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| 1 | Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects显示文摘Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018. | Qihao Wu Bastien Nay Min Yang Yeke Ni Hong Wang Ligong Yao Xuwen Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 2 | Total Synthesis of (±)-Calanolide A and Its Anti-HIV Activity显示文摘Anti-HIV agent (±)-calanolide A has been synthesized by a four-step approach startingfrom phloroglucinol, including the Pechmann reaction, Friedel-Crafts acylation, cyclization,chromenylation and Luche reduction. | Chun Mei ZHOU Lin WANG Ming Long ZHANG Zhi Zhong ZHAO (Institute of Materia Medica, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing 100050)Xing Quan ZHANG Xiang Hong CHEN Hong Shan CHEN (Institute of Medicinal Biotechno | 1998 | Chinese Chemical Letters1998，9，5： | 3 |
| 3 | The [4+2] Cycloaddition of 2-Pyrone in Total Synthesis显示文摘Diels-Alder reaction is one of the most important reactions in organic synthesis and has witnessed great achievements in total syntheses of complex natural products.In this review,we will focus on the [4+2] cycloaddition that utilizes 2-pyrone as the diene component.Major advances of its applications in the total syntheses of natural products in the past fifty years will be discussed here. | Quan Cai | 2019 | Chinese Journal of Chemistry2019，37，9： | 3 |
| 4 | Total Synthesis of the Natural Product-Pinosylvin and its Analog显示文摘We synthesised a natural product (10), isolated from G.parvifolium, and its analog. The synthetic product was characterized by elemental analysis and 1H-NMR in comparision with the corresponding natural product. | Zhi Song PIAO Lin WANG Zhi Zhong ZHAO | 2000 | Chinese Chemical Letters2000，11，8： | 2 |
| 5 | Total Synthesis of (±)-Cordatolide A and its Anti-HIV Activity显示文摘The natural product (±)-cordatolide A has been synthesized by a four-step approach starting from phloroglucinol, including Pechmann reaction, Friedel-Crafts acylation, cyclization. chromenylation and Luche reduction. | Qi GAO Lin WANG Xiao Tian LIANG (Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050) | 1999 | Chinese Chemical Letters1999，10，8： | 1 |
| 6 | An Improved Synthesis of the Natural Product Isorhapontigenin显示文摘 | Lian QIAN Zhi Song PIAO Lin WANG Zhi Zhong ZHAO | 2000 | Chinese Chemical Letters2000，11，3： | 1 |
| 7 | First total synthesis of (±)-trolline显示文摘Trolline, a new bioactive alkaloid was isolated in 2004. We reported herein the first total synthesis of (±)-trolline, in two steps and 18.0% overall yield. | Qiu Qin He Chao Mei Liu Ke Li | 2007 | Chinese Chemical Letters2007，18，6： | 1 |
| 8 | A modified total synthesis of cystothiazole A显示文摘A modified total synthesis of cystothiazole A is described. In this synthetic strategy, a one-step transformation of acylated oxazolidinone to β-ketoester has been successfully applied, thus making the synthetic route more efficient. This method may also be potentially applied in synthesis of other related β-substituted-β-methoxyl acrylates (bb-MOAs). | YueXia Bai JiLai Bao Jun Ren ZhongWen Wang | 2009 | Science China Chemistry2009，52，9： | 0 |
| 9 | Regioselective Synthesis of Two Novel 4-alkenyloxy-2,6-dihydroxyacetophenones显示文摘Two novel Acetophenones, 4-(1’-geranyloxy) - 2, 6-dihydroxyacetophenone 1 and 4- (1’-farnesyl ) - 2, 6-dihydroxyacetophenone 2 isolated from the fruit of Evodia merrillii and from theaerial parts of Borronia ramosa respectively have been synthesized by starting from 2,4,6-trihydroxyacetophenone 3. | Chu Sheng HUANG Zhe ZHANG Shu Hua LI Yu Lin LI (National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000) | 1998 | Chinese Chemical Letters1998，9，9： | 0 |
