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| 1 | Ischemia/reperfusion injury and cardioprotective mechanisms:Role of mitochondria and reactive oxygen species显示文摘Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of acute myocardial infarction(AMI).However reperfusion is responsible for additional myocardial damage,which likely involves opening of the mitochondrial permeability transition pore(mPTP).In reperfusion injury,mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability.Major mechanisms of mitochondrial dysfunction include the long lasting opening of mPTPs and the oxidative stress resulting from formation of reactive oxygen species(ROS).Several signaling cardioprotective pathways are activated by stimuli such as preconditioning and postconditioning,obtained with brief intermittent ischemia or with pharmacological agents.These pathways converge on a common target,the mitochondria,to preserve their function after ischemia/reperfusion.The present review discusses the role of mitochondria in cardioprotection,especially the involvement of adenosine triphosphate-dependent potassium channels,ROS signaling,and the mPTP.Ischemic postconditioning has emerged as a new way to target the mitochondria,and to drastically reduce lethal reperfusion injury.Several clinical studies using ischemic postconditioning during angioplasty now support its protective effects,and an interesting alternative is pharmacological postconditioning.In fact ischemic postconditioning and the mPTP desensitizer,cyclosporine A,have been shown to induce comparable protection in AMI patients. | Maria-Giulia Perrelli Pasquale Pagliaro Claudia Penna | 2011 | World Journal of Cardiology2011，3，6： | 64 |
| 2 | Expansion of the Cathaysian Oldland through the Ordovician-Silurian transition:Emerging evidence and possible dynamics显示文摘Located northwest of the Jiangshan-Shaoxing Fault Zone,western and northwestern Zhejiang and northeastern Jiangxi provinces experienced major changes in bio-and litho-facies and paleogeography through the Ordovician-Silurian transition (late Katian,Hirnantian,and early Rhuddanian),as manifested by stratigraphic,paleontologic and synecologic records.Three geographic units under consideration are South,Central,and North areas.The western margin of the South area was occupied by the Huaiyu Mountains,whereas the other two parts were covered by the Zhe-Gan Sea during late Katian (Late Ordovician) time.In the early stage of the Changwu Formation deposition (late Katian),the sea was deepening northeastward,but with shallower conditions in the southwest and deeper conditions in the northeast.During mid to late stages of Changwu Formation deposition (latest Katian),the sea became much shallower and the sea bottom was uplifted substantially,which occurred somewhat prior to the global trend.During the Hirnantian (latest Ordovician) and early Rhuddanian (earliest Silurian),the study region became a shallow bay under expansion of the Cathaysian Oldland.There occurred a major drop of sea level and great changes in benthic biota with the occurrence of many new immigrants through the Ordovician-Silurian transition,which are closely related to a unique regional orogeny.The Yangtze and Cathaysian blocks may have amalgamated within the South China Paleoplate during this interval to cause the continuous uplifting and northwestward expansion of the Cathaysian Oldland. | RONG JiaYu ZHAN RenBin XU HongGen HUANG Bing YU GuoHua | 2010 | Science China Earth Sciences2010，53，1： | 37 |
| 3 | 基于Transition SST模型的高雷诺数圆柱绕流数值研究显示文摘为了研究高雷诺数下圆柱绕流边界层的转捩现象和圆柱尾迹近壁区的流动特征,首先通过在典型雷诺数下采用Transition SST四方程转捩模型模拟圆柱绕流得到的结果与实验结果及采用SST k-ω两方程湍流模型模拟结果的对比分析,验证了Transition SST模型在模拟高雷诺数下圆柱绕流的优越性,并较为准确地预测出了圆柱绕流边界层的转捩现象及尾迹近壁区的流动特征。然后分别对亚临界区、临界区、超临界区和过临界区的圆柱绕流问题进行了数值模拟,分析了不同雷诺数下圆柱绕流的流场结构及圆柱表面压力系数、摩擦力系数的变化规律,研究了圆柱绕流近壁区的流动特征、边界层转捩的流动机理、转捩位置及其随雷诺数的变化规律。结果表明,亚临界区二维圆柱绕流边界层发生层流分离,无分离泡和转捩现象;临界区和超临界区二维圆柱绕流边界层先产生了分离泡现象,之后流动发生了转捩并在转捩后发生湍流分离;过临界区二维圆柱绕流边界层流动在转捩之后发生湍流分离,无分离泡现象;在临界区、超临界区和过临界区,二维圆柱绕流边界层转捩位置随雷诺数增大向前驻点移动。 | 雷娟棉 谭朝明 | 2017 | 北京航空航天大学学报2017，43，2： | 34 |
