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| 1 | 汉麻及剑麻纤维红外光谱研究显示文摘首先采用一维中红外(MIR)光谱开展了汉麻及剑麻纤维结构研究,实验发现:汉麻及剑麻纤维的一维MIR光谱吸收模式包括:νOH-一维、νas CH2-一维、νs CH2-一维、νC=O-一维、νC=C-一维、δCH2-一维和νC-O-一维。采用一维变温中红外(TD-MIR)光谱,进一步开展了汉麻及剑麻纤维的热稳定性研究,研究发现:在303 K^393 K的温度范围内,汉麻及剑麻纤维热稳定性进一步降低,并进一步进行了机理研究。研究开拓了一维MIR光谱及一维TD-MIR技术在重要的植物纤维(汉麻及剑麻纤维)结构及热稳定性的研究范围。 | 王维 张蕊 戎媛 王雪琪 吴士龙 齐哲真 刘昊雨 于宏伟 | 2020 | 纺织科学与工程学报2020，37，3： | 63 |
| 2 | Apoptosis and the target genes of microRNA-21显示文摘MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.Through functional suppression,miR-21 is implicated in practically every walk of oncogenic life:the promotion of cell proliferation,invasion and metastasis,genome instability and mutation,inflammation,replicative immortalization,abnormal metabolism,angiogenesis,and evading apoptosis,immune destruction,and growth suppressors.In particular,miR-21 is strongly involved in apoptosis.In this article,we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis.This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21. | Lindsey E.Becker Buscaglia | 2011 | Chinese Journal of Cancer2011，30，6： | 49 |
| 3 | MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘 | Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. | 2010 | 中国神经肿瘤杂志2010，8，1： | 37 |
| 4 | 网球拍吸汗带分子结构研究显示文摘采用中红外(MIR)光谱开展了网球拍吸汗带分子结构研究。实验发现3种网球拍吸汗带分子的中红外吸收模式主要包括:ν_(asCH3)、ν_(asCH2)、ν_(sCH3)、ν_(sCH2)、ν_(C=O)和ν_(C=C)。研究发现3种品牌网球拍吸汗带主要化学结构相同,均为聚氨酯。本项研究拓展了MIR光谱在体育纺织品领域的研究范围,具有重要的应用研究价值。 | 孟露 孙皓 秦佳慧 黄靖 贾涵 何宇涵 吴子腾 于宏伟 | 2022 | 纺织科学与工程学报2022，39，1： | 30 |
| 5 | miR-125b Confers Resistance of Ovarian Cancer Cells to Cisplatin by Targeting Pro-apoptotic Bcl-2 Antagonist Killer 1显示文摘Chemotherapy is the preferred therapeutic approach for advanced ovarian cancer,but a successful long-term treatment is prevented by the development of drug resistance.Recent works have underlined the involvement of non-coding RNAs,microRNAs(miRNAs) in cancer development,with several conjectures regarding their possible involvement in the evolution of drug resistance.This study is to investigate the promoting effects and mechanism of miR-125b involved in the development of chemoresistance in ovarian cancer.The different expression of miR-125b in cisplatin-sensitive ovarian cancer cell line(OV2008) and its resistant variant(C13*) was identified by real-time PCR.An in vitro cytotoxicity assay and apoptosis assay using CCK-8 assay and flow cytometry,were carried out to detect the effect of miR-125b and Bak1 on cisplatin resistance of cells.Real-time PCR,Western blotting and luciferase