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| 1 | Review on“Long-Dan”,one of the traditional Chinese medicinal herbs recorded in Chinese Pharmacopoeia显示文摘“Long-Dan”is an important traditional Chinese medicinal(TCM)herb used widely for the treatment of inflammation,hepatitis,rheumatism,cholecystitis,and tuberculosis.In the Chinese Pharmacopoeia,the roots and rhizomes of four species from the genus Gentiana(Gentianaceae)are recorded as the original materials of“Long-Dan”,called Gentianae Radix et Rhizoma.The species included G.manshurica,G.scabra,G.triflora and G.rigescens,which are distributed in different areas of China.Though iridoid and secoiridoid glucosides were reported as the main constituents in“Long-Dan”,these four different species also resulted in different minor components,which may related to their pharmacological activities.Herein,we summarized the herbal textual study,distribution,chemical constituents,biological investigation and quality control of the recorded“Long-Dan”origins in Chinese Pharmacopoeia during the period 1960 to 2011. | Yan-Ming WANG Min XU Dong WANG Hong-Tao ZHU Chong-Ren YANG Ying-Jun ZHANG | 2012 | Natural Products and Bioprospecting2012，2，1： | 20 |
| 2 | A review of the phytochemistry and pharmacological activities of Ephedra herb显示文摘Ephedra herb is a traditional Chinese medicine with a long history. Conventionally, it was used as a folk phytomedicine in many ancient medical books and traditional prescriptions. Up to date, a variety of specific ingredients have been found in Ephedra herb, mainly including alkaloids, flavonoids, tannins, polysaccharides, organic acids, volatile oils, and many other active compounds. These components from Ephedra herb account for its use as the accurate treatment of cold, cough, cardiovascular and immune system disease, cancer, microbial infection, and other diseases. Moreover, with the fast development of novel chemistry and medicine technology, new chemical constituents and pharmacological effects of Ephedra herb are increasingly identified, demonstrating their great potential for various diseases treatment. Therefore, further detailed understanding and investigation of this ancient herb will offer new opportunities to develop novel therapeutics. This study systematically reviews its progress of phytochemistry, traditional and modern pharmacology based on research data that have been reported, aiming at providing useful insight for commercial exploitation, further study and precision medication of Ephedra herb in future. | MIAO Shuang-Man ZHANG Qi BI Xiao-Bao CUI Jin-Long WANG Meng-Liang | 2020 | Chinese Journal of Natural Medicines2020，18，5： | 15 |
| 3 | Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev.显示文摘Objective:To study the morphology,biochemistry and bioactivity of the epidermal glands of the glandular morphotype of Christella parasitica(C.parasitica)(L.) H.Lev.Methods: Morphological studies on epidermal glands were earned out by using light microscope and scanning electron microscope.To prepare the extract,the shade-dried fronds of glandular morphotype were soaked in acetone.For antibacterial studies paper disc method was followed by using various pathogenic bacteria.Results:Detailed micromorphological,phytochemical and bioactivity studies on a medicinal fern C.parasitica(L.) H.Lev.showed its inlraspecific variation in antibacterial activity.The presence or absence of the epidermal glands was the key factor for antibacterial activity in the morphovariants of this species.The epidermal glands were orange-coloured,stalked and elongated ones of about 84.2μm×45μm,and distributed on the undersurface of cosla,coslules and veins in croziers,young and mature leaves.Frequency of glands varied from 15/cm on costa in mature leaves to 140/cm on costules in croziers.The acetone extract of the glands showed antibacterial activities and also toxic effect against mosquito larvae and tadpoles of frog.Preliminary phytochemical analysis and HPLC studies of the gland extract showed the presence of various kinds of terpenoids,alkaloids,tannins,saponins and flavonoids in it.Conclusions:The present study shows that epidermal glands of the glandular morphotype of C. parasitica(L.) H.Lev.have several bioactive compounds and such rare moiphovariant should be conserved in nature.The next step is to isolate the pure compounds and to screen the bioactivity of individual compounds of the epidermal glands. | Paul Raj K Irudayaraj V Johnson M Patric Raja D | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 14 |
