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| 1 | Developing the plate tectonics from oceanic subduction to continental collision显示文摘The studies of continental deep subduction and ultrahigh-pressure metamorphism have not only promoted the development of solid earth science in China, but also provided an excellent opportunity to advance the plate tectonics theory. In view of the nature of subducted crust, two types of subduction and collision have been respectively recognized in nature. On one hand, the crustal subduction occurs due to underflow of either oceanic crust (Pacific type) or continental crust (Alpine type). On the other hand, the continental collision proceeds by arc-continent collision (Himalaya-Tibet type) or continent-continent collision (Dabie-Sulu type). The key issues in the future study of continental dynamics are the chemical changes and differential exhumation in continental deep subduction zones, and the temporal-spatial transition from oceanic subduction to continental subduction. | ZHENG YongFei YE Kai ZHANG LiFei | 2009 | Chinese Science Bulletin2009，54，15： | 24 |
| 2 | Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells显示文摘目的: 在 anti-atherosclerosis.Methods 上调查保护的效果和杂种狗枯茗的可能的机制: 从 apoE 大美人拿的动脉粥样硬化患者损害的词法变化(apoE^(-/-))mice 被染色的 hematoxylin 曙红决定。细胞内部的类脂化合物微滴和类脂化合物层次是由油红O染色的 assayed , caveolin-1 的 HPLC.The 蛋白质表示被西方的 blotting.Translocation 和甾醇反应元素绑定 protein-1 ( SREBP-1 )的表示确定被免疫荧光 analysis.Results 间接地检测: 20 mg ·k g~的管理( -1)·d^(-1)curcumin 到apoE^(为 4 个月的 -/-)mice 导致了动脉粥样硬化患者损害的50%减小并且作为与模型组相比在 caveolin-1 表示水平产出5褶层增加。有 50 mg ·L ~的老鼠脉管的平滑肌房间( VSMC ) pretreated (为 48 h 的 -1)ox-lipid 密度脂蛋白( ox-LDL )增加了细胞的类脂化合物内容,并且刺激了 SREBP-1 易位,但是减少 装载level.Lipid 的房间在各种各样的集中暴露了到杂种狗枯茗的 caveolin-1 表示( 12.5,25 ,并且 50 亩摩尔 ·L ^( -1))for 不同持续时间( 0,6,12,24 ,和 48 h )显著地减少了细胞的类脂化合物微滴的数字和区域,全部的胆固醇,胆固醇酉旨,并且伴随 caveolin-1 表示的举起的免费胆固醇铺平(近似3褶层);到原子核的从细胞质的 SREBP-1 的易位与暴露于 N-acetyl-Leu-Leu-norleucinal 的 装载models.Lipid 的 VSMC 相比被禁止,一个 SREBP-1 朊酶禁止者, SREBP-1 的显示出的增加的原子易位,减少的 caveolin-1 表示水平,并且在调整细胞的类脂化合物 levels.Conclusion 上面:姜黄色素通过经由 SREBP-1 的原子易位的抑制增加 caveolin-1 表示在有教养的 VSMC 禁止 ox-LDL-induced 胆固醇累积。 | Hao-yu YUAN Shuang-yu KUAN Xing ZHENG Hong-yan LING Yun-Bo YANG Peng-Ke YAN Kai LI Duan-Fang LIAO | 2008 | Acta Pharmacologica Sinica2008，29，5： | 21 |
| 3 | Bionic Mechanism and Kinematics Analysis of Hopping Robot Inspired by Locust Jumping显示文摘 | Diansheng Chen Junmao Yin Kai Zhao Wanjun Zheng Tianmiao Wang | 2011 | Journal of Bionic Engineering2011，8，4： | 19 |
| 4 | Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion显示文摘AIM: To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion (I/R) in mice.METHODS: The superior mesenteric artery (SMA) of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-min reperfusion. In another set of experiments, R1 was continuously infused (10 mg/kg per hour) from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. Hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell (RBC) velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate transaminase (AST) in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) in plasma were evaluated by flow cytometry. E-selectin and intercellular adhesion molecule-1 (ICAM-1) in hepatic tissue were examined by immunofluorescence. RESULTS: After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1.CONCLUSION: R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury. The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils. | Wei-Xing Chen Fang Wang, Yu-Ying Liu, Qing-Jiang Zeng, Kai Sun, Xin Xue, Xiang Li, Ji-Ying Yang, Li-Hua An,Bai-He Hu, Jin-Hui Yang, Chuan-She Wang, Zhi-Xin Li, Lian-Yi Liu, Yan Li, Jun Zheng, Fu-Long Liao, Dong Han,Jing-Yu Fan, Jing-Yan Han Fang Wang Yu-Ying Liu Qing-Jiang Zeng Kai Sun Xin Xue Xiang Li Ji-Ying Yang Li-Hua An Bai-He Hu Jin-Hui Yang Chuan-She Wang Zhi-Xin Li Lian-Yi Liu Yan Li Jun Zheng Fu-Long Liao Dong Han Jing-Yu Fan Jing-Yan Han | 2008 | World Journal of Gastroenterology2008，14，1： | 17 |
