disruptors. Based mainly on our recent findings, this review outlines the research progress of molecular mechanism on endocrine disrupting effects of environmental low-dose BPA, existing problems and some consideration for future studies. | Zhiguo Sheng Cong Wang Furong Ren Yuxiang Liu Benzhan Zhu | 2019 | Journal of Environmental Sciences2019，31，1： | 6 |
| 13 | 玉米赤霉烯酮的毒害作用及对种猪繁殖性能的影响显示文摘玉米赤霉烯酮是一种非甾体雌激素样作用的霉菌毒素。大量研究表明,玉米赤霉烯酮具有生殖发育毒性、免疫毒性,对肿瘤发生也有一定影响。本文综述了玉米赤霉烯酮的毒性毒害作用及对种猪繁殖性能的影响,以引起养殖者的高度重视。 | 王春梅 王庆林 | 2010 | 畜牧与兽医2010，42，10： | 6 |
| 14 | Effects of environmental contaminants on fertility and reproductive health显示文摘Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area. | Yanmin Ma Xin He Keyan Qi Tong Wang Yongchao Qi Lele Cui Fengbang Wang Maoyong Song | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 15 | 转sFat-1基因猪生理生化指标与繁殖性能测定(摘要)(英文)显示文摘[目的]评价转sFat-1基因猪的健康状况,为猪育种选择优良个体提供依据。[方法]测定21头阴性试验对照猪和20头转sFat-1基因阳性猪15项生理生化指标和繁殖性能。[结果]部分转sFat-1基因猪肝功能受到轻度损伤,繁殖能力也有轻度下降。[结论]猪生理生化指标和繁殖性能测定能够成为转基因猪环境安全评价的有效方法之一。 | 华文君 刘西梅 程妮 乔宪凤 郑新民 Wen-Jun Xi-mei Xian-feng Xin-min | 2010 | Agricultural Science & Technology2010，11，5： | 5 |
| 16 | A New Idea of Sinian Doushantuo'an Metaphyte Fossils from Xiuning, Anhui Province显示文摘This paper gives a summary of the fossil data from the Sinian Doushantuo’ an Lantian Formation in the Xiuning area, Anhui Province, China, and reports the genital butt structure comparable to that of some modern advanced algae and the fossil structure comparable to the dehiscence of sporangia as well as the ontogenetic phenomenon occurring possibly from the formation of embryos by zygote germination to the production of sessile benthonic algal adults. This phenomenon furnishes a useful clue to the further study of the life history of alternate generations in advanced algae and provides megafossil evidence for the sex differentiation of metaphytic algae. | Tang Feng, National Geological Museum of China, Xisi, Beijing 100034Yin Chongyu and Gao LinzhiInstitute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang, Beijing 100037 Fei Zhenbi | 1997 | Acta Geologica Sinica(English Edition)1997，71，4： | 5 |
| 17 | Transcriptome analysis of the effect of pyrroloquinoline quinone disodium(PQQ·Na2) on reproductive performance in sows during gestation and lactation显示文摘Background: Pyrroloquinoline quinone(PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor. The objective of this study was to investigate the effects of pyrroloquinoline quinone disodium(PQQ·Na2) on reproductive performance in sows.Results: Dietary supplementation with PQQ·Na2 significantly increased the total number of piglets born, the number of piglets born alive and the born alive litter weight. It also increased the antioxidant status in the placenta, plasma and milk. The concentration of NO was significantly increased in the plasma and placenta. RNA-seq analysis showed that462 unigenes were differentially expressed between the control(Con) treatment and PQQ treatment groups.Among these unigenes, 199 were upregulated, while 263 unigenes were downregulated. The assigned functions of the unigenes covered a broad range of GO categories. Reproduction(27, 7.03%) and the reproduction process(27, 7.03%) were assigned to the biological process category. By matching DEGs to the KEGG database, we identified 29 pathways.Conclusions: In conclusion, dietary supplementation with PQQ·Na2 in gestating and lactating sows had positive effects on their reproductive performance. | Boru Zhang Chenxi Wang Wei Yang Hongyun Zhang Qingwei Meng Baoming Shi Anshan Shan | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 5 |
| 18 | An overview of studies on psychological well-being in children born following assisted reproductive technologies显示文摘Over the course of the past 35 years,assisted reproductive technologies(ARTs)have been increasingly used worldwide,while debates on their safety have been generated.Birth defects and imprinting disorders were reported in previous research.Thus,the psychological development of children born following ARTs has become a major concern nowadays.This review gives a systematic view of psychological well-being of children conceived by different types of ART,including in vitro fertilization,intracytoplasmic sperm injection(ICSI),preimplantation genetic diagnosis/screening,and in vitro maturation.The previous studies are analyzed in three sections:(1)cognitive,motor,and language developments,(2)behavior problems and socio-emotional development,and(3)parent-child relationship.We conclude that although the majority of the studies on cognitive,motor,and language developments reported comparable achievements in the ART group vs.the naturally conceived group,lower intelligence quotient(IQ)scores,worse visual-motor ability or locomotor development,and delayed receptive language competence were found in the ART group.The results on the socio-emotional development were reassuring.As for the behavior problems,a higher prevalence of behavior problems existed in ART children;moreover,ICSI children were found to be at a higher risk of autism than the general population.Meanwhile,ART parents tended to have positive parental attitudes and be more protective of their children.Some suggestions for further research are also given in this review. | Qi-tao ZHAN Pei-pei PAN Xiang-rong XU Hang-ying LOU Yi-yun LOU Fan JIN | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，11： | 4 |
| 19 | Impact of PRRSV on activation and viability of antigen presenting cells显示文摘Porcine reproductive and respiratory syndrome(PRRS) is one of the most important diseases of swine industry. The causal agent, PRRS-virus(PRRSV), is able to evade the host immune response and survive in the organism causing transient infections. Despite all scientific efforts, there are still some gaps in the knowledge of the pathogenesis of this disease. Antigen presenting cells(APCs), as initiators of the immune response, are located in the first line of defense against microorganisms, and are responsible for antigen recognition, processing and presentation. Dendritic cells(DCs) are the main type of APC involved in antigen presentation and they are susceptible to PRRSV infection. Thus, PRRSV replication in DCs may trigger off different mechanisms to impair the onset of a host effective immune response against the virus. On the one side, PRRSV may impair the basic functions of DCs by regulating the expression of major histocompatibility complex class Ⅱ and CD80/86. Other strategy followed by the virus is the induction of cell death of APCs by apoptosis, necrosis or both of them. The impairment and/or cell death ofAPCs could lead to a failure in the onset of an efficient immune response, as long as cells could not properly activate T cells. Future aspects to take into account are also discussed in this review. | Irene M Rodríguez-Gómez Jaime Gómez-Laguna Librado Carrasco | 2013 | World Journal of Virology2013，2，4： | 4 |
| 20 | Preliminary Confirmation of Gynogenetic Reproductive Mode in Artificial Multiple Tetraploid Ailogynogenetic Silver Crucian Carp显示文摘I Introduction Artificial multiple tetraploid allogynogenetic silver crucian carp is a special individual, which was discovered from artificially propagated populations of allogynogenetic silver crucian carp and has the obviously enhanced growth rates. One of its main specialities is that the fish maintains the whole chromosomes (162) of silver crucian carp (Carassius auratus gibelio) and fuses one chromosome set of haploid sperm (50 chromosomes ) of | 桂建芳 梁绍昌 朱蓝菲 蒋一珪 | 1993 | Chinese Science Bulletin1993，38，1： | 4 |
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