| 4 | Two pairs of unusual scalemic enantiomers from Isatis indigotica leaves显示文摘Two pairs of unusual scalemic enantiomers with a novel carbon skeleton of 2-[1'-(''-hydroxy-3'',5''-dimethoxyphenyl)ethyl]-2-methoxyindolin-3-one, named isatidifoliumindolinones A–D(1–4), were isolated from an aqueous extract of Isatis indigotica leaves(da qing ye). Their structures including absolute configurations were determined by spectroscopic data analysis combined with comparison of their experimental CD and calculated ECD spectra. Validity of the ECD spectra calculation to assign the absolute configurations is discussed. Plausible biosynthetic pathways of 1–4 are proposed.Stereochemistry-dependent activity against LPS-induced NO production in BV2 cells was observed,and among the stereoisomers compound 4 is most active. | Da-Wei Li Qing-Lan Guo Xian-Hua Meng Cheng-Gen Zhu Cheng-Bo Xu Jian-Gong Shi | 2016 | Chinese Chemical Letters2016，27，12： | 9 |
| 5 | Mining chemodiversity from biodiversity:pharmacophylogeny of medicinal plants of Ranunculaceae显示文摘This paper reports a pharmacophylogenetic study of a medicinal plant family,Ranunculaceae,investigating the correlations between their phylogeny,chemical constituents,and pharmaceutical properties.Phytochemical,ethnopharmacological,and pharmacological data were integrated in the context of the systematics and molecular phylogeny of the Ranunculaceae.The chemical components of this family included several representative metabolic groups:benzylisoquinoline alkaloids,ranunculin,triterpenoid saponin,and diterpene alkaloids,among others.Ranunculin and magnoflorine were found to coexist in some genera.The pharmacophylogenetic analysis,integrated with therapeutic information,agreed with the taxonomy proposed previously,in which the family Ranunculaceae was divided into five sub-families:Ranunculoideae,Thalictroideae,Coptidoideae,Hydrastidoideae,and Glaucidioideae.It was plausible to organize the sub-family Ranunculoideae into ten tribes.The chemical constituents and therapeutic efficacy of each taxonomic group were reviewed,revealing the underlying connections between phylogeny,chemical diversity,and clinical use,which should facilitate the conservation and sustainable utilization of the pharmaceutical resources derived from the Ranunculaceae. | HAO Da-Cheng XIAO Pei-Gen MA Hong-Ying PENG Yong HE Chun-Nian | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 6 |
| 6 | Influence of mental stress on platelet bioactivity显示文摘It is well established that various mental stress conditions contribute, or at least influence, underlying pathophysiological mechanisms in somatic, as well as in psychiatric disorders; blood platelets are supposed to represent a possible link in this respect. The anculeated platelets are the smallest corpuscular elements circulating in the human blood. They display different serotonergic markers which seem to reflect the central nervous serotonin metabolism. They are known as main effectors in haematological processes but recent research highlights their role in the innate and adaptive immune system. Platelets are containing a multitude of pro-inflammatory and immune-modulatory bioactive compounds in their granules and are expressing immune-competent surface markers. Research gives hint that platelets activation and reactivity is increased by mental stress. This leads to enhanced cross talk with the immune system via paracrine secretion, receptor interaction and formation of platelet leucocyteaggregates. Recently it has been demonstrated that the immune system can have a remarkable impact in the development of psychiatric disorders. Thereforeplatelets represent an interesting research area in psychiatry and their role as a possible biomarker has been investigated. We review the influence of mental stress on what is termed platelet bioactivity in this article, which subsumes the mainly immune-modulatory activity of platelets in healthy volunteers, elderly persons with chronic care-giving strain, patients with cardiovascular diseases who are prone to psychosocial stress, as well as in patients with posttraumatic stress disorder. Research data suggest that stress enhances platelet activity, reactivity and immune-modulatory capacities. | Pia Koudouovoh-Tripp Barbara Sperner-Unterweger | 2012 | World Journal of Psychiatry2012，2，6： | 6 |
