|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection显示文摘Esophageal cancer (EC) is one of the most deadly malignant diseases. Several studies revealed that variations of the phospholipase C epsilon 1 (PLCE1) gene were associated with EC susceptibility. PLCE1 is located downstream of the epidermal growth factor receptor (EGFR) pathway. Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclea匚 In this study, the associations between genetic variants in the EGFR/PLCE1 pathway and prognosis in 124 esophageal squamous cell carcinoma (ESCC) patients with radical resection were explored. The results showed that CC genotype of both PLCE1 rsl7109671 and EGFR rs2072454 was associated with ESCC prognosis. Multivariate analysis revealed that patients with the two unfavorable genotypes had the worst overall survival (OS) or disease-free survival (DFS)(HR=6.099, 95%CI=1.903-19.552;HR=3.994, 95%CI=1.49-10.702, respectively). Additionally, combination of SNPs and tumor stage could better predict OS (for AUC, 0.774 vs. 0.709) and PFS (for AUC, 0.773 vs. 0.704) than tumor stage alone.In conclusion, genetic variants of the EGFR/PLCE1 may be predictors of the prognosis of ESCC after surgery. The individuals with the CC genotype of PLCE1 rsl7109671 and EGFR rs2072454 should receive more aggressive treatments. | Yu-li WANG Ye YUAN Xiao-xiao LUO Guang-yuan HU Ping G0NG | 2019 | Current Medical Science2019，39，3： | 7 |
| 2 | 白地霉净化和资源化玉米淀粉工业废水的试验条件研究显示文摘玉米淀粉工业废水是高浓度有机废水.利用其培养白地霉不仅可以净化玉米淀粉废水,还可以收获有用的菌体蛋白.研究表明当白地霉净化和资源化玉米淀粉废水的最佳条件为:不经灭菌处理的废水中添加0.1%KH2PO4、24 h振荡培养白地霉时,玉米淀粉废水的COD去除率为90%以上,每吨玉米淀粉废水可收获干燥SCP 1.6 kg以上,净化后废水的pH值为7左右. | 李玉 李其久 尹依婷 李毅然 魏伯峰 王小禹 李素玉 | 2008 | 辽宁大学学报(自然科学版)2008，35，1： | 6 |
| 3 | VASC: Dimension Reduction and Visualization of Single-cell RNA-seq Data by Deep Variational Autoencoder显示文摘Single-cell RNA sequencing(scRNA-seq) is a powerful technique to analyze the transcriptomic heterogeneities at the single cell level. It is an important step for studying cell subpopulations and lineages, with an effective low-dimensional representation and visualization of the original scRNA-Seq data. At the single cell level, the transcriptional fluctuations are much larger than the average of a cell population, and the low amount of RNA transcripts will increase the rate of technical dropout events. Therefore, scRNA-seq data are much noisier than traditional bulk RNA-seq data. In this study, we proposed the deep variational autoencoder for scRNA-seq data(VASC), a deep multi-layer generative model, for the unsupervised dimension reduction and visualization of scRNA-seq data. VASC can explicitly model the dropout events and find the nonlinear hierarchical feature representations of the original data. Tested on over 20 datasets, VASC shows superior performances in most cases and exhibits broader dataset compatibility compared to four state-of-the-art dimension reduction and visualization methods. In addition, VASC provides better representations for very rare cell populations in the 2D visualization. As a case study, VASC successfully re-establishes the cell dynamics in pre-implantation embryos and identifies several candidate marker genes associated with early embryo development. Moreover, VASC also performs well on a 10× Genomics dataset with more cells and higher dropout rate. | Dongfang Wang Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，5： | 5 |
| 4 | Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level显示文摘Alzheimer’s disease cannot be cured as of yet.Our current understanding on the causes of Alzheimer’s disease is limited.To develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are crucial.In recent years,Alzheimer’s disease research underwent a paradigm shift.According to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the pathology.Knowledge on every cell type adds an alternative approach and hope for the efforts towards the treatment.Neural stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy individuals.Therefore,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for clinics.However,this provocative idea requires further evidence and tools for investigation.Recently,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s disease.In this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research. | Mehmet Ilyas Cosacak Prabesh Bhattarai Caghan Kizil | 2020 | Neural Regeneration Research2020，15，5： | 4 |