| 4 | Rural vitalization in China:A perspective of land consolidation显示文摘The core objective of rural vitalization is to systemically establish a coupling pattern of various rural development elements including population,land and industry.As one of the prerequisites,land resources is required to be optimally allocated via land consolidation.Con seque ntly,la nd con solidati on con tributes greatly to population agglomeration,industrial developme nt and resources support under the con text of combati ng rural decline.Based on the key eleme nts affecting rural development,this paper elaborates the con no tation of rural vitalization and land consolidation in the new era as well as their relationships.Furthermore,the paper analyzes the alternative paths for achieving rural vitalization via land consolidation,and discusses the future directions of land consolidation and rural vitalization.The conclusions are drawn as follows:(1)To cope with the loss and decline of the intrinsic elements in rural areas,rural vitalization is a development strategy aimed at realizing economic,political,cultural and ecological rejuvenation in rural area by reshaping socio?economic morphology and spatial pattern in rural territory.(2)From the perspective of rural vitalization,land consolidation is endowed with new connotation,which should not only target at activating the key elements of rural development,but also place emphasis on coordimating material space and spirit core as well as integrating the restructuring of the physical space and the rural gov?ernance system.(3)Land consolidation should be compatible with regional natural conditions and the current stage of socio-economic development.According to the principle of regional planning and classification strategy,the appropriate models and paths should be adopted to promote the benign interactions of population,land and industry based on engineering techniques and ecological means.(4)Under the background of national strategy of rural vitaliza?tion,it is n ecessary to reshape the value orientati on of la nd con solidation based on a scie tific understanding of urban-rural relations and rural territorial functions,coordinate land consolidation planning and rural vitalization planning under the unified spatial planning system,and explore the new model combining land consolidation and multifunctional agriculture. | LONG Hualou ZHANG Yingnan TU Shuangshuang | 2019 | Journal of Geographical Sciences2019，29，4： | 33 |
| 5 | 内蒙古克什克腾旗小东沟斑岩型钼矿床成岩成矿机制探讨显示文摘本文选取内蒙古克什克腾旗的小东沟斑岩型钼矿区作为研究区,它位于西拉沐伦钼矿带的西南部。对小东沟岩体进行了主微量元素、SHRIMP锆石U-Pb定年等地球化学方面的研究;对岩体中的钾长石和含矿矿物辉钼矿进行了普通铅同位素分析。小东沟岩体具有高硅富钾、REE含量低、Zr含量高、无负铕异常、高ε_(Nd)(t)、低Sr_i等特点,指示岩浆起源于加厚新生下地壳的熔融,同时具有高温、快速熔融、快速析离逃离源区的特点;小东沟岩体的SHRIMP锆石U-Pb定年结果为142±2Ma,对应140Ma左右主应力场由南北向转为东西向的构造体制大转折时期,这个时期大兴安岭处于伸展的构造环境下,底侵作用发育,地幔物质可以添加到下地壳熔融形成的岩浆中;对岩体钾长石和辉钼矿进行的普通铅同位素分析显示前者具有从造山带-地幔过渡的特征,后者则显示有地幔特征,说明成岩、成矿物质来自两个不同的源区,下地壳的岩浆和地幔含矿流体发生了混合。通过以上的分析,结合水-岩浆物理反应的实验结果,本文提出小东沟斑岩型钼矿床的成矿模式:大兴安岭地区在早白垩世伸展的构造背景下,地幔含矿流体加入受底侵作用加热的下地壳中使之熔融形成岩浆,随后更多的地幔含矿流体进入岩浆房,促使其迅速析离逃逸出源区,二者一起上升侵位。在岩浆温度较高时,地幔含矿流体和岩浆大致以较稳定的液态不混溶的状态共存;当岩浆和流体侵位到较浅深度时,压力下降,温度降低,晶体增多,流体-岩浆体系变得不稳定,岩浆被流体分割成许多很小的岩浆团。流体中H^+、K^+和各种成矿元素的存在使之必然会和岩浆或冷却后形成的岩石发生蚀变反应,并晶出成矿矿物,形成现在我们看到的具有浸染状矿化现象的小东沟斑岩型钼矿床。 | 覃锋 刘建明 曾庆栋 罗照华 | 2009 | 岩石学报2009，25，12： | 29 |
| 6 | The construction of Markov processes in random environments and the equivalence theorems显示文摘In sec.1, we introduce several basic concepts such as random transition function, p-m process and Markov process in random environment and give some examples to construct a random transition function from a non-homogeneous density function. In sec.2, we construct the Markov process in random enviromment and skew product Markov process by p - m process and investigate the properties of Markov process in random environment and the original process and environment process and skew product process. In sec. 3, we give several equivalence theorems on Markov process in random environment. | HU DiheSchool of Mathematics and Statistics, Wuhan University, Wuhan 430072, China | 2004 | Science China Mathematics2004，47，4： | 27 |
