Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects

查看全文 作　　者：Wasin [1]Charerntantanakul

机构地区：[1]Research Laboratory for Immunity Enhancement in Humans and Domestic Animals, Program of Biotechnology, Faculty of Science, Maejo University

出　　处：《World Journal of Virology》索引2012年第1卷第1期,共8页

基　　金：The Thailand Research Fund,NO.DIG5180032 摘　　要：Porcine reproductive and respiratory syndrome virus(PRRSV) infection is the leading cause of economic casualty in swine industry worldwide. The virus can cause reproductive failure, respiratory disease, and growth retardation in the pigs. This review deals with current status of commercial PRRS vaccines presently used to control PRRS. The review focuses on the immunogenicity, protective efficacy and safety aspects of the vaccines. Commercial PRRS modified-live virus(MLV) vaccine elicits delayed humoral and cell-mediated immune responses following vaccination. The vaccine confers late but effective protection against genetically homologous PRRSV, and partial protection against genetically heterologous virus. The MLV vaccine is of concern for its safety as the vaccine virus can revert to virulence and cause diseases. PRRS killed virus(KV) vaccine, on the other hand, is safe but confers limited protection against either homologous or heterologous virus. The KV vaccine yet helps reduce disease severity when administered to the PRRSV-infected pigs. Although efforts have been made to improve the immunogenicity, ef-ficacy and safety of PRRS vaccines, a better vaccine is still needed in order to protect against PRRSV. 关键词：PORCINE REPRODUCTIVE and RESPIRATORY syndrome virus VACCINE

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Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects

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