| 5 | Comet assay and cytokinesis-blocked micronucleus test for monitoring the genotoxic effects of X-ray radiation in humans显示文摘Obejctive To assess the genotoxic effects of X ray radiation on human populations Methods The single cell gel electrophoresis (SCGE) and cytokinesis blocked micronucleus (CBMN) test were applied as biological dosimeters to detect DNA damage and abnormalities in human peripheral lymphocytes of subpopulation exposed to X ray radiation The subjects were divided into four groups: 12 radiation patients; 13 intervention radiation therapy doctors; 32 radiation diagnostians; 28 controls Results The average comet lengths of the four groups were 128 17±4 49?μm, 88 09±5 39?μm, 72 68±2 57?μm and 32 87±0 57?μm, respectively The difference in average comet length between any two groups was highly significant ( P <0 01) The average micronucleated cell (MNC) rates (‰) of the four groups were 12 33±0 85, 9 75±1 02, 8 48±0 66 and 3 18±0 36, respectively The difference of MNC rates of Group 1 vs 3, 1 vs 4, 2 vs 4 and 3 vs 4 was highly significant ( P <0 01), and the difference of Group 1 vs 2 was significant ( P <0 05), but there was no difference of MNC rate in Group 2 vs 3 ( P >0 05) Conclusions This study showed that both the comet assay and the CBMN test could be used to monitor populations exposed to X ray radiation, but the comet assay seems to be more sensitive than the CBMN | 何继亮 陈玮琳 金力奋 金海燕 | 2000 | Chinese Medical Journal2000，，10： | 4 |
| 6 | Applications of single cell RNA sequencing to research of stem cells显示文摘Stem cells(SCs)with their self-renewal and pluripotent differentiation potential,show great promise for therapeutic applications to some refractory diseases such as stroke,Parkinsonism,myocardial infarction,and diabetes.Furthermore,as seed cells in tissue engineering,SCs have been applied widely to tissue and organ regeneration.However,previous studies have shown that SCs are heterogeneous and consist of many cell subpopulations.Owing to this heterogeneity of cell states,gene expression is highly diverse between cells even within a single tissue,making precise identification and analysis of biological properties difficult,which hinders their further research and applications.Therefore,a defined understanding of the heterogeneity is a key to research of SCs.Traditional ensemble-based sequencing approaches,such as microarrays,reflect an average of expression levels across a large population,which overlook unique biological behaviors of individual cells,conceal cell-to-cell variations,and cannot understand the heterogeneity of SCs radically.The development of high throughput single cell RNA sequencing(scRNA-seq)has provided a new research tool in biology,ranging from identification of novel cell types and exploration of cell markers to the analysis of gene expression and predicating developmental trajectories.scRNA-seq has profoundly changed our understanding of a series of biological phenomena.Currently,it has been used in research of SCs in many fields,particularly for the research of heterogeneity and cell subpopulations in early embryonic development.In this review,we focus on the scRNA-seq technique and its applications to research of SCs. | Xiao Zhang Lei Liu | 2019 | World Journal of Stem Cells2019，11，10： | 3 |
| 7 | Microscope laser light scattering spectroscopy and its applications to non-invasive in situ real time measurements on single intact cells显示文摘The principle of the technique of microscope laser light scattering spectroscopy, its development and applications to the studies on single intact cells, including our work on non-invasive in situ real time measurements on single intact erythrocyte simultaneously at the levels of cellular, sub-cellular and intracellular molecules, are introduced. | HUANG YaoxiongInstitute of Biomedical Engineering, Ji’nan University, Guangzhou 510632, China | 2000 | Chinese Science Bulletin2000，45，22： | 3 |