| 5 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 6 | Total salvianolic acid improves ischemia-reperfusion-induced microcirculatory disturbance in rat mesentery显示文摘AIM:To investigate the effect of total salvianolic acid(TSA) on ischemia-reperfusion(I/R)-induced rat mesenteric microcirculatory dysfunctions.METHODS:Male Wistar rats were randomly distributed into 5 groups(n = 6 each):Sham group and I/R group(infused with saline),TSA group,TSA + I/R group and I/R + TSA group(infused with TSA,5 mg/kg per hour).Mesenteric I/R were conducted by a ligation of the mesenteric artery and vein(10 min) and subsequent release of the occlusion.TSA was continuously infused either starting from 10 min before the ischemia or 10 min after reperfusion.Changes in mesenteric microcirculatory variables,including diameter of venule,velocity of red blood cells in venule,leukocyte adhesion,free radicals released from venule,albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope.Meanwhile,the expression of adhesion molecules CD11b/CD18 on neutrophils was evaluated by flow cytometry.Ultrastructural evidence of mesenteric venules damage was assessed after microcirculation observation.RESULTS:I/R led to multiple responses in mesenteric post-capillary venules,including a significant increase in the adhesion of leukocytes,production of oxygen radicals in the venular wall,albumin efflux and enhanced mast cell degranulation in vivo.All the I/R-induced manifestations were significantly reduced by pre-or post-treatment with TSA,with the exception that the I/R-induced increase in mast cell degranulation was inhibited only by pre-treatment with TSA.Moreover,preor post-treatment with TSA significantly attenuated the expression of CD11b/CD18 on neutrophils,reducing the increase in the number of caveolae in the endothelial cells of mesentery post-capillary venules induced by I/R.CONCLUSION:The results demonstrated that TSA protects from and ameliorates the microcirculation disturbance induced by I/R,which was associated with TSA inhibiting the production of oxygen-free radicals in the venular wall and the expression of CD11b/CD18 on neutrophils. | Ming-Xia Wang Yu-Ying Liu Bai-He Hu Xiao-Hong Wei Xin Chang Kai Sun Jing-Yu Fan Fu-Long Liao ChuanShe Wang Jun Zheng Jing-Yan Han Ming-Xia Wang | 2010 | World Journal of Gastroenterology2010，16，42： | 15 |
| 7 | 儿童期接受双侧斜疝手术所致梗阻性无精子症的临床特征及治疗策略显示文摘儿童期斜疝手术是输精管梗阻的常见原因之一。输精管输精管吻合术可重建输精管道,使部分患者精液中可检出精子并自然受孕。与输精管结扎术后吻合术不同的是,斜疝术后输精管长期不通畅可导致继发性附睾梗阻。自2007年7月至2012年6月,共有62名幼时有双侧斜疝手术史的梗阻性无精子症患者在我中心接受治疗。总体再通率和自然妊娠率分别为56.5%(35/62)和25.8%(16/62)。48.4%(30/62)的患者接受腹股沟区的双侧VV吻合术,再通率和自然妊娠率分别为76.7%(23/30)和36.7%(11/30)。30.6%的患者由于附睾梗阻接受双侧VV吻合术和单/双侧输精管附睾显微吻合术,再通率和自然妊娠率分别降至63.2%(12/19)和26.3%(5/19)。21.O%(13/62)由于未查见输精管远侧断端仅接受精道探查术。我们的研究认为精道显微吻合是治疗儿童期斜疝手术所致梗阻性无精子症的有效方法。 | Xiang-Feng Chen Hong-Xiang Wang Yi-Dong Liu Kai Sun Li-Xin Zhou Yi-Ran Huang Zheng Li Ping Ping | 2014 | Asian Journal of Andrology2014，16，5： | 14 |
| 8 | Pollution characteristics of atmospheric dustfall and heavy metals in a typical inland heavy industry city in China显示文摘Through field sampling of atmospheric dustfall in regions of Zhuzhou City, China for a period of one year, the deposition fluxes of atmospheric dustfall and five heavy metals contained inside, including Cr, As, Cd, Hg and Pb, were analyzed. Meanwhile the enrichment factor and index methods were used to analyze the pollution characteristics of heavy metals of atmospheric dustfall in Zhuzhou. The annual deposition flux of atmospheric dustfall in Zhuzhou was 50.79 g/(m^2·year), while the annual deposition fluxes of Cr, As, Cd, Hg and Pb were 9.80, 59.69, 140.09, 0.87 and 1074.91 mg/(m^2·year), respectively.The pollution level of atmospheric dustfall in Zhuzhou was relatively lower compared with most other cities in China, but the deposition fluxes of As, Cd, Hg and Pb in atmospheric dustfall in Zhuzhou were much higher than that in most cities and regions around the world. Cd is the