| 7 | Role of epithelial-mesenchymal transition in gastric cancer initiation and progression显示文摘Gastric cancer is one of the most common malignant tumors worldwide.Due to its intricate initiation and progression mechanisms,early detection and effective treatment of gastric cancer are difficult to achieve.The epithelial-mesenchymal transition(EMT)is characterized as a fundamental process that is critical for embryonic development,wound healing and fibrotic disease.Recent evidence has established that aberrant EMT activation in the human stomach is closely associated with gastric carcinogenesis and tumor progression.EMT activation endows gastric epithelial cells with increased characteristics of mesenchymal cells and reduces their epithelial features.Moreover,mesenchymal cells tend to dedifferentiate and acquire stem cell or tumorigenic phenotypes such as invasion,metastasis and apoptosis resistance as well as drug resistance during EMT progression.There are a number of molecules that indicate the stage of EMT(e.g.,E-cadherin,an epithelial cell biomarker);therefore,certain transcriptional proteins,especially E-cadherin transcriptional repressors,may participate in the regulation of EMT.In addition,EMT regulation may be associated with certain epigenetic mechanisms.The aforementioned molecules can be used as early diagnostic markers for gastric cancer,and EMT regulation can provide potential targets for gastric cancer therapy.Here,we review the role of these aspects of EMT in gastric cancer initiation and development. | Zhao Peng Chen-Xiao Wang Er-Hu Fang Guo-Bin Wang Qiang Tong | 2014 | World Journal of Gastroenterology2014，20，18： | 28 |
| 8 | Epithelial-mesenchymal transition- activating transcription factors- multifunctional regulators in cancer显示文摘The process of epithelial to mesenchymal transition(EMT), first noted during embryogenesis, has also been reported in tumor formation and leads to the development of metastatic growth. It is a naturally occurring process that drives the transformation of adhesive,non-mobile epithelial like cells into mobile cells with a mesenchymal phenotype that have ability to migrate to distant anatomical sites. Activating complex network of embryonic signaling pathways, including Wnt, Notch,hedgehog and transforming growth factor-β pathways,lead to the upregulation of EMT activating transcription factors, crucial for normal tissue development and maintenance. However, deregulation of tightly regulated pathways affecting the process of EMT has been recently investigated in various human cancers. Given the critical role of EMT in metastatic tumor formation,better understanding of the mechanistic regulation provides new opportunities for the development of potential therapeutic targets of clinical importance. | Minal Garg | 2013 | World Journal of Stem Cells2013，5，4： | 26 |
| 9 | Transition prediction of a hypersonic boundary layer over a cone at small angle of attack——with the improvement of e^N method显示文摘The problem of transition prediction for hypersonic boundary layers over a sharp cone has been studied in this work. The Mach number of the oncoming flow is 6, the cone half-angle is 5o,and the angle of attack is 1o. The conventional eN method is used, but the transition location so obtained is obviously incorrect. The reason is that in the conventional method, only the amplifying waves are taken into account, while in fact, for different meridians the decay processes of the disturbances before they begin to grow are different. Based on our own previous work, new interpretation and essential improvement for the eN method are proposed. Not only the amplification process but also the decay process is considered. The location, where by linear stability theory, the amplitude of disturbance wave is amplified from its initial small value to 1%, is considered to be the transition location. The new result for transition prediction thus obtained is found to be fairly satisfactory. It is also indicated that for the calculation of base flow, boundary layer equations can be used for a small angle of attack. Its computational cost is much smaller than those for DNS. | SU CaiHong1 & ZHOU Heng1,2 1 Department of Mechanics, Tianjin University, Tianjin 300072, China 2 Liu-Hui Center of Applied Mathematics, Nankai University and Tianjin University, Tianjin 300072, China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，1： | 26 |
| 10 | Seasonal Transition of Summer Rainy Season over Indochina and Adjacent Monsoon Region显示文摘SeasonalTransitionofSummerRainySeasonoverIndochinaandAdjacentMonsoonRegionJunMatsumotoDepartmentofGeography,UniversityofTokyo... | Jun MatsumotoDepartment of Geography, University of Tokyo 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan | 1997 | Advances in Atmospheric Sciences1997，14，2： | 26 |