reporter assay were used to detect whether Bak1 is a target of miR-125b.As compared with OV2008 cells,the expression levels of miR-125b in C13* cells were increased.It was found that the up-regulation of microRNA-125b caused a marked inhibition of cisplatin-induced cytotoxicity and apoptosis and a subsequent increase in the resistance to cisplatin in OV2008 and C13* cells.Moreover,Bak1 was a direct target of miR-125b,and down-regulation of Bak1 suppressed cisplatin-induced apoptosis and led to an increased resistance to cisplatin.Our study indicates that miR-125b has a significantly promoting effect on chemoresistance of C13* cells and up-regulation of miR-125b expression contributes to cisplatin resistance through suppression of Bak1 expression.This finding has important implications in the development of targeted therapeutics for overcoming cisplatin resistance in ovarian cancer. | 孔繁飞 孙朝阳 王中显 韩凌斐 翁丹卉 卢运萍 陈刚 | 2011 | Journal of Huazhong University of Science and Technology(Medical Sciences)2011，31，4： | 19 |
| 6 | 阴沟肠杆菌Ⅰ类整合酶基因及质粒AmpC酶基因检测显示文摘目的明确我院临床分离的阴沟肠杆菌中Ⅰ类整合酶基因(intⅠ1)、qacE△1-sulⅠ基因和质粒Am鄄pC酶基因(AmpCMIR、AmpCDHA)存在状况。方法采用ATB药敏试验板微量肉汤法测定临床分离的20株阴沟肠杆菌对20种抗菌药物的敏感性,采用聚合酶链反应(PCR)技术检测耐药基因。结果该20株菌呈现多重耐药,对亚胺培南和美罗培南均敏感,对阿莫西林、阿莫西林/克拉维酸、头孢噻吩和头孢西丁完全耐药,头孢吡肟和复方新诺明的耐药率分别为25.0%和85.0%,对氨基糖苷类抗生素的耐药率在60.0%~90.0%之间,其余的耐药率在80.0%~95.0%之间。intⅠ1、qacE△1-sulⅠ、MIR和DHA基因的阳性株数(%)分别为19株(95.0%)、17株(85.0%)、17株(85.0%)、1株(5.0%)。结论我院临床分离的阴沟肠杆菌多重耐药严重,intⅠ1、qacE△1-sulⅠ和MIR基因携带率很高。在阴沟肠杆菌中检出intⅠ1、qacE△1-sulⅠ以及质粒型AmpCMIR基因在我国大陆均属首次报道。 | 黄支密 诸葛青云 糜祖煌 秦玲 陈榆 单浩 史伟峰 | 2005 | 江西医学检验2005，23，1： | 19 |
| 7 | 藤梨根有效组分抑制胃癌BGC-823细胞增殖与迁移作用的研究显示文摘目的研究藤梨根有效组分对胃癌BGC-823细胞的体外增殖、迁移能力的影响,并初步探讨其相关机制。方法利用不同浓度的藤梨根粗多糖与总三萜组合(熊果酸、齐墩果酸)处理细胞,MTT法检测细胞增殖活性,确定藤梨根有效组分最佳配比,划痕实验观察藤梨根有效组分对细胞运动能力的影响,Transwell小室模型研究其对细胞迁移能力的影响,基因芯片分析抑制BGC-823细胞增殖与迁移相关基因表达,qPCR检测miR-630基因的表达水平。结果与空白对照组相比,当藤梨根粗多糖的浓度为0.5g/L,熊果酸与齐墩果酸的浓度比为8∶1,各成分之间具有强协同作用,确定为藤梨根有效组分,其可显著抑制BGC-823细胞增殖与迁移,基因芯片分析和qPCR结果表明与其增加miR-630表达相关。结论藤梨根有效组分能显著抑制胃癌BGC-823细胞的体外增殖和迁移能力,其机制可能与miR-630的表达水平增加有关。 | 徐楚韵 张光霁 楼招欢 徐浩 申力 | 2018 | 南京中医药大学学报2018，34，6： | 19 |
| 8 | Circulating micro RNA, mi R-122 and mi R-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma显示文摘AIM: To explore the potential usefulness of serum miR-122 and miR-221 as non-invasive diagnostic markers of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS: This prospective study was conducted on 90 adult patients of both sex with HCV-related chronic liver disease and chronic hepatitis C related HCC. In addition to the 10 healthy control individuals, patients