typical heavy metal element in atmospheric dustfall in Zhuzhou, and both the enrichment factor and pollution index of Cd were the highest. Cd, Hg, Pb and As in atmospheric dustfall were mainly from human activities. According to the single-factor index, Nemerow index and pollution load index analyses, the atmospheric dustfall in Zhuzhou could easily cause severe heavy metal pollution to urban soil, and the most polluting element was Cd, followed by Pb, As and Hg. Only the pollution level of Cr lay in the safety region and mainly originated from natural sources. | Jinhe Wang Xi Zhang Qing Yang Kai Zhang Yue Zheng Guanhua Zhou | 2018 | Journal of Environmental Sciences2018，30，9： | 14 |
| 9 | Survey for late-onset hypogonadism among old anti middle-aged males in Shanghai communities显示文摘这研究寻求了在上海社区在老、中年的男性调查迟了发作的性腺机能减退(LOH ) ,用症状 20 评估系统和性别荷尔蒙层次的大小。40-70 年的男性的 1000 个案例被调查。在使男性( ADAM )变老的变老的男症状( AMS )规模和雄激素缺乏问询表在调查的开始被使用,由性别的测量列在后面荷尔蒙相关的因素(全部的睾丸激素( TT ),免费睾丸激素(英尺),性别荷尔蒙绑定血球素( SHBG )和睾丸激素( Bio-T )的 bioavailability )。有 977 张有效问询表。AMS 和 ADAM 显示出的 LOH 积极的率是 59.88 %并且 84.65 %分别地;价值与病人的年龄增加了。与性别荷尔蒙大小有关有 946 结果,它显示出下列结果:TT 不与老化有关(P> 0.05 ) ;SHBG 的层次与年龄增加了;并且英尺和 Bio-T 与年龄减少了。在在 LOH 积极、 LOH 否定的病人之间的英尺有重要差别,作为由 ADAM 出现。在摘要,当英尺和 Bio-T 与老化减少了时, TT 层次不与老化有关,尽管 SHBG 确实增加了。临床上, LOH 的诊断不能基于浆液 TT 水平。 | Kai Sun GuoTQing Liang Xiang-Feng Chen Ping Ping Wen-Liang Yao Shi-Jun Zhang Bo Wang Ying-Hao Sun Zheng Li | 2012 | Asian Journal of Andrology2012，14，2： | 13 |
| 10 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 11 | Soil microbial community structure and function responses to successive planting of Eucalyptus显示文摘Many studies have shown soil degradation after the conversion of native forests to exotic Eucalyptus plantations. However, few studies have investigated the long-term impacts of short-rotation forestry practices on soil microorganisms. The impacts of Eucalyptus successive rotations on soil microbial communities were evaluated by comparing phospholipid fatty acid(PLFA) abundances,compositions, and enzyme activities of native Pinus massoniana plantations and adjacent 1st, 2nd, 3rd, 4th generation Eucalyptus plantations. The conversion from P. massoniana to Eucalyptus plantations significantly decreased soil microbial community size and enzyme activities, and increased microbial physiological stress. However, the PLFA abundances formed '∪' shaped quadratic functions with Eucalyptus plantation age. Alternatively, physiological stress biomarkers, the ratios of monounsaturated to saturated fatty acid and Gram+ to Gram- bacteria, formed '∩' shaped quadratic functions, and the ratio of cy17:0 to 16:1ω7c decreased with plantation age. The activities of phenol oxidase, peroxidase, and acid phosphatase increased with Eucalyptus plantation age, while the cellobiohydrolase activity formed '∪' shaped quadratic functions. Soil N:P, alkaline hydrolytic nitrogen, soil organic carbon, and understory cover largely explained the variation in PLFA profiles while soil N:P, alkaline hydrolytic nitrogen, and understory cover explained most of the variability in enzyme activity. In conclusion, soil microbial structure and function under Eucalyptus plantations were strongly impacted by plantation age. Most of the changes could be explained by altered soil resource availability and understory cover associated with successive planting of Eucalyptus. Our results highlight the importance of plantation age for assessing the impacts of plantation conversion as well as the importance of reducing disturbance for plantation management. | Falin Chen Hua Zheng Kai Zhang Zhiyun Ouyang Huailin Li Bing Wu Qian Shi | 2013 | Journal of Environmental Sciences2013，25，10： | 12 |