| 7 | Anemone medicinal plants:ethnopharmacology,phytochemistry and biology显示文摘The Ranunculaceae genus Anemone(order Ranunculales),comprising more than 150 species,mostly herbs,has long been used in folk medicine and worldwide ethnomedicine.Various medicinal compounds have been found in Anemone plants,especially triterpenoid saponins,some of which have shown anti-cancer activities.Some Anemone compounds and extracts display immunomodulatory,antiinflammatory,antioxidant,and antimicrobial activities.More than 50 species have ethnopharmacological uses,which provide clues for modern drug discovery.Anemone compounds exert anticancer and other bioactivities via multiple pathways.However,a comprehensive review of the Anemone medicinal resources is lacking.We here summarize the ethnomedical knowledge and recent progress on the chemical and pharmacological diversity of Anemone medicinal plants,as well as the emerging molecular mechanisms and functions of these medicinal compounds.The phylogenetic relationships of Anemone species were reconstructed based on nuclear ITS and chloroplast markers.The molecular phylogeny is largely congruent with the morphology-based classification.Commonly used medicinal herbs are distributed in each subgenus and section,and chemical and biological studies of more unexplored taxa are warranted.Gene expression profiling and relevant 'omics' platforms could reveal differential effects of phytometabolites.Genomics,transcriptomics,proteomics,and metabolomics should be highlighted in deciphering novel therapeutic mechanisms and utilities of Anemone phytometabolites. | Da-Cheng Hao Xiaojie Gu Peigen Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 6 |
| 8 | An in vitro evaluation of novel NHA/zircon plasma coating on 316L stainless steel dental implant显示文摘The surface characteristics of an implant that influence the speed and strength of osseointegration include crystal structure and bioactivity. The aim of this study was to evaluate the bioactivity of a novel natural hydroxyapatite/zircon(NHA/zircon) nanobiocomposite coating on 316L stainless steel(SS) dental implants soaking in simulated body fluid. A novel NHA/zircon nanobiocomposite was fabricated with 0(control),5, 10, and 15 wt% of zircon in NHA using ball mill for 1 h. The composite mixture was coated on SS implants using a plasma spray method.Scanning electron microscopy(SEM) was used to evaluate surface morphology, and X-ray diffraction(XRD) was used to analyze phase composition and crystallinity(Xc). Further, calcium ion release was measured to evaluate the coated nanobiocomposite samples. The prepared NHA/zircon coating had a nanoscale morphological structure with a mean crystallite size of 30–40 nm in diameter and a bone-like composition,which is similar to that of the biological apatite of a bone. For the prepared NHA powder, high bioactivity was observed owing to the formation of apatite crystals on its surface. Both minimum crystallinity(Xc=41.1%) and maximum bioactivity occurred in the sample containing 10 wt% of zircon because of minimum Xcand maximum biodegradation of the coating sample. | Ebrahim Karamian Mahmood Reza Kalantar Motamedi Amirsalar Khandan Parisa Soltani Sahel Maghsoudi | 2014 | Progress in Natural Science:Materials International2014，24，2： | 6 |
| 9 | High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing显示文摘High performance hydroxyapatite(HA)ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing(DLP)three-dimensional(3D)printing technology.It was found that the sintering atmosphere of wet C02 can dramatically improve the densification process and thus lead to better mechanical properties.HA ceramics with a relative density of 97.12%and a three-point bending strength of 92.4 MPa can be achieved at a sintering temperature of 1300℃,which makes a solid foundation for application in bone engineering.Furthermore,a relatively high compressive strength of 4.09 MPa can be also achieved for a DLP-printed p-cell triply periodic minimum surface(TPMS)structure with a porosity of 74%,which meets the requirement of cancellous bone substitutes.A further cell proliferation test demonstrated that the sintering atmosphere of wet CO2 led to improve cell vitality after 7 days of cell culture Moreover,with the possible benefit from the bio-inspired structure,the 3D-printed TPMS structure significantly improved the cell vitality,which is crucial for early osteogenesis and osteointegration. | Yongxia YAO Wei QIN Bohang XING Na SHA Ting JIAO Zhe ZHAO | 2021 | Journal of Advanced Ceramics2021，10，1： | 5 |
| 10 | Diversity,bioactivities,and metabolic potentials of endophytic actinomycetes isolated from traditional medicinal plants in Sichuan,China显示文摘The present study was designed to determine the taxonomic diversity and metabolic activity of the actinomycetes community, including 13 traditional medicinal plants collected in Sichuan province, China, using multiple approaches such as morphological and molecular identification methods, bioactivity assays, and PCR screening for genes involved in antibiotics biosynthesis. 