| 10 | Total Synthesis of 16-Acetoxy-6,7-didehydroferruginyl Methyl Ether显示文摘An efficient synthetic route have been developed to 16-acetoxy-6,7-didehydroferruginyl methyl ether. | Yong Hong GAN An Pai LI Ping Yan BIE Xin Fu PAN (Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University.Lanzhou. 730000 ) | 2000 | Chinese Chemical Letters2000，11，6： | 0 |
| 11 | Cytotoxic polyacetylenes isolated from the roots and rhizomes of Notopterygium incisum显示文摘Phytochemical investigation on the roots and rhizomes of Notopterygium incisum led to the isolation of a new polyacetylene, notopolyenol A (1), along with thirteen known analogues (2-14). Their structures were elucidated by extensive analyses of NMR and HRMS data, and the absolute configuration of 1 was unambiguously determined as 3 R by comparison of its retention time and ECD curve with those of synthetic enantiomers (-)-1 and (+)-1, whose absolute configurations were established by using the modified Mosher's method. Subsequent activity screening revealed that (3 S)-1 exhibited the most significant cytotoxicity against MCF-7, H1299, and HepG2 cancer cells with IC_(50) values of 1.3 μmol/L,0.6μmol/L and 1.4μmol/L, respectively. | Xikang Zheng Xiaoqing Zheng Chen Zhang Qingying Zhang Yong Jiang Pengfei Tu | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 12 | Total syntheses of dehydrobotrydienal, dehydrobotrydienol and 10-oxodehydrodihydrobotrydial显示文摘In this paper,we report the concise total syntheses of three botryane sesquiterpenoids:dehydrobotrydienal,dehydrobotrydienol,and 10-oxodehydrodihydrobotrydial.The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes,and further oxidative aromatization and oxidation to complete the total syntheses. | Zichun Zhang Dandan Zhao Yingdong He Zhen Yang Jianxian Gong | 2019 | Chinese Chemical Letters2019，30，8： | 0 |
| 13 | CHEMICAL SYNTHESIS OF A GENE FOR RAT'S ATRIAL NATRIURETIC FACTOR显示文摘Atrial natriuretic factor (ANF), a sort of peptide hormones, was secreted by mammalian cardiac atria, Recently, it has been demonstrated that ANF exhibits a marked natriuresis, diuresis, vascular relaxation and hypotension. ANF would | 施文 闵永洁 杨迪 王启松 | 1989 | Chinese Science Bulletin1989，34，11： | 0 |
| 14 | TOTAL SYNTHESIS OF CURVULARIN-TYPE MACROLIDES 12-OXOCURVULARIN AND CITREOFURAN显示文摘TOTAL SYNTHESIS OF CURVULARIN-TYPE MACROLIDES 12-OXOCURVULARIN AND CITREOFURANTOTALSYNTHESISOFCURVULARIN-TYPEMACROLIDES12-OXO... | Sheng LAI and Xiang GAO (School of Pharmacy, West China University of Medical Sciences, Chengdu 610041)Yoshikazu SHIZURI and Shosuke YAMAMURA (Department of Chemistry, Faculty of Science and Technology,Keio University, Hiyoshi, Yokohama 223, Japan) | 1994 | Chinese Chemical Letters1994，5，6： | 0 |
| 15 | STUDIES ON THE TOTAL SYNTHESIS OF(-)-(2R,5S)-2-METHYL-5-HYDROXYMETHYL-δ-VALEROLACTONE显示文摘STUDIES ON THE TOTAL SYNTHESIS OF(-)-(2R,5S)-2-METHYL-5-HYDROXYMETHYL-δ-VALEROLACTONESTUDIESONTHETOTALSYNTHESISOF(-)-(2R,5S)-... | He Ping ZENG(Department of Chemistry, South China Normal Universitys Guangzhou 510631) | 1994 | Chinese Chemical Letters1994，5，4： | 0 |
| 16 | Recent Advances of Transition Metal-Mediated Oxidative Rad- ical Reactions in Total Synthesis of Indole Alkaloids显示文摘Over the past decades, transition metal-mediated oxidative radical reactions have been discovered and devel-oped as a robust and conceptually novel approach for organic synthesis. This mini-review details the background,recent advances, and synthetic applications of transition metal-mediated oxidative radical reactions in indole alka-loids biomimetic synthesis. The organization of each section is based on the kind of indole alkaloids. | Kangjiang Liang Chengfeng Xia | 2017 | Chinese Journal of Chemistry2017，35，3： | 0 |