| 12 | Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats显示文摘AIM To observe the effect of herb-partitioned moxibustion(HPM) on expression of colonic cytokines in ulcerative colitis(UC) rats.METHODS A UC rat model was established by protein immunization in combination with topical chemical stimulation.Rats in the HPM group(n = 8) received HPM at bilateral Tianshu(ST25) points.The gross injury and pathological scores of the colon were recorded.The expression profile of colonic cytokines was assayed using the protein microarray technique.Specific differential cytokines were selected and verified by ELISA.The corresponding Uni Prot Accessions of the differentially expressed cytokines were retrieved in the Uni Prot database.The pathways involved were analyzed with the help of the KEGG PATHWAY database.The DAVID database was used for functional cluster and pathway analysis.RESULTS HPM improved colon injuries in UC rats,manifested by accelerated repair of ulcers and alleviation of inflammation,and the gross injury and pathological scores both significantly decreased(P < 0.01).Fold change > 1.3 or < 0.77 was taken as the screening standard.There were 77 down-regulated and 9 up-regulated differentially expressed colonic cytokines in the HPM group compared with the model group,and expression of 20 differed significantly(P < 0.05).Twelve of the 20 significantly differentially expressed cytokines [β-catenin,interleukin-1 receptor 6(IL-1 R6),IL-1β,B7-1,nerve growth factor receptor,AMP-activated protein kinase-α1,neuropilin-2,orexin A,adipocyte differentiation-related protein,IL-2,Fas and Fas L] were up-regulated in the model group(n = 3,compared with the normal group) but downregulated in the HPM group(n = 3,compared with the model group).Functional cluster analysis showed that the differentially expressed colonic cytokines in the HPM group regulated apoptosis and protein phosphorylation.KEGG pathway analysis showed that 52 down-regulated and 7 up-regulated differentially expressed colonic cytokines in the HPM group had pathways.The pathways that interacted between the cytokines and their receptors accounted for the largest proportion(28 of the downregulated and 5 of the up-regulated cytokines).CONCLUSION HPM promotes the repair of colon injuries in UC rats,which is related to the regulation of several abnormally expressed cytokines. | Dan Zhang Yan-Bo Ren Kai Wei Jue Hong Yan-Ting Yang Li-Jie Wu Ji Zhang Zheng Shi Huan-Gan Wu Xiao-Peng Ma | 2018 | World Journal of Gastroenterology2018，24，30： | 11 |
| 13 | Research progress in ZnO single-crystal:growth, scientific understanding, and device applications显示文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research. | Feng Huang Zhang Lin Wenwen Lin Jiye Zhang Kai Ding Yonghao Wang Qinghong Zheng Zhibing Zhan Fengbo Yan Dagui Chen Peiwen Lv Xian Wang | 2014 | Chinese Science Bulletin2014，59，12： | 11 |
| 14 | Unveiling the enigma of refractory carbon in the ocean显示文摘INTRODUCTION The ocean holds a tremendous reservoir of refractory dissolved organic carbon (RDOC)that plays an important role in carbon cycling and climate change [1].However,the origin of the RDOC has been an enigma for half a century. This perspective is to address why the enigma deserves scientific efforts and illustrate a robust scheme--the Microbial Carbon Pump (MCP)-to unveil the enigma from molecular to ecosystem levels,Through generation of intrinsic RDOC (RDOCt)under specific biotic and abiotic environmental conditions,as well as through derivation of diverse organic molecules at extremely low concentrations (RDOCc). | Nianzhi Jiao Ruanhong Cai Qiang Zheng Kai Tang Jihua Liu Fanglue Jiao Douglas Wallace Feng Chen Chao Li Rudolf Amann Ronald Benner Farooq Azam | 2018 | National Science Review2018，5，4： | 10 |