119 endophytic actinomycetes were recovered; 80 representative strains were chosen for 16 S r RNA gene partial sequence analyses, with 66 of them being affiliated to genus Streptomyces and the remaining 14 strains being rare actinomycetes. Antimicrobial tests showed that 12(15%) of the 80 endophytic actinomycetes displayed inhibitory effects against at least one indicator pathogens, which were all assigned to the genus Streptomyces. In addition, 87.5% and 58.8% of the isolates showed anticancer and anti-diabetic activities, respectively. Meanwhile, the anticancer activities of the isolates negatively correlated with their anti-diabetic activities. Based on the results of PCR screening, five genes, PKS-I, PKS-II, NRPS, ANSA, and oxy B, were detected in 55.0%, 58.8%, 90.0%, 18.8% and 8.8% of the 80 actinomycetes, respectively. In conclusion, the PCR screening method employed in the present study was conducive for screening and selection of potential actinomycetes and predicting potential secondary metabolites, which could overcome the limitations of traditional activity screening models. | QIU Peng FENG Zhi-Xiang TIAN Jie-Wei LEI Zu-Chao WANG Lei ZENG Zhi-Gang CHU Yi-Wen TIAN Yong-Qiang | 2015 | Chinese Journal of Natural Medicines2015，13，12： | 5 |
| 11 | Terpenoids of Sinularia soft corals:chemistry and bioactivity显示文摘Soft corals of the genus Sinularia are one of the most widespread soft corals.They are a rich source of bioactive su bstances with intriguing and unique structural features.The present paper reviews the latest progress in the chemistry and pharmacological activities of terpenoids from Sinularia soft corals and provides a perspective on future areas of research interest. | Wen-ting Chen Yan Li Yue-wei Guo | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 4 |
| 12 | Synthesis, Characterization and Bioactivity of Complexes of Rare Earth with Bis-Schiff Base from Furoylpyrazolone显示文摘Eleven new complexes of rare earths with bis Schiff base derived from N,N’ bis[(1 phenyl 3 methyl 5 oxo 4 pyrazolinyl)α furylmethylidyne] ethylenediimine ((HPMαFP) 2en) were synthesized. On the basis of elemental analysis and molar conductance, a general formula of the complexes, [RE(HPMαFP) 2 en(NO 3) 2]NO 3 (RE=La, Pr, Nd, Sm, Eu, Tb, Dy, Ho, Er, Yb,Y), was given. The complexes were characterized by IR, UV visible, 1H NMR, 13 C NMR and fluorescence. The results show that the bis Schiff base is a quadridentate ligand and the rare earth ions exhibit coordination of eight in the complexes. The antibacterial experiments indicate that they have high antibacterial activities against S. aureus, B. subtillis, E. coli, E.carotovora, C. flaccumfaciens. | 李锦州 李刚 于文锦 | 2000 | Journal of Rare Earths2000，18，3： | 4 |
| 13 | Chemistry and biology of Pestalotiopsis-derived natural products显示文摘Species within the fungal genus Pestalotiopsis have become a topic of research in many microbial-chemical and pharmacological laboratories because they contain structurally complex,biologically active metabolites.This article is a follow-up to a previous review(Xu,Ebada,and Proksch,Fungal Divers 44:15–31,2010).It focuses particularly on new findings concerning the chemistry and bioactivity of Pestalotiopsis sp.,covering a period ranging from August 2010 to August 2013.Some 160 metabolites were isolated from Pestalotiopsis species during this period and their structures are reported within a biogenetic context.Bioassays showed antitumor,antifungal,and antimicrobial activities to be the most notable bioactivities of secondary metabolites isolated from this genus.The biogenetic pathways associated with the alkaloids,sesquiterpenes,quinines,xanthones,and lactones covered in this review are highlighted. | Jing Xu Xiaobo Yang Qiang Lin | 2014 | Fungal Diversity2014，，3： | 4 |
| 14 | Multifunctional zinc ion doped sol-gel derived mesoporous bioactive glass nanoparticles for biomedical applications显示文摘Mesoporous bioactive glasses have been widely investigated for applications in bone tissue regeneration and,more recently,in soft tissue repair and wound healing.In this study we produced mesoporous bioactive glass nanoparticles(MBGNs)based on the SiO2-CaO system.With the intention of adding subsidiary biological function,MBGNs were doped with Zn2+ions.Zn-MBGNs with 8 mol%ZnO content were synthesized via microemulsion assisted sol-gel method.The synthesized particles were homogeneous in shape and size.They exhibited spherical shape,good dispersity,and a size of 130±10 nm.The addition of zinc precursors did not affect the morphology of particles,while their specific surface area increased in comparison to MBGNs.The presence of Zn2+ions inhibited the formation of hydroxycarbonate apatite(HCAp)on the particles after immersion in simulated body fluid(SBF).No formation of HCAp crystals on the surface of Zn-MBGNs could be observed after 14 days of immersion.Interestingly,powders containing relatively high amount of zinc released Zn2+ions in low concentration(0.6-1.2 mg L^−1)but in a sustained manner.This releasing feature enables Zn-MBGNs to avoid potentially toxic levels of Zn2+ions,indeed Zn-MBGNs were seen to improve the differentiation of osteoblast-like cells(MG-63).Additionally,Zn-MBGNs showed higher ability to adsorb proteins in comparison to MBGNs,which could indicate a favourable later attachment of cells.Due to their advantageous morphological and physiochemical properties,Zn-MBGNs show great potential as bioactive fillers or drug delivery systems in a variety of applications including bone regeneration and wound healing. | Zuzana Neščáková Kai Zheng Liliana Liverani Qaisar Nawaz Dagmar Galusková Hana Kaňková Martin Michálek Dušan Galusek Aldo R.Boccaccini | 2019 | Bioactive Materials2019，4，1： | 3 |
