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| 1 | 中药九里香的研究进展显示文摘中药九里香始载于《岭南采药录》,其气香,味辛、微苦,具有行气止痛、活血散瘀之功效,用于胃痛、风湿痹痛,也可外用治疗牙痛、跌扑肿痛、虫蛇咬伤。历年出版的《中华人民共和国药典》中,除1985和1990年版外,其余各版均收录有九里香。其来源为芸香科植物九里香Murraya exotica L.和千里香Murraya paniculata(L.)Jack的干燥叶和带叶嫩枝。 | 梁海珍 刘冰语 屠鹏飞 姜勇 | 2016 | 中国医院用药评价与分析2016，16，11： | 10 |
| 2 | THE STRUCTURE OF ARMILLARIZIN,A NEW PROTOILLUDANE SESQUITERPENOID AROMATIC ESTER FROM ARMILLARIA MELLEA(VAHL.EX FR)QUEL.显示文摘A new protoilludane sesquiterpenoid aromatic ester,named armillarizin(1)has been isolated from the artificially cultured mycelium of Armillaria me-llea(Vahl.ex Fr)Quel.(Tricholomataceae).Its structure was deduced on the ba-sis of spectral analyses.The relative configuration was established from thenuclear Overhauser effects and from the values of ~1H-~1H coupling constants. | Jun Shan YANG Ya Lun SU Yu Lan WANG Xiao Zhang FENG De Quan YU Xiao Tian LIANG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,100050 | 1990 | Chinese Chemical Letters1990，1，2： | 8 |
| 3 | A NOVEL NEOLIGNAN, BIONDININ A, FROM MAGNOLIA BIONDII PAMP显示文摘A novel neolignan, biondinin A, was isolated from the flower buds of Magnolia biondii Pamp. The structure was established as 3,3’,4’- trimethoxy-4,9’-dihydroxy-6.8’,9-O-7’-neolignan. It is the first reported neolignan possessing the skeleton of benzo-oxa-cyclooctane. | | 1992 | Chinese Chemical Letters1992，3，2： | 1 |
| 4 | Correlation between expression of 1 α-hydroxylase and hypocalcaemia in rats with severe pancreatitis显示文摘Objective:To investigate the essential biochemical indices like 1-hydroxylase and hypocalcaemia in the rats with severe acute pancreatitis and explore the correlation between them.Methods:A total of 120 SPF grade Wistar male rats which were in similar physiological status were selected and randomly divided into two groups:sham group(SO group) and severe acute pancreatitis group(SAP group).Then they were divided into 1 h,3 h,6 h,and 12 h subgroups according to the killing lime.The severe acute pancreatitis model was established by retrograde injection of 5%sodium taurocholate.Serum calcium,serum creatinine,serum urea nitrogen and serum amylase were measured at different time.Serum 1,25 dihydroxy vitamin D3 level was determined by enzyme linked immunosorbentassay.The expression of 1-hydroxylase protein in the kidney tissue was determined with Western blotting and immunohistochemistry to observe its location.The pathologic features of the kidney tissue section was observed under light microscope and submicroscopic structure of the proximal convoluted tubule epithelial cell was observed under transmission electron microscope.Results:Compared with the SO group,rats in the SAP group showed continuous pathological injury as time went by.There was significant increase in serum creatinine,serum urea nitrogen and serum amylase in SAP group compared with the SO group 1,3,6,12 hours after the operation(P<0.05).There was significant decrease in serum calcium and 1,25 dihydroxy vitamin D3 3.6,12 hours after the operation(P<0.05).It also showed that the expression of the 1-hydroxylase protein in kidney tissues was upregulated at 1 h.3 h and decreased at 6h,12 h compared with the SO group.The serum calcium,1,25 dihydroxy vitamin D3 and the expression of the 1-hydroxylase