| 15 | Size distribution and source of heavy metals in particulate matter on the lead and zinc smelting affected area显示文摘In order to understand the size distribution and the main kind of heavy metals in particulate matter on the lead and zinc smelting affected area, particulate matter(PM) and the source samples were collected in Zhuzhou, Hunan Province from December 2011 to January 2012 and the results were discussed and interpreted. Atmospheric particles were collected with different sizes by a cascade impactor. The concentrations of heavy metals in atmospheric particles of different sizes, collected from the air and from factories, were measured using an inductively coupled plasma mass spectrometry(ICP-MS). The results indicated that the average concentration of PM, chromium(Cr), arsenic(As), cadmium(Cd) and lead(Pb) in PM was177.3 ± 33.2 μg/m^3, 37.3 ± 8.8 ng/m^3, 17.3 ± 8.1 ng/m^3, 4.8 ± 3.1 ng/m^3 and 141.6 ± 49.1 ng/m^3,respectively. The size distribution of PM displayed a bimodal distribution; the maximum PM size distribution was at 1.1–2.1 μm, followed by 9–10 μm. The size distribution of As, Cd and Pb in PM was similar to the distribution of the PM mass, with peaks observed at the range of1.1–2.1 μm and 9–10 μm ranges while for Cr, only a single-mode at 4.7–5.8 μm was observed. PM(64.7%), As(72.5%), Cd(72.2%) and Pb(75.8%) were associated with the fine mode below 2.1 μm,respectively, while Cr(46.6%) was associated with the coarse mode. The size distribution characteristics, enrichment factor, correlation coefficient values, source information and the analysis of source samples showed that As, Cd and Pb in PM were the typical heavy metal in lead and zinc smelting affected areas, which originated mainly from lead and zinc smelting sources. | Kai Zhang Fahe Chai Zilong Zheng Qing Yang Xuecai Zhong Khanneh Wadinga Fomba Guangzhu Zhou | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 16 | Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders显示文摘Orexins comprise two neuropeptides produced by orexin neurons in the lateral hypothalamus and are released by extensive projections of these neurons throughout the central nervous system. Orexins bind and activate their associated G protein-coupled orexin type 1 receptors(OX1Rs) and OX2Rs and act on numerous physiological processes, such as sleep-wake regulation, feeding, reward,emotion, and motivation. Research on the development of orexin receptor antagonists has dramatically increased with the approval of suvorexant for the treatment of primary insomnia. In the present review, we discuss recent findings on the involvement of the orexin system in the pathophysiology of psychiatric disorders, including sleep disorders,depression, anxiety, and drug addiction. We discuss the actions of orexin receptor antagonists, including selective OX1R antagonists (SORA1s), selective OX2R antagonists(SORA2s), and dual OX1/2R antagonists (DORAs), in the treatment of these disorders based on both preclinical and clinical evidence. SORA2s and DORAs have more pronounced efficacy in the treatment of sleep disorders,whereas SORA1s may be promising for the treatment of anxiety and drug addiction. We also discuss potential challenges and opportunities for the application of orexin receptor antagonists to clinical interventions. | Ying Han Kai Yuan Yongbo Zheng Lin Lu | 2020 | Neuroscience Bulletin2020，36，4： | 10 |
| 17 | Microbial aerosol characteristics in highly polluted and nearpristine environments featuring different climatic conditions显示文摘There is an increasing interest in understanding ambient bioaerosols due to their roles both in health and in climate. Here, we deployed an Ultraviolet Aerodynamic Particle Sizer to monitor viable(fluorescent) bioaerosol concentration levels at city centers(highly polluted) and their corresponding suburbs(near pristine)(total 40 locations) in 11 provinces featuring different climate zones in China between July 16 and 28, 2013. The concentration levels of viable bioaerosol particles(Bio PM) of [0.5 lm were measured, and corresponding percentages of Bio PM%(biological fraction of total PM) and Bio PM2.5%(biological fraction of PM2.5) in particulate matter(PM)and Bio PM, respectively, were determined. For some key cities, indoor viable bioaerosol levels were also obtained.In addition, bacterial structures of the air samples collected across these monitoring locations were studied using