| 8 | Heavy ion-induced single event upset sensitivity evaluation of 3D integrated static random access memory显示文摘Heavy ion-induced single event upsets(SEUs)of static random access memory(SRAM), integrated with three-dimensional integrated circuit technology, are evaluated using a Monte Carlo simulation method based on the Geant4 simulation toolkit. The SEU cross sections and multiple cell upset(MCU) susceptibility of 3D SRAM are explored using different types and energies of heavy ions.In the simulations, the sensitivities of different dies of 3D SRAM show noticeable discrepancies for low linear energy transfers(LETs). The average percentage of MCUs of 3D SRAM increases from 17.2 to 32.95%, followed by the energy of ^(209)Bi decreasing from 71.77 to 38.28 MeV/u. For a specific LET, the percentage of MCUs presents a notable difference between the face-to-face and back-toface structures. In the back-to-face structure, the percentage of MCUs increases with a deeper die, compared with the face-to-face structure. The simulation method and process are verified by comparing the SEU cross sections of planar SRAM with experimental data. The upset cross sections of the planar process and 3D integrated SRAM are analyzed. The results demonstrate that the 3D SRAM sensitivity is not greater than that of the planar SRAM. The 3D process technology has the potential to be applied to the aerospace and military fields. | Xue-Bing Cao Li-Yi Xiao Ming-Xue Huo Tian-Qi Wang Shan-Shan Liu Chun-Hua Qi An-Long Li Jin-Xiang Wang | 2018 | Nuclear Science and Techniques2018，29，3： | 3 |
| 9 | SSCC: A Novel Computational Framework for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data显示文摘Clustering is a prevalent analytical means to analyze single cell RNA sequencing (scRNA-seq) data but the rapidly expanding data volume can make this process computationally challenging. New methods for both accurate and efficient clustering are of pressing need. Here we proposed Spearman subsampling-clustering-classification (SSCC),a new clustering framework based on random projection and feature construction,for large-scale scRNA-seq data. SSCC greatly improves clustering accuracy,robustness,and computational efficacy for various state-of-the-art algorithms benchmarked on multiple real datasets. On a dataset with 68,578 human blood cells,SSCC achieved 20%improvement for clustering accuracy and 50-fold acceleration,but only consumed 66%memory usage,compared to the widelyused software package SC3. Compared to k-means,the accuracy improvement of SSCC can reach 3-fold. An R implementation of SSCC is available at https://github.com/Japrin/sscClust. | Xianwen Ren Liangtao Zheng Zemin Zhang | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 3 |
| 10 | Epigenetic states and expression of imprinted genes in human embryonic stem cells显示文摘AIM: To investigate the epigenetic states and expres- sion of imprinted genes in five human embryonic stem cell (hESC) lines derived in Taiwan. METHODS: The heterozygous alleles of single nucleo- tide polymorphisms (SNPs) at imprinted genes were analyzed by sequencing genomic DNAs of hESC lines and the monoallelic expression of the imprinted genes were confirmed by sequencing the cDNAs. The expres- sion profiles of 32 known imprinted genes of five hESC lines were determined using Affymetrix human genome U133 plus 2.0 DNA microarray. RESULTS: The heterozygous alleles of SNPs at seven imprinted genes, IPW , PEG10 , NESP55 , KCNQ1 , ATP10A ,TCEB3C and IGF2 , were identified and the monoallelic expression of these imprinted genes except IGF2 were confirmed. The IGF2 gene was found to be imprinted in hESC line T2 but partially imprinted in line T3 and not imprinted in line T4 embryoid bodies. Ten imprinted genes, namely GRB10 , PEG10 , SGCE, MEST , SDHD , SN- RPN , SNURF , NDN , IPW and NESP55 , were found to be highly expressed in the undifferentiated hESC lines and down-regulated in differentiated derivatives. The UBE3A gene abundantly expressed in undifferentiated hESC lines and further up-regulated in differentiated tissues. The expression levels of other 21 imprinted genes were relatively low in undifferentiated hESC lines and five of these genes (TP73 , COPG2 , OSBPL5 , IGF2 and ATP10A ) were found to be up-regulated in differentiated tissues. CONCLUSION: The epigenetic states and expression of imprinted genes in hESC lines should be thoroughly studied after extended culture and upon differentiation in order to understand epigenetic stability in hESC lines before their clinical applications. | Steven Shoei-Lung Li Sung-Liang Yu Sher Singh | 2010 | World Journal of Stem Cells2010，2，4： | 3 |