were stratified into; interferon-na?ve chronic hepatitis C(CH)(n = 30), post-hepatitis C compensated cirrhosis(LC)(n = 30) and treatment-naive HCC(n = 30). All patients and controls underwent full clinical assessment and laboratory investigations in addition to the evaluation of the level of serum miR NA expression by RT-PCR.RESULTS: There was a significant fold change in serum mi RNA expression in the different patient groups when compared to normal controls; mi R-122 showed significant fold increasing in both CH and HCC and significant fold decrease in LC. On the other hand, mi R-221 showed significant fold elevation in both CH and LC groups and significant fold decrease in HCC group(P = 0.01). Comparing fold changes in miR NAs in HCC group vs non HCC group(CH and Cirrhosis), there was non-significant fold elevation in miR-122(P = 0.21) and significant fold decreasing in miR-221 in HCC vs non-HCC(P = 0.03). ROC curve analysis for miR-221 yielded 87% sensitivity and 40% specificity for the differentiation of HCC patients from non-HCC at a cutoff 1.82. CONCLUSION: Serum miR-221 has a strong potential to serve as one of the novel non-invasive biomarkers of HCC. | Hassan El-Garem Ayman Ammer Hany Shehab Olfat Shaker Mohammed Anwer Wafaa El-Akel Heba Omar | 2014 | World Journal of Hepatology2014，6，11： | 18 |
| 9 | miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines显示文摘化疗是为 colorectal 腺癌癌症的重要治疗;然而, colorectal 腺癌房间经常开发抵抗到化学疗法的药,导致恶化和差的耐心的预后。药抵抗的发展经常是一个 multifactor 过程,它包含了几基因和细胞的机制。microRNAs 是否定地在 post-transcriptional 水平调整基因表示的内长的小非编码的 RNA。在现在的学习,我们在调整 colorectal 腺癌房间 SW620 和 SW480 的药敏感调查了 microRNAs 的可能的角色。使用 microRNA 表达式数组和我们发现了房间展出了的那 SW620 的量的反向的 transcriptase (RT )-PCR, 与 SW480 房间相比提高了 miR-20a 表示。另外,这二房间行显示了不同敏感到化学疗法的药氟尿嘧啶, oxaliplatin,和 teniposide。miR-20a 的调整改变了 SW620 和 SW480 房间的敏感到这些药;miR-20a 击倒敏化的 SW620 房间到化学疗法的代理人,而在 SW480 房间的 miR-20a 的 overexpression 导致了 chemoresistance。内长的 BNIP2 mRNA 和 BNIP2 蛋白质层次是相反地由量的 RT-PCR 和西方的污点分析与是的 miR-20a 层次有关检测了。荧光记者试金显示出在 miR-20a 和 BNIP2 3UTR 之间的一个直接相互作用。一起拿,我们的调查结果建议 miR-20a 可以在 colorectal 腺癌癌症房间药抵抗起一个作用并且可以是对在 colorectal 腺癌的化疗药抵抗的一个治疗学的目标。 | Huijuan Chai Min Liu Ruiqing Tian Xin Li Hua Tang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 18 |
