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| 1 | Stability analysis of large-scale stope using stage subsequent fillingmining method in Sijiaying iron mine显示文摘To improve mining production capacity, a stage subsequent filling mining(SSFM) method is employed for Sijiaying iron mine. The height of the stage stope is approximately 100 m. As there are farmlands and villages on the surface of the mine, the surface deformation should be controlled when the ore is mined out for the purpose of stope stability and minimizing surface subsidence. In this paper, according to the site-specificgeological conditions, the self-stability of the stagefi lling body was analyzed, and the failure mechanism of back filling body was defined. Thus the relationship between the exposed height of filling body and the required strength was obtained. Next, the stability of back filling body and the characteristics of surface subsidence due to mining of 450 m level were analyzed using physical modeling.Finally, a three-dimensional numerical model was established using FLAC3 D, with which the surface subsidence and the stability of stope were achieved. The results show that the stope basically remains stable during the two-step recovery process. The maximum magnitude of the incline is 10.99 mm/m, a little larger than the permissible value of 10 mm/m, and the horizontal deformation is 5.9 mm/m,approaching the critical value of 6.0 mm/m, suggesting that the mine design is feasible for safety mining. | Zhiqiang Yang Shuhua Zhai Qian Gao Maohui Li | 2015 | 岩石力学与工程学报2015，34，1： | 15 |
| 2 | Comparison of concomitant and subsequent cholangiocarcinomas associated with hepatolithiasis:Clinical implications显示文摘AIM:To compare the outcomes of concomitant cholangiocarcinoma(C-CCA)and subsequent cholangiocar-cinoma(S-CCA)associated with hepatolithiasis. METHODS:From December 1987 to December 2007, 276 patients underwent hepatic resection for hepa-tolithiasis in Changhua Christian Hospital.Sixty-five patients were excluded due to incomplete medical records and the remaining 211 patients constituted our study population base.Ten patients were diag-nosed with C-CCA based on the preoperative biopsy or postoperative pathology.During the follow-up period, 12 patients developed S-CCA.The diagnosis of S-CCA was made by image-guided biopsy or by pathology if surgical intervention was carried out.Patient charts were reviewed to collect clinical information.Parameters such as CCA incidence,interval from operation to CCA diagnosis,interval from CCA diagnosis to disease-related death,follow-up time,and mortality rate were calculated for both the C-CCA and S-CCA groups.The outcomes of the C-CCA and S-CCA groups were math-ematically compared and analysed. RESULTS:Our study demonstrates the clinical implications and the survival outcomes of C-CCA and S-CCA. Among the patients with unilateral hepatolithiasis,the incidence rates of C-CCA and S-CCA were fairly similar (4.8%vs 4.5%,respectively,P=0.906).However,for the patients with bilateral hepatolithiasis,the incidence rate of S-CCA(12.2%)was higher than that of C-CCA (4.7%),although the sample size was limited and the difference between two groups was not statistically sig-nificant(P=0.211).The average follow-up time was 56 mo for the C-CCA group and 71 mo for the S-CCA group.Regard to the average time intervals from operation to CCA diagnosis,S-CCA was diagnosed after 67 mo from the initial hepatectomy.The average time intervals from the diagnoses of CCA to disease-related death was 41 mo for the C-CCA group and 4 mo for the S-CCA group,this difference approached statistical sig-nificance(P=0.075).Regarding the rates of overall and disease-related mortality,the C-CCA group had signifi-cantly lower overall mortality(70%vs 100%,P=0.041) and disease-related mortality(60%vs 100%,P=0.015) than the S-CCA group.For the survival outcomes of two groups,the Kaplan-Meier curves corresponding to each group also demonstrated better survival outcomes for the C-CCA group(log rank P=0.005).In the C-CCA group,three patients were still alive at the time of data analysis,all of them had free surgical margins and did not have pathologically proven lymph node metastasis at the time of the initial hepatectomy.In the S-CCA group,only one patient had chance to undergo a second hepatectomy,and all 12 S-CCA patients had died at the time of data analysis. CONCLUSION:C-CCA has better outcomes than S-CCA.The first hepatectomy is crucial because most patients with recurrent CCA or S-CCA are not eligible for repeated surgical intervention. | Chia-Cheng Lin Ping-Yi Lin Yao-Li Chen | 2013 | World Journal of Gastroenterology2013，19，3： | 13 |