| 11 | Modelling flow transition in a hypersonic boundary layer with Reynolds-averaged Navier-Stokes approach显示文摘Based on Reynolds-averaged Navier-Stokes approach,a laminar-turbulence transition model is proposed in this study that takes into account the effects of different instability modes associated with the variations in Mach numbers of compressible boundary layer flows.The model is based on k-ω-γ three-equation eddy-viscosity concept with k representing the fluctuating kinetic energy,ωthe specific dissipation rate and the intermittency factorγ.The particular features of the model are that:1)k includes the non-turbulent,as well as turbulent fluctuations;2)a transport equation for the intermittency factorγis proposed here with a source term set to trigger the transition onset;3)through the introduction of a new length scale normal to wall,the present model employs the local variables only avoiding the use of the integral parameters,like the boundary layer thicknessδ,which are often cost-ineffective with the modern CFD(Computational Fluid Dynamics)methods;4)in the fully turbulent region,the model retreats to the well-known k-ωSST(Shear Stress Transport)model.This model is validated with a number of available experiments on boundary layer transitions including the incompressible,supersonic and hypersonic flows past flat plates,straight/flared cones at zero incidences,etc.It is demonstrated that the present model can be successfully applied to the engineering calculations of a variety of aerodynamic flow transition. | WANG Liang FU Song | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 22 |
| 12 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 13 | The existence and uniqueness of q-process in ran-dom environment显示文摘We introduce some basic concepts such as random (sub-)transition function,q-function in random environment, q-process in random environment and some basic lemmas. For any continuous q-function in random environment, we prove that the q-process in random environment always exists, and that any q-process in random environment satisfies the random Kolmogorov backward equation and the minimal q-process in random environment always exists. When q is a continuous and conservative q-function in random environment, the necessary and sufficient conditions for the uniqueness of q-process in random environment are given. Finally the special cases, homogeneous random transition functions and homogeneous q-processes in random environments are considered. | HU Dihe | 2004 | Science China Mathematics2004，47，5： | 21 |
| 14 | Diverse and variable sex determination mechanisms in vertebrates显示文摘Sex is prevalent in nature and sex determination is one of the most fundamental biological processes, while the way of initiating female and male development exhibits remarkable diversity and variability across vertebrates. The knowledge on why and how sex determination mechanisms evolve unusual plasticity remains limited. Here, we summarize sex determination systems,master sex-determining genes and gene-regulatory networks among vertebrates. Recent research advancements on sex determination system transition are also introduced and discussed in some non-model animals with multiple sex determination mechanisms. This review will provide insights into the origin, transition and evolutionary adaption of different sex determination strategies in vertebrates, as well as clues for future perspectives in this field. | Xi-Yin Li Jian-Fang Gui | 2018 | Science China(Life Sciences)2018，61，12： | 20 |
| 15 | Mechanisms of fibrogenesis in liver cirrhosis:The molecular aspects of epithelial-mesenchymal transition显示文摘Liver injuries are repaired by fibrosis and regeneration.The cause of fibrosis and diminished regeneration,especially in liver cirrhosis,is still unknown.Epithelialmesenchymal transition(EMT) has been found to be associated with liver fibrosis.The possibility that EMT could contribute to hepatic fibrogenesis reinforced the concept that activated hepatic stellate cells are not the only key players in the hepatic fibrogenic process and that other cell types,either hepatic or bone marrow-derived cells could contribute to this process.Following an initial enthusiasm for the discovery of this novel pathway in fibrogenesis,more recent research has started to cast serious doubts upon the real relevance of this phenomenon in human fibrogenetic disorders.The debate on the authenticity of EMT or on its contribution to the fibrogenic process has become very animated.The overall result is a general confusion on the meaning and on the definition of several key aspects.The aim of this article is to describe how EMT participates to hepatic fibrosis and discuss the evidence of supporting this possibility in order to reach reasonable and useful conclusions. | Sun-Jae Lee Kyung-Hyun Kim Kwan-Kyu Park | 2014 | World Journal of Hepatology2014，6，4： | 18 |