protein in kidney tissues of the SAP group showed sustaining decrease.Western blotting showed positive correlation between the 1-hydroxylase expression and serum calcium at 3 h.6 h and 12 h(r=0.976,P<0.001;r=0.948.P<0.001;r=0.742,P=0.001) and also positive correlation between the 1-hydroxylase expression and serum1,25 dihydroxy vitamin D3 at 1 h,3 h,6 h and 12 h(r=0.935,P<0.001;r=0.952,P<0.001;r=0.917.P<0.001:r=0.874,P<0.001).Conclusions:At the early stage of the kidney injury,the expression of 1-hydroxylase in the kidney tissue is reduced with the progress of the disease and the decrease in its activity has a correlation with the hypocalcaemia. | Ping Zhou Li Chang Xiao-Hong Zhang You-Dai Chen Xuan-Lin Feng Lei Deng Jian-Dong Wang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 1 |
| 5 | LIQUID CRYSTAL POLYMERS WITH TWO-DIMENSIONAL MESOGENIC UNITS显示文摘A series of 'liquid crystal polymers with two-dimensional mesogeuic units' were synthesized by the polycondensations of the monomer 2, 5-dihydroxybenzylidene-4-phenetidine with a diacid chloride selected from a series of α, ω-bis(4-chloroformylphenyloxy)carbonylalkues. This is the first series of polymers reported under the newly proposed concept 'liquid crystal polymers with two dimensional mesogenic units'. | Qi Feng ZHOU~*, Zhi Cai Chemistry Department, Peking University, Beijing 100871 Robert W. LENZ Polymer Science & Engineering, University of Massschusetts, Amherst, MA 01003, USA | 1991 | Chinese Chemical Letters1991，2，8： | 1 |
| 6 | Naloxegol显示文摘由阿斯利康公司和Nektar生物医药公司联合开发的药物naloxegol于2014年9月16日获FDA批准上市[1],商品名为Movantik。该药为口服药物,属于外周μ-阿片受体拮抗剂,为纳洛酮的聚乙二醇化衍生物,临床上用于治疗慢性非癌性疼痛的成人患者因使用阿片类药物而引起的便秘。Naloxegol的中文化学名称:17-烯丙基-4,5α-环氧-3,14-二羟基-6α-(3,6,9,12,15,18,21-七氧代二十一烷-1-基)吗啡喃; | 李硕 郭春 | 2015 | 中国药物化学杂志2015，25，2： | 1 |
| 7 | NEW STEROIDAL CONSTITUENTS FROM AMALOCALYX YUNNANESIS----Ⅰ.显示文摘Two C21-steroids,named amalogenin A amd amaloside A were isola-ted from the rhizome of Amalocalyx yunnanesis.Their structures were estab-lished by analysis on the spectra of NMR including 1H-1H cosy,13C-1H COSYand confirmed by X-ray diffraction. | Ying Jie HU Xiao Ling SHEN,Laboratory of Phytochemistry,Southwest Forestry College,Kunming 650224 Quan Zhang MU,Laboratory of Phytochemistry,Kunming Institute of Botany,Academia Sinica Yang LU Qi Tai ZHENG Institute of Materia Medica,Chinese Academy of Medical Sciences. | 1991 | Chinese Chemical Letters1991，2，9： | 1 |
| 8 | RELATIONSHIP BETWEEN ACTIVITIES OF CYTOCHROME P-450 MONOOXYGENASES IN HUMAN PLACENTAL MICROSOMES AND BINDING OF BENZO(A)PYRENE METABOLITES TO CALF THYMUS DNA.显示文摘Benzo(a)pyrene metabolism in human placental microsomes fromsmokers was studied.Benzo(a)pyrene metabolites were separatedusing high pressure liquid chromatographic technique. Reactionof benzo(a)pyrene with microsomal fraction of placenta fromindividuals who smoke cigarette during pregnency yields 7。 | Ke Won Kang | 1991 | 癌变.畸变.突变1991，3，S1： | 0 |
| 9 | ^(13)C-NMR STUDIES OF DIOLS CONTAINING NUCLEIC ACID BASES AND THEIR O,O'-DIACETOXY DERIVATIVES显示文摘I. INTRODUCTION In our previous articles, we reported the synthesis of diol monomers such as 1,3-dihydroxy-2-methyl-2-propyl and β, β’-dihydroxyethyl derivatives of thymine and uracil and their polycondensation with the active diamides of benzotriazole such as 1, 1’-(isoph-thaloyl)bisbenzotriazole (IPBBT) and 1, 1’-(sebacoyl)bisbenzotriazole (SeBBT), | 陆承勋 朱新邨 潘景岐 肖朝东 杨扬 | 1987 | Chinese Science Bulletin1987，32，18： | 0 |