| 10 | Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene显示文摘AIM:To evaluate the biological and clinical characteristics of miR-622 in gastric cancer. METHODS:We analyzed the expression of miR-622 in 57 pair matched gastric neoplastic and adjacent non-neoplastic tissues by quantitative real-time polymerase chain reaction. Functional analysis of miR-622 expression was assessed in vitro in gastric cancer cell lines with miR-622 precursor and inhibitor. The roles of miR-622 in tumorigenesis and tumor metastasis were analyzed using a stable miR-622 expression plasmid in nude mice. A luciferase reporter assay was used to assess the effect of miR-622 on inhibitor of growth family,member 1 (ING1) expression. RESULTS:Expression of miR-622 was down-regulated in gastric cancer. MiR-622 was found involved in differentia-tion and lymphatic metastasis in human gastric cancer. Ectopic expression of miR-622 promoted invasion,tumorigenesis and metastasis of gastric cancer cells both in vitro and in vivo. ING1 is a direct target of miR-622. CONCLUSION:These findings help clarify the molecular mechanisms involved in gastric cancer metastasis and indicate that miR-622 modulation may be a bona fide treatment of gastric cancer. | Xiao-Bo Guo Chang-Qing Jing Le-Ping Li Li Zhang Yu- Long Shi Jin-Shen Wang Jing-Lei Liu Chen-Sheng Li | 2011 | World Journal of Gastroenterology2011，17，14： | 16 |
| 11 | 白头翁汤对溃疡性结肠炎小鼠肠道miR-19a表达的影响显示文摘目的通过观察疾病活动指数(DAI)、组织病理学变化,研究白头翁汤对小鼠实验性溃疡性结肠炎的治疗作用,并进一步研究miR-19a的表达,探讨其治疗作用的可能机制。方法选取40只c57小鼠,随机等分为4组(10只/组):正常对照组、模型组(DSS)、治疗组(DSS+白头翁汤)和阳性对照组(DSS+5-ASA)。给予各模型组小鼠自由饮用3.5%DSS溶液以及相应药物灌胃,正常对照组自由饮用同等量的饮用水。每天观察并记录DAI评分,7 d后处死小鼠,取肠道炎症组织观察病理变化。RT-qPCR方法检测miR-19a表达变化。结果模型组小鼠的DAI评分及病理学评分显著高于对照组。DSS+白头翁汤组的DAI评分及病理学评分显著低于DSS模型组,说明白头翁汤对于小鼠实验性溃疡性结肠炎有一定的疗效。模型组miR-19a的表达显著低于对照组,DSS+白头翁汤组miR-19a的表达显著高于DSS模型组,提示白头翁汤可以通过增加miR-19a的表达而起到减轻炎症的作用。结论白头翁汤对于小鼠实验性溃疡性结肠炎有一定的疗效,可能通过增加miR-19a的表达而发挥作用。 | 周鹏志 刘凤斌 罗琦 孙嫣 丁飞跃 陈斌 | 2012 | 南方医科大学学报2012，32，11： | 16 |
| 12 | 腹腔镜和开腹手术方式治疗低位直肠癌的疗效对比及对血浆miR-21表达水平的影响显示文摘目的探讨腹腔镜和开腹手术方式治疗治疗低位直肠癌的疗效对比及对血浆miR-21表达水平的影响。方法选择2011年2月至2015年2月收治的低位直肠癌患者120例,按照患者治疗意愿分为腹腔镜手术组和开腹手术组,每组60例。使用RT-PCR方法检测两组患者治疗前后血浆miR-21表达水平变化。对比分析两组患者术后近期效果和血浆miR-21表达水平的差异,并分析一年后的预后结果。结果腹腔镜组患者手术时间、术中出血量、腹壁切口长度、术后肛门排气时间、进流食时间、留置尿管时间、术后下床活动时间、术后住院时间、术后使用镇痛剂人数、术中或术后输血人数等均明显优于开腹组患者,差异均有统计学意义(P<0.05);腹腔镜组患者手术后并发症发生率为5.0%,明显低于开腹组的23.33%,差异有统计学意义(P<0.05)。两组患者治疗后血浆miR-21表达水平均明显下降(P<0.05),腹腔镜组下降结果明显优于对照组(P<0.05)。1年后的预后结果表明,腹腔镜组在术后肿瘤致死率、复发率和一年生存率上显著优于开腹组(P<0.05)。结论腹腔镜手术治疗低位直肠癌效果明显优于开腹手术治疗,且患者血浆miR-21表达水平可能成为预测腹腔镜手术治疗效果的敏感性指标。 | 陈振伟 黄卫华 徐勇 桑洁 | 2017 | 临床和实验医学杂志2017，16，6： | 15 |