| 15 | In-vitro bioactivity evaluation and physical properties of an epoxy-based dental sealer reinforced with synthesized fluorine-substituted hydroxyapatite, hydroxyapatite and bioactive glass nanofillers显示文摘The purpose of this study was to evaluate the physical properties and bioactivity potential of epoxy-based dental sealers modified with synthesized bioactive glass(BAG),hydroxyapatite(HA)and fluorine substituted hydroxyapatite(FHA)nanoparticles.The synthesized powders were incorporated at 10%and 20%into the epoxy-based dental sealer.The setting time,flow and solubility and microhardness of the modified and unmodified samples were examined.The bioactivity was evaluated using FESEM-EDX and elemental mapping,ATR-FTIR and XRD.The flow value of all of the experimental groups except the FHA modified samples,was greater than 20 mm.Concerning solubility,no specimens exhibited more than 1%weight loss.The solubility value of the FHA groups was statistically significant lower than other groups(p≤0.001).The mean hardness values of all of the modified samples were significantly higher than the unmodified group(p≤0.001).Regarding bioactivity,in vitro study revealed that after 3 days immersion in SBF a compact and continuous calcium phosphate layer formed on the surface of epoxy sealers containing BAG and HA nanoparticles.Based on these results,the addition of BAG and HA nanoparticles did not adversely alter the physical properties of epoxy sealers.Additionally,they improved the in vitro bioactivity of the epoxy sealer. | Bahaa Abdulrazzaq Jerri Al-Bakhsh Farhad Shafiei Atieh Hashemian Kiana Shekofteh Behnam Bolhari Marjan Behroozibakhsh | 2019 | Bioactive Materials2019，4，1： | 3 |
| 16 | Bioactive peptides: A review显示文摘Bioactive peptides(BP)are organic substances formed by amino acids joined by covalent bonds known as amide or peptide bonds.Although some BP exist free in its natural source,the vast majority of known BP are encrypted in the structure of the parent proteins and are released mainly by enzymatic processes.Some BP have been prepared by chemical synthesis.BP play a significant role in human health by affecting the digestive,endocrine,cardiovascular,immune,and nervous systems.BP are considered the new generation of biologically active regulators;they can prevent oxidation and microbial degradation in foods and also improve the treatment of various diseases and disorders,thus increasing the quality of life.The growing interest in BP has incentivized the scientific community and the food industry to exploring the development of new food additives and functional products based on these peptides.The present review highlights the recent findings on the identification,bioassays,and use of BP,as well as their potential use as food additives and in the development of functional products. | Adrián Sánchez Alfredo Vázquez | 2017 | Food Quality and Safety2017，1，1： | 3 |
| 17 | Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation显示文摘The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte containing calcium and phosphate,a hydrothermal treatment enabled secondary microporous hydroxyapatite(HA)coating,and a further bone morphogenetic protein-2(BMP-2)loading treatment through immersion and freeze-drying.The treatment led to an orderly secondary microporous coating containing HA nano-particles and evenly distributed BMP-2 in the porous coatings.As a result,osteoblasts could adhere and grow well on the coatings with a high cell adhesion rate and cell functional activity.The in-situ shear testing indicated that the interfacial strength had been enhanced significantly.Improvement of the bond formation and osseointegration with the titanium implant is attributed to increased surface area for the cell to attach,creating voids for the cell to grow in,and activating titanium surface by introducing bioactive ingredients such as HA and BMP-2. | Sen Yu Zhe Yu Dagang Guo Hui Zhu Minghua Zhang Jianye Han Zhentao Yu Yemin Cao Gui Wang | 2022 | Journal of Materials Science & Technology2022，，5： | 3 |