pyrosequencing. Bio PM concentration levels ranged from2.1 9 104 to 2.4 9 105/m3 for city centers [Bio PM% =6.4 %(±6.3 %)] and 0.5 9 104 to 4.7 9 105/m3 for suburbs [Bio PM% = 10 %(±8.7 %)]. Distinctive bioaerosol size distribution patterns were observed for different climate zones, e.g., some had fluorescence peaks at 3 lm, while the majority had peaks at 1 lm. Ambient bacterial aerosol community structures were also found different for different geophysical locations. Results suggest that there was a poor overall relationship between PM and Bio PM across 40 monitoring locations(R2= 0.081, two-tailed P value =0.07435). Generally, city centers had higher PM concentrations than suburbs, but not Bio PM and Bio PM%. Indoor bioaerosol levels were found at least tenfold higher than those corresponding outdoors. Bacillus was observed to dominate the bacterial aerosol community in the air sample. | Kai Wei Yunhao Zheng Jing Li Fangxia Shen Zhuanglei Zou Hanqing Fan Xinyue Li Chang-yu Wu Maosheng Yao | 2015 | Science Bulletin2015，60，16： | 10 |
| 18 | Biomass-derived porous carbon highly efficient for removal of Pb(Ⅱ) and Cd(Ⅱ)显示文摘The utilization of abundant and renewable biomass to fabricate advanced functional materials is considered a promising route for environmental applications.Herein,Lignin-based porous carbon with layered graphene-like structure(LPC)is successfully synthesized and applied to efficiently remove Pb(Ⅱ)and Cd(Ⅱ).The as-synthesized LPC materials are systematically characterized and these results show that LPC has a porous graphene-like structure,facilitating the diffusion and immobilization of heavy metal ions.The influence of different reaction parameters(solution pH,initial concentration of metal ions,contact time and adsorbent amount)on the adsorption performance is investigated in details.The results demonstrate that LPC can achieve superior adsorption capacities of 250.5 mg·g^-1 for Pb(Ⅱ)and 126.4 mg·g^-1 for Cd(Ⅱ),which are far superior to the previously reported adsorbents.Pseudo-second order kinetics model and Freundlich isotherm model describe the adsorption process well.Furthermore,the exhausted LPC can be regenerated easily and exhibits the removal efficiency of 96%and 92%for Pb(Ⅱ)and Cd(Ⅱ)after five continuous runs,respectively.This study shows a sustainable strategy for the design of porous carbon material from na?ve biomass and highlights the great potential in wastewater treatment. | Anqi Wang Zhikeng Zheng Ruiqi Li Di Hu Yiran Lu Huixia Luo Kai Yan | 2019 | Green Energy & Environment2019，4，4： | 10 |
| 19 | Hemolymphangioma: A rare differential diagnosis of cystic-solid or cystic tumors of the pancreas显示文摘We report a case of pancreatic hemolymphangioma. Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. The incidence of this disease in the pancreas is extremely rare. To the best of our knowledge, only seven cases have been reported worldwide (PubMed). A 39-year-old woman with a oneday history of abdominal pain was admitted to our hospital. There was no obvious precipitating factor. The preoperative examination, including ultrasonography and computed tomography, showed a cystic-solid tumor in the pancreas, and it was considered to be a mucinous cystadenoma or cystadenocarcinoma. Pancreaticbody-tail resection combined with splenectomy was performed. After the operation, the tumor was pathologically demonstrated to be a pancreatic hemolymphangioma. Although pancreatic hemolymphangioma is rare, we believe that it should be considered in the differential diagnosis of cystic-solid tumors of the pancreas, particularly when there is no sufficient evidence for diagnosing cystadenoma, cystadenocarcinoma or some other relatively common disease of the pancreas. | Fei Dong Yi Zheng Jian-Jun Wu Yan-Biao Fu Kai Jin Ming Chao | 2013 | World Journal of Gastroenterology2013，19，22： | 10 |
| 20 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
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