| 3 | Genome triplication drove the diversification of Brassica plants显示文摘The genus Brassica belongs to the plant family Brassicaceae,which includes many important crop species that are used as oilseed,condiments,or vegetables throughout the world.Brassica plants comprise many diverse species,and each species contains rich morphotypes showing extreme traits.Brassica species experienced an extra whole genome triplication(WGT)event compared with the model plant Arabidopsis thaliana.Whole genome sequencing of the Brassica species Brassica rapa,Brassica oleracea and others demonstrated that WGT plays an important role in the speciation and morphotype diversification of Brassica plants.Comparative genomic analysis based on the genome sequences of B.rapa and A.thaliana clearly identified the WGT event and further demonstrated that the translocated Proto-Calepine Karyotype(tPCK,n57)was the diploid ancestor of the three subgenomes in B.rapa.Following WGT,subsequent extensive genome fractionation,block reshuffling and chromosome reduction accompanied by paleocentromere descent from the three tPCK subgenomes during the rediploidization process produced stable diploid species.Genomic rearrangement of the diploid species and their hybridization then contributed to Brassica speciation.The subgenome dominance effect and biased gene retention,such as the over-retention of auxin-related genes after WGT,promoted functional gene evolution and thus propelled the expansion of rich morphotypes in the Brassica species.In conclusion,the WGT event initiated subsequent genomic and gene-level evolution,which further drove Brassica speciation and created rich morphotypes in each species. | Feng Cheng Jian Wu Xiaowu Wang | 2014 | Horticulture Research2014，1，1： | 11 |
| 4 | Relationship between Placenta Location and Resolution of Second Trimester Placenta Previa显示文摘This prospective study was conducted to assess the rate of resolution of second trimester placenta previa in women with anterior placenta and posterior placenta, and that in women with and without previous cesarean section. In this study, placenta previa was defined as a placenta lying within 20 mm of the internal cervical os or overlapping it. We recruited 183 women diagnosed with previa between 20+0 weeks and 25+6 weeks. They were grouped according to their placenta location(anterior or posterior) and history of cesarean section. Comparative analysis was performed on demographic data, resolution rate of previa and pregnancy outcomes between anterior group and posterior group, and on those between cesarean section group and non-cesarean section group. Women with an anterior placenta tended to be advanced in parity(P=0.040) and have increased number of dilatation and curettage(P=0.044). The women in cesarean section group were significantly older(P=0.000) and had more parity(P=0.000), gravidity(P=0.000), and dilatation and curettage(P=0.048) than in non-cesarean section group. Resolution of previa at delivery occurred in 87.43% women in this study. Women with a posterior placenta had a higher rate of resolution(P=0.030), while history of cesarean section made no difference. Gestational age at resolution was earlier in posterior group(P=0.002) and non-cesarean section group(P=0.008) than in anterior group and cesarean section group correspondingly. Placenta location and prior cesarean section did not influence obstetric outcomes and neonatal outcomes. This study indicates that it is more likely to have subsequent resolution of the previa when the placenta is posteriorly located for women who are diagnosed with placenta previa in the second trimester. | 冯云 李学银 肖娟 李伟 刘静 曾雪 陈曦 陈凯月 范磊 陈素华 | 2017 | Journal of Huazhong University of Science and Technology(Medical Sciences)2017，37，3： | 7 |