| 10 | Effect of long-term low-dose lα,25-dihydroxy vitamin D_3 on the expression of aquaporin 2 in kidneys of uremic rats显示文摘Objecfive To investigate the effect of long-term low-dose1α,25-dihydroxy vitamin D3[1,25(OH)2D3] on rat kidney aquaporin(AQP) 2 expression in 5/6 nephrectomized rats.Methods Twelve | 李红芬 | 2013 | China Medical Abstracts(Internal Medicine)2013，30，2： | 0 |
| 11 | STUDIES ON THE PRENYLFLAVONOIDS PART Ⅲ.SYNTHESIS OF(±)EUCHRENONE A_8显示文摘(±)Euchrenonc a8,7,2’-dihydroxy-8,5’-di(γ,γ-dimethylallyl)-4’-methoxyflavanone,hasbeen synthesized by the condensation of 2-hydroxy-4-methoxymethoxy-3-(γ,γ-dimethylallyl)acctophenonc with 4-methoxy-2-methoxymethoxy-5-(γ,γ-dimethylallyl)benzaldchyde followed bycyclization and demethoxymethylation. | Hua Wu SHAO Fang Jie ZHANG Yu Lin LI State key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 | 1993 | Chinese Chemical Letters1993，4，3： | 0 |
| 12 | TOTAL SYNTHESIS OF(+)-7-EPI-GONIDFUFURONE显示文摘First total synthesis of natural styryl-furone,(+)-7-epi-goniofufurone 1,from D-glycero-D-gulo-heptono-γ-lactone in eight steps(13%overall)is described.The absolute stereochemistry of 1 is confirmed. | Zhao Hui ZHOU Department of Chemistry,Xiamen University,Xiamen 361005 | 1993 | Chinese Chemical Letters1993，4，6： | 0 |
| 13 | SYNTHESIS AND CHARACTERIZATION OF POLYSULFONE-POLYESTER BLOCK COPOLYMERS显示文摘The synthesis and characterization of polysulfone (PSF)-polyester (PE) block copolymers were studied. Polysulfone-polyester block copolymers containing segments of PSF and PE (i.e. PPT, PBT, PHT, PDET, PTET) were synthesized by interaction of dihydroxy-alcohol (propanediol, butanediol, hexanediol, diethylene-glycol, triethylene-glycol) | 丁有骏 陈琦 | 1986 | Chinese Science Bulletin1986，31，7： | 0 |
| 14 | PARTIAL LEAST-SQUARES(PLS)REGRESSION AND SPECTROPHOTOMETRY AS APPLIED TO THE ANALYSIS OF MULTICOMPONENT MIXTURES显示文摘The UV absorption spectra of o-naphthol,α-naphthylamine,2,7-dihydroxy naphthalene,2,4-dimethoxy ben-zaldehyde and methyl salicylate,overlap severely;therefore it is impossible to determine them in mixtures bytraditional spectrophotometric methods.In this paper,the partial least-squares(PLS)regression is appliedto the simultaneous determination of these compounds in mixtures by UV spectrophtometry without anypretreatment of the samples.Ten synthetic mixture samples are analyzed by the proposed method.Themean recoveries are 99.4%,996%,100.2%,99.3% and 99.1%,and the relative standard deviations(RSD)are 1.87%,1.98%,1.94%,0.960% and 0.672%,respectively. | Xin An LIU Le Ming SHI Zhi Hong XU Zhong Xiao PAN Zhi Liang LI Ying GAO Laboratory No.502,Institute of Chemical Defense,Beijing 102205 Laboratory of Computer Chemistry,Institute of Chemical Metallurgy,Chinese Academy of Sciences,Beijing 100080 | 1991 | Chinese Chemical Letters1991，2，3： | 0 |