| 17 | Total synthesis of(+)-lentiginosine via a key Au catalysis显示文摘Total syntheses of(+)-lentiginosine and its 8a-epimer using a gold-catalyzed oxidative cyclization as the key step were realized.The gold chemistry,reported previously in a 4+2 synthesis of piperidin-4-ones,tolerates functionalized structures and is compatible with several protecting strategies albeit with low diastereose lectivities. | CUI Li & ZHANG LiMing Department of Chemistry & Biochemistry,University of California,Santa Barbara,CA 93106,USA | 2010 | Science China Chemistry2010，53，1： | 0 |
| 18 | Total synthesis of 5R,5-(1'R-hydroxy-2'-phenylethyl)-γ-lactone显示文摘The latest and highly efficient asymmetric dihydroxylation was employed to create the chiral vicinal dihydroxy group of the title compound 1, which has been synthesized from phenylacetaldehyde through 6 steps with a total yield of 61%. | YU, Li-Bing WANG, Zhi-QinShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China | 1994 | Chinese Journal of Chemistry1994，12，6： | 0 |
| 19 | Total synthesis of Yingzhaosu B and its three diastereoisomers显示文摘Yingzhaosu B (1), coexisting with Yingzhaosu A (2) which is an antimalarialprinciple in the traditional Chinese herbal medicine Yingzhao (Artabotrys uncina-tus (L.) Merr.), is a polyhydroxy bisabolene compound. Although its structure wasproposed by Liang and coworkers in 1979, the stereochemistry remained unsettled.From biogenetic viewpoint, it is reasonable to assume that the configuration of 4-Cin Yingzhaosu B is S as that in Yingzhaosu A. Recently, the synthesis of | XU, Xing-Xiang XIE, XuShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China | 1994 | Chinese Journal of Chemistry1994，12，4： | 0 |
| 20 | In situ ATR-FTIR Combined with SIMPLISMAAlgorithm to Investigate the Synthesis Mechanism of 4-Amino-3,5-dimethyl Pyrazole显示文摘In situ attenuated total refletion-Fourier transform infrared spectroscopy(ATR-FTIR) was used to monitorand acquire spectral information on the synthesis of 4-amino-3,5-dimethyl pyrazole. Principal component analy-sis(PCA) was used to determine the number of principle components(PCs). The score vectors of the PCs were ana-lysed using the simple-to-use interactive self-modelling mixture analysis(SIMPLISMA) algorithm to obtain spectraland concentration profiles for the reactants, intermediates and product. The vibrational frequencies of the interme-diates were calculated via density ftmctional theory(DFT) at the level of the B3LYP/6-31 l++G(d,p) basis set, and thegeometrical configurations of the intermediates were simultaneously optimized. Finally, a reasonable synthesismechanism for 4-amino-3,5-dimethyl pyrazole was determined based on the changes observed in the feature peaks.The results from the SIMPLISMA algorithm correlated well with the quantttm chemistry calculations. This provedthat the SIMPLISMA algorithm combined with ATR-FTIR can be used to detemfine the synthesis mechanism for4-amino-3,5-dimethyl pyrazole and can even provide a new, useful method to explore dynamic synthesis reactionmechanisms. | GAO Xinyu MA Junxiu RUAN Fangqi ZHANG Tianlong LI Hua | 2016 | Chemical Research in Chinese Universities2016，32，6： | 0 |
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