| 5 | Targeted therapy for hepatocellular carcinoma显示文摘The last 3 years have seen the emergence of promising targeted therapies for the treatment of hepatocellular carcinoma(HCC).Sorafenib has been the mainstay of treatment for a decade and newer modalities were ineffective and did not confer any increased therapeutic benefit until the introduction of lenvatinib which was approved based on its non-inferiority to sorafenib.The subsequent success of regorafenib in HCC patients who progress on sorafenib treatment heralded a new era of second-line treatment and was quickly followed by ramucirumab,cabozantinib,and the most influential,immune checkpoint inhibitors(ICIs).Over the same period combination therapies,including anti-angiogenesis agents with ICIs,dual ICIs and targeted agents in conjunction with surgery or other loco-regional therapies,have been extensively investigated and have shown promise and provided the basis for exciting clinical trials.Work continues to develop additional novel therapeutic agents which could potentially augment the presently available options and understand the underlying mechanisms responsible for drug resistance,with the goal of improving the survival of patients with HCC. | Ao Huang Xin-Rong Yang Wen-Yuan Chung Ashley R.Dennison Jian Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 6 | Pre-course student performance prediction with multi-instance multi-label learning显示文摘Dear editor,Studying courses is one of the most basic and important tasks for college students.For each new course,the initial period of learning is crucial for students,and seriously influences subsequent learning activities.However,given a large number of classes in universities,it has become impossible for teachers to keep track of the individual performance of each student.In these circumstances,it is desirable to predict each student’s performance on a certain course prior to its commencement. | Yuling MA Chaoran CUI Xiushan NIE Gongping YANG Kashif SHAHEED Yilong YIN | 2019 | Science China(Information Sciences)2019，62，2： | 5 |
| 7 | Multiscale computational understanding and growth of 2D materials:a review显示文摘The successful discovery and isolation of graphene in 2004,and the subsequent synthesis of layered semiconductors and heterostructures beyond graphene have led to the exploding field of two-dimensional(2D)materials that explore their growth,new atomic-scale physics,and potential device applications.This review aims to provide an overview of theoretical,computational,and machine learning methods and tools at multiple length and time scales,and discuss how they can be utilized to assist/guide the design and synthesis of 2D materials beyond graphene. | Kasra Momeni Yanzhou Ji Yuanxi Wang Shiddartha Paul Sara Neshani Dundar E.Yilmaz Yun Kyung Shin Difan Zhang Jin-Wu Jiang Harold S.Park Susan Sinnott Adri van Duin Vincent Crespi Long-Qing Chen | 2020 | npj Computational Materials2020，，1： | 4 |
| 8 | 中国精神分裂症分子遗传研究(英文) | 崔东红 江开达 | 2012 | 上海精神医学2012，24，04X： | 4 |
| 9 | Comment on “Anterior lamellar recession for management of upper eyelid cicatricial entropion and associated eyelid abnormalities”显示文摘Dear Editor,I read with great interest the article by Gawdat et al^([1]).The authors evaluated the functional and aesthetic outcomes of upper eyelid cicatricial entropion correction using anterior lamellar recession(ALR)combined with procedures addressing the associated conditions including dermatochalasis。 | Naser Owji | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 4 |
| 10 | Seasonal variance of salinity tolerance of a copepod Drepanopus bispinosus in an Antarctic littoral saline lake (Burton Lake)显示文摘In Burton Lake (an Antarctic littoral saline lake), as one of the overwinter species, the female Drepanopus bispinosus reach adult form in autumn. and early winter.For the subsequent life period of more than eight months, the animals experience such changing environment as increasing salinities from approximately 33 (in May) to 39 (in November). There is a considerable difference of salinity tolerance of female adults between summer and winter populations.Winter collected copepods survived lower salinities than summer collected copepods in this experiment. The upward shift in their salinity tolerance range is related to the development of field acclimation to salinity. Respiration rates of the summer animals showed a visible increase over those of winter copepods in simitar salinity and temperature conditions, thus supporting the above conclusion. | D.S.Eslake H.R.Burton | 1989 | Acta Oceanologica Sinica1989，8，1： | 3 |