| 13 | miR-137靶向下调SETD7表达对缺氧复氧诱导的心肌细胞氧化应激的影响研究显示文摘目的探讨miR 137对缺氧复氧诱导的心肌细胞损伤的作用及其机制。方法心肌细胞H9C2分为空白组、缺氧复氧组、缺氧复氧组+miR con、缺氧复氧+miR 137组、缺氧复氧+miR 137+pcDNA组、缺氧复氧+miR 137+pcDNA SETD7组。qPCR检测H9C2细胞中miR 137和SETD7 mRNA表达,Western blot检测SETD7、Cyclin D1、Cleaved Caspase 3蛋白表达,MTT法检测细胞增殖,比色法检测LDH、MDA水平,流式细胞仪检测细胞凋亡,TargetScan预测结合双荧光素酶报告实验分析miR 137和SETD7的靶向关系。结果缺氧复氧明显降低H9C2细胞中miR 137、Cyclin D1表达量和细胞存活率(P<0.05),显著提高SETD7 mRNA及蛋白水平、LDH活性、MDA含量、Cleaved Caspase 3蛋白水平和细胞凋亡率(P<0.05)。上调miR 137表达促进缺氧复氧处理H9C2细胞内miR 137、Cyclin D1表达量和细胞存活率(P<0.05),明显降低SETD7蛋白、LDH、MDA、Cleaved Caspase 3水平和细胞凋亡率(P<0.05)。miR 137靶向调控SETD7表达。过表达SETD7部分逆转miR 137保护缺氧复氧处理H9C2细胞的作用。结论miR 137通过靶向下调SETD7表达来促进缺氧复氧处理的心肌细胞增殖并抑制细胞凋亡,保护缺氧复氧诱导的心肌细胞氧化应激损伤。 | 王彦利 李纪明 罗进光 | 2019 | 分子诊断与治疗杂志2019，11，6： | 13 |
| 14 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 15 | Silicon photonic platforms for mid-infrared applications [Invited]显示文摘Silicon photonic integrated circuits for telecommunication and data centers have been well studied in the past decade, and now most related efforts have been progressing toward commercialization. Scaling up the silicon-oninsulator(SOI)-based device dimensions in order to extend the operation wavelength to the short mid-infrared(MIR) range(2–4 μm) is attracting research interest, owing to the host of potential applications in lab-on-chip sensors, free space communications, and much more. Other material systems and technology platforms, including silicon-on-silicon nitride, germanium-on-silicon, germanium-on-SOI, germanium-on-silicon nitride, sapphireon-silicon, Si Ge alloy-on-silicon, and aluminum nitride-on-insulator are explored as well in order to realize low-loss waveguide devices for different MIR wavelengths. In this paper, we will comprehensively review silicon photonics for MIR applications, with regard to the state-of-the-art achievements from various device demonstrations in different material platforms by various groups. We will then introduce in detail of our institute's research and development efforts on the MIR photonic platforms as one case study. Meanwhile, we will discuss the integration schemes along with remaining challenges in devices(e.g., light source) and integration. A few application-oriented examples will be examined to illustrate the issues needing a critical solution toward the final production path(e.g., gas sensors). Finally, we will provide our assessment of the outlook of potential futureresearch topics and engineering challenges along with opportunities. | TING HU BOWEI DONG XIANSHU LUO TSUNG-YANG LIOW JUNFENG SONG CHENGKUO LEE GUO-QIANG LO | 2017 | Photonics Research2017，5，5： | 13 |
