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| 1 | Mechanism of arterial remodeling in chronic allograft vasculopathy显示文摘Chronic allograft vasculopathy(CAV)remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years.CAV is characterized by concentric and diffuse neointimal formation,medial apoptosis,infiltration of lymphocyte or inflammatory cells,and deposition of extracellular matrix both in arteries and veins.Recent studies have shown that stem cells derived from the recipient contribute to neointimal formation under the regulation of chemokines and cytokines.Arterial remodeling in allografts eventually causes ischemic graft failure.The pathogenesis is multi-factorial with both immunologic and non-immunological factors being involved.The immunological factors have been discussed extensively in other articles.This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury,accumulation of smooth muscle-like cells in the neointimal,medial smooth muscle cell apoptosis,adventitial fibrosis,and deposition of extracellular matrix. | Qichang Zheng Shanglong Liu Zifang Song | 2011 | Frontiers of Medicine2011，5，3： | 0 |
| 2 | Angiotensin-converting-enzyme Inhibitors in Treatment of Atherosclerotic Peripheral Arterial Disease显示文摘Objective To evaluate the treatment efficacy of perindopril in correcting endothelial dysfunction in patients with atherosclerotic peripheral arterial disease(PAD).Methods 85 patients with atherosclerotic PAD were divided into 3 groups and undergone endotheliotropic treatment with perindopril.The functional state of endothelium(FSE)was evaluated in all patients by checking the following biochemical parameters:nitric oxide(Ⅱ)(NO),endothelin-1(E-1),C-reactive protein(CRP),superoxide dismutase(SOD),integral assessment of lipid peroxidation(LPO),glutathione peroxidase(GPx).Results Basal level of NO secretion in operated patients was the lowest.SOD level in operated patients increased by 102.7%,143.24%,164.86%and 175.67%directly after the operation as well as 1,3 and 6 months following the surgery respectively,but E-1 level decreased by 82%,70%,78%,and 90%.The results of GPx level and LPO analysis confirmed favorable effects of perindopril on biochemical status in patients with atherosclerotic PAD.Conclusion Perindopril is effective in stimulating NO(Ⅱ)secretion and correcting FSE.Perindopril may be used for prophylaxis of restenosis of reconstruction area following operative treatment in patients with atherosclerotic PAD. | I.A.SUCHKOV R.E.KALININ | 2013 | 宁夏医科大学学报2013，35，7： | 0 |
| 3 | Endovascular Irradiation Prevents Sm ooth Muscle CellPro-liferation and Neointim alHyperplasia in Rabbits显示文摘The present study examined the temporal responses and the efficacy of 192Ir HDR endovascular irradiation for preventing smooth muscle cell proliferation of rabbit iliac arteries after PTA with a cutting balloon catheter. Endovascular irradiation with 12 Gy was randomly performed on the one side of iliac arterial segment with the unirradiated side serving as a control. Animals were euthanatized 1, 2, 3, 4, 8 and 12 week(s) after angioplasty. Histopathological and immunohistochemical studies were carried out. Histopathology showed repair of the dissection by cellular accumulation and a striking reduction in the amount of neointimal hyperplasia in the irradiated arteries as compared with control vessels. A peak of PCNA positive ratio was in neointima of the control arterial segments at a week. 2 - 4 weeks after irradiation, the neointimal PCNA positive ratio was still significantly increased in the control arterial segments compared with the irradiated arterial segments. After 8 weeks, PCNA positive ratio was below 1 % in both irradiated arterial segments and the control. Our results showed that the 192Ir HDR afterloading irradiation with a dose of 12 Gy can be considered sufficient for inhibiting neointimal hyperplasia in angioplastized rabbit iliac arteries with cutting balloon catheter. | XU Linfeng 1, WU Yudan 2, FENG Gansheng 1 1 Department of Radiology, Xiehe Hospital, Tongji Medical University, Wuhan 430030 2Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan 430030 Oguchi M, Yokota H, Nakagawa T, Yam | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 0 |
| 4 | The Origin of Neointimal Smooth Muscle Cells in Transplant Arteriosclerosis from Recipient Bone-marrow Cells in Rat Aortic Allograft显示文摘In order to investigate the origin of neointimal smooth muscle cells in transplant arterio- sclerosis in rat aortic allograft, sex-mismatched bone marrow transplantation was performed from male Wistar rats to female Wistar rats. Four weeks after transplantation, the aortic transplant model was established by means of micro-surgery in rats. The recipients were divided into 4 groups: female Wistar-female Wistar aortic isografts, female SD-female Wistar aortic allografts, male SD-male Wis- tar aortic allografts, female SD-chimera Wistar aortic allografts. Eight weeks after transplantation, aortic grafts were removed at autopsy and processed for histological evaluation and immunohisto- chemistry. The results indicated that excessive accumulation of α-SMA-positive smooth muscle cells resulted in significant neointima formation and vascular lumen stricture in rat aortic allografts. Neointima assay revealed that the neointimal area and NIA/MA ratio of transplanted artery were sig- nificantly increased in all of aortic allograft groups as compared with those in aortic isograft group (P<0.01). Neointimal smooth muscle cells were harvested from cryostat sections of aortic allograft by microdissection method. The Sry gene-specific PCR was performed, and the result showed that a dis- tinct DNA band of 225 bp emerged in the male-male aortic allograft group and chimera aortic al- lograft group respectively, but not in the female-female aortic allograft group. It was suggested that recipient bone-marrow cells, as the origin of neointimal smooth muscle cells, contributed to the pathological neointimal hyperplasia of aortic allograft and transplant arteriosclerosis. | 宋自芳 李伟 郑启昌 尚丹 舒晓刚 管思明 | 2007 | Journal of Huazhong University of Science and Technology(Medical Sciences)2007，27，3： | 0 |
| 5 | Very late thrombosis 12 years after bare metal stent deployment显示文摘Percutaneous coronary intervention (PCI) is currentlythe most commonly used revascularization techniquein the management of symptomatic coronary disease.However, late stent thrombosis (LST) and in-stentrestenosis (ISR) are the most serious late complicationrelated to PCI. Traditionally, intimal hyperplasia afterbare metal stent (BMS) implantation has been consideredstable, with an early peak between 6 months and 1 yearand a late quiescent period thereafter. Recent studies havereported that one-third of the patients with ISR after BMSimplantation presented with acute coronary syndrome(ACS), which is not regarded as clinically benign. Seung-Jung et alj reported that in-stent neoatherosclerosis is thefinal common pathway of late stent failure. Here we reporta patient presenting ACS in whom intravascular ultrasound(IVUS) imaging showed very late thrombosis due toatheromatous changes and neointima plaque rupture 12years after BMS implantation. | | 2014 | Chinese Medical Journal2014，，6： | 0 |
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