| 11 | Immunotherapy in pancreatic cancer:Unleash its potential through novel combinations显示文摘Pancreatic cancer is the third leading cause of cancer mortality in both men and women in the United States,with poor response to current standard of care,short progression-free and overall survival.Immunotherapies that target cytotoxic T lymphocyte antigen-4,programmed cell death protein-1,and programmed death-ligand 1 checkpoints have shown remarkable activities in several cancers such as melanoma,renal cell carcinoma,and nonsmall cell lung cancer due to high numbers of somatic mutations,combined with cytotoxic T-cell responses.However,single checkpoint blockade was ineffective in pancreatic cancer,highlighting the challenges including the poor antigenicity,a dense desmoplastic stroma,and a largely immunosuppressive microenvironment.In this review,we will summarize available clinical results and ongoing efforts of combining immune checkpoint therapies with other treatment modalities such as chemotherapy,radiotherapy,and targeted therapy.These combination therapies hold promise in unleashing the potential of immunotherapy in pancreatic cancer to achieve better and more durable clinical responses by enhancing cytotoxic T-cell responses. | Songchuan Guo Merly Contratto George Miller Lawrence Leichman Jennifer Wu | 2017 | World Journal of Clinical Oncology2017，8，3： | 3 |
| 12 | Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma显示文摘AIM: To investigate the associations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma(HCC). METHODS: We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospital of Guangxi Medical University and 1200 non-tumor patients from the First Affiliated Hospital of Guangxi Medical University. General demographic characteristics, behavioral information, and hematological indices were collected by unified questionnaires. Genomic DNA was isolatedfrom peripheral venous blood using Phenol-Chloroform. The genotyping was performed using the Sequenom Mass ARRAY i PLEX genotyping method. The association between genetic polymorphisms and risk of HCC was shown by P-value and the odd ratio(OR) with 95% confidence interval(CI) using the unconditional logistic regression after adjusting for age, sex, nationality, smoking, drinking, family history of HCC, and hepatitis B virus(HBV) infection. Moreover, stratified analysis was conducted on the basis of the status of HBV infection, smoking, and alcohol drinking.RESULTS: The HCC risk was lower in patients with the MCM4 rs2305952 CC(OR = 0.22, 95%CI: 0.08-0.63, P = 0.01) and with the CHEK1 rs515255 TC, TT, TC/TT(OR = 0.73, 95%CI: 0.56-0.96, P = 0.02; OR = 0.67, 95%CI: 0.46-0.97, P = 0.04; OR = 0.72, 95%CI: 0.56-0.92, P = 0.01, respectively). Conversely, the HCC risk was higher in patients with the KAT2 B rs17006625 GG(OR = 1.64, 95%CI: 1.01-2.64, P = 0.04). In addition, the risk was markedly lower for those who were carriers of MCM4 rs2305952 CC and were also HBs Ag-positive and non-drinking and nonsmoking(P < 0.05, respectively) and for those who were carriers of CHEK1 rs515255 TC, TT, TC/TT and were also HBs Ag-negative and non-drinking(P < 0.05, respectively). Moreover, the risk was higher for those who were carriers of KAT2 B rs17006625 GG and were also HBs Ag-negative(P < 0.05).CONCLUSION: Of 12 cell cycle pathway genes, MCM4, CHEK1 and KAT2 B polymorphisms may be associated with the risk of HCC. | Yue-Li Nan Yan-Ling Hu Zhi-Ke Liu Fang-Fang Duan Yang Xu Shu Li Ting Li Da-Fang Chen Xiao-Yun Zeng | 2016 | World Journal of Gastroenterology2016，22，24： | 2 |
| 13 | Differential gene network analysis from single cell RNA-seq显示文摘Study of gene expression has been arguably the most activeresearch field in functional genomics. Over the last two decades,various high-throughput technologies, from gene expressionmicroarray to RNA-seq, have been widely applied to the whole-genome profiling of gene expression. The commonality of these ex-periments is that they measure the gene expression levels of"bulk"sample, which pools a large number (often in the scale of millions)of cells, and thus the measurements reflect the average expressionof a population of cells. | Yikai Wang Hao Wu Tianwei Yu | 2017 | Journal of Genetics and Genomics2017，44，6： | 2 |