| 16 | miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β显示文摘miR-142 和 miR-223 作为造血的特定的 microRNAs 被识别了。miR-223 在 myeloid 系开发有关键功能。然而, miR-142 的功能仍然保持不清楚。在这研究,我们发现那 miR-142, miR-223 稀释了造血的房间,和那 miR-223 的增长通过 LMO2-L/-S isoforms 和 CEBP- 尾的起来调整的 miR-142 表示。miR-223 否定地 post-transcriptionally 调整了 LMO2-L/-S isoforms 和 CEBP- 尾,当 CEBP- 尾断然调整了 LMO2-L/-S isoforms 并且否定地两个都 LMO2-L/-S isoforms 调整了 miR-142 时。这些结果揭示一条新奇 miR-223 鈥擟E BP-尾鈥擫M O2 鈥攎i R-142 规章的小径,它在造血作用有枢轴的功能。 | Wei Sun Wenwen Shen Shuang Yang Fen Hu Huihui Li Tian-Hui Zhu | 2010 | Cell Research2010，20，10： | 12 |
| 17 | 血浆miR-192、miR-29c水平对2型糖尿病肾病诊断的临床意义显示文摘目的探讨血浆微小RNA 192(miR 192)与微小RNA 29c(miR 29c)联合检测对2型糖尿病肾病的诊断价值。方法选取2017年12月至2018年12月本院收治的166例2型糖尿病患者为研究对象,分为糖尿病无肾损害组(DM组)与糖尿病肾病组(DN组),同时以同时期本院健康体检健康人群60例为正常对照组(NC组)。采用实时荧光定量聚合酶链反应(qRT PCR)检测各组血浆miR 192、miR 29c的表达水平;采用酶联免疫吸附法(ELISA)检测尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平;采用Pearson法分析DN患者血浆miR 192、miR 29c与NGAL的相关性;采用受试者工作特征曲线(ROC)分析血浆miR 192、miR 29c表达对DN的诊断价值;分析血浆miR 192、miR 29c联合诊断DN的诊断效能。结果与NC组比较,DM组与DN组患者尿NGAL水平、miR 29c的表达水平显著升高(P<0.05),DN组显著高于DM组(P<0.05);与NC组相比,DM组与DN组患者血浆miR 192的表达水平均显著降低(P<0.05),DN组显著低于DM组(P<0.05);miR 192与尿NGAL呈负相关(r=-0.338,P=0.002),miR 29c与尿NGAL呈正相关(r=0.516,P<0.001);miR 192诊断DN的灵敏度52.50%,特异度75.58%;miR 29c诊断DN的灵敏度50.00%,特异度86.05%;联合诊断灵敏度97.50%,特异度95.34%,准确度为96.39%;联合检测时灵敏度与准确度均高于单项检测(P<0.05)。结论血浆miR 192、miR 29c表达异常与2型糖尿病肾病发生发展密切相关,二者联合检测可提高2型糖尿病肾病诊断效能。 | 何爽 黄萍 范明娟 | 2019 | 分子诊断与治疗杂志2019，11，6： | 11 |
| 18 | 单硬脂酸甘油酯中红外光谱研究显示文摘采用中红外(MIR)光谱研究了单硬脂酸甘油酯分子的结构。实验发现:单硬脂酸甘油酯分子的红外吸收模式主要包括:ν_(asCH_(3)-单硬脂酸甘油酯)、ν_(sCH_(3)-单硬脂酸甘油酯)、ν_(asCH_(2)-单硬脂酸甘油酯)、ν_(sCH_(2)-单硬脂酸甘油酯)、ν_(C=O-单硬脂酸甘油酯)、δ_(CH_(2)-单硬脂酸甘油酯)、δ_(sCH_(3)-单硬脂酸甘油酯)和γ_(CH_(2)-单硬脂酸甘油酯)。进一步开展了单硬脂酸甘油酯分子的变温中红外(TD-MIR)光谱研究。实验发现:随着测定温度的升高(303~393 K),单硬脂酸甘油酯分子主要官能团对应的红外吸收频率及强度均有明显的改变,并进一步进行了相关机理的研究。 | 于宏伟 王晓萱 李佳欣 张紫婷 韩明达 贺璇儿 | 2021 | 塑料助剂2021，，4： | 9 |
| 19 | 胶质纤维酸性蛋白(GFAP)在神经系统中的研究进展显示文摘 | 邓莉 袁琼兰 | 2005 | 泸州医学院学报2005，28，2： | 8 |
| 20 | CEA、NSE、SCCA联合miR-21检测与肺癌患者临床病理特征、疗效及预后的相关性研究显示文摘目的研究癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、鳞状上皮癌细胞抗原(SCCA)联合miR 21检测与肺癌患者临床病理特征、疗效及预后的相关性。方法选择87例肺癌患者作为实验组和同期体检的健康人作为对照组,采用电化学发光免疫法检测各组患者血清中CEA、NSE、SCCA的表达,实时定量PCR检测血清中miR 21的表达,治疗前分析肿瘤标志物CEA、NSE、SCCA及miR 21与肺癌患者中的性别、年龄、病理类型及TNM分期临床病理特征的相关性,治疗后分析与疗效及预后的相关性。结果①与对照组相比,实验组患者CEA、NSE、SCCA及miR 21的表达水平显著升高,差异有统计学意义(P<0.05);②CEA、SCCA、miR 21的表达水平与肺癌患者临床病理特征无关,差异无统计学意义(P>0.05),NSE与肺癌的TNM分期相关,差异有统计学意义(P<0.05);③CEA、NSE、SCCA及miR 21的表达水平与疗效相关,差异有统计学意义(P<0.05);④生存曲线显示,CEA、NSE、SCCA及miR 21的表达水平与患者生存预后相关,差异有统计学意义(P<0.05);⑤4种指标联合诊断肺癌的灵敏度显著优于单项指标,差异有统计学意义(P<0.05)。结论肺癌患者血清中CEA、NSE、SCCA和miR 21的表达水平显著高于正常人,可作为肺癌的诊断、疗效及预后的指标。 | 汤乔雅 宫郡茗 马艳凌 | 2019 | 分子诊断与治疗杂志2019，11，6： | 8 |
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