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| 1 | 先天性内耳畸形的MSCT和MRI表现显示文摘 | 韩萍 马辉 孔祥泉 | 2005 | 放射学实践2005，20，12： | 15 |
| 2 | 脾脏非霍奇金淋巴瘤临床病理学研究显示文摘目的 探讨脾脏非霍奇金淋巴瘤 (SNHL)的形态学特点、免疫表型及鉴别诊断。方法 对 39例SNHL进行形态学观察及免疫组化ABC法分析 ,使用抗体包括CD3、CD4 5RO、CD5 6、CD79α、CD2 0、CD6 8、Mac387、CD5、CD10、bcl 2、CD2 3、CD4 3、cyclinD1、IgM、IgD等。 结果 39例SNHL中有B细胞淋巴瘤 (BCL) 2 4例 ,包括小淋巴细胞性淋巴瘤 (SLL) 4例 ,套细胞淋巴瘤 (MCL) 4例 ,滤泡性淋巴瘤 (FL) 5例 ,边缘区淋巴瘤 (MZL) 6例 ,弥漫大B细胞性淋巴瘤 (DLBCL) 5例 ,其中 2例为大多叶核细胞淋巴瘤。T细胞淋巴瘤 (TCL) 11例 ,其中肝脾T细胞淋巴瘤 2例 ,非特异性TCL 9例。组织细胞性淋巴瘤 4例。结论 脾脏淋巴瘤病理类型多样 ,掌握其形态学特征 ,熟悉各类型的免疫表型的异同点对诊断与鉴别诊断有重要意义。 | 张丽 李百周 徐天蓉 虞梅宁 朱荣 范钦和 | 2003 | 临床与实验病理学杂志2003，19，1： | 10 |
| 3 | Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss显示文摘Objective: To identify presence of inflammasome activated in mouse cochlea with sensorineural hearing loss(SNHL) caused by cytomegalovirus(CMV) infection.Method: MCMV was injected into the right cerebral hemisphere in neonatal BALB/c mice at 2000 pfu virus titers. Auditory brainstem responses(ABRs) were tested to evaluate hearing at 21 days. Histopathological studies were conducted to confirm localizations of MCMV infected cells in the inner ear. Expression of inflammasome related factors was assessed by immunofluorescence, Quantitative real-time PCR and Western blotting.Results: In the mouse model of CMV induced SNHL, inflammasome related kinase Caspase-1 and downstream inflammatory factor IL-1b and IL-18 were found increased and activated after CMV infection in the cochlea. These factors could further up-regulate expression of IL-6 and TNFa. These inflammatory factors are neurotoxicity and may contribute to hearing impairment. Furthermore, we also detected significantly increased AIM2 protein that accumulated in the SGN of cochleae with CMV infection.Significance: We have shown that inflammasome as a novel inherent immunity mechanism may contribute to hearing impairment.Conclusion: Our data indicate that imflammasome assemble in mouse inner ear in response to CMV infection. We have revealed a novel pathology event in CMV induced SNHL involving activation of inflammasome in mouse cochlea. Additionally, we have shown that inflammasome may be a novel target for prevention and treatment of CMV related SNHL. | Xi Shi Yanfen Dong Ya Li ZenLu Zhao Huan Li Shiwei Qiu Yaohan Li Weiwei Guo Yuehua Qiao | 2015 | Journal of Otology2015，10，4： | 9 |
| 4 | 感觉神经性耳聋的MRI研究显示文摘目的评价MRI检查方法对探讨感觉神经性耳聋(SNHL)各种病因的价值。方法用SE和快速自旋回波(FSE)序列对495例临床诊断为SNHL的患者进行磁共振检查。结果MRI发现颅内病变211例(42.6%),其中95例(19.2%)的SNHL病因为听觉传导通路上的病变。11例内耳区病变为感觉性耳聋,另外84例听神经或脑内听觉传导纤维受损为神经性耳聋。84例中62例病变位于内听道和桥小脑角区,脑内病变为22例。结论SNHL病人MRI检查应包括从耳蜗到颞横回的全部听觉传导通路。肿瘤、梗死软化、多发硬化、炎症、纡曲血管和囊肿都可引起SNHL。 | 王武 张雪哲 卢延 洪闻 陆立 黄振国 | 1998 | 中华放射学杂志1998，32，6： | 1 |
| 5 | 国际文摘显示文摘8头颈癌患者放化疗和放疗后的感觉神经性耳聋:文献系统评价
Sensorineural hearing loss in patients with head and neck cancer after chemoradiotherapy and radiotherapy: A systematic review of the literature. Theunissen EA,Bosma SC,Zuur CL,et al. Head Neck, 2013 Nov 7.
头颈癌患者放疗(RT)和以顺铂为主的放化疗(CRT)可以引起感觉神经性耳聋fSNHL)。该文旨在回顾CRT与RT引起的SNHL,并作进一步探究。以“放疗”,“耳毒性”,“头颈鳞癌”及其同义词为关键词,在Medline和Embase进行检索。 | 张凌 | 2014 | 中国口腔颌面外科杂志2014，12，2： | 0 |
| 6 | 儿童感音神经性耳聋的CT研究进展显示文摘感音神经性耳聋(sensorineural hearingloss,SNHL)为临床常见病,病变部位包括内耳、内听道和桥小脑角以及脑内几个部分。婴幼儿SNHL主要是由于内耳,尤其是耳蜗或前庭耳蜗神经发育异常所致。先天性内耳畸形是儿童SNHL的主要病因,其群体发病率约为1/2000-1/6000,明确其畸形直接影响预后和处理。随着高分辨率CT的出现,对于内耳大体形态学畸形的诊断率明显提高,但是只有一些明显、严重的畸形能够被明确识别,对于一些细微的异常则容易漏诊。本文对儿童SNHL内耳异常的CT测量研究及其一些新观点进行总结。 | 郭勇(综述) 白芝兰(审校) | 2010 | 实用放射学杂志2010，26，9： | 0 |
| 7 | 大前庭水管综合征听力学特征研究进展显示文摘 | 高尚 敖华飞 | 2007 | 听力学及言语疾病杂志2007，15，1： | 0 |
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