| 14 | A case study on the detailed reproducibility of a Human Cell Atlas project显示文摘Background:Reproducibility is a defining feature of a scientific discovery.Reproducibility can be at different levels for different types of study.The purpose of the Human Cell Atlas (HCA) project is to build maps of molecular signatures of all human cell types and states to serve as references for future discoveries.Constructing such a complex reference atlas must involve the assembly and aggregation of data from multiple labs,probably generated with different technologies.It has much higher requirements on reproducibility than individual research projects.To add another layer of complexity,the bioinformatics procedures involved for single-cell data have high flexibility and diversity.There are many factors in the processing and analysis of single-cell RNA-seq data that can shape the final results in different ways.Methods:To study what levels of reproducibility can be reached in current practices,we conducted a detailed reproduction study for a well-documented recent publication on the atlas of human blood dendritic cells as an example to break down the bioinformatics steps and factors that are crucial for the reproducibility at different levels.Results:We found that the major scientific discovery can be well reproduced after some efforts,but there are also some differences in some details that may cause uncertainty in the future reference.This study provides a detailed case observation on the on-going discussions of the type of standards the HCA community should take when releasing data and publications to guarantee the reproducibility and reliability of the future atlas.Conclusion:Current practices of releasing data and publications may not be adequate to guarantee the reproducibility of HCA.We propose building more stringent guidelines and standards on the information that needs to be provided along with publications for projects that evolved in the HCA program. | Kui Hua Xuegong Zhang | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，2： | 1 |
| 15 | Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program显示文摘Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window.We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mespl cardiovascular progenitor cells lead to the formation of extremely dilated and enlarged heart due to defective cardiomyocyte(CM)differentiation.Transcriptome analysis revealed unusual upregulation of vascular gene expression in Dgcr8 cKO hearts.Single cell RNA sequencing study further confirmed the increase of angiogenesis genes in single Dgcr8 cKO CM.We also performed global microRNA profiling of E9.5 heart for the first time,and identified that miR-541 was transiently highly expressed in E9.5 hearts.Interestingly,introducing miR-541 back into microRNA-free CMs partially rescued their defects,downregulated angiogenesis genes and significantly upregulated cardiac genes.Moreover,miR-541 can target Ctgf and inhibit endothelial function.Our results suggest that micro-RNAs are required to suppress abnormal angiogenesis gene program to maintain CM differentiation. | Xi Chen Lin Wang Rujin Huang Hui Qiu Peizhe Wang Daren Wu Yonglin Zhu Jia Ming Yangming Wang Jianbin Wang Jie Na | 2019 | Protein & Cell2019，10，5： | 1 |
| 16 | Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion显示文摘Dear Editor,Over a half-century ago,Dr.Leonard Hayflick described the phenotype of a finite lifespan for human fibroblasts being passaged in in vitro cell culture(Hayflick et al.,1961),a phenomenon today known as replicative cellular senescence.Cellular senescence has been defined as a state in which cells lose their potential to divide and are permanently arrested in either the G1,or arguably the G2 stage of the cell cycle(Mao et al.,2012).In addition to replicative cellular senescenee—which is induced by large amounts of DNA damage at telomeres due to loss of the specialized T-loop structure—xogenous sublethal stresses such as ionizing radiati on,genotoxic chemicals or hyper-activated on cogenes may also trigger a similar form of senescence,stress induced premature cellular senescenee(SIPS). | Huanyin Tang Anke Geng Tengjiao Zhang Chen Wang Ying Jiang Zhiyong Mao | 2019 | Protein & Cell2019，10，5： | 1 |
