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1Variations of stable isotopic compositions in precipitation on the Tibetan Plateau and its adjacent regions显示文摘There is no temperature effect in the southern Tibetan Plateau and South Asia to the south of the Tanggula Mountains. Amount effect has been observed at a few sampling stations accounting for about a half of the statistical stations. There is notable temperature effect in the middle and northern Tibetan Plateau and its adjacent Central Asia to the north of the Tanggula Mountains. Because vapor directly originates from low-latitude oceans, the relative heavy ( 18O with small variation characterizes the rainfall in South Asia. A sharp depletion of the stable isotopic compositions in precipitation takes place from Kyangjin on the southern slope of the Himalayas to the Tanggula Mountains in the middle plateau. From the Tanggula Mountains to the northern Tibetan Plateau, the ( 18O in precipitation increases with increasing latitude.章新平 Masayoshi NAKAWO 姚檀栋 韩健康 谢自楚 2002Science China Earth Sciences2002,45,6:39
2Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure显示文摘Objective:To investigate the alteration of plasma levels of omentin-1 and visfatin in elderly patients with coronary heart disease(CHD)and heart failure.Methods:Plasma omentin-1 and visfatin levels were measured in 90 subjects(29 stable angina pectoris(SAP)cases,30 unstable angina pectoris(UAP)cases and 31 age-and sex-matched healthy controls(age≥60 years)by enzyme-linked immunosorbent assay methods.According to the New York Heart Association classification.59 CHDs were divided into three groups:functional I class,11 cases;functional II/III class,36 cases;and functional IV class,12 cases.Results:The plasma level of omentin-1in CHO patients was significantly lower than thai of the control group.Otnenlin-lin SAP group and UAP group were significantly lower compared to the control group(there was no statistical significance between UAP group and SAP group;P>0.05).The plasma level of visfatin in CHD patients was significandy higher than that of the control group.Similarly,visfatin in SAP group and UAP group were all significantly higher compared to the control group,while there was no statistical significance between UAP group,and SAP group.The plasma omentin-1 level was negatively correlated with SBP(r=-0.264,P<0.05),positively correlated with HDL-c level(r=0.271,P<0.05);the plasma visfatin level was positively correlated with TC(r=0.292,P<0.05),negatively correlated with HDL-c level(r=-0.266,P<0.05).There was a negative correlation between plasma omentin-1 and visfatin levels(r=-0.280,P<0.05).Moreover,multiple linear stepwise regression analysis showed that omentin-1 and visfatin levels might be affected by HDL-c level.Logistic regression analysis showed that visfatin could be an independent risk factor of CHD.Conclusions:Decreased levels of omentin-1 and increased levels of visfatin may be involved in the occurrence and development of CHD.Omentin-1 and visfatin,independently,may be protective and pro-inflammatory cytokines.Additionally,both omentin-1 and visfatin may be related to lipid metabolism.Visfatin may be an independent risk factor of CHD.Xiu-Hua Wang Ling-Zhi Dou Can Gu Xiao-Qing Wang 2014Asian Pacific Journal of Tropical Medicine2014,7,1:38
3Relation between stable isotope in monsoon precipitation in southern Tibetan Plateau and moisture transport history显示文摘The moisture transport history to the south of the Tibetan Plateau was modeled using the meteorological data provided by NCEP in this paper, and the modeled results were compared with the measured δ18O in the south of the Tibetan Plateau. The relation between δ18O in precipitation in the south of the Tibetan Plateau and moisture trajectories was discussed. The results show that the extremely low δ18O in precipitation in the south of the Tibetan Plateau is always related to the moisture from the low-level sea surface evaporation. The long-distance transport of moisture also contributes to low δ18O in precipitation probably due to the rainout process during moisture transport. It is also found that lowδ18O in precipitation is also related with deep layer transport of moisture, and with intensive condensation in the upper layers of the atmosphere, resulting in low δ18O because of depletion of heavy isotopes in deep condensation. However, high δ18O in precipitation whether in monsoon period or not田立德 姚檀栋 A.Numaguti 段克勤 2001Science China Earth Sciences2001,44,S1:30
4Effect and Safety of Guanxinning Tablet(冠心宁片) for Stable Angina Pectoris Patients with Xin(Heart)-Blood Stagnation Syndrome:A Randomized,Multicenter,Placebo-Controlled Trial显示文摘Objective: To investigate the effect and safety of Guanxinning Tablet(冠心宁片, GXN) for the treatment of stable angina pectoris patients with Xin(Heart)-blood stagnation syndrome(XBSS). Methods: One hundred and sixty stable angina pectoris patients with XBSS were randomly assigned to receive GXN(80 cases) or placebo(80 cases, Guanxinning simulation tablets, mainly composed of lactose), 4 tablets(0.38 g/tablet), thrice daily for 12 weeks. After treatment, an exercise stress test(treadmill protocol), Chinese medicine(CM) syndrome score, electrocardiogram(ECG), and nitroglycerin withdrawal rate were evaluated and compared in the patients between the two groups. Meanwhile, adverse events(AEs) were evaluated during the whole clinical trial. Results: Compared with the control group, the time extension of exercise duration in the GXN group increased 29.28±17.67 s after treatment(P>0.05);moreover, the change of exercise duration in the GXN group increased 63.10±96.96 s in subgroup analysis(P<0.05). The effective rates of angina pectoris, CM syndrome and ECG as well as nitroglycerin withdrawal rate were 81.33%, 90.67%, 45.76%, and 70.73%, respectively in the GXN group, which were all significantly higher than those in the control group(40.58%, 75.36%, 26.92%, 28.21%, respectively, P<0.05). Conclusion: GXN was a safe and effective treatment for stable angina pectoris patients with XBSS at a dose of 4 tablets, thrice daily.SUN Ming-yue MIAO Yang JIN Min DONG Yao-rong LIU Shu-rong WANG Mu-lan GAO Rui 2019Chinese Journal of Integrative Medicine2019,25,9:22
5Comprehensive geochemical identification of highly evolved marine carbonate rocks as hydrocarbon-source rocks as exemplified by the Ordos Basin显示文摘This study reversed the developing environments of hydrocarbon-source rocks in the Ordos Basin and evaluated carbonate rocks as hydrocarbon-source rocks and their distributions on account of the fact that China’s marine carbonate rocks as hydrocarbon-source rocks are character- ized by intensive thermal evolution and relatively low abundance of organic matter, by taking the Lower Paleozoic of the Ordos Basin for example and in light of the calculated enrichment coefficients of trace elements, the REE distribution patterns, the mathematical statistics analysis of elements and carbon isotopes and their three-dimensional diagrammatization in combination with the necessary organic parameters. As for the Ordos Basin, TOC=0.2% is an important boundary value. Studies have shown that in the strata where TOC is greater than 0.2%, Ba is highly enriched with positive δ 13Ccarb shifts and δ 13Corg less than ?28‰, reflecting a thigh paleo-productivity, high burial amounts of organic matter, relatively good hydrocarbon-generating potentiality and intensive REE fractionation. All these indicated that the settlement rates are low and the geological conditions are good for the preservation of organic matter, hence favoring the development of hydrocarbon-source rocks. The Klimory and Wulalik formations show certain regularities in those aspects and, therefore, they can be regarded as the potential effective hydrocarbon-source rocks. In the strata where total TOC is less than 0.2%, the contents of Ba are low, δ 13Ccarb values are mostly negative, and δ 13Corg values range from ?24‰― ?28‰, demonstrating low burial amounts of organic matter, poor potentialities of hydrocarbon gen- eration, weak REE fractionation and rapid settlement rates. These facts showed that most of the hy- drocarbon-source rocks were formed in shallow-water, high-energy oxidizing environments, thus un- favoring the development of hydrocarbon-source rocks. It is feasible to make use of the geochemical method to comprehensively assess the highly evolved marine carbonates rocks as potential hydro- carbon-source rocks and their distributions.Tenger 2006Science China Earth Sciences2006,49,4:20
6δD values of escaped H_2 from hot springs at the Tengchong Rehai geothermal area and its origin显示文摘Here we give the δD values of escaped H2 from hot springs at the Tengchong Rehai and adjacent regions, and deal with a genetic correlation between the increment H2 in escaped gases from middle-shallow reservoirs and the H2S, CH4 derived from deep sources. Isotopic compositions of H2 indicate that the generation of increment H2 may be related to recent strong activity of N-W trending fault at the Rehai area. Trace monitoring the H2 release could be significant in order to keep watch on present activity of that fault.SHANGGUAN Zhiguan & HUO Weiguo Institute of Geology, China Seismological Bureau, Beijing 100029, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2002Chinese Science Bulletin2002,47,2:18
7Relations between oxygen stable isotopic ratios in precipitation and relevant meteorological factors in southwest China显示文摘The correlations of isotopic ratios in precipitation with temperature, air pressure and humidity at dif- ferent altitudes, in southwest China, are analyzed. There appear marked negative correlations for the δ 18O in precipitation with precipitation amount, vapor pressure and atmospheric precipitable water (PW) at Mengzi, Simao and Tengchong stations on synoptic timescale; the marked negative correlations between the δ 18O in precipitation and the diurnal mean temperature at 400 hPa, 500 hPa, 700 hPa and 850 hPa are different from the temperature effect in middle-high-latitude inland. Moreover, the notable positive correlation between the δ 18O in precipitation and the dew-point deficit △Td at different altitudes is found at the three stations. On annual timescale, the annual precipitation amount weighted mean δ 18O display the negative correlations not only with annual precipitation but also with annual mean temperature at 500 hPa. It can be deduced that, in the years with abnormally strong summer monsoon, more warm and wet air from low-latitude oceans is transported northward along the vapor channel located in southwest China and generates abnormally strong rainfall on the way. Meanwhile, the ab- normally strong condensation process will release more condensed latent heat into atmosphere, and lead to the rise of atmospheric temperature during rainfall, but decline of the δ 18O in precipitation. On the contrary, in the years with abnormally weak summer monsoon, the abnormally weak condensation process will release less condensed latent heat into atmosphere, and lead to the decline of atmos- pheric temperature during rainfall, but increase of the δ 18O in precipitation.ZHANG XinPing LIU JingMiao SUN WeiZheng HUANG YiMin ZHANG JianMing 2007Science China Earth Sciences2007,50,4:17
8Distribution and fractionation mechanism of stable carbon isotope of coalbed methane显示文摘The stable carbon isotope values of coalbed methane range widely, and also are gener- ally lighter than that of gases in normal coal-formed gas fields with similar coal rank. There exists strong carbon isotope fractionation in coalbed methane and it makes the carbon isotope value lighter. The correlation between the carbon isotope value and Ro in coalbed methane is less obvious. The coaly source rock maturity cannot be judged by coalbed methane carbon isotope value. The carbon isotopes of coalbed methane become lighter in much different degree due to the hydrodynamics. The stronger the hydrodynamics is, the lighter the CBM carbon isotopic value becomes. Many previous investigations indicated that the desorption-diffusion effects make the carbon isotope value of coalbed methane lighter. However, the explanation has encountered many problems. The authors of this arti- cle suggest that the flowing groundwater dissolution to free methane in coal seams and the free methane exchange with absorbed one is the carbon isotope fractionation mechanism in coalbed methane. The flowing groundwater in coal can easily take more 13CH4 away from free gas and com- paratively leave more 12CH4. This will make 12CH4 density in free gas comparatively higher than that in absorbed gas. The remaining 12CH4 in free gas then exchanges with the adsorbed methane in coal matrix. Some absorbed 13CH4 can be replaced and become free gas. Some free 12CH4 can be ab- sorbed again into coal matrix and become absorbed gas. Part of the newly replaced 13CH4 in free gas will also be taken away by water, leaving preferentially more 12CH4. The remaining 12CH4 in free gas will exchange again with adsorbed methane in the coal matrix. These processes occur all the time. Through accumulative effect, the 12CH4 will be greatly concentrated in coal. Thus, the stable carbon isotope of coalbed methane becomes dramatically lighter. Through simulation experiment on wa- ter-dissolved methane, it had been proved that the flowing water could fractionate the carbon isotope of methane, and easily take heavy carbon isotope away through dissolution.QIN Shengfei1, TANG Xiuyi2, SONG Yan1 & WANG Hongyan3 1. Research Institute of Petroleum Exploration and Development, PetroChina, Beijing 100083, China 2. Anhui Science and Technology College, Huainan 232000, China 3. Langfang Branch, Research Institute of Petroleum Exploration and Development, PetroChina, Langfang 065007, China 2006Science China Earth Sciences2006,49,12:14
9Reconstruction of summer temperature (June-August) at Mt.Helan,China,from tree-ring stable carbon isotope values since AD 1890显示文摘From stable carbon isotope analysis of tree-rings of Chinese pine (Pinus tabulaeformis) from Mt. Helan, China, we found that high-δ13C values were related to high mean temperatures from June to August (T68), and low-δ 13C values corresponded to low T68. From these data, a transfer function has been used to reconstruct summer temperatures (T68) for the Mt. Helan region. The explained variance of reconstruction is 34.9% (F=15.01, p<0.001). The time period containing the highest summer temperatures in northern China (late 1920-1930s) was confirmed by our reconstruction. The data indicate that there is a tele-connection between summer temperatures in Mt. Helan area and sea-surface-temperatures in the tropical Pacific. The extreme low temperature periods around the years of 1920 and 1947 for Mt. Helan region correspond well to the cold climate in the tropical Pacific. Along with other analyses, this suggests that climate variations in the Mt. Helan region are driven not only by local events, but also by the global climate. Significant periodicities appearing in the reconstruction are 2.56 and 2.63 years.刘禹 马利民 蔡秋芳 安芷生 刘卫国 高玲瑜 2002Science China Earth Sciences2002,45,12:14
10GRAIN BOUNDARY REORGANIZATION IN INTERMETALLIC COMPOUNDS NiAl AND FeAl显示文摘Computer simulation of grain boundaries(GB) was carried out in Fe and ordered alloys NiAl and FeAl with B2 superlattice. In this work symmetrical tilt grain boundaries =5[100](012) and = 5[100](013) are studied. The atomic interaction has been described by Morse empirical central- force potentials.The atomic structure and energy of GB were investigated by means of construction of -surface using full atomic relaxation by method of molecular statics. It is shown that = 5 tilt GBs in Fe, Ni3Al and NiAl have several steady states. Comparison of our results with geometrical model of coincidence site lattice (CSL) was carried out. GBs in model CSL are unstable, the stabilization is achieved by additional displacement at some vector along the plane of defect.M.D. Starostenkov, B. F. Demyanov, E.A. Kuklina and E. G. Sverdlova General Physics Department, Altai State Technical University, Lenin st 46, Barnaul, 656099, Russia 2000Acta Metallurgica Sinica(English Letters)2000,13,2:13
11Formation mechanism of carbonate cemented zones adjacent to the top overpressured surface in the central Junggar Basin,NW China显示文摘Carbonate cemented zones are normally adjacent to the top overpressured surface in the central Junggar Basin,NW China.Stable carbon and oxygen isotopic compositions and petrological investigations of carbonate cements in the carbonate cemented zones indicate that:(1) carbonate cements are composed dominantly of ferrocalcite,ferroan dolomite,and ankerite;(2) carbonate cements are formed under a high temperature circumstance in the subsurface,and organic fluid migration has an important effect on the formation of them;and(3) carbon and oxygen ions in the carbonate cements migrate from the underlying overpressured system.This suggests that the occurrence of carbonate cemented zones in this region results from multiple phases of organic fluid expulsion out of the overpressure compartment through geological time.This study provides a plausible mechanism of the formation of carbonate cemented zones adjacent to the top overpressured surface in the clastic sedimentary basins,and has an important implication for understanding the internal correlation between the formation of carbonate cemented zones adjacent to top overpressured surface and geofluids expulsion out of overpressured system.YANG Zhi1,2,ZOU CaiNeng1,3,HE Sheng2,LI QiYan1,HE ZhiLiang3,WU HengZhi5,CAO Feng1,MENG XianLong4,WANG FuRong2 & XIAO Qilin21 State Key Laboratory of EOR,Research Institute of Petroleum Exploration & Development,PetroChina,Beijing 100083,China 2 Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education,China University of Geosciences,Wuhan 430074,China 3 State Key Laboratory of EOR,Research Institute of Petroleum Exploration & Development,Petrochina,Beijing 100083,China 4 Research Institute of Petroleum Exploration and Production,SINOPEC,Beijing 100083,China 5 Southwest Branch Company,SINOPEC,Chengdu 610051,China 2010Science China Earth Sciences2010,53,4:12
12New Families in the Stable Homotopy of Spheres RevisitedLIN Jin Kun Department of Mathematics. Nankai University. Tianjin 300071. P. R. China 2002Acta Mathematica Sinica,English Series2002,18,1:12
13Stepwise paleoceanographic changes during the lastdeglaciation in the southern South China Sea: Records of stable isotope and microfossils显示文摘Quantitative analyses of microfossils and stable isotopic analysis were carried out for Core SCS-12 in the southwestern slope of the South China Sea (SCS). A high-resolution paleoceanographic record for the last 13 ka was revealed with the AMS 14 C dates. The southern SCS has experienced stepwise paleoceanographic changes since the last deglaciation. The oxygen isotopic stage 1/2 boundary around 12.05 ka B.P. and the end of the last deglaciation around 7.70 ka B.P. are two rapid change periods (corresponding to the termination I\-A and termination I\-B, respectively), in between is a slow change period. The authors infer that the sea level stood at -110 m before the termination I\-A, roughly the same as today after the termination I\-B, and about -50 m in between. Subsequently, the average winter sea surface temperature and salinity obviously increased while paleo-productivity decreased since 12.05 ka B.P. The early Holocene CaCO\-3 preservation spike, coupled with a high abundance of pteropoda and CaCO\-3 content, occurred around 7.70 ka B.P.翦知湣 陈民本 林慧玲 汪品先 1998Science China Earth Sciences1998,41,2:11
14Mantle-derived magmatic gas releasing features at the Rehai area, Tengchong county, Yunnan Province, China显示文摘This paper deals with the chemical and isotopic compositions of escaped gases from the Rehai geothermal area in Tengchong county of Yunnan Province. Results indicate that there is the mantle-derived magmatic intrusion in shallow crust at this area. Modern mantle-derived mag-matic volatiles are being released currently in a steady stream by way of active faults. The escaped gases are mostly composed of CO2, together with subordinate amounts of H2S, N2, H2, CH4, SO2, CO and He. At the studied area, the north-south directed fault is the deepest, and it may be interlinked with the deep-seated thermal reservoir that would be directly recharged by the mantle-derived magmatic volatile. The He, C isotopic evidence reveals that the modern active magma beneath Rehai area may originate from the historical mantle-derived magma which caused the latest eruptive activity of volcanoes in that region.上官志冠 白春华 孙明良 2000Science China Earth Sciences2000,43,2:11
15A “GC-rich” method for mammalian gene expression:A dominant role of non-coding DNA GC content in the regulation of mammalian gene expression显示文摘High mammalian gene expression was obtained for more than twenty different proteins in different cell types by just a few laboratory scale stable gene transfections for each protein.The stable expression vectors were constructed by inserting a naturally-occurring 1.006 kb or a synthetic 0.733 kb DNA fragment(including intron) of extremely GC-rich at the 5’ or/and 3’ flanking regions of these protein genes or their gene promoters.This experiment is the first experimental evidence showing that a non-coding extremely GC-rich DNA fragment is a super 'chromatin opening element' and plays an important role in mammalian gene expression.This experiment has further indicated that chromatin-based regulation of mammalian gene expression is at least partially embedded in DNA primary structure,namely DNA GC-content.Gilbert Rishton Matthew (Mizhou) HUI 2010Science China(Life Sciences)2010,53,1:10
16Characteristics of an early Holocene climate and environment from lake sediments in Ebinur region, NW China显示文摘The characteristics of climatic environment in the early Holocene epoch were studied through analyzing environmental proxies from the sediments in the Ebinur Lake--a closed one in the arid region. The pollen assemblage and other geochemical indices showed that, the temperature was somewhat low in the period (8.0-11.5 cal kaBP) as a whole, but in the early period (11.5-10.6 cal kaBP) the temperature was higher, in company with more precipitation. In the conversion period from the early Holocene epoch to the middle Holocene epoch (8.9-8.0 cal kaBP) the climate fluctuated remarkably. Particularly the three layers of peat sediment revealed the strong instability of climate in the early Holocene epoch in the Ebinur region. All information on the development of peat and the experimental data of pollen and stable isotopes implied that, the climatic condition at 8.2, 8.6 and 10.5 cal kaBP was characterized by noticeable cold and humidness, and could be regarded as three cold and humid events in the early Holocene epoch.WU Jinglu SHEN Ji WANG Sumin JIN Zhangdong YANG Xiangdong 2005Science China Earth Sciences2005,48,2:10
17Seasonal variations of stable isotope in precipitation and moisture transport at Yushu,eastern Tibetan Plateau显示文摘Precipitation δ 18O at Yushu, eastern Tibetan Plateau, shows strong fluctuation and lack of clear seasonality. The seasonal pattern of precipitation stable isotope at Yushu is apparently different from either that of the southwest monsoon region to the south or that of the inland region to the north. This different seasonal pattern probably reflects the shift of different moisture sources. In this paper, we present the spatial comparison of the seasonal patterns of precipitation δ 18O, and calculate the moisture transport flux by using the NCAR/NCEP reanalysis data. This allows us to discuss the relation between moisture transport flux and precipitation δ 18O. This study shows that both the southwest monsoon from south and inland air mass transport from north affected the seasonal precipitation δ 18O at Yushu, eastern Tibetan Plateau. Southwest monsoon brings the main part of the moisture, but southwest transport flux is weaker than in the southern part of the Tibetan Plateau. However, contribution of the inland moisture from north or local evaporation moisture is enhanced. The combined effect is the strong fluctuation of summer precipitation δ 18O at Yushu and comparatively poor seasonality.TIAN LiDe MA LingLong YU WuSheng LIU ZhongFang YIN ChangLiang ZHAO ZhongPing TANG Wei WANG Yu 2008Science China Earth Sciences2008,51,8:9
18Global significance of the carbon cycle in the karst dynamic system:evidence from geological and ecological processes显示文摘On the basis of proposing the existence of a karst carbon cycle and carbon sink at a watershed scale,this paper provides four pieces of evidence for;the integration of geology and ecology during the carbon cycle processes m the karst dynamic system,and estxmated the karst carbon sink effect using the methods of comparative monitoring of paired watersheds and the carbon stable isotope tracer technique.The results of the soil carbon cycle in Maocun,Guilin,showed that the soil carbon cycle in the karst area,the weathering and dissolution of carbonate rocks under the soil,resulted in a lower soil respiration of 25% in the karstoarea than in a non-karst area (sandstone and shale),and the carbon isotope results indicated that 13.46% of the heavy carbon of the hmestone is involved in the soil carbon cycle.The comparative monitoring results m paxred watersheds,suggesting that the HCO3 concentration m a karst spring is 10 times that of a rivulet in a non-karst area,while the concentration of inorganic carbon flux is 23.8 times.With both chemical stoichiometry and carbon stable isotopes,the proportion of carbon in karst springs derived from carbonate rocks was found to be 58.52% and 37.65% respectively.The comparison on carbon exchange and isotopes at the water-gas interface between the granite and carbonate rock basins in the Li River showed that the CO2 emission of the karst water is 10.92 times that of the allogenic water from the non-karst area,while the carbon isotope of HCO3^- in karst water is lighter by 8.62%.However,this does not mean that the karst water body has a larger carbon source effect.On the contrary,it means the karst water body has a greater karst carbon sink effect.When the karst subterranean stream in Zhaidi,Guilin,is exposed at the surface,carbon-rich karst water stimulated the growth of aquatic plants.The values of carbon stable isotopes in the same species of submerged plants gradually becomes heavier and heavier,and the 512 m flow process has a maximum range of 15.46%.The calculation results showed that 12.52% of inorganic carbon is converted into organic carbon.According to the data that has been published,the global karst carbon sink flux was estimated to be 0.53-0.58 PgC/a,equivalent to 31.18%-34.41% of the global forest carbon sink flux.In the meanwhile,the karst carbon sink flux in China was calculated to be 0.051 PgC/a,accounting for 68% of its forest carbon sink flux.Jian-hua Cao Xia Wu Fen Huang Bill Hu Chris Groves Hui Yang Chun-lai Zhang 2018China Geology2018,1,1:9
19Variable universe stable adaptive fuzzy control of nonlinear system显示文摘A kind of stable adaptive fuzzy control of nonlinear system is implemented using variable universe method. First of all, the basic structure of variable universe adaptive fuzzy controllers is briefly introduced. Then the contraction-expansion factor that is a key tool of variable universe method is defined by means of integral regulation idea, and a kind of adaptive fuzzy controllers is designed by using such a contraction-expansion factor. The simulation on first order nonlinear system is done. Secondly, it is proved that the variable universe adaptive fuzzy control is asymptotically stable by use of Lyapunov theory. The simulation on the second order nonlinear system shows that its simulation effect is also quite good. Finally a useful tool, called symbolic factor, is proposed, which may be of universal significance. It can greatly reduce the settling time and enhance the robustness of the system.李洪兴 苗志宏 王加银 2002Science China(Technological Sciences)2002,45,3:9
20Clinical and molecular features of young-onset colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression.Veroushka Ballester Shahrooz Rashtak Lisa Boardman 2016World Journal of Gastroenterology2016,22,5:9
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