| 11 | Ischemia and reperfusion injury of the spinal cord:experimental strategies to examine postischemic paraplegia显示文摘Thoracoabdominal aortic replacement,necessary in case of injuries,aneurysms and dissections,shows a high complication rate as a consequence of the perioperative ischemia/reperfusion-sequence(I/R).Clamping above and below the lesion leads to the spinal cord suffering from ischemia.Clamping times of less than 30 minutes show only a small risk of neurological deficit,while longer | Florian Simon Alexander Oberhuber | 2016 | Neural Regeneration Research2016，11，3： | 3 |
| 12 | Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events显示文摘The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.Ongoing concerns of emergent variants include possible recombinants,as genome recombination is an important evolutionary mechanism for the emergence and re-emergence of human viral pathogens.In this study,we identified diverse recombination events between two Omicron major subvariants(BA.1 and BA.2)and other variants of concern(VOCs)and variants of interest(VOIs),suggesting that co-infection and subsequent genome recombination play important roles in the ongoing evolution of SARS-CoV-2.Through scanning high-quality completed Omicron spike gene sequences. | Junxian Ou Wendong Lan Xiaowei Wu Tie Zhao Biyan Duan Peipei Yang Yi Ren Lulu Quan Wei Zhao Donald Seto James Chodosh Zhen Luo Jianguo Wu Qiwei Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 13 | PRELIMINARY REPORT ON THE FIELD WORK IN 1986 AT TUNG-GUR,NEI MONGOL显示文摘Tung-gur is one of the few Chinese mammalian fossil localities of world reputation. It was discovered by the Third Central Asiatic Expedition organized by the American Museum of Natural History in 1928, and was extensively excavated later in 1930. The subsequent preliminary investigation of the excavated material revealed as many as 27 species of extinct animals, among which the shovel-tusked masto- | 邱占祥 阎德发 陈冠芳 邱铸鼎 | 1988 | Chinese Science Bulletin1988，33，5： | 2 |
| 14 | Erratum:On the Correct Form of the Saha Equation for Two-Temperature Plasmas[Chin.Phys.Lett.16(1999)193]显示文摘A typographic error has been found in lines 5-8 on the left column of page 195.'……for and only for a single temperature plasma system with T_(e)=T_(h)=T,the condition dG≤0(or dF≤0)reduces to dG<0(or dF≤0)'should be corrected as '……for and only for a single temperature plasma system with T_(e)=T_(h)=T,the condition dG≤0(or dF≤0)reduces to dG≤0(or dF≤0)'.This error has no effect on the subsequent derivation or the conclusions of the paper. | 韩鹏 陈熙 李和平 | 1999 | Chinese Physics Letters1999，16，5： | 1 |
| 15 | Study on electrode process of myoglobin at a polymerized Toluidine Blue film electrode显示文摘This paper reports the use of an electrochemically polymerized Toluidine Blue (TB) filmelectrode.The film on platinum electrode surface was analyzed with ESCA.The heterogeneouselectron transfer processes of myoglobin at the polymerized TB film electrode have been investigatedusing in situ UV-visible spectroelectrochemistry.The formal potential(E°′)and electron transfernumber(n)of myoglobin were calculated as E°′=0.045 V(vs.NHE)and n=0.99.The exhaustivereduction and oxidation electrolyses are achieved in 130 s and 110 s respectively,during a potential stepbetween-0.4 V and+0.4 V.A formal heterogeneous electron transfer rate constant(ksh)of 1.09×10-4 cm/s and a transfer coefficient(α)of 0.47 were obtained by cyclic voltabsorptometry,whichindicated that myoglobin underwent a quasi-reversible electrode process at the polymerized TB filmelectrode. | DONG,Shao-Jun CHU,Qing-Hui Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,Jilin 130022 Present address:Applied Chemical Department,Fushun Petroleum Institute,Fushun,Liaoning 143001. | 1993 | Chinese Journal of Chemistry1993，11，1： | 1 |