| 16 | A recording phase lag between ocean and continent climate changes: constrained by the Matuyama/Brunhes polarity boundary显示文摘The Matuyama/Brunhes polarity boundary (MBPB) is recorded in Chinese loess L8, which is associated with the glacial period. It is proved that loess L8 is capable of recording earth’s secular variation, and the lock-in depth in Chinese loess is no more than that of marine sediments. Comparison with the location of MBPB in Chinese loess and marine sediments, it is put forward that there is a recording phase lag between ocean and continent climate changes. | Rixiang Zhu Yongxin Pan Bin Guo Qingsong Liu | 1998 | Chinese Science Bulletin1998，43，19： | 16 |
| 17 | Down.regulation of E.cadherin enhances prostate cancer chemoresistance via Notch signaling显示文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance. | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T. Keller Yi Lu Jian Zhang | 2017 | Chinese Journal of Cancer2017，36，3： | 16 |
| 18 | Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy显示文摘BACKGROUND Esophageal cancer is a common digestive tract tumor that is generally treated with radiotherapy.Poor responses to radiotherapy in most patients generally result in local radiotherapy failure,so it is essential to find new radiosensitizers that can enhance the response of cancer cells to radiotherapy and improve the survival of esophageal cancer patients with radiation resistance.The long noncoding RNA(lncRNA)Rpph1 is highly expressed in human gastric cancer tissues,and represses breast cancer cell proliferation and tumorigenesis.However,the expression of lncRNA Rpph1 in esophageal cancer and its relationship with radio-sensitivity has not been studied.AIM To explore the value of lncRNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy.METHODS Eighty-three patients with esophageal cancer admitted to Qilu Hospital of Shandong University and 90 healthy participants who received physical examinations were collected as research participants.The expression of Rpph1 was determined by qRT-PCR.siRNA-NC and siRNA-Rpph1 were transfected into esophageal cancer cell lines,and cells without transfection were designated as the blank control group.Cell survival was tested by colony formation assays,and the levels of proteins related to apoptosis and epithelial-mesenchymal transitions were determined by Western blot assays.Cell proliferation was assessed by MTT assays,cell apoptosis by flow cytometry,and cell migration by wound-healing assays.Changes in cell cycle distribution were monitored.RESULTS Rpph1 was highly expressed in esophageal carcinoma,making it a promising marker for the diagnosis of esophageal cancer.Rpph1 could also be used to distinguish different short-term responses,T stages,N stages,and clinical stages of esophageal cancer patients.The results of 3-year overall survival favored patients with lower Rpph1 expression over patients with higher Rpph1 expression(P<0.05).In vitro and in vivo experiments showed that silencing Rpph1 expression led to higher sensitivity of esophageal cancer cells to radiotherapy,stronger apoptosis in esophageal cancer cells induced by radiotherapy,higher expression of Bax and caspase-3,and lower expression of Bcl-2(Bax,caspase-3,and Bcl-2 are apoptosis-related proteins).Additionally,silencing Rpph1 attenuated radiation-induced G2/M phase arrest,and significantly inhibited the expression of proteins involved in cell proliferation,migration,and epithelial-mesenchymal transition regulation in esophageal cancer cells.CONCLUSION Rpph1 is highly expressed in esophageal cancer.Silencing Rpph1 expression can promote cell apoptosis,inhibit cell proliferation and migration,and increase radio-sensitivity. | Zhen-Yang Li Hui-Fen Li Ying-Ying Zhang Xue-Lan Zhang Bing Wang Jiang-Ting Liu | 2020 | World Journal of Gastroenterology2020，26，15： | 16 |