| 15 | STUDIES ON THE POLAROGRAPHIC ADSORPTIVE COMPLEX WAVES OF GERMANIUM-ALIZANRIN COMPLEXONE (ALC)显示文摘The polarographie adsorptive complex waves of rare earth-ALG, indium-ALC and gallium-ALG have been reported. The reaction between germanium and ALC has been studied by Nazarenko et al. using spectrophotometric method. In the present paper, the polarographic behaviors of germanium-ALC are studied. Three adsorptive complex waves of germanium-ALG have been obtained in NH3-NH4Cl buffer solution. The P4(Ep= -1.06V) is the most sensitive one among them. The limit of detection is 1 × 10-7M for germanium and the sensitivity is higher than photometry by one order. | 李南强 尚晓 | 1987 | Chinese Science Bulletin1987，32，5： | 0 |
| 16 | YUNNANXOL AND YUNNANXAHINE——TWO NEW TETRACYCLIC TAXANE DITERPENOIDS FROM TAXUS YUNNANENSIS显示文摘Two new tetracyclic taxane diterpenoids----yunnanxol(1)and yunnanxamine(2)have been isolated from the bark of Taxusyunnanensis Cheng et L.K.Fu.Their structures have been establishedfrom the spectral data,mainly from MS,highfield 1H NMR,1H-1H COSY,13C NMR,13C-1H COSY and 13C-1H COLOC spectroscopies. | Wei Ming CHEN Jin Yun ZHOU Pei Ling ZHANG Qi Cheng FANG Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050, | 1993 | Chinese Chemical Letters1993，4，8： | 0 |
| 17 | PREPARATION OF ENANTIOMERICALLY PURE SYN-4,5-DIHYDROXY CARBOXYLIC ACID LACTONES BY MICROBIAL REDUCTION显示文摘Enantiomerically pure syn-4,5-dihydroxy carboxylic acid lactones were prepared by microbial reduction of acyl lactones with resting cell of Aspergillus niger. | Jian Xin GU,Zu Yi LI,GUo Qiang LIN~* Shanghai Institute of Organic Chemistry,Academia Sinica 345 Lingling Lu,Shanghai 200032 | 1991 | Chinese Chemical Letters1991，2，5： | 0 |
| 18 | TOTAL SYNTHESIS OF 3α,4α-OXIDOAGAROFURAN AND (-)-3β,4α-DIHYDROXY-β-DIHYDROAGAROFURAN显示文摘TOTALSYNTHESISOF3α,4α-OXIDOAGAROFURANAND(-)-3β,4α-DIHYDROXY-β-DIHYDROAGAROFURANFaJunNAN;XinCHEN;ZhaoMingXIONG;TongShuangLI;Yu... | Fa Jun NAN Xin CHEN Zhao Ming XIONG Tong Shuang LI Yu Lin LI(State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000.) | 1994 | Chinese Chemical Letters1994，5，1： | 0 |
| 19 | PREPARATION AND CHARACTERISTICS OF MOLYBDENUM AND TUNGSTEN SQUARATE COMPLEXES显示文摘Squaric acid (3,4-dihydroxy-3-cyclobutene-1,2-dione) is a four-membered ring oxocarbon compound. The complexes of squaric acid with some divalent and trivalent metals have been investigated. No molybdenum and tungsten squarate complexes, however, have been reported. We have found that molybdenum and tungsten squarate complexes can be prepared under selected conditions. Three mmol of sodium tungstate dihydrate in 5 ml of water was mixed with | 徐民良 何艳贞 GORDON A. PARKBR | 1988 | Chinese Science Bulletin1988，33，22： | 0 |
| 20 | CLINICAL OBSERVATION AND TREATMENT OF HYPERKINESIA IN CHILDREN BY TRADITIONAL CHINESE MEDICINE显示文摘Sixty-six children with hyperkinesia were treated with the Yizhi (wit-increasing) syrup, af-ter which their scores on behavior dropped, their school records improved, and the rate of appearance of soft neurotic signs lowered, all three changes being significant, giving a total effectiveness rate of 84.8%. After the treatment, examination of the 24-hour urine showed significant increases in its content of norepinephrine (NE), dopamine (DA), 3-4 dihydroxy phenylacetic acid (DOPAC), cyclic adenosine monophosphate (cAMP), and creatinine (Cr). | 孙远岭 王玉润 瞿秀华 王骏彧 方军 章连 | 1994 | Journal of Traditional Chinese Medicine1994，14，2： | 0 |
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