| 17 | Progress in Single Cell Sequencing Technology显示文摘Cells are the basic unit of life structure and life activities.Because of the complex micro-environment of cells,the content of components that play a key role is relatively small,so single-cell analysis is extremely challenging.In recent years,single-cell sequencing technology has been developed and matured.Single-cell sequencing can reveal the composition and physiological diversity of cells,and the existing single-cell separation technology,single-cell whole genome amplification technology,single The principles and applications of cell whole transcriptome amplification technology and single cell transcriptome sequencing are summarized and summarized. | Qicai Ma Wenli Wu Na Ye Xingdong Wang Ping Yan Heping Pan | 2019 | Journal of Zoological Research2019，1，1： | 1 |
| 18 | Real-time observation of dynamic heterogeneity of gold nanorods on plasma membrane with darkfield microscopy显示文摘The plasma membrane possesses a complicated structure, on which the protein clusters are randomly but orderly distributed to maintain the regular morphology and function of cells. Investigating the detailed dynamic behaviors of nanoparticles(NPs) on cytomembrane is of great importance to understand cellular mechanisms and advance the bio-nano technologies for drug delivery, photothermal therapy, immunotherapy, etc. In this work, to study the dynamic heterogeneous interactions between NPs and cell membrane with high resolution, we established a simple method to efficiently track the translational and rotational diffusion of individual gold nanorods(AuNRs) on cell membranes. This method is based on that an anisotropic AuNR appears as a colored spot under a darkfield microscope(DFM) equipped with a color camera. While obtaining its lateral position, the polar angle of the AuNR can be calculated simultaneously from intensity difference between the R and G channels. Careful analysis shows that the lateral motion of single AuNRs do not follow normal Brownian diffusion, which could be attributed to their hop diffusion in the dynamically varying picket-fence structure of the live cell membrane. Furthermore, 4 different rotationtranslation patterns of the AuNR are observed due to spatiotemporal heterogeneity of the cytomembrane. This simple but robust method for simultaneously obtaining the location and orientation of anisotropic plasmonic nanoparticles could be further applied to the analysis of complicated biological and biomedical processes. | Feng Ge Jianfeng Xue Zonghua Wang Bin Xiong Yan He | 2019 | Science China Chemistry2019，62，8： | 1 |
| 19 | Association between KITLG Gene Polymorphisms and Testicular Germ Cell Tumors:A Systematic Review and Meta-analysis显示文摘It has been reported that c-KIT ligand(KITLG)gene polymorphisms may be associated with testicular germ cell tumors(TGCT).Owing to mixed and inconclusive results,we con ducted a systematic review and meta-analysis to summarize and clarify this association.A systematic search of studies on the association between KITLG gene polymorphisms and TGCT susceptibility was conducted in databases.Odds ratios and 95%confidence intervals were used to pool the effect size.Six articles were included in our systematic review and meta-analysis.Compared with adenine(A),KITLG rs995030 guanine(G)might be associated with increased risk of TGCT.There are insufficient data to fully confirm the association between KITLG rs4474514 and TGCT susceptibility.Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis. | Jia-xuan QIN Zong-long CAI Yu-feng YANG Jin-chun XING Xuan ZHUANG | 2019 | Current Medical Science2019，39，5： | 0 |
| 20 | Relationship between ERCC1 (C8092A) single nucleotide polymorphism and efficacy/toxicity of platinum based chemotherapy in advanced non-small cell lung cancer patients显示文摘To assses the effect of single nucleotide polymorphism of excision repair cross-complementation group 1 C8092A on the clinical outcome and toxicity in advanced stage non-small cell lung cancer patients receiving first line platinum based chemotherapy.MethodsThis article is a review of the current research on single nucleotide polymorphism and its effect on treatment outcome and toxicity of advanced stage lung cancer.Conclusion The observations indicate that more advanced studies and trials on C8092A SNPs are needed so as to assess if it could be used as a potential biomarker in the future. | 韦克 周彩存 | 2011 | 外科研究与新技术2011，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员