| 18 | Microstructure and bioactivity of a cold sprayed rough/porous Ta coating on Ti6Al4V substrate显示文摘To improve the bioactivity and biocompatibility of titanium implants,a rough/porous tantalum(Ta)coating was firstly prepared on Ti6Al4V substrate by cold spraying.The results indicated that the surface of Ta coating is extremely rough with lots of visible holes,because of poor deposition quality.Microstructure and microhardness results showed that different layers appeared in the inner and outer parts of coatings,corresponding to porosity,due to lack of subsequent compaction.The simulated body fluid(SBF)soaking test showed that spherical apatite sediments were mineralized on rough/porous surface in SBF after 2–4 weeks,which demonstrated that the cold sprayed Ta coating had good bioactivity.This was mainly attributed to the rough/porous surface of Ta coating obtained by cold spraying,which is conducive to the heterogeneous nucleation of apatite on it. | TANG JunRong ZHAO ZhiPo CUI XinYu WANG JiQiang XIONG TianYing | 2020 | Science China(Technological Sciences)2020，63，5： | 3 |
| 19 | Mesoporous bioactive glass composition effects on degradation and bioactivity显示文摘Mesoporous bioactive glasses(MBGs)are promising materials for regenerative medicine,due to their favorable properties including bioactivity and degradability.These key properties,but also their surface area,pore structure and pore volume are strongly dependent on synthesis parameters and glass stoichiometry.However,to date no systematic study on MBG properties covering a broad range of possible compositions exists.Here,24 MBG compositions in the SiO_(2)-CaO-P_(2)O_(5) system were synthesized by varying SiO_(2)(60-90 mol%),CaO and P_(2)O_(5) content(both 0 to 40 mol-%),while other synthesis parameters were kept constant.Mesopore characteristics,degradability and bioactivity were analysed.The results showed that,within the tested range of compositions,mesopore formation required a molar SiO_(2) content above 60%but was independent of CaO and P_(2)O_(5) content.While mesopore size did not depend on glass stoichiometry,mesopore arrangement was influenced by the SiO_(2) content.Specific surface area and pore volume were slightly altered by the SiO_(2) content.All materials were degradable;however,degradation as well as bioactivity,i.e.the ability to form a CaP mineral on the surface,depended on stoichiometry.Major differences were found in early surface reactions in simulated body fluid:where some MBGs induced direct hydroxyapatite crystallization,high release of calcium in others resulted in calcite formation.In summary,degradation and bioactivity,both key parameters of MBGs,can be controlled by glass stoichiometry over a broad range while leaving the unique structural parameters of MBGs relatively unaffected.This allows targeted selection of material compositions for specific regenerative medicine applications. | M.Schumacher P.Habibovic S.van Rijt | 2021 | Bioactive Materials2021，6，7： | 2 |
| 20 | Biotechnological intervention in Betelvine(Piper betle L.):A review on recent advances and future prospects显示文摘Betelvine(Piper betle L.) is cultivated for its deep green heart shaped leaf for(15-20) million Indian and 2 billion foreign consumers annually. The crop provides Rs(6 000-7 000) million of national income per year and at the same time leaves worth Rs(30-40) million is exported to other countries. The leaves are not only used directly for chewing purposes but also possesses antioxidant, anti-inflammatory, anti-apoptotic, anti-cancer and anti-microbial properties. Besides, the leaves also contain eugenol rich essential oil(1%-3%) which is the source for medicine, stimulant, antiseptic, tonic and other ayurvedic formulations. The essential oil also contains chavibetol, caryophyllene and methyl eugenol which are the potent source for preparation in ayurvedic medicine and herbal products. Cost of betelvine essential oil is 10$ per 5 mL. In spite of its great economical and medicinal importance betelvine is still neglected by the researchers for proper characterization and authentication for selection of elite landraces. Lack of awareness among people, use of same planting material for many generations, existing of many synonyms for a single landraces, no proper characterization of available landraces are some of the significant constraints for its commercialization. Our review endeavours a complete advance in the research on betelvine, existing lacunae for its proper characterization and commercial cultivation. It also attempts to provide a comprehensive account on biotechnological interventions made in betelvine aimed at complementing conventional programmes for improvement of this nutraceutically important cash crop. | Suryasnata Das Reena Parida I.Sriram Sandeep Sanghamitra Nayak Sujata Mohanty | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 2 |
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