| 19 | Expression and significance of E-cadherin,N-cadherin,transforming growth factor-β1 and Twist in prostate cancer显示文摘Objective:To study the expression of E-cadherin,N-cadherin,TGF-|3 1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer.Methods:The expression of E-cadherin,N-cadherin,TGF-β1 and Twist protein in 59 prostate cancer tissues and 21 adjacent tissues were detected by immunohistochemical SABC staining,and the correlation with clinicopathological features was analyzed.Results:Positive rates of E-cadherin,N-cadherin,TGF-β1 and Twist were 32.2%,54.2%,71.2%and 74.6%,respectively,in prostate cancer tissues and 85.7%,9.52%,19.0%and 9.52%,respectively,in cancer—adjacent tissues,with significant differences between the two groups(P<0.05).The reduced expression of E-cadherin was related to the differentiation of prostate cancer tissues and PSA level,but was not associated with clinical stage,lymph node metastasis,bony metastasis and age.The increased expression of N-cadherin,TGF-β1 and Twist was related to the differentiation of prostate cancer tissues,clinical stage,lymph node metastasis,bony metastasis,but not to age.The difference in positive expression of N-cadherin and TGF-β1 was significant between PSA≤20μg/L group and PSA>20μg/L group,but the positive expression of Twist was not significant between groups.The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also highly negatively correlated with that of Twist The expression of TGF-β1 was correlated with those of E-cadherin,N-cadherin and Twist.Conclusions:The reduced expression of E-cadherin,abnormal expression of N-cadherin,transformation form E-cadherin to N-cadherin and the increased expression of TGF-β1 and Twist play an important role in the occurrence and development of prostate cancer. | Ge-Liang Liu Han-Jie Yang Tian Liu Yun-Zhao Lin | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，1： | 15 |
| 20 | NUMERICAL STUDY ON THE DYNAMIC AND THERMODYNAMIC EFFECTS OF THE QINGHAI-XIZANG PLATEAU ON THE SEASONAL TRANSITION IN THE EARLY SUMMER IN EAST ASIA显示文摘By employing a five-layer seasonal numerical weather prediction model and utilizing the National MeteorologicalCenter (NMC) objective analysis data on May 10,1991 as the initial field,three numerical experiments——diabatic withorography,adiabatic with orography and adiabatic without orography——have been carried out to investigate the dy-namic and thermodynamic effects of the Qinghai-Xizang Plateau (hereafter the Plateau) on the seasonal transition inthe early summer in East Asia.The results show that the typical seasonal transition features such as the northward shiftof the subtropical westerly jet stream,the adjustment of the long-wave in middle and high latitudes and the changes ofthe circulation in the lower troposphere can be well simulated,if the dynamic and thermodynamic effects of the Plateauare both considered in the model as in the experiment adiabatic with orography.In other two experiments,it is failed tosimulate out the seasonal transition features.The results also show that the thermodynamic effect of the Plateau acts on the atmosphere as a gradually enhancedheating source in the early summer,which makes the air temperature in 500 hPa over the Plateau increase by nearly 10℃in a month and accelerates the northward shift of the subtropical westerly jet stream about seven latitudes more north-ward in twenty days and helps the shifted jet maintain at the northern periphery of the Plateau.It is also helpful to theformation and maintenance of the Lake Balchas trough and the northward and westward extension of the Pacificsubtropical high.On the other hand,the dynamic effect of the Plateau weakens the northward shift of the subtropicalwesterly jet stream and barricades the westward extension of the Pacific subtropical high.If only the dynamic effect ofthe Plateau is considered in the model without consideration of the thermodynamic effect of the Plateau,not only theshifted jet withdraws southward but also the simulated Lake Balchas trough is 10 longitudes more eastward than that inthe diabatic experiment,and the simulated Pacific subtropical high is more eastward and northward.However,the dy-namic effect of the Plateau strengthens the vertical movements in the west and east of the Plateau and makes thelow-level jet maintain in the southeast of the Plateau.The path of the cold air and the tunnel of the water vapor in thelower troposphere during the seasonal transition period in the early summer in East Asia are determined by the couplingof the dynamic and thermodynamic effects of the Plateau. | 郑庆林 吴军 | 1995 | Acta meteorologica Sinica1995，9，1： | 15 |
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