| 16 | Can we protect the brain via preconditioning?Role of microRNAs in neuroprotection显示文摘Preconditioning stimulus:Preconditioning is an adaptive response,whereby a small dose of a harmful substance protects the brain from a subsequent damaging insult(Dirnagl et al.,2009).The concept of preconditioning was first described in an ischemic heart model,it was observed that brief ischemic episodes protect against a subsequent ischemic insult(Murry | Sean Quinlan Eva M.Jimenez-Mateos | 2016 | Neural Regeneration Research2016，11，3： | 1 |
| 17 | Study on potassium bromodifluoroacetate Convenient approaches to the syntheses of trifluoromethylated compounds显示文摘Treatment of potassium bromodifluoroacetate(1)with alkyl halides in thepresence of copper,iodide and potassium fluoride in DMF at 85—90℃ for 3—5h gavethetrifluoromethylated derivatives in moderate to high yields. | LI,Heng-Duo Zhejiang Normal University,Jinghua,Zhejiang 321004DUAN,Jian-Xing SU,De-Bao CHEN,Qing-Yun Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 | 1993 | Chinese Journal of Chemistry1993，11，4： | 1 |
| 18 | Targeted quantitative profiling of metabolites and gene transcripts associated with 4-aminobutyrate (GABA) in apple fruit stored under multiple abiotic stresses显示文摘4-Aminobutyrate accumulates in plants under abiotic stress.Here,targeted quantitative profiling of metabolites and transcripts was conducted to monitor glutamate-and polyamine-derived 4-aminobutyrate production and its subsequent catabolism to succinate or 4-hydroxybutyrate in apple(Malus x domestica Borkh.)fruit stored at 0°C with 2.5 kPa O2 and 0.03 or 5 kPa CO2 for 16 weeks.Low-temperature-induced protein hydrolysis appeared to be responsible for the enhanced availability of amino acids during early storage,and the resulting higher glutamate level stimulated 4-aminobutyrate levels more than polyamines.Elevated CO2 increased the levels of polyamines,as well as succinate and 4-hydroxybutyrate,during early storage,and 4-aminobutyrate and 4-hydroxybutyrate over the longer term.Expression of all of the genes likely involved in 4-aminobutyrate metabolism from glutamate/polyamines to succinate/4-hydroxybutyrate was induced in a co-ordinated manner.CO2-regulated expression of apple GLUTAMATE DECARBOXYLASE 2,AMINE OXIDASE 1,ALDEHYDE DEHYDROGENASE 10A8 and POLYAMINE OXIDASE 2 was evident with longer term storage.Evidence suggested that respiratory activities were restricted by the elevated CO2/O2 environment,and that decreasing NAD+availability and increasing NADPH and NADPH/NADP+,respectively,played key roles in the regulation of succinate and 4-hydroxybutyate accumulation.Together,these findings suggest that both transcriptional and biochemical mechanisms are associated with 4-aminobutyrate and 4-hydroxybutyrate metabolism in apple fruit stored under multiple abiotic stresses. | Carolyne J.Brikis Adel Zarei Greta Z.Chiu Kristen L.Deyman Jingyun Liu Christopher P.Trobacher Gordon J.Hoover Sanjeena Subedi Jennifer R.DeEll Gale G.Bozzo Barry J.Shelp | 2018 | Horticulture Research2018，5，1： | 1 |
| 19 | Chemical Mechanisms of Prebiotic Chirality Amplification显示文摘This review article surveys the recent experimental findings that suggest alternative chemical models of directed chirality amplification at the early,prebiotic Earth.It is believed that the chirality amplification step followed the initial emergence of small enantiomeric imbalance and preceded(as a necessary condition)the occurrence of homochiral biopolymers,assembled from enantiomerically pure building blocks.This work focuses on the chemical nature of possible mechanisms of primordial chirality enhancement,without going into detail of the preceding and subsequent phases of origination of biological homochirality and life on Earth.These mechanisms are discussed through the prism of integrity of biological natural selection and chemical kinetic selection. | Konstantin P.Bryliakov | 2020 | Research2020，，1： | 1 |
| 20 | 摄食障碍、体重减轻和初潮后发生闭经少女患者恢复月经所需的体重 | Swenne I